Effector CD4+ T cells, the cytokines they generate, and GVHD: something old and something new

Phenotype Switching by Inflammation-Inducing Polarized Th17 Cells, but Not by Th1 Cells

(2014) G. Shi et al.   JOURNAL OF IMMUNOLOGY

Cutaneous GVHD is associated with the expansion of tissue-localized Th1 and not Th17 cells

(2010) R. Broady et al.   BLOOD

Stem cell mobilization with G-CSF induces type 17 differentiation and promotes scleroderma

(2010) G. R. Hill et al.   BLOOD

Th17/Treg ratio in human graft-versus-host disease

(2010) P. Ratajczak et al.   BLOOD

Cytokine gene expression in peripheral blood mononuclear cells during graft-versus-host disease after allogeneic bone marrow transplantation

(2010) Junji Tanaka et al.   BRITISH JOURNAL OF HAEMATOLOGY

Epigenetic Instability of Cytokine and Transcription Factor Gene Loci Underlies Plasticity of the T Helper 17 Cell Lineage

(2010) Ryuta Mukasa et al.   IMMUNITY

Pathogenesis and Management of Graft-versus-Host Disease

(2010) Sung W. Choi et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Biology of interleukin-22

(2010) Kerstin Wolk et al.   Seminars in Immunopathology

Regulatory Mechanisms in Graft-versus-Host Responses

(2009) Matthias Edinger et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Interleukin 17 Is Not Required for Autoimmune-Mediated Pathologic Damage during Chronic Graft-versus-Host Disease

(2009) Xiao Chen et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

T helper17 Cells Are Sufficient But Not Necessary to Induce Acute Graft-Versus-Host Disease

(2009) Cristina Iclozan et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethality

(2009) L. K. Jasperson et al.   BLOOD

The role of B cells in the pathogenesis of graft-versus-host disease

(2009) A. Shimabukuro-Vornhagen et al.   BLOOD

Acute graft-versus-host disease: from the bench to the bedside

(2009) G. Socie et al.   BLOOD

Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease

(2009) T. Yi et al.   BLOOD

Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells

(2009) Natalia Martin-Orozco et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

(2009) Di Yu et al.   IMMUNITY

Late Developmental Plasticity in the T Helper 17 Lineage

(2009) Yun Kyung Lee et al.   IMMUNITY

Th9 and allergic disease

(2009) Pejman Soroosh et al.   IMMUNOLOGY

Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling

(2009) Stefanie Eyerich et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-9 as a mediator of Th17-driven inflammatory disease

(2009) Elizabeth C. Nowak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Follicular helper T cells are required for systemic autoimmunity

(2009) Michelle A. Linterman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A protective function for interleukin 17A in T cell–mediated intestinal inflammation

(2009) William O'Connor Jr et al.   NATURE IMMUNOLOGY

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells

(2009) Sara Trifari et al.   NATURE IMMUNOLOGY

Human Langerhans cells induce distinct IL-22-producing CD4+ T cells lacking IL-17 production

(2009) H. Fujita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-17–Producing T-Helper Cells as New Potential Player Mediating Graft-Versus-Host Disease in Patients Undergoing Allogeneic Stem-Cell Transplantation

(2009) Erica Dander et al.   TRANSPLANTATION

Murine Models of Chronic Graft-versus-Host Disease: Insights and Unresolved Issues

(2008) Yu-Waye Chu et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease

(2008) T. Yi et al.   BLOOD

IL-17 contributes to CD4-mediated graft-versus-host disease

(2008) L. W. Kappel et al.   BLOOD

In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations

(2008) M. J. Carlson et al.   BLOOD

Th memory for interleukin-17 expression is stablein vivo

(2008) Maria H. Lexberg et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Combined Th2 cytokine deficiency in donor T cells aggravates experimental acute graft-vs-host disease

(2008) Isao Tawara et al.   EXPERIMENTAL HEMATOLOGY

CD4+T-regulatory cells: toward therapy for human diseases

(2008) Sarah E. Allan et al.   IMMUNOLOGICAL REVIEWS

IL-21 and TGF-β are required for differentiation of human TH17 cells

(2008) Li Yang et al.   NATURE

Differentiation of human TH-17 cells does require TGF-β!

(2008) Anne O'Garra et al.   NATURE IMMUNOLOGY

Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset

(2008) Marc Veldhoen et al.   NATURE IMMUNOLOGY

IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells

(2008) Valérie Dardalhon et al.   NATURE IMMUNOLOGY

A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

(2008) Elisabetta Volpe et al.   NATURE IMMUNOLOGY

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

(2008) Nicolas Manel et al.   NATURE IMMUNOLOGY

Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality

(2007) L. K. Jasperson et al.   BLOOD