Article
Biochemistry & Molecular Biology
Jinhui Ma, Jiangbo Chen, Heng Wang, Danghui Lu, Kai Liang
Summary: This study investigated the effect and mechanism of Aryl hydrocarbon receptor (AhR) on angiogenesis in acute limb ischemia (ALI). The results showed that activated AhR in ALI models was translocated to the nucleus and down-regulated VEGF expression, thereby inhibiting endothelial angiogenesis. Additionally, AhR loss promoted cell viability, angiogenesis, and migration, and elevated the levels of VEGF, Tie2, and Ang2.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Qiang Luo, Chaoqiang Fan, Wang Ying, Xue Peng, Yiyang Hu, Zhaohui Luan, Shaosong Ye, Chunli Gong, Yu Huang, Yufeng Xiao, Yang Chen, Malcolm Xing, Lei Wang, Shiming Yang
Summary: This article presents a bis-pyrene-based nanoprobe that can be used for the diagnosis of early gastric cancer through BLE technique. The probe can stably remain in the tumor and emit fluorescence for imaging under BLE. Experimental results demonstrate the successful identification and highlighting of angiogenesis sites in early gastric cancer using this probe.
Article
Pharmacology & Pharmacy
Romain Giraud, Anais Moyon, Stephanie Simoncini, Anne-Claire Duchez, Vincent Nail, Corinne Chareyre, Ahlem Bouhlel, Laure Balasse, Samantha Fernandez, Loris Vallier, Guillaume Hache, Florence Sabatier, Francoise Dignat-George, Romaric Lacroix, Benjamin Guillet, Philippe Garrigue
Summary: This study tracked radiolabeled endothelial large extracellular vesicles (LEVs) in a mouse model and found that LEVs can homing to the ischemic area after ischemia, which is positively correlated with reperfusion intensity and improved motility function.
Article
Peripheral Vascular Disease
Yunke Ren, Xinying Chu, Janaka Senarathna, Akanksha Bhargava, Warren L. Grayson, Arvind P. Pathak
Summary: This study developed a new multimodality imaging approach to characterize the remodeling vasculature and its effects on osteogenesis in a preclinical calvarial defect model. The results showed that angiogenic evolution played a crucial role in calvarial bone regeneration, preceding osteogenesis and corresponding to distinct phases of bone healing.
Article
Biochemistry & Molecular Biology
Anna Di Carlo, Sara Beji, Silvia Palmerio, Mario Picozza, Marco D'Agostino, Vincenzo Petrozza, Roberta Melchionna, Antonia Germani, Alessandra Magenta, Elena De Falco, Daniele Avitabile
Summary: Nucleophosmin (NPM) is secreted by human vein endothelial cells in response to stress conditions, showing pro-inflammatory and angiogenic activities both in vitro and in vivo. The secretion of NPM is time dependent and unrelated to cell necrosis within 24 hours. This study suggests a potential autocrine/paracrine role of NPM in regulating angiogenesis and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sally L. Elshaer, Hang-soo Park, Laura Pearson, William D. Hill, Frank M. Longo, Azza B. El-Remessy
Summary: The study found that modulating the neurotrophin receptor p75(NTR) can enhance the vascular protection of MSCs in an acute model of retinal ischemia/reperfusion, reducing the formation of acellular capillaries and promoting angiogenic response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Fei Liu, Laisi Song, Zhiqiang Lu, Tingwei Sun, Jingwen Lun, Chengbin Zhou, Xiouou Sun, Wen Tan, Haishan Zhao
Summary: The study demonstrates that isosteviol has a protective effect against myocardial infarction and can promote angiogenesis, improve cardiac function parameters, enhance endothelial cell proliferation and branching, and have a positive impact on vascular growth and endothelial cell proliferation in zebrafish embryos.
CELL AND TISSUE RESEARCH
(2022)
Article
Orthopedics
Jia-jia Qian, Qi Xu, Wei-min Xu, Ren Cai, Gui-cheng Huang
Summary: ACLT surgery can lead to time-dependent degeneration of cartilage in mice. Increased ADAMTS5-positive cells and decreased COL-II in OA cartilage, along with angiogenesis and inflammation, were important pathological changes. The expression of the VEGF-A/VEGFR2 signaling pathway was correlated with the degree of KOA.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Oncology
Ali Abdalla, Chandraprabha Murali, Amr Amin
Summary: This study reveals for the first time the antiangiogenic potential of safranal and proposes its possible underlying mechanism in the treatment of hepatocellular carcinoma (HCC).
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Vanessa Coelho-Santos, Andree-Anne Berthiaume, Sharon Ornelas, Heidi Stuhlmann, Andy Y. Shih
Summary: The study reveals that brain capillary networks originate exclusively from cortical ascending venules, with early, long-range sprouts connecting venules to upstream arteriolar input, establishing the backbone of the capillary bed, and short-range sprouts contributing to expansion of anastomotic connectivity within the capillary bed.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Alexandru Florea, Felix M. Mottaghy, Matthias Bauwens
Summary: Angiogenesis plays a crucial role in tumor growth, with molecular imaging becoming an integral part of cancer therapy. Both direct and indirect targeting tracers show potential value in clinical settings. Combining multiple targeting tracers into one agent may be a promising approach for evaluating tumor vascularization and vitality in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Zhiyang Li, Heng Zhang, Yujie Sun, Zhuangzhuang Feng, Bijia Cui, Jingxia Han, Yinan Li, Huijuan Liu, Tao Sun
Summary: Angiogenesis plays a crucial role in embryologic development, growth, and tissue repair, but dysregulation of this process is a hallmark of various pathologies, including cancer. Existing methods for evaluating cell vascular formation are often limited to static analysis, leading to bias. Researchers have developed code scripts to study the dynamic angiogenesis process, allowing for the screening of drugs that can affect various parameters of vascular formation. Animal experiments have confirmed the efficacy of these drugs in inhibiting blood vessel formation, providing a new perspective for angiogenesis research and drug development.
Article
Ophthalmology
Mingliang Zhang, Joyce Tombran-Tink, Songyang Yang, Xiaomin Zhang, Xiaorong Li, Colin J. Barnstable
Summary: PEDF inhibits early mitogenic signals of VEGF-A in primate retinal endothelial cells by binding to VEGF-R2 and preventing downstream signaling, thereby blocking the growth of new blood vessels.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Oncology
Hongyuan Lu, Cen Wu, Xiao-wen Jiang, Qingchun Zhao
Summary: This study found that the ADAM-17 inhibitor ZLDI-8 significantly inhibits angiogenesis and vasculogenic mimicry (VM) in drug-resistant NSCLC by suppressing the Notch1-HIF1αVEGF signaling pathway. This study lays the foundation for the discovery of drugs that inhibit angiogenesis and VM in drug-resistant NSCLC.
Article
Multidisciplinary Sciences
Charissa Poon, Petteri Teikari, Muhammad Febrian Rachmadi, Henrik Skibbe, Kullervo Hynynen
Summary: In this study, the first annotated dataset of rodent cerebrovasculature, MiniVess, was introduced. The dataset consists of 70 3D image volumes with segmented ground truths, created using various methods. The availability of annotated datasets is crucial for the development and testing of machine learning tools for biomedical image analysis.