Article
Biochemistry & Molecular Biology
Juan Du, Qiang Sun, Zhihao Wang, Feng Wang, Fangfang Chen, Hao Wang, Guokai Shang, Xiaomei Chen, Shifang Ding, Chen Li, Dawei Wu, Wei Zhang, Ming Zhong, Yihui Li
Summary: Ischemia-reperfusion injury (IR) is a major cause of acute kidney injury (AKI), and currently there are no effective drugs for it. Exosomes derived from tubular epithelial cells under IR conditions may hold therapeutic potential for IR-related AKI by promoting cell proliferation and reducing inflammation. Further research is needed to explore the clinical applications of these exosomes in treating AKI.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Izumi Nagayama, Kaori Takayanagi, Hajime Hasegawa, Akito Maeshima
Summary: In this study, the expression and localization of follistatin in normal and ischemic rat kidneys were examined, and urinary follistatin levels were measured to assess its potential as a biomarker for acute kidney injury. The results showed that follistatin was mainly localized in the distal tubules of the cortex in normal kidneys, while it was also present in the distal tubules of both the cortex and outer medulla in ischemic kidneys. Urinary follistatin levels were significantly increased in ischemic rats and correlated with the duration of ischemia, the follistatin-positive area, and the acute tubular damage area.
Article
Medicine, General & Internal
Hye Bin Kang, Chae Kyu Lim, Jongwan Kim, Sang Jun Han
Summary: Renal ischemia/reperfusion (I/R) injury is a major cause of acute kidney injury (AKI) characterized by increased oxidative stress, inflammatory responses, and tubular cell death. Oxypurinol, an active metabolite of allopurinol, showed therapeutic potential in ischemic AKI by reducing kidney inflammation, oxidative stress, and apoptosis via induction of the cytoprotective enzyme HO-1.
FRONTIERS IN MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Yakun Li, Bingyang Xu, Jun Yang, Lu Wang, Xiaosheng Tan, Xiaofan Hu, Lingjuan Sun, Song Chen, Lan Zhu, Xiaoping Chen, Gang Chen
Summary: Liraglutide exerts protective effects against renal ischemia-reperfusion injury by inhibiting HMGB1 nuclear-cytoplasmic translocation and release, partially dependent on GLP-1R. This demonstrates its therapeutic potential in the prevention and treatment of organ IRI.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Theodoros Eleftheriadis, Georgios Pissas, Spyridon Golfinopoulos, Maria Efthymiadi, Vassilios Liakopoulos, Ioannis Stefanidis
Summary: Inhibition of malate dehydrogenase-2 (MDH-2) protects renal cells from death or senescence caused by ischemia-reperfusion injury. MDH-2 inhibition reduces oxidative stress and inflammation, and maintains cell proliferation capacity.
Article
Biochemistry & Molecular Biology
Su Woong Jung, Jung-Woo Seo, Seon Hwa Park, Yang Gyun Kim, Ju-Young Moon, Sangdun Choi, Sang-Ho Lee
Summary: TIP1 demonstrated significant protective effects in a mouse model of renal IRI, reducing plasma creatinine levels, alleviating tubular injury, inhibiting inflammatory cytokine expression, decreasing apoptosis and oxidative stress levels, and reducing cell infiltration, suggesting potential benefits in attenuating kidney damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Qin Yang, Hong-mei Zang, Tian Xing, Shao-fei Zhang, Chao Li, Yao Zhang, Yu-hang Dong, Xiao-wei Hu, Ju-tao Yu, Jia-gen Wen, Juan Jin, Jun Li, Ren Zhao, Tao-tao Ma, Xiao-ming Meng
Summary: Gyp XLIX exerts significant renal protective effects in AKI by inhibiting renal dysfunction and alleviating inflammation and cell death. Mechanistically, Gyp XLIX mediates its effects by suppressing IGFBP7 levels and activating downstream signaling through the IGF1R kinase. These findings provide new insights for the potential clinical application of Gyp XLIX in AKI treatment.
Article
Pharmacology & Pharmacy
Xu Jing, Dandan Ren, Fei Gao, Ye Chen, Xiao Wu, Yue Han, Qingsheng Han, Liang Li, Xiaojie Wang, Wei Tang, Yan Zhang
Summary: Recent studies have shown that PDCD4 plays a critical role in modulating signal transduction pathways in acute kidney injury (AKI). Inhibition of PDCD4 or tyrosine kinase Fgr, and targeting the NOTCH1 pathway may have therapeutic potential for mitigating AKI.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Medicine, General & Internal
Fangfei Zhang, Jianyong Yin, Li Liu, Shuiying Liu, Guangyuan Zhang, Yiwei Kong, Yajun Wang, Niansong Wang, Xiangmei Chen, Feng Wang
Summary: In this study, the researchers investigated the therapeutic effects of IL-17C blockade on AKI and DN. They found that delayed IL-17C neutralization can protect against renal ischemia-reperfusion injury and attenuate DN in mice. They also discovered that IL-17C expression is increased in patients with DN and IL-17C blockade can reduce albuminuria, mesangial matrix accumulation, and podocyte loss in DN.
Article
Cell Biology
Dajun Liu, Ying Liu, Xiaotong Zheng, Naiquan Liu
Summary: The study revealed the crucial role of MEG3 in renal ischemia-reperfusion injury by promoting mitophagy and inducing apoptosis. Furthermore, MEG3 was found to bind with miR-145-5p, leading to upregulation of RTKN and activation of the Wnt/beta -catenin pathway. This positive feedback loop contributes to renal IRI and suggests potential therapeutic targets for treating renal injury.
CELL DEATH & DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Young Sook Lee, Hadi Javan, Jo-Anna Reems, Ling Li, Jessica Lusty, Christine Schaaf, Jan Pierce, John D. Phillips, Craig H. Selzman
Summary: Cell-free human amniotic fluid, a naturally derived cocktail composed of thousands of proteins involved with innate immunity and anti-inflammation, significantly reduces injury and preserves cardiac function in a model of rodent myocardial ischemia-reperfusion, suggesting its potential as a cardioprotective adjunct.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Chemistry, Medicinal
Maged E. Mohamed, Nora Tawfeek, Samar S. Elbaramawi, Mahmoud H. Elbatreek, Eman Fikry
Summary: In this study, the chemical composition of ARBE was identified and the interaction between the major components of ARBE and RIRI-related targets was investigated using network pharmacology. The experimental results demonstrated the nephroprotective effect of ARBE in a rat model of RIRI.
Article
Biochemistry & Molecular Biology
Jiarui Feng, Lilong Zhang, Enfu Xue, Zhendong Qiu, Ning Hu, Kunpeng Wang, Yingru Su, Weixing Wang
Summary: In this study, the role of the celiac ganglion (CG) in hepatic ischemia-reperfusion injury (HIRI) was investigated. The results showed that silencing Bmal1 expression in the CG can reduce liver fat reserve, hepatocyte apoptosis, and liver fibrosis, and increase liver glycogen accumulation. Furthermore, the downregulation of Bmal1 can suppress the levels of hepatic neurotransmitters norepinephrine and neuropeptide Y, as well as sympathetic nerve activity in HIRI. Additionally, decreased Bmal1 expression in the CG can reduce inflammation, oxidative stress, and increase glutathione levels in the liver. These findings suggest that reducing Bmal1 expression in the CG can improve hepatocyte injury in HIRI.
Article
Cell & Tissue Engineering
Zejia Sun, Jiyue Wu, Qing Bi, Wei Wang
Summary: This study found that USC-Exo can protect against kidney ischemia/reperfusion injury (IRI) by regulating ASCL4-mediated ferroptosis, and lncRNA TUG1 plays an important regulatory role in this process.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Oncology
Dongdong Zhu, Yuanyu Zhao, Yi Luo, Xiaoqian Qian, Zhen Zhang, Gengru Jiang, Fengfu Guo
Summary: The study found that the Irg1-itaconate axis plays an important protective role in ischemia-reperfusion injury and acute kidney injury, providing potential therapeutic targets to control AKI.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Cell Biology
Yutaro Mori, Amrendra K. Ajay, Jae-Hyung Chang, Shan Mou, Huiping Zhao, Seiji Kishi, Jiahua Li, Craig R. Brooks, Sheng Xiao, Heung-Myong Woo, Venkata S. Sabbisetti, Suetonia C. Palmer, Pierre Galichon, Li Li, Joel M. Henderson, Vijay K. Kuchroo, Julie Hawkins, Takaharu Ichimura, Joseph Bonventre
Summary: Tubulointerstitial abnormalities can predict the progression of diabetic kidney disease, with KIM-1 playing a crucial role in this process. Targeting KIM-1 could be a potential therapeutic approach to alleviate renal damage.
Article
Food Science & Technology
Y. Ramirez-Rodriguez, V Ramirez, K. Robledo-Marquez, N. Garcia-Rojas, P. Rojas-Morales, N. Arango, J. Pedraza-Chaverri, O. N. Medina-Campos, J. M. Perez-Rojas, R. Flores-Ramirez, R. Winkler, L. Riego-Ruiz, Joyce Trujillo
Summary: This study aimed to investigate the effect of pitaya juice concentrate (PJC) on cisplatin-induced nephrotoxicity. The results showed that PJC had a renoprotective effect by attenuating renal dysfunction, structural damage, apoptosis activation, and oxidative stress, and it was related to changes in the tumor necrosis factor-alpha and renal nitric oxide pathways.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Medicine, Research & Experimental
Hilda Minerva Gonzalez-Sanchez, Jea-Hyun Baek, Julia Weinmann-Menke, Amrendra Kumar Ajay, Julia Forgan-Farnam Charles, Masaharu Noda, Ruth Anne Franklin, Patricia Rodriguez-Morales, Vicki Rubin Kelley
Summary: Myeloid cell mediated mechanisms regulate synovial joint inflammation. IL-34 and PTPRZ limit arthritis by reducing neutrophil recruitment and intra-synovial neutrophil extracellular traps, thereby alleviating synovial and bone erosion. IL-34 and PTPRZ levels are elevated in rheumatoid arthritis patients and correlate with disease activity.
LABORATORY INVESTIGATION
(2022)
Article
Oncology
Minghua Cao, Karol Nawalaniec, Amrendra K. Ajay, Yueming Luo, Romana Moench, Yanfei Jin, Sheng Xiao, Li-Li Hsiao, Ana Maria Waaga-Gasser
Summary: This study explores the role of PDE4 in ccRCC and its potential as a therapeutic target. The results demonstrate that PDE4 inhibition reduces cell proliferation and increases intracellular cAMP expression. PDE4D depletion and/or inhibition attenuates the MAPK/ERK signaling pathway and enhances the effectiveness of the TKI sorafenib in inhibiting cell survival.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Cell Biology
Amrendra K. Ajay, Li Zhao, Shruti Vig, Mai Fujiwara, Sudhir Thakurela, Shreyas Jadhav, Andrew Cho, I-Jen Chiu, Yan Ding, Krithika Ramachandran, Arushi Mithal, Aanal Bhatt, Pratyusha Chaluvadi, Manoj K. Gupta, Sujal Shah, Venkata S. Sabbisetti, Ana Maria Waaga-Gasser, David A. Frank, Gopal Murugaiyan, Joseph Bonventre, Li-Li Hsiao
Summary: This study reveals the important role of STAT3 in kidney fibrosis, with its phosphorylation occurring in tubular epithelial cells in acute kidney injury and expanded to interstitial cells in fibrosis. By regulating inflammation and differentiation of pericytes into myofibroblasts, STAT3 promotes fibrosis progression. Additionally, STAT3 binds to the Collagen1a1 promoter, further enhancing its profibrotic effect.
Review
Obstetrics & Gynecology
Victoria Ramirez, Regina J. Bautista, Oswaldo Frausto-Gonzalez, Nelly Rodriguez-Pena, Eduardo Tena Betancourt, Claudia J. Bautista
Summary: The DOHaD approach investigates the influence of early events experienced by mothers during reproduction on the developmental programming of children, with vulnerable populations globally facing high rates of obesity and metabolic diseases. In addition to traditional lifestyle factors, emerging environmental changes also impact offspring development negatively.
REPRODUCTIVE SCIENCES
(2023)
Article
Multidisciplinary Sciences
Ruhar Singh, Abhijeet Kumar, Jitendra Subhash Rane, Rajni Khan, Garima Tripathi, Amrendra K. Ajay, Amresh Prakash, Shashikant Ray
Summary: The vaccination drive against COVID-19 worldwide was successful, but the second wave of infections was more severe. New variants of SARS-CoV-2 emerged, which could escape antibodies in convalescent or vaccinated individuals, leading to increased reinfections and deaths. This study identified inhibitors with high binding affinity to the spike glycoprotein and ACE2 receptor of SARS-CoV-2, suggesting their potential as drugs against the virus.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Barbara Flasz, Marta Dziewiecka, Amrendra K. Ajay, Monika Tarnawska, Agnieszka Babczynska, Andrzej Kedziorski, Lukasz Napora-Rutkowski, Patrycja Zietara, Ewa Swierczek, Maria Augustyniak
Summary: The genotoxic effects of graphene oxide (GO) were examined in the species Acheta domesticus, focusing on DNA damage parameters, DNA damage response parameters, and global methylation. The study found that the sensitivity to GO varied among different life stages and strains, with larvae and young imago being more susceptible. However, the DNA damage response parameters were not significantly affected by life stage, strain, or GO exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Wenhu Zhan, Daqiang Li, Priya Saha, Rong Wang, Hao Zhang, Amrendra K. Ajay, Christa Deban, George Sukenick, Jamil Azzi, Gang Lin
Summary: We report the discovery and development of potent and highly selective inhibitors of human constitutive proteasome chymotryptic activity (fi5c). In the optimization of a novel class of inhibitors, structure-activity relationship studies focused on N-cap, C-cap, and side chain of the chemophore asparagine. Compound 32 exhibits the greatest potency and selectivity among the inhibitors tested. Docking studies provide a structural explanation for their potency and selectivity. Kinetic studies reveal a reversible and noncompetitive inhibition mechanism. Compound 32 penetrates cells to engage the proteasome target, potently and selectively killing multiple myeloma cells by synergizing with a fi5i-selective inhibitor.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Editorial Material
Genetics & Heredity
Jaspreet Kaur Dhanjal, Rajkumar Singh Kalra, Dhanendra Tomar, Amrendra K. Ajay
FRONTIERS IN GENETICS
(2023)
Article
Pharmacology & Pharmacy
Amrendra K. Ajay, Philip Chu, Poojan Patel, Christa Deban, Chitran Roychowdhury, Radhika Heda, Ahmad Halawi, Anis Saad, Nour Younis, Hao Zhang, Xiuju Jiang, Mahmoud Nasr, Li-Li Hsiao, Gang Lin, Jamil R. Azzi
Summary: Chordomas are rare bone tumors, accounting for approximately 1-4% of all malignant bone tumors and 20% of primary tumors of the spinal column. The underlying mechanism of chordoma is unknown, making it challenging to treat. In this study, a small molecule screening identified potential compounds that can inhibit chordoma cell proliferation, and proteasomal inhibitors were discovered as promising molecules for targeted therapy.
Review
Food Science & Technology
Zeltzin Alejandra Ceja-Galicia, Ana Karina Aranda-Rivera, Isabel Amador-Martinez, Omar Emiliano Aparicio-Trejo, Edilia Tapia, Joyce Trujillo, Victoria Ramirez, Jose Pedraza-Chaverri
Summary: Chronic kidney disease is a growing health problem characterized by diverse symptomatology, including dyslipidemia. Dyslipidemia increases the risk of cardiovascular diseases and mortality in CKD patients. It is necessary to explore new therapies, such as curcuminoids, to mitigate the use of medications in CKD treatment.
Article
Biochemistry & Molecular Biology
Barbara Flasz, Amrendra K. Ajay, Monika Tarnawska, Agnieszka Babczynska, Lukasz Majchrzycki, Andrzej Kedziorski, Lukasz Napora-Rutkowski, Ewa Swierczek, Maria Augustyniak
Summary: The use of nanoparticles like graphene oxide (GO) in nanocomposite industries is increasing rapidly. Concerns have been raised regarding GO entering the environment and becoming nanopollutants. Exposure to environmental pollutants at low concentrations may have long-lasting effects on subsequent generations, especially on DNA stability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Immunology
Murugaiyan Gopal, Mai Fujiwara, Radhika Raheja, Lucien Garo, Amrendra Ajay, Tanuja Chitnis, Howard L. Weiner, Roopali Gandhi
JOURNAL OF IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Mai Fujiwara, Radhika Raheja, Lucien P. Garo, Amrendra K. Ajay, Ryoko Kadowaki-Saga, Sukrut H. Karandikar, Galina Gabriely, Rajesh Krishnan, Vanessa Beynon, Anu Paul, Amee Patel, Shrishti Saxena, Dan Hu, Brian C. Healy, Tanuja Chitnis, Roopali Gandhi, Howard L. Weiner, Gopal Murugaiyan
Summary: This study reveals the crucial role of microRNA-92a (miR-92a) in central nervous system autoimmune diseases. Elevated miR-92a level in experimental autoimmune encephalomyelitis (EAE) contributes to the progression of the disease, while loss of miR-92a attenuates EAE. Mechanistically, miR-92a restricts the induction and suppressive capacity of regulatory T cells (Tregs), while supporting the responses of inflammatory T cells (Th17) by targeting the transcription factor Foxo1. Additionally, miR-92a inhibitor therapy improves EAE by enhancing Treg responses and suppressing inflammatory T cell responses.
JOURNAL OF CLINICAL INVESTIGATION
(2022)