Article
Biology
Almut S. Eisele, Jason Cosgrove, Aurelie Magniez, Emilie Tubeuf, Sabrina Tenreira Bento, Cecile Conrad, Fanny Cayrac, Tamar Tak, Anne-Marie Lyne, Jos Urbanus, Leila Perie
Summary: This study used cellular barcoding to trace the differentiation of mouse hematopoietic stem and progenitor cells (HSPCs) after exposure to EPO. The researchers found that EPO can directly act on multipotent progenitor cells (MPP) and modulate fate by remodeling the clonal composition of the MPP pool.
Article
Immunology
Shufeng Luo, Huiling Lin, Lan Zhu, Hai-Tian Chen, Siqian Yang, Jinheng Li, Mingyu Liu, Limin Zheng, Chong Wu
Summary: Under stress conditions, HSPCs can interpret danger signals into cytokine signals to modify hematopoietic output. A flow cytometry-based method was developed to assess intracellular cytokines in HSPCs, revealing distinct regulatory modes of cytokine production depending on subset, cytokine, disease, organ, and species. This technical advance helps to better understand HSPC heterogeneity based on differential cytokine production.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Runfeng Miao, Harim Chun, Xing Feng, Ana Cordeiro Gomes, Jungmin Choi, Joao P. Pereira
Summary: This study reveals that a complex homeostatic balance between hematopoietic stem cells (HSCs) and hematopoietic progenitor cells is maintained through competition for a limited amount of cell signaling molecule. When early hematopoietic progenitors fail to interact with specific cells, HSC numbers increase.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Fa Wang, Christopher Ting, Kent A. Riemondy, Michael Douglas, Kendall Foster, Nisha Patel, Norihito Kaku, Alexander Linsalata, Jean Nemzek, Brian M. Varisco, Erez Cohen, Jasmine A. Wilson, David W. H. Riches, Elizabeth F. Redente, Diana M. Toivola, Xiaofeng Zhou, Bethany B. Moore, Pierre A. Coulombe, M. Bishr Omary, Rachel L. Zemans
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease caused by impaired regeneration of alveolar epithelial cells after injury. Genetic variants of human keratin 8 (KRT8) are associated with IPF. In mouse models, transitional cells and fibrosis resolve, while in human IPF, transitional AECs evolve into an aberrant basaloid state that persists with progressive fibrosis.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Immunology
Carsten Riether
Summary: Adult bone marrow hematopoietic stem cells (HSCs) maintain their function through interactions with regulatory T cells (Tregs). In leukemia, these regulatory mechanisms are disrupted, leading to compromised treatment outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell & Tissue Engineering
Jianan Jiang, Jinhua Qin, Jisheng Li, Xiaosong Lin, Bowen Zhang, Zeng Fan, Lijuan He, Quan Zeng, Wen Yue, Min Zheng, Xuetao Pei, Yanhua Li
Summary: This study found that the small molecule Ricolinostat can promote the differentiation of megakaryocytic cells from HSPCs, increase the proliferation of megakaryocytic cells, and decrease the secretion of IL-8 and the expression of CXCR2, thereby improving the efficiency of megakaryocytic differentiation of HSPCs.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Immunology
Lifei Hou, Koichi Yuki
Summary: CD11a plays a critical role in leukocyte arrest and immunological synapse formation, but its role in the bone marrow is not well studied. This research showed that CD11a is expressed on all subsets of hematopoietic stem and progenitor cells (HPSCs). CD11a deficiency enhances HSPCs activity under LPS stimulation, possibly by upregulating the production of IL-27 to promote cell proliferation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Daniel E. Morales-Mantilla, Bailee Kain, Duy Le, Anthony R. Flores, Silke Paust, Katherine Y. King
Summary: This study suggests that hematopoietic stem and progenitor cells (HSPCs) have the potential to be used as a new therapeutic strategy for sepsis. Infusion of HSPCs in mice with sepsis resulted in improved survival rates and reduced inflammation. These findings highlight the important immunomodulatory role of HSPCs and their potential for treating sepsis.
Article
Cell Biology
Diego A. Lopez, April C. Apostol, Eric J. Lebish, Clint H. Valencia, Mari Carmen Romero-Mulero, Polina Pavlovich, Gloria E. Hernandez, E. Camilla Forsberg, Nina Cabezas-Wallscheid, Anna E. Beaudin
Summary: Adult hematopoietic stem and progenitor cells respond to inflammation and infection, and fetal hematopoietic stem and progenitor cells also respond to prenatal inflammation, shaping post-natal hematopoiesis and immune cell function. Maternal immune activation causes diverse responses in fetal hematopoietic stem and progenitor cells, including changes in quiescence, expansion, and lineage-biased output.
Review
Immunology
Lindsey B. B. Crawford
Summary: Human betaherpesviruses, including HCMV, HHV-6a, HHV-6b, and HHV-7, infect and establish latency in CD34+ HPCs. The interactions between these viruses and host HPCs regulate viral lifecycle and latency. Precise manipulation of host and viral factors contribute to viral genome maintenance, increased host cell survival, and manipulation of the cellular environment. This review highlights the complexities of betaherpesvirus latency and HPC virus-host interactions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Engineering, Biomedical
Wenjing Li, Haiwei Liang, Yanxiao Ao, Baixue Tang, Junyang Li, Ning Li, Jianwei Wang, Yanan Du
Summary: Hematopoietic stem cells (HSCs) have the ability to differentiate into all blood cells and immune cells. By simulating the bone marrow microenvironment, we designed degradable scaffolds to regulate the fate of HSCs. In vivo transplantation confirmed the importance of the scaffolds in maintaining hematopoietic function, providing a foundation for parameter design in 3D HSC culture systems.
Review
Developmental Biology
Suwei Gao, Yifan Zhang, Feng Liu
Summary: For a long time, it was believed that self-renewing and multipotent hematopoietic stem cells (HSCs) were the main contributors to both embryonic and adult hematopoiesis. However, recent studies have shown that native hematopoiesis is not solely driven by hierarchical differentiation of HSCs, but rather by hematopoietic progenitor cells (HPCs). These findings help redefine our understanding of the cellular origins of embryonic and adult hematopoiesis and highlight the differences in revealing HSC potential versus HSC fate using different approaches.
Article
Engineering, Biomedical
Yun Chang, Ramizah Syahirah, Stephanie N. Oprescu, Xuepeng Wang, Juhyung Jung, Scott H. Cooper, Sandra Torregrosa-Allen, Bennett D. Elzey, Alan Y. Hsu, Lauren N. Randolph, Yufei Sun, Shihuan Kuang, Hal E. Broxmeyer, Qing Deng, Xiaojun Lian, Xiaoping Bao
Summary: This study demonstrates the successful generation of AGM-like hematopoietic system from human pluripotent stem cells through temporal manipulation of Wnt signaling. The generated hematopoietic progenitor cells resemble primary cord blood HSCs at the transcriptional level and exhibit lymphoid and myeloid potential in vitro. The cells also show the ability to home to a definitive hematopoietic site, rescue bloodless zebrafish, and engraft and repopulate in mouse recipients.
Review
Cell & Tissue Engineering
Pijus K. Barman, Helen S. Goodridge
Summary: Balanced production of immune cells is important for immune surveillance, and commensal microbes can influence hematopoietic stem and progenitor cell (HSPC) activity. HSPCs sense microbes through pattern recognition receptors and cytokine receptors, and the long-term effects of microbial stimuli on HSPCs are significant. There may be a connection between myeloid-biased hematopoiesis and elevated levels of microbiome-derived components in aging and metabolic stress. Trained immunity-based vaccines that exploit microbial stimulation of HSPCs show promise.
Article
Biochemistry & Molecular Biology
You Jung Hwang, Dong-Yeop Shin, Min-Jung Kim, Hyosun Jang, Soyeon Kim, Hyunwon Yang, Won Il Jang, Sunhoo Park, Sehwan Shim, Seung Bum Lee
Summary: This study found that SR1 could alleviate radiation-induced hematopoietic injury. It increased the survival rate and promoted the recovery of peripheral blood cell counts in irradiated mice. In vitro experiments also showed that SR1 increased the population of human hematopoietic stem/progenitor cells, reduced radiation-induced DNA damage and apoptosis. These results suggest that SR1 may be a potential radiomitigator for hematopoietic injury.
Article
Virology
Basavaraj Binjawadagi, Yashavanth Shaan Lakshmanappa, Zhu Longchao, Santosh Dhakal, Jagadish Hiremath, Kang Ouyang, Duan-Liang Shyu, Jesus Arcos, Shang Pengcheng, Aaron Gilbertie, Federico Zuckermann, Jordi B. Torrelles, Daral Jackwood, Ying Fang, Gourapura J. Renukaradhya
ARCHIVES OF VIROLOGY
(2016)
Review
Immunology
Randy R. Brutkiewicz
JOURNAL OF IMMUNOLOGY
(2016)
Article
Virology
Yanhua Li, Duan-Liang Shyu, Pengcheng Shang, Jianfa Bai, Kang Ouyang, Santosh Dhakal, Jagadish Hiremath, Basavaraj Binjawadagi, Gourapura J. Renukaradhya, Ying Fang
JOURNAL OF VIROLOGY
(2016)
Article
Microbiology
Varun Dwivedi, Cordelia Manickam, Santosh Dhakal, Basavaraj Binjawadagi, Kang Ouyang, Jagadish Hiremath, Mahesh Khatri, Jacquelyn Gervay Hague, Chang Won Lee, Gourapura J. Renukaradhya
VETERINARY MICROBIOLOGY
(2016)
Review
Agriculture, Dairy & Animal Science
Joan K. Lunney, Ying Fang, Andrea Ladinig, Nanhua Chen, Yanhua Li, Bob Rowland, Gourapura J. Renukaradhya
ANNUAL REVIEW OF ANIMAL BIOSCIENCES, VOL 4
(2016)
Article
Immunology
Jianyun Liu, Randy R. Brutkiewicz
Review
Immunology
Randy R. Brutkiewicz, Laura Yunes-Medina, Jianyun Liu
CURRENT OPINION IN IMMUNOLOGY
(2018)
Article
Immunology
Jianyun Liu, Richard M. Gallo, Masood A. Khan, Gourapura J. Renukaradhya, Randy R. Brutkiewicz
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Immunology
Jianyun Liu, Richard M. Gallo, Masood A. Khan, Abhirami K. Iyer, Ian M. Kratzke, Randy R. Brutkiewicz
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Article
Immunology
Mohamed Elaish, Ming Xia, John M. Ngunjiri, Amir Ghorbani, Hyesun Jang, K. C. Mahesh, Michael C. Abundo, Santosh Dhakal, Renukaradhya Gourapura, Xi Jiang, Chang-Won Lee
Article
Nanoscience & Nanotechnology
Sankar Renu, Ashley D. Markazi, Santosh Dhakal, Yashavanth S. Lakshmanappa, Revathi Shanmugasundaram, Ramesh K. Selvaraj, Gourapura J. Renukaradhya
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Correction
Multidisciplinary Sciences
Ping Li, Julia R. Walsh, Kevin Lopez, Abdulkadir Isidan, Wenjun Zhang, Angela M. Chen, William C. Goggins, Nancy G. Higgins, Jianyun Liu, Randy R. Brutkiewicz, Lester J. Smith, Hidetaka Hara, David K. C. Cooper, Burcin Ekser
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Ping Li, Julia R. Walsh, Kevin Lopez, Abdulkadir Isidan, Wenjun Zhang, Angela M. Chen, William C. Goggins, Nancy G. Higgins, Jianyun Liu, Randy R. Brutkiewicz, Lester J. Smith, Hidetaka Hara, David K. C. Cooper, Burcin Ekser
Summary: In vitro evaluation of human immune responses to genetically modified porcine cells provides an efficient method to identify ideal combinations of genetic modifications for improving pig-to-human compatibility, which should accelerate the application of xenotransplantation to humans.
SCIENTIFIC REPORTS
(2021)
Review
Veterinary Sciences
Santosh Dhakal, Gourapura J. Renukaradhya
VETERINARY RESEARCH
(2019)
Article
Veterinary Sciences
Kang Ouyang, Jagadish Hiremath, Basavaraj Binjawadagi, Duan-Liang Shyu, Santosh Dhakal, Jesus Arcos, Rose Schleappi, Lynette Holman, Michael Roof, Jordi B. Torrelles, Gourapura J. Renukaradhya
VETERINARY RESEARCH
(2016)