Article
Biochemistry & Molecular Biology
Fabian Bohlaender, Sabrina Weissmueller, Dennis Riehl, Marcus Gutscher, Joerg Schuettrumpf, Stefanie Faust
Summary: The study aims to investigate the functional aspects of the IgA component in trimodulin, a new plasma-derived polyvalent immunoglobulin preparation, and demonstrates its potent immunomodulatory and anti-pathogenic effects, especially on neutrophil function.
Article
Clinical Neurology
Lu Lin, Abrar Al-Faraj, Neishay Ayub, Pablo Bravo, Sudeshna Das, Lorenzo Ferlini, Ioannis Karakis, Jong Woo Lee, Shibani S. Mukerji, Christopher R. Newey, Jay Pathmanathan, Myriam Abdennadher, Charles Casassa, Nicolas Gaspard, Daniel M. Goldenholz, Emily J. Gilmore, Jin Jing, Jennifer A. Kim, Eyal Y. Kimchi, Harshad S. Ladha, Steven Tobochnik, Sahar Zafar, Lawrence J. Hirsch, M. Brandon Westover, Mouhsin M. Shafi
Summary: This study demonstrates that seizures and other epileptiform abnormalities are common in patients with COVID-19 undergoing continuous EEG monitoring and are associated with adverse clinical outcomes.
ANNALS OF NEUROLOGY
(2021)
Article
Immunology
Wanyin Hou, Sufang Shi, Xujie Zhou, Suxia Wang, Qingqing Cai, Pei Chen, Lijun Liu, Li Zhu, Jicheng Lv, Hong Zhang
Summary: This study investigates the role of CFH/CFHRs gene variants in IgAN with microangiopathy. The results show that CFH variants are associated with the development and progression of IgAN with microangiopathy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Y. Saleh, I. Jarratt-Barnham, P. Petitet, E. Fernandez-Egea, S. G. Manohar, M. Husain
Summary: Motivational deficits in treatment resistant schizophrenia are characterized by reduced reward sensitivity and less effort aversion during effort-based decision making. These behavioral changes are associated with negative symptoms and cognitive impairment, but not with antipsychotic treatment or positive symptoms.
MOLECULAR PSYCHIATRY
(2023)
Article
Genetics & Heredity
Che Kang Lim, Paola G. Bronson, Jezabel Varade, Timothy W. Behrens, Lennart Hammarstroem
Summary: The etiology of IgAD differs depending on the genetic background of HLA susceptibility haplotypes, highlighting the importance of genetic risk factors in this primary immune deficiency.
FRONTIERS IN GENETICS
(2021)
Review
Urology & Nephrology
Micaela Gentile, Luis Sanchez-Russo, Leonardo Riella, Alberto Verlato, Joaquin Manrique, Simona Granata, Enrico Fiaccadori, Francesco Pesce, Gianluigi Zaza, Paolo Cravedi
Summary: Immunoglobulin A (IgA) nephropathy (IgAN) is a common kidney disease characterized by the deposition of IgA antibodies in the glomerulus. This leads to kidney damage and can progress to end-stage kidney disease. The disease involves a complex immune process and is influenced by genetic and environmental factors.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Hao Wei, Ji-Yang Wang
Summary: Transcytosis of polymeric IgA and IgM mediated by pIgR is essential for mucosal immunity. The J chain plays a crucial role in the formation and recognition of polymeric IgA and IgM by pIgR, while MZB1 may act as a regulator to facilitate IgA and IgM transcytosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Michael Ruzicka, Sonja Wurm, Lars Lindner, Martin Dreyling, Michael Von Bergwelt-Baildon, Stefan Boeck, Clemens Giessen-Jung, Valeria Milani, Joachim H. Stemmler, Marion Subklewe, Oliver Weigert, Karsten Spiekermann
Summary: Thrombocytopenia after COVID-19 vaccination should be diagnosed to exclude vaccine-induced immune thrombotic thrombocytopenia (VITT) and, if confirmed, treated according to current ITP guidelines. Re-vaccination of patients seems feasible under close monitoring of blood counts and using a vaccine that differs from the one triggering the initial episode of VA-ITP.
Article
Anesthesiology
Sarasa Tohyama, Matthew R. Walker, Jia Y. Zhang, Joshua C. Cheng, Mojgan Hodaie
Summary: The study utilized diffusion tensor imaging (DTI) to identify microstructural abnormalities in the brainstem trigeminal fibers as a common biomarker of surgical response in trigeminal neuralgia (TN), which may vary across different subtypes of TN. Abnormalities in the affected pontine trigeminal fibers were found to distinguish treatment nonresponders from responders, with the degree of abnormalities associated with the likelihood of surgical response across TN subtypes. This highlights the potential value of DTI as a noninvasive tool for predicting treatment response and understanding differences in TN treatment outcomes.
Article
Immunology
Jie Hou, Li Zhang, Hao Wu, Pujun Gao, Zhonggao Xu
Summary: The study revealed that in patients with IgA nephropathy, levels of circulating CD14+Tim-3+ cells were elevated and correlated with pathological features, indicating a potential involvement of Tim-3+ monocytes/macrophages in the pathogenesis of the disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Psychology, Multidisciplinary
Massimiliano Buoli, Enrico Capuzzi, Alice Caldiroli, Alessandro Ceresa, Cecilia Maria Esposito, Cristina Posio, Anna Maria Auxilia, Martina Capellazzi, Ilaria Tagliabue, Teresa Surace, Francesca Legnani, Luisa Cirella, Martina Di Paolo, Guido Nosari, Francesco Zanelli Quarantini, Massimo Clerici, Fabrizia Colmegna, Antonios Dakanalis
Summary: TRD patients were older, had longer illness duration, were more often treated with psychiatric poly-therapy, had more severe depressive symptoms, had lower bilirubin levels, and had more history of suicide attempts and antidepressant treatments. Candidate biomarkers such as bilirubin levels and NLR were associated with TRD, indicating a predisposition to suicidal behaviors. Future research should replicate these findings for new treatment targets and prevention strategies.
BEHAVIORAL SCIENCES
(2022)
Article
Medicine, General & Internal
Camille Cohen, Severine Coulon, Kanit Bhukhai, Antoine Neuraz, Michael Dussiot, Guillemette Fouquet, Marie-Benedicte Le Stang, Martin Flamant, Francois Vrtovsnik, Aurelie Hummel, Bertrand Knebelmann, Laurent Mesnard, Eric Rondeau, Thiago T. Maciel, Fabrizia Favale, Nicole Casadevall, Thao Nguyen-Khoa, Stephane Moutereau, Christophe Legendre, Marc Benhamou, Renato C. Monteiro, Olivier Hermine, Khalil El Karoui, Ivan C. Moura
Summary: The involvement of IgA1 in unexplained polycythemia/erythrocytosis (PE) of IgA nephropathy (IgAN) patients was evaluated in this study. It was found that IgA1 plays a role in regulating erythropoiesis and elevated IgA1 levels increase the sensitivity of erythroid progenitors to Epo.
Article
Gastroenterology & Hepatology
Hussein Mahajna, Bram Verstockt, Daniel Bergemalm, Fabiana Castiglione, Fransisco Rodriguez-Moranta, Edoardo Savarino, Frank Hoentjen, Talat Bessissow, Jagoda Pokryszka, Anneline Cremer, Piotr Eder, Marie Truyens, Anat Yerushalmy-Feler, Maria Jose Garcia, Uri Kopylov
Summary: The study evaluated the clinical presentation and outcome of ITP in patients with IBD. The majority of ITP cases occurred after the diagnosis of IBD and responded well to regular ITP treatment.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Immunology
Merle Sauer, Joerg Scheffel, Stefan Frischbutter, Pavel Kolkhir, Yi-Kui Xiang, Frank Siebenhaar, Sabine Altrichter, Marcus Maurer, Martin Metz, Karoline Krause
Summary: Lower levels of serum IgA in CSU are associated with lower IgE levels and features of autoimmune urticaria. Screening for serum IgA and IgE levels in CSU patients is recommended as potential disease biomarkers. Increased prevalence of recurrent angioedema and concomitant autoimmunity were observed in patients with lower IgA and IgE levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Chaoyang Li, Meng Sun, Ranran Li, Shuwen Wang, Linlin Shao, Miao Xu, Meiyue Yao, Lin Wang, Ming Hou, Qi Feng, Jun Peng
Summary: This study retrospectively investigated 458 patients with ITP and found that 7.6% of them had comorbid T2DM. Patients with pre-existing T2DM had a better response to therapy, especially when metformin was included in the treatment regimen.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)