Review
Oncology
Lukas John, Maria Theresa Krauth, Klaus Podar, Marc-Steffen Raab
Summary: Multiple Myeloma is a cancer of plasma cells in the bone marrow. Pathway-directed therapy combined with personalized medicine can improve treatment outcomes. Targeting specific signaling pathways and conducting precision medicine trials may fundamentally change treatment strategies for Multiple Myeloma.
Article
Food Science & Technology
Tongxi Zhou, Guanjun Song, Di Tian, Qinghua Liu, Jinhua Shen, Xinzhou Yang, Ping Zhao
Summary: Nuciferine found in lotus leaves has been shown to improve hyperlipemia and hyperglycemia. In vitro studies revealed that nuciferine stimulates the translocation of glucose transporter 4 (GLUT4) through G protein-PLC-PKC and AMPK pathways, and increases intracellular Ca2+ levels through G protein-PLC-IP3-IP3R pathway, both of which promote glucose uptake. In vivo experiments using KK-Ay mice demonstrated that nuciferine ameliorates symptoms of insulin resistance, abnormal lipid metabolism, and weight gain induced by a high-fat diet. This research highlights the potential of nuciferine in the treatment of type 2 diabetes mellitus.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Entomology
Yan Li, Sha-Sha Wang, Su Wang, Shi-Gui Wang, Bin Tang, Fang Liu
Summary: Glut4 plays a key role in insect reproduction, and its interference may lead to decreased ovarian development and yolk formation, thereby affecting the fertility of insects.
Article
Biochemistry & Molecular Biology
Beth A. Griesel, Satoshi Matsuzaki, Albert Batushansky, Timothy M. Griffin, Kenneth M. Humphries, Ann Louise Olson
Summary: This study using 3T3-L1 adipocytes as a model system found that an increase in glucose uptake during the first 3 days of differentiation promoted the expansion of the adipocyte metabolome and proteome. The positive effects were specifically due to increased expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), highlighting its critical role in regulating cellular metabolic remodeling for adipocyte differentiation and maturation.
Article
Oncology
Niklas Kehl, Michael Kilian, Julius Michel, Tim R. Wagner, Sebastian Uhrig, Alexander Brobeil, Lilli-Sophie Sester, Sven Blobner, Simon Steiger, Michael Hundemer, Niels Weinhold, Karsten Rippe, Stefan Froehling, Stefan B. Eichmueller, Lukas Bunse, Carsten Mueller-Tidow, Hartmut Goldschmidt, Michael Platten, Marc-Steffen Raab, Mirco J. Friedrich
Summary: Multiple myeloma (MM) is a rare and aggressive hematological malignancy, and its classification and evolution can be deciphered by molecular features. IgE type MM is a subtype with a small percentage but poor prognosis, and currently there is limited genetic and immunological data available. In this study, comprehensive analysis at the genomic and immune repertoire level revealed the pathophysiological mechanisms and potential targeted therapy opportunities for IgE type MM.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Endocrinology & Metabolism
Jinhee Hwang, Debbie C. Thurmond
Summary: The impaired GLUT4 translocation and defects in SNARE proteins and their regulators are closely related to the pathogenesis of diabetes. Novel functions of SNARE proteins in pathways not typically associated with SNAREs may provide new therapeutic targets for combating insulin resistance and diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ilka Guenther, Gerald Rimbach, Sandra Nevermann, Cathrina Neuhauser, Verena Stadlbauer, Bettina Schwarzinger, Clemens Schwarzinger, Ignacio R. Ipharraguerre, Julian Weghuber, Kai Lueersen
Summary: Medicinal plant extracts are being explored as alternative treatments for diabetes, with avens root extract showing promising results in inhibiting key enzymes and reducing blood glucose levels in in-vivo models. The high polyphenolic content of avens root extract warrants further investigation for potential use in treating hyperglycemia in human and rodent models.
FRONTIERS IN PHARMACOLOGY
(2021)
Letter
Oncology
Quan Ren, Yingling Zu, Hongchang Su, Qiumei Lu, Bin Xiang, Yanping Luo, Jishuai Zhang, Yongping Song
Summary: Researchers synthesized four single VHH-directed anti-BCMA CAR-NK cells and improved their cytotoxicity by altering intracellular and hinge regions, as well as ectopically expressing IL-15. In vitro and in vivo experiments demonstrated that BCMA-CD28-IL15 CAR-NK cells exhibited strong killing ability and cytokine secretion against BCMA+ tumor cells, indicating their potential application in multiple myeloma treatment.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Article
Integrative & Complementary Medicine
Chih-Chieh Chen, Chong-Kuei Lii, Chia-Wen Lo, Yi-Hsueh Lin, Ya-Chen Yang, Chin-Shiu Huang, Haw-Wen Chen
Summary: DeAND can improve insulin resistance in muscles by activating the AMP-activated protein kinase (AMPK) signaling pathway, leading to enhanced glucose uptake and insulin sensitivity.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Evert Njomen, Allison Vanecek, Theresa A. Lansdell, Ya-Ting Yang, Peter Z. Schall, Christi M. Harris, Matthew P. Bernard, Daniel Isaac, Omar Alkharabsheh, Anas Al-Janadi, Matthew B. Giletto, Edmund Ellsworth, Catherine Taylor, Terence Tang, Sarah Lau, Marc Bailie, Jamie J. Bernard, Vilma Yuzbasiyan-Gurkan, Jetze J. Tepe
Summary: This article introduces a treatment method for multiple myeloma that reduces MYC protein levels by enhancing the activation of 20S proteasome, thereby reducing cancer cell growth and improving apoptotic signaling. The experiments demonstrate the potential of this method in in vitro and in vivo models.
Review
Cell Biology
Ignacio J. Cardona-Benavides, Cristina de Ramon, Norma C. Gutierrez
Summary: This review summarizes the main genetic abnormalities in multiple myeloma and their therapeutic approaches, highlighting certain mutations as potential targets for personalized medicine.
Review
Cell Biology
Zachary S. Bernstein, E. Bridget Kim, Noopur Raje
Summary: Multiple Myeloma is a hematologic malignancy characterized by the proliferation of monoclonal plasma cells in the bone marrow, often leading to bone disease and osteolytic lesions. Treatment options can include osteoclast inhibitory therapies to delay and reduce the risk of skeletal-related events.
Article
Genetics & Heredity
Alice Williamson, Dougall M. Norris, Xianyong Yin, K. Alaine Broadaway, Anne H. Moxley, Swarooparani Vadlamudi, Emma P. Wilson, Anne U. Jackson, Vasudha Ahuja, Mette K. Andersen, Zorayr Arzumanyan, Lori L. Bonnycastle, Stefan R. Bornstein, Maxi P. Bretschneider, Thomas A. Buchanan, Yi-Cheng Chang, Lee-Ming Chuang, Ren-Hua Chung, Tine D. Clausen, Peter Damm, Graciela E. Delgado, Vanessa D. de Mello, Josee Dupuis, Om P. Dwivedi, Michael R. Erdos, Lilian Fernandes Silva, Timothy M. Frayling, Christian Gieger, Mark O. Goodarzi, Xiuqing Guo, Stefan Gustafsson, Liisa Hakaste, Ulf Hammar, Gad Hatem, Sandra Herrmann, Kurt Hojlund, Katrin Horn, Willa A. Hsueh, Yi-Jen Hung, Chii-Min Hwu, Anna Jonsson, Line L. Karhus, Marcus E. Kleber, Peter Kovacs, Timo A. Lakka, Marie Lauzon, I-Te Lee, Cecilia M. Lindgren, Jaana Lindstroem, Allan Linneberg, Ching-Ti Liu, Jian'an Luan, Dina Mansour Aly, Elisabeth Mathiesen, Angela P. Moissl, Andrew P. Morris, Narisu Narisu, Nikolaos Perakakis, Annette Peters, Rashmi B. Prasad, Roman N. Rodionov, Kathryn Roll, Carsten F. Rundsten, Chloe Sarnowski, Kai Savonen, Markus Scholz, Sapna Sharma, Sara E. Stinson, Sufyan Suleman, Jingyi Tan, Kent D. Taylor, Matti Uusitupa, Dorte Vistisen, Daniel R. Witte, Romy Walther, Peitao Wu, Anny H. Xiang, Bjoern Zethelius, Emma Ahlqvist, Richard N. Bergman, Yii-Der Ida Chen, Francis S. Collins, Tove Fall, Jose C. Florez, Andreas Fritsche, Harald Grallert, Leif Groop, Torben Hansen, Heikki A. Koistinen, Pirjo Komulainen, Markku Laakso, Lars Lind, Markus Loeffler, Winfried Marz, James B. Meigs, Leslie J. Raffel, Rainer Rauramaa, Jerome I. Rotter, Peter E. H. Schwarz, Michael Stumvoll, Johan Sundstrom, Anke Toenjes, Tiinamaija Tuomi, Jaakko Tuomilehto, Robert Wagner, Ines Barroso, Mark Walker, Niels Grarup, Michael Boehnke, Nicholas J. Wareham, Karen L. Mohlke, Eleanor Wheeler, Stephen O'Rahilly, Daniel J. Fazakerley, Claudia Langenberg
Summary: Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states. Genome-wide association analyses of two oral glucose tolerance test-derived measures of postprandial insulin resistance discover ten new loci. Functional characterization identifies nine candidate genes implicated in the regulation of GLUT4.
Review
Chemistry, Analytical
Mara Heckmann, Gerald Klanert, Georg Sandner, Peter Lanzerstorfer, Manfred Auer, Julian Weghuber
Summary: This article reviews the methods used to quantify the translocation of GLUT4 to the plasma membrane, including microscopy-based techniques and biochemical and spectrometric approaches. These methods are of great importance in researching and identifying substances with insulinomimetic properties.
METHODS AND APPLICATIONS IN FLUORESCENCE
(2022)
Article
Multidisciplinary Sciences
Aditi Sharma, Remya Nair, Abhinav Achreja, Anjali Mittal, Pulkit Gupta, Kamakshi Balakrishnan, Claudia L. Edgar, Olamide Animasahun, Bhakti Dwivedi, Benjamin G. Barwick, Vikas A. Gupta, Shannon M. Matulis, Manoj Bhasin, Sagar Lonial, Ajay K. Nooka, Arun P. Wiita, Lawrence H. Boise, Deepak Nagrath, Mala Shanmugam
Summary: This study reveals the link between metabolic state and therapy resistance in multiple myeloma. Suppression of the electron transport chain increases resistance to proteasome inhibitors. Mitochondrial stress-induced resistance can be alleviated by specific drugs.
Article
Oncology
Xochiquetzal U. Martinez, Arnab Chowdhury, Tracey Stiller, Joycelynne Palmer, Matthew Loscalzo, Estella Barrios, Farah R. Abdulla, Jasmine Zain, Steven T. Rosen, Christiane Querfeld
Summary: This study found that the impairment of quality of life in cutaneous lymphoma patients correlates with gender, age, race/ethnicity, and stage of mycosis fungoides/Sezary syndrome. While Sezary syndrome patients experience the most negative impact on quality of life, other sub-types of cutaneous lymphomas also affect quality of life and lead to psychosocial distress. The findings highlight the importance of assessing quality of life in all cutaneous lymphoma patients and further exploring disparities across demographic groups.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
Xu Cao, Bolei Li, Jing Chen, Jessica Dang, Siqi Chen, E. Gulsen Gunes, Bo Xu, Lei Tian, Sabina Muend, Mustafa Raoof, Christiane Querfeld, Jianhua Yu, Steven T. Rosen, Yingyu Wang, Mingye Feng
Summary: The study found that blocking CD47 and using cabazitaxel can significantly promote the programmed cell removal of TNBC cells, inhibiting tumor development and metastasis, providing a promising new strategy for TNBC treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Dermatology
N. A. Trum, J. Zain, X. U. Martinez, V Parekh, M. Afkhami, F. Abdulla, K. R. Carson, S. T. Rosen, C. L. Bennett, C. Querfeld
Summary: MAR incidence is higher in CTCL patients than previously reported. Diagnosis and treatment of MAR should be emphasized to improve outcomes.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Lei Huang, Ramireddy Bommireddy, Luis E. Munoz, Rohini N. Guin, Changyong Wei, Amanda Ruggieri, Ashwathi P. Menon, Xiaoxian Li, Mala Shanmugam, Taofeek K. Owonikoko, Suresh S. Ramalingam, Periasamy Selvaraj
Summary: The study demonstrates that transducing tdTomato and luciferase into LL/2 cells can slow tumor growth, alter the tumor microenvironment, and increase tumor-infiltrating lymphocytes. Interestingly, this transgenic expression does not affect LL/2 tumors' response to anti-PD-1 and anti-CTLA-4 antibodies.
Review
Immunology
Sanjay Chandrasekaran, Christopher Ronald Funk, Troy Kleber, Chrystal M. Paulos, Mala Shanmugam, Edmund K. Waller
Summary: PI3K-delta and PI3K-gamma play critical roles in T-cell biology by regulating T-cell function and phenotype. Inhibiting these pathways may be a promising approach for modulating T-cell responses in immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Li Du, Wei Liu, Flavia Pichiorri, Steven T. Rosen
Summary: This study identified SUMOylation as a potential mechanism regulating lenalidomide resistance in multiple myeloma. Inhibition of SUMOylation can enhance sensitivity to lenalidomide by downregulating IRF4 expression.
CANCER GENE THERAPY
(2023)
Letter
Hematology
Remya Nair, Vimal Subramaniam, Benjamin G. Barwick, Vikas A. Gupta, Shannon M. Matulis, Sagar Lonial, Lawrence H. Boise, Ajay K. Nooka, Kuzhali Muthumalaiappan, Mala Shanmugam
Article
Dermatology
Zhen Han, Renee J. Estephan, Xiwei Wu, Chingyu Su, Yate-Ching Yuan, Hanjun Qin, Sung Hee Kil, Corey Morales, Daniel Schmolze, James F. Sanchez, Lei Tian, Jianhua Yu, Marcin Kortylewski, Steven T. Rosen, Christiane Querfeld
Summary: Cutaneous T cell lymphoma (CTCL) is a malignant tumor characterized by chronic inflammation. This study found that miR-155-5p, miR-130b-3p, and miR-21-3p positively correlated with immune checkpoint gene expression in CTCL and were enriched in the IL-6/Jak/signal transducer and activator of transcription signaling pathway.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Letter
Oncology
Vikas A. Gupta, Shannon M. Matulis, Benjamin G. Barwick, R. Devin Bog, Conrad W. Shebelut, Mala Shanmugam, Paola Neri, Nizar J. Bahlis, Madhav V. Dhodapkar, Leonard T. Heffner, Craig C. Hofmeister, Nisha S. Joseph, Sagar Lonial, Jonathan L. Kaufman, David L. Jaye, Ajay K. Nooka, Lawrence H. Boise
BLOOD CANCER JOURNAL
(2022)
Article
Multidisciplinary Sciences
Aditi Sharma, Remya Nair, Abhinav Achreja, Anjali Mittal, Pulkit Gupta, Kamakshi Balakrishnan, Claudia L. Edgar, Olamide Animasahun, Bhakti Dwivedi, Benjamin G. Barwick, Vikas A. Gupta, Shannon M. Matulis, Manoj Bhasin, Sagar Lonial, Ajay K. Nooka, Arun P. Wiita, Lawrence H. Boise, Deepak Nagrath, Mala Shanmugam
Summary: This study reveals the link between metabolic state and therapy resistance in multiple myeloma. Suppression of the electron transport chain increases resistance to proteasome inhibitors. Mitochondrial stress-induced resistance can be alleviated by specific drugs.
Review
Biotechnology & Applied Microbiology
Thuy Phan, Xu Hannah Zhang, Steven Rosen, Laleh G. Melstrom
Summary: Gastrointestinal cancers are a major cause of cancer-related morbidity and mortality worldwide. The p38 signaling pathway, particularly p38 gamma, plays a crucial role in cancer development and metastasis. This article provides an overview of p38 and p38 gamma in gastrointestinal cancers, as well as discusses the potential of targeting p38 gamma as a therapy.
CANCER GENE THERAPY
(2023)
Article
Dermatology
Zhen Han, Xiwei Wu, Hanjun Qin, Yate-Ching Yuan, Jasmine Zain, D. Lynne Smith, Oleg E. Akilov, Steven T. Rosen, Mingye Feng, Christiane Querfeld
Summary: This study investigated the effects of CD47 and PD-L1 immune checkpoint blockades on cutaneous T-cell lymphoma (CTCL). The results showed that dual targeting of CD47 and PD-L1 enhanced immune activity and suppressed tumor growth.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Meeting Abstract
Hematology
Heather Lin, A. K. M. Nawshad Hossian, Biaggio Uricoli, Ruby Mei Freeman, Dejah A. Blake, Jonathan Legier, Remya Nair, Jean L. Koff, Mala Shanmugam, Erik Dreaden, Sarwish Rafiq
Article
Hematology
Christopher Ronald Funk, Shuhua Wang, Kevin Z. Chen, Alexandra Waller, Aditi Sharma, Claudia L. Edgar, Vikas A. Gupta, Shanmuganathan Chandrakasan, Jaquelyn T. Zoine, Andrew Fedanov, Sunil S. Raikar, Jean L. Koff, Christopher R. Flowers, Silvia Coma, Jonathan A. Pachter, Sruthi Ravindranathan, H. Trent Spencer, Mala Shanmugam, Edmund K. Waller
Summary: Manufacturing CART cells with PI3K delta/gamma inhibitor enriches CD8(+) CART cells with stem-like qualities and enhances the efficacy in eliminating CLL in vivo.
Review
Pharmacology & Pharmacy
Melissa Cheng, Jasmine Zain, Steven T. Rosen, Christiane Querfeld
Summary: This review discusses the recent advancements in biological and novel therapeutics for the management of CTCL. Mogamulizumab and brentuximab vedotin have been approved for CTCL treatment, providing valuable options for patients. Other therapies such as immune checkpoint inhibitors, miRNA inhibitors, and peptide inhibitors show promising results in clinical trials. However, further studies are needed to determine the long-term effectiveness of these treatments.
EXPERT OPINION ON EMERGING DRUGS
(2022)