Proper desensitization of CXCR4 is required for lymphocyte development and peripheral compartmentalization in mice

CXC Chemokine Ligand 12 Promotes CCR7-Dependent Naive T Cell Trafficking to Lymph Nodes and Peyer's Patches

(2014) Z. Bai et al.   JOURNAL OF IMMUNOLOGY

The CXCR4 antagonist plerixafor is a potential therapy for myelokathexis, WHIM syndrome

(2011) D. C. Dale et al.   BLOOD

The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome

(2011) D. H. McDermott et al.   BLOOD

The CXCR7 chemokine receptor promotes B-cell retention in the splenic marginal zone and serves as a sink for CXCL12

(2011) H. Wang et al.   BLOOD

Sequential desensitization of CXCR4 and S1P5 controls natural killer cell trafficking

(2011) K. Mayol et al.   BLOOD

Dual Roles for Rac2 in Neutrophil Motility and Active Retention in Zebrafish Hematopoietic Tissue

(2011) Qing Deng et al.   DEVELOPMENTAL CELL

T Lymphocytes Negatively Regulate Lymph Node Lymphatic Vessel Formation

(2011) Raghu P. Kataru et al.   IMMUNITY

Follicular dendritic cells help establish follicle identity and promote B cell retention in germinal centers

(2011) Xiaoming Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Three chemokine receptors cooperatively regulate homing of hematopoietic progenitors to the embryonic mouse thymus

(2011) L. Calderon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prodrugs of a CXC Chemokine-12 (CXCL12) Neutraligand Prevent Inflammatory Reactions in an Asthma Model in Vivo

(2011) Vincent Gasparik et al.   ACS Medicinal Chemistry Letters

Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome

(2010) K. B. Walters et al.   BLOOD

Oligoclonality, impaired class switch and B-cell memory responses in WHIM syndrome

(2010) Peter J. Mc Guire et al.   CLINICAL IMMUNOLOGY

Site-specific Phosphorylation of CXCR4 Is Dynamically Regulated by Multiple Kinases and Results in Differential Modulation of CXCR4 Signaling

(2010) John M. Busillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMD3100 is a potent antagonist at CXCR4R334X, a hyperfunctional mutant chemokine receptor and cause of WHIM syndrome

(2010) David H. McDermott et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow

(2010) Kyle J. Eash et al.   JOURNAL OF CLINICAL INVESTIGATION

The bone marrow: a site of neutrophil clearance

(2010) S. M. Rankin   JOURNAL OF LEUKOCYTE BIOLOGY

An Essential Role of the Cytoplasmic Tail of CXCR4 in G-Protein Signaling and Organogenesis

(2010) Darran G. Cronshaw et al.   PLoS One

Stromal cell-derived factor 1α and CXCR4: newly defined requirements for efficient thymic β-selection

(2010) Michelle L. Janas et al.   TRENDS IN IMMUNOLOGY

A quadrivalent HPV vaccine induces humoral and cellular immune responses in WHIM immunodeficiency syndrome

(2010) Alessandra Handisurya et al.   VACCINE

Safety and preliminary efficacy of plerixafor (Mozobil) in combination with chemotherapy and G-CSF: an open-label, multicenter, exploratory trial in patients with multiple myeloma and non-Hodgkin's lymphoma undergoing stem cell mobilization

(2009) M J Dugan et al.   BONE MARROW TRANSPLANTATION

Clinical and genetic diagnosis of warts, hypogammaglobulinemia, infections, and myelokathexis syndrome in 10 patients

(2009) Laura Tassone et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CXCR4 acts as a costimulator during thymic β-selection

(2009) Paul C Trampont et al.   NATURE IMMUNOLOGY

Impaired Recruitment of Grk6 and β-Arrestin2 Causes Delayed Internalization and Desensitization of a WHIM Syndrome-Associated CXCR4 Mutant Receptor

(2009) Peter J. McCormick et al.   PLoS One

CXCR4 dimerization and  -arrestin-mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM syndrome

(2008) B. Lagane et al.   BLOOD

WHIM syndrome: congenital immune deficiency disease

(2008) Toshinao Kawai et al.   CURRENT OPINION IN HEMATOLOGY

Neutrophil mobilization and clearance in the bone marrow

(2008) Rebecca C. Furze et al.   IMMUNOLOGY

Small Neutralizing Molecules to Inhibit Actions of the Chemokine CXCL12

(2008) Muriel Hachet-Haas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY