Article
Multidisciplinary Sciences
Nadine Kamenjarin, Katrin Hodapp, Felix Melchior, Gregory Harms, Ann- Kathrin Hartmann, Joschka Bartneck, Sabine Muth, Verena K. Raker, Christian Becker, Anna Brand, Bjorn E. Clausen, Markus P. Radsak, Hansjorg Schild, Hans Christian Probst
Summary: Tissue-resident memory CD8+ T cells (TRM) in the skin require epidermal Langerhans cells, which cross-present keratinocyte-derived antigens, for their reactivation to provide protection against reinfection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Rasha Msallam, Bernard Malissen, Pierre Launay, Ulrich Blank, Gregory Gautier, Jean Davoust
Summary: This study investigates the regulatory functions of mast cells (MCs) in the skin, focusing on their interaction with regulatory T lymphocytes (Tregs) and Langerhans cells (LCs) during passive cutaneous anaphylaxis (PCA) responses. The researchers found that Tregs increased their contact time with MCs during PCA, suggesting an anti-inflammatory role in preventing further MC activation.
Article
Cell Biology
Tiffany Shi, Astha Malik, Annika Yang vom Hofe, Louis Matuschek, Mary Mullen, Celine S. Lages, Ramesh Kudira, Ruchi Singh, Wujuan Zhang, Kenneth D. R. Setchell, David Hildeman, Chandrashekhar Pasare, Brandee Wagner, Alexander G. Miethke
Summary: In this study, we found that activation of the nuclear receptor FXR by pharmacological agonists can reduce bile acid synthesis and suppress the production of inflammatory factors by inflammatory cells, thereby blocking the progression of liver bile duct injury. Deletion of FXR leads to abnormal responses in T(H)1 and T(H)17 lymphocytes, making mice resistant to the therapeutic effects of FXR agonist treatment. Therefore, hepatic macrophages are potential targets for the treatment of cholestatic liver diseases.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Peter Seiringer, Stefanie Eyerich, Kilian Eyerich, Daniela Dittlein, Anna Caroline Pilz, Emanuele Scala, Johannes Ring, Heidrun Behrendt, Andrea Cavani, Claudia Traidl-Hoffmann
Summary: The study found that keratinocytes partially inhibit T cell proliferation and cytokine production, with this effect depending on the keratinocyte/T cell ratio and soluble factors. This shows that keratinocytes play a critical role in controlling inflammatory processes in the skin.
Article
Oncology
Chester Lai, George Coltart, Andrew Shapanis, Conor Healy, Ahmad Alabdulkareem, Sara Selvendran, Jeffrey Theaker, Matthew Sommerlad, Matthew Rose-Zerilli, Aymen Al-Shamkhani, Eugene Healy
Summary: The study identified a significant presence of CD8+CD103+ TRMs in cutaneous squamous cell carcinomas, with their expression in the tumor being associated with poorer clinical outcomes for patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Dermatology
Werner Kempf, Tony Petrella, Rein Willemze, Patty Jansen, Emilio Berti, Marco Santucci, Eva Geissinger, Lorenzo Cerroni, Eve Maubec, Maxime Battistella, John Goodlad, Emmanuella Guenova, Katariina Lappalainen, Annamari Ranki, Paul Craig, Eduardo Calonje, Blanca Martin, Sean Whittaker, Ilske Oschlies, Ulrike Wehkamp, Jan P. Nicolay, Marion Wobser, Julia Scarisbruck, Nicola Pimpinelli, Rudi Stadler, Katrin Kerl French, Pietro Quaglino, Jinran Lin, Lianjun Chen, Michaela Beer, Patrick Emanuel, Stephane Dalle, Alistair Robson
Summary: The study retrospectively analyzed a series of 46 patients and biopsies by the international EORTC Cutaneous Lymphoma Group. The dermal CD8(+) lymphoproliferations were categorized into three groups: cutaneous acral CD8(+) T-cell lymphoma, primary cutaneous CD8(+) peripheral T-cell lymphoma, unspecified/NOS, and cutaneous CD8(+) lymphoproliferations associated with congenital immunodeficiency syndromes.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Immunology
Antonio Bensussen, Maria Angelica Santana, Otoniel Rodriguez-Jorge
Summary: CD8+T lymphocytes are key cells of the immune system that protect against various threats. Metabolic disturbances can inhibit the differentiation and function of these cells, but overactivation of mTORC2 may restore their functionality.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Federica Agliano, Timofey A. Karginov, Antoine Menoret, Anthony Provatas, Anthony T. Vella
Summary: NAM has been found to affect T cell responses by impairing the transition of naive T cells into effector T cells, as well as impacting effector T cells themselves. NAM enhances the glycolysis of effector T cells while reducing the production of IFN gamma. These findings suggest that NAM has the potential to be a powerful treatment for diseases associated with T cell hyperactivation.
Article
Oncology
Najmeh Bozorgmehr, Isobel Okoye, Olaide Oyegbami, Lai Xu, Amelie Fontaine, Nanette Cox-Kennett, Loree M. Larratt, Mark Hnatiuk, Andrei Fagarasanu, Joseph Brandwein, Anthea C. Peters, Shokrollah Elahi
Summary: The study found that CD160 was the most upregulated co-inhibitory receptor in patients with CLL, and its expression was associated with an exhausted T cell phenotype. EVs were identified as a source of CD160 in the plasma of CLL patients. Additionally, a dominantly proinflammatory cytokine profile, especially elevated interleukin-16, was observed in CLL patients' plasma.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Multidisciplinary Sciences
Aenne Harberts, Constantin Schmidt, Joanna Schmid, Daniel Reimers, Friedrich Koch-Nolte, Hans-Willi Mittruecker, Friederike Raczkowski
Summary: IRF4 is essential for the activation and reactivation of CD8(+) memory T cells, but does not affect their overall survival. However, the formation and maintenance of CD8(+) tissue-resident memory T cells appears to depend on IRF4.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Xingyuan Zhai, Kai Liu, Hongkun Fang, Quan Zhang, Xianjun Gao, Fang Liu, Shangshang Zhou, Xinming Wang, Yujia Niu, Yazhen Hong, Shu-Hai Lin, Wen-Hsien Liu, Changchun Xiao, Qiyuan Li, Nengming Xiao
Summary: C1qbp plays a crucial role in the differentiation of effector CD8(+) T cells by regulating mitochondrial oxidative phosphorylation, affecting levels of acetyl-coenzyme A and fumarate, influencing the methylation status of H3K27, and impacting the transcriptional levels of effector genes.
Review
Immunology
Takafumi Numata, Kazutoshi Harada, Susumu Nakae
Summary: Mast cells are cells present in all vascularized tissues of the body and play a role in releasing inflammatory and regulatory mediators. They can be activated through various receptors and contribute to host defense against pathogens and inflammation. However, excessive or inappropriate mast cell activation can lead to various disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Benedetta De Ponte Conti, Annarita Miluzio, Fabio Grassi, Sergio Abrignani, Stefano Biffo, Sara Ricciardi
Summary: The systematic analysis on translation rate of tumor-infiltrating lymphocytes (TILs) in humans and mice shows that high translation levels are associated with mTORC1 activation and low levels are correlated with hypoxia. CD8 translating cells exhibit a cytotoxic phenotype, while CD4 translating cells are mainly regulatory T cells with immunosuppressive functions.
Article
Medicine, Research & Experimental
Shweta Mahajan, Aria Alexander, Zachary Koenig, Nicholas Saba, Nina Prasanphanich, David A. Hildeman, Claire A. Chougnet, Emily Defranco, Sandra Andorf, Tamara Tilburgs
Summary: Decidual CD8(+) T cells play a critical role in providing immunity to infection and immune tolerance for fetal and placental antigens. These cells include shared blood T cells and unique decidual T cells, and the specificity of decidual CD8(+) T cells is closely related to their function and tissue residency.
Article
Immunology
Beatriz Coutinho de Oliveira, Ailton Alvaro da Silva, Marton Kaique de Andrade Cavalcante, Maria Edileuza Felinto de Brito, Maria Carolina Accioly Brelaz de Castro, Vanessa Lucilia Silveira de Medeiros, Rafael de Freitas e Silva, Valeria Rego Alves Pereira
Summary: Cutaneous Leishmaniasis (CL) is a skin ulcer disease caused by protozoans, and there is no vaccine available. Previous research identified T cell epitopes of Leishmania braziliensis and tested their ability to rescue memory T cells during natural infection. The study found increased frequencies of TCM and TEM, especially in the CD8 compartment, during CL. These results suggest a potentially immunogenic profile of the peptides and support the development of anti-Leishmania formulations.
Article
Biophysics
Johannes Schetelig, Patrice Chevallier, Michel van Gelder, Jennifer Hoek, Olivier Hermine, Ronjon Chakraverty, Paul Browne, Noel Milpied, Michele Malagola, Gerard Socie, Julio Delgado, Eric Deconinck, Ghandi Damaj, Sebastian Maury, Dietrich Beelen, Stephanie Nguyen Quoc, Paneesha Shankara, Arne Brecht, Jiri Mayer, Mathilde Hunault-Berger, Joerg Bittenbring, Catherine Thieblemont, Stephane Lepretre, Henning Baldauf, Liesbeth C. de Wreede, Olivier Tournilhac, Ibrahim Yakoub-Agha, Nicolaus Kroeger, Peter Dreger
Summary: This study investigated the bridging treatment with idelalisib for CLL patients prior to alloHCT. Results suggest that idelalisib may be considered as a potential option for bridging therapy, but intensified clinical monitoring is necessary due to the high risk of acute GVHD.
BONE MARROW TRANSPLANTATION
(2021)
Editorial Material
Immunology
Zhi Li, Rebecca Lamb, Mark C. Coles, Clare L. Bennett, Carrie A. Ambler
Summary: The absence of CD11c+ cells delays wound closure and epidermal proliferation, likely due to defects in the activation of the IL-23-IL-22 axis that is required for wound healing.
Editorial Material
Biochemistry & Molecular Biology
Clare L. Bennett
Editorial Material
Genetics & Heredity
Patrick A. da Roza, Hugh D. Goold, Ian T. Paulsen
TRENDS IN GENETICS
(2022)
Article
Health Care Sciences & Services
Rowan Howell, Matthew A. Clarke, Ann-Kathrin Reuschl, Tianyi Chen, Sean Abbott-Imboden, Mervyn Singer, David M. Lowe, Clare L. Bennett, Benjamin Chain, Clare Jolly, Jasmin Fisher
Summary: The COVID-19 pandemic has put healthcare systems under immense pressure globally. This study presents an executable disease-stage signalling network model to predict effective repurposed drug combinations for treating COVID-19 at different stages. Through in silico screening, the study identified nine new drug combinations, with Camostat and Apilimod showing potential in suppressing viral replication in the early stage of severe disease. The study highlights the use of mechanistic modelling in rapidly evaluating personalized treatment options and provides a novel resource and expandable model system to respond to pandemic needs.
NPJ DIGITAL MEDICINE
(2022)
Review
Psychology, Clinical
Deniz Fikretoglu, Marie-Louise Sharp, Amy B. Adler, Stephanie Belanger, Helen Benassi, Clare Bennett, Richard Bryant, Walter Busuttil, Heidi Cramm, Nicola Fear, Neil Greenberg, Alexandra Heber, Fardous Hosseiny, Charles W. Hoge, Rakesh Jetly, Alexander McFarlane, Joshua Morganstein, Dominic Murphy, Meaghan O'Donnell, Andrea Phelps, Don J. Richardson, Nicole Sadler, Paula P. Schnurr, Patrick Smith, Robert Ursano, Miranda Van Hooff, Simon Wessely, David Forbes, David Pedlar
Summary: Military service is associated with increased risk of mental health problems and under-utilization of mental health services in military populations. Recent research from Five-Eyes nations indicates improvements in access to mental healthcare at a broad population level, but additional barriers such as concerns around confidentiality and career impact persist. New initiatives are needed to address these barriers, with a focus on evidence-based, theoretically-driven, and culturally-sensitive approaches.
CLINICAL PSYCHOLOGY REVIEW
(2022)
Article
Cell Biology
Heather C. West, James Davies, Stephen Henderson, Oluyori K. Adegun, Sophie Ward, Ivana R. Ferrer, Chanidapa A. Tye, Andres F. Vallejo, Laura Jardine, Matthew Collin, Marta E. Polak, Clare L. Bennett
Summary: Research has shown that T cell pathology in the skin leads to the influx of monocytes, but little is known about the fate of recruited cells and the long-term impact on cutaneous immune homeostasis. In a murine model of acute graft-versus-host disease (aGVHD) and patient samples, it was found that pathology induces dermis-specific macrophage differentiation and these macrophages continue to dominate the dermal compartment after aGVHD resolution. Exposure of the altered dermal niche to topical haptens results in hyper-activation of regulatory T cells (Treg), but also a breakdown in local tolerance. Macrophages imprinted by the disease express increased IL-1 beta and are predicted to interact differently with cutaneous Treg, resulting in the loss of T cell regulation in the resolved skin. Therefore, T cell pathology leaves an immunological scar in the skin, preventing immune homeostasis from being re-established.
Article
Multidisciplinary Sciences
Dariusz R. Kutyna, Cristobal A. Onetto, Thomas C. Williams, Hugh D. Goold, Ian T. Paulsen, Isak S. Pretorius, Daniel L. Johnson, Anthony R. Borneman
Summary: The Synthetic Yeast Genome Project (Sc2.0) aims to design and build the next generation of industrial microbes. To address the lack of phenotypic diversity in the laboratory strain, researchers created a new chromosome containing diverse pan-genomic elements. This provides phenotypic plasticity to the Sc2.0 parent strain and expands its range of applicable carbon sources.
NATURE COMMUNICATIONS
(2022)
Article
Health Care Sciences & Services
Cathryn Smith, Clare Bennett, Kate Morgan, Judith Carrier, Jitka Klugarova, Miloslav Klugar
Summary: The study aimed to assess compliance with evidence-based criteria for clinical supervision among district nurses and improve knowledge and engagement in clinical supervision activities in the workplace. Through educational training and clinical supervision sessions, participants' compliance increased. The results of the study showed a significant increase in compliance with all criteria.
JBI EVIDENCE IMPLEMENTATION
(2022)
Article
Multidisciplinary Sciences
Briardo Llorente, Thomas C. Williams, Hugh D. Goold, Isak S. Pretorius, Ian T. Paulsen
Summary: Human enterprises in space require addressing the challenge of maintaining a healthy diet during long-duration voyages and habitation. By consolidating multiple sensory and nutritional attributes into microorganisms, customizable food production systems with minimal resources, space, and waste can be developed. Bioengineered microbial-based food, such as a yeast collection bioengineered for optimal nutrition and diverse attributes, has the potential to support human space exploration and revolutionize Earth's food manufacturing, promoting self-sufficiency and reducing pressure on natural ecosystems.
NATURE COMMUNICATIONS
(2022)
Review
Multidisciplinary Sciences
Tomi Lazarov, Sergio Juarez-Carreno, Nehemiah Cox, Frederic Geissmann
Summary: Embryo-derived tissue-resident macrophages are the first cells of the hematopoietic lineage in metazoans and play crucial roles in tissue growth, homeostasis, and repair. These specialized macrophages are distinct from other types of macrophages and sense and integrate local and systemic information to support the needs of specific tissue cells. Dysfunction of resident macrophages can lead to various diseases, emphasizing their importance in human health. This review provides an overview of macrophage physiology and its significance in human diseases, which can guide future research studies.
Article
Multidisciplinary Sciences
Rowan Howell, James Davies, Matthew A. Clarke, Anna Appios, Yashoda Jayal, Ben Ringham-Terry, Isabel Boned Del Rio, Jasmin Fisher, Clare L. Bennett
Summary: Researchers have developed an in silico model to investigate the interaction between melanomas and Langerhans cells (LCs). The model suggests that melanomas do not activate LC migration to lymph nodes until they reach a critical size, due to a positive TNF-alpha feedback loop. Experimental testing confirms that treating primary tumors with MAPK pathway inhibitors can prevent LC migration. The study also predicts treatment combinations that can bypass LC dysfunction.
Review
Immunology
Clare L. Bennett, Georgia Perona-Wright
Summary: Macrophages play crucial roles in tissue homeostasis, defense, and repair, with functions specific to each tissue. The recruitment of monocytes is influenced by metabolic factors, but the metabolic phenotype may be more determined by macrophage longevity.
MUCOSAL IMMUNOLOGY
(2023)
Correction
Multidisciplinary Sciences
Tomi Lazarov, Sergio Juarez-Carreno, Nehemiah Cox, Frederic Geissmann
Article
Physics, Multidisciplinary
Shujie Li, Carlos Yero, Jennifer Rittenhouse West, Clare Bennett, Wim Cosyn, Douglas Higinbotham, Misak Sargsian, Holly Szumila-Vance
Summary: This is a study on color transparency in baryons, where observing the onset of color transparency will provide a new means of studying the nuclear strong force. The article describes an experiment that uses specific kinematics to explore the potential signal of the onset of color transparency with increased sensitivity compared to previous experiments.