Article
Multidisciplinary Sciences
Lan-Ping Xu, Zheng-Li Xu, Shun-Qing Wang, De-Pei Wu, Su-Jun Gao, Jian-Min Yang, Ling-Hui Xia, Qi-Fa Liu, Ming Jiang, Hai Bai, Xi Zhang, Xin Wang, Xiao-Jun Huang
Summary: In recent years, haploidentical stem cell transplantation has made significant progress in treating severe aplastic anemia. Through a multicenter prospective study, it was found that salvage transplantation with haploidentical donors can achieve favorable long-term outcomes, including high survival rates and quality of life recovery.
Article
Oncology
Hongchen Liu, Xiaoli Zheng, Chengtao Zhang, Jiajun Xie, Beibei Gao, Jing Shao, Yan Yang, Hengxiang Wang, Jinsong Yan
Summary: The study demonstrated the efficacy of haploidentical bone marrow transplantation (haplo-BMT) for patients with severe aplastic anemia II (SAA-II), achieving a 3-year overall survival and disease-free survival rate of 86.4% +/- 0.73%. This indicates that haplo-BMT could be considered as an alternative treatment strategy for SAA-II patients lacking HLA-matched donors.
FRONTIERS OF MEDICINE
(2021)
Article
Medicine, General & Internal
Ziqi Wan, Miao Chen, Bing Han
Summary: This study conducted a non-randomized, single-arm trial to investigate the efficacy and safety of Avatrombopag (AVA) in refractory/relapsed/intolerant non-severe aplastic anaemia (NSAA) patients. The results showed that AVA has good efficacy and tolerability in NSAA patients, and earlier treatment and relapsed/intolerant AA patients may have better short-term response rates.
ANNALS OF MEDICINE
(2023)
Article
Hematology
Nidhi Aggarwal, Ash Lee Manley, Ruba Shalhoub, Jibran Durrani, Olga Rios, Jennifer Lotter, Bhavisha A. Patel, Colin O. Wu, Neal S. Young, Emma M. Groarke
Summary: Immune severe aplastic anemia (SAA) is characterized by bone marrow destruction and pancytopenia caused by immune response. This study presents the long-term results of a clinical trial using alemtuzumab, showing its efficacy in treating relapsed SAA patients. The study observed durable long-term responses in some patients, but also noted the need for long-term monitoring due to prolonged immunosuppression.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Medicine, General & Internal
Hongmin Li, Lingling Fu, Bixi Yang, Hui Chen, Jie Ma, Runhui Wu
Summary: This study investigated the efficacy of Cyclosporine monotherapy in the management of children with non-severe aplastic anemia (NSAA). The results showed that patients with mild NSAA had the lowest response rate to CsA, while transfusion-dependent patients had a positive response. Patients with lower platelet count and higher interleukin 10 level were more likely to have a positive response to CsA, while a higher level of fetal hemoglobin was a negative factor.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Jiang Ji, Ziqi Wan, Jing Ruan, Yuan Yang, Qinglin Hu, Zesong Chen, Chen Yang, Miao Chen, Bing Han
Summary: This trial compared the efficacy of eltrombopag (EPAG)+tacrolimus versus EPAG monotherapy in patients with refractory/relapsed acquired aplastic anaemia (AA). The overall response rate was higher in the EPAG+tacrolimus group compared to the EPAG alone group, but there were no significant differences in safety, clonal evolution, and survival between the two groups. A subgroup analysis suggested that EPAG+tacrolimus may have better efficacy in patients under 60 years old.
BLOOD CANCER JOURNAL
(2023)
Review
Immunology
Zahra Kmira, Khirallah Sabrine, Guermazi Monia, Akkari Imen, Chiba Dorra, Bannour Rania, Fathallah Neila, Bouteraa Walid, Zaier Monia, Ben Youssef Yosra, Regaieg Haifa, Khelif Abderrahim
Summary: This paper presents a case of acute hepatitis and aplastic anemia (AA) following the COVID-19 vaccine. The patient developed acute hepatitis three weeks after receiving the Pfizer/BioNTech vaccine and subsequently developed gum bleeding and pancytopenia, leading to a diagnosis of AA. It is difficult to determine whether AA is associated with acute hepatitis or the coronavirus vaccine.
Article
Hematology
Tycel Phillips, Henry Chan, Constantine S. Tam, Alessandra Tedeschi, Patrick Johnston, Sung Yong Oh, Stephen Opat, Hyeon-Seok Eom, Heather Allewelt, Jennifer C. Stern, Ziwen Tan, William Novotny, Jane Huang, Judith Trotman
Summary: The study demonstrates favorable outcomes for patients with relapsed/refractory marginal zone lymphoma and follicular lymphoma treated with the selective Bruton's tyrosine kinase inhibitor zanubrutinib. The results support zanubrutinib as a potentially meaningful addition to available therapies for these patients.
Article
Pharmacology & Pharmacy
Xuan Gao, Zhu-Li Bian, Xiao-Hong Qiao, Xiao-Wen Qian, Jun Li, Guo-Mei Shen, Hui Miao, Yi Yu, Jian-Hua Meng, Xiao-Hua Zhu, Jun-Ye Jiang, Jun Le, Ling Yu, Hong-Sheng Wang, Xiao-Wen Zhai
Summary: This study developed a population pharmacokinetic model of cyclosporine (CsA) in Chinese pediatric patients with acquired aplastic anemia (AA) and identified body weight and total bilirubin level as important factors affecting the pharmacokinetics of CsA.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Yuanyuan Shao, Weiwei Qi, Xiaomei Zhang, Ningyuan Ran, Chunyan Liu, Rong Fu, Zonghong Shao
Summary: Patients with severe aplastic anemia (SAA) show abnormalities in both their plasma metabolomes and intestinal microbial compositions, which might reflect the molecular mechanisms involved in the defective immunity that characterizes SAA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Hematology
Tatsuhiro Sakamoto, Naoshi Obara, Yumiko Maruyama, Takayasu Kato, Naoki Kurita, Keiichiro Hattori, Yasuhito Suehara, Hidekazu Nishikii, Yasuhisa Yokoyama, Mamiko Sakata-Yanagimoto, Kensuke Usuki, Shigeru Chiba
Summary: A retrospective evaluation of 19 patients with relapsed or refractory aplastic anemia who received first-line rATG treatment in two centers between 2009 and 2020 revealed that IST2-rATG is effective and safe in treating this disease.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Xing-An Wang, Ju-Pi Li, Kang-Hsi Wu, Shun-Fa Yang, Yu-Hua Chao
Summary: Aplastic anemia is a rare but life-threatening disease characterized by low blood cell count and reduced cellularity in the bone marrow. Mesenchymal stem cell dysfunction is believed to play a role in the development of the disease. This review provides a comprehensive understanding of the involvement of mesenchymal stem cells in acquired idiopathic aplastic anemia and discusses their clinical application. The pathophysiology of the disease, properties of mesenchymal stem cells, and results of mesenchymal stem cell therapy in animal models are also described. The authors anticipate that more patients with aplastic anemia can benefit from mesenchymal stem cell therapy in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Hematology
Emma M. Groarke, Bhavisha A. Patel, Fernanda Gutierrez-Rodrigues, Olga Rios, Jennifer Lotter, Daniela Baldoni, Annie St Pierre, Ruba Shalhoub, Colin O. Wu, Danielle M. Townsley, Neal S. Young
Summary: The study compared pediatric patients under 18 years of age who received EPAG plus standard IST with a historical cohort who received IST alone, indicating that EPAG did not improve outcomes in children with treatment-naive SAA. However, in adults, EPAG significantly improved overall response rate. Younger children had lower response rates compared to adolescents.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Medicine, Research & Experimental
Wei Xu, Shenmiao Yang, Constantine S. Tam, John F. Seymour, Keshu Zhou, Stephen Opat, Lugui Qiu, Mingyuan Sun, Tingyu Wang, Judith Trotman, Ling Pan, Sujun Gao, Jianfeng Zhou, Daobin Zhou, Jun Zhu, Yuqin Song, Jianda Hu, Ru Feng, Haiwen Huang, Dan Su, Miao Shi, Jianyong Li
Summary: This study demonstrates that Zanubrutinib has long-term benefits and a favorable safety profile in the treatment of patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). Early utilization of Zanubrutinib is associated with better clinical outcomes.
ADVANCES IN THERAPY
(2022)
Article
Hematology
Zhuxin Zhang, Qinglin Hu, Chen Yang, Miao Chen, Bing Han
Summary: In this retrospective study, the efficacy and safety of Eltrombopag (ELT) and Avatrombopag (AVA) in relapsed/refractory aplastic anemia (AA) patients were compared. The study found that AVA was more suitable for patients with abnormal liver or renal function, and compared to ELT, AVA had a shorter time to response and fewer adverse events.
THERAPEUTIC ADVANCES IN HEMATOLOGY
(2023)
Article
Hematology
Diego V. Cle, Elias H. Atta, Danielle S. P. Dias, Carlos B. L. Lima, Mariana Bonduel, Gabriela Sciuccati, Larissa A. Medeiros, Michel M. de Oliveira, Patricia B. Blum Fonseca, Sara T. O. Saad, Nelson Hamerschlak, Marco A. Salvino, Marlene P. Garanito, Antonio Pazin-Filho, Phillip Scheinberg, Rodrigo T. Calado
ANNALS OF HEMATOLOGY
(2018)
Article
Oncology
Phillip Scheinberg
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
(2018)
Article
Oncology
John P. Leonard, Marek Trneny, Koji Izutsu, Nathan H. Fowler, Xiaonan Hong, Jun Zhu, Huilai Zhang, Fritz Offner, Adriana Scheliga, Grzegorz S. Nowakowski, Antonio Pinto, Francesca Re, Laura Maria Fogliatto, Phillip Scheinberg, Ian W. Flinn, Claudia Moreira, Jose Cabecadas, David Liu, Stacey Kalambakas, Pierre Fustier, Chengqing Wu, John G. Gribben, Maria Calaminici, Christiane Copie-Bergman, Armando Lopez-Guillermo, Owen O'Connor, Michael Williams, Stefan Suciu, Benjamin Levine, Julie Kern
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Article
Hematology
Thomas Winkler, Xing Fan, James Cooper, Ronan Desmond, David J. Young, Danielle M. Townsley, Phillip Scheinberg, Sophia Grasmeder, Andre Larochelle, Marie Desierto, Janet Valdez, Jennifer Lotter, Colin Wu, Ruba N. Shalhoub, Katherine R. Calvo, Neal S. Young, Cynthia E. Dunbar
Review
Immunology
Antonio M. Risitano, Serena Marotta, Patrizia Ricci, Luana Marano, Camilla Frieri, Fabiana Cacace, Michela Sica, Austin Kulasekararaj, Rodrigo T. Calado, Phillip Scheinberg, Rosario Notaro, Regis Peffault de Latour
FRONTIERS IN IMMUNOLOGY
(2019)
Editorial Material
Hematology
Phillip Scheinberg
LANCET HAEMATOLOGY
(2019)
Editorial Material
Hematology
Phillip Scheinberg
Article
Hematology
Bruno Quintino de Oliveira, Luiz F. B. Catto, Barbara A. A. Santana, M. Florencia Tellechea, Priscila S. Scheucher, Phillip Scheinberg, Rodrigo T. Calado
Summary: Eltrombopag increases the numbers of CD34(+) cells and multipotent progenitors in patients with immune aplastic anaemia, suggesting a potential role in expanding these cell populations in vivo. No aberrant phenotype was observed in the analysed samples.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Review
Hematology
Phillip Scheinberg
Summary: The advances in the management of aplastic anaemia (AA) have been successful, with better understanding of the mechanisms underlying the reduction of hematopoietic stem cells (HSCs) and improvements in supportive care. Efforts to increase immunosuppression potency and stimulate HSCs have not achieved better outcomes, but the use of thrombopoietin receptor agonists (Tpo-RA) has been effective in stimulating early HSCs despite high endogenous Tpo levels.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Meeting Abstract
Hematology
A. Pinto, J. Gribben, M. Trneny, K. Izutsu, N. H. Fowler, X. Hong, H. Zhang, F. Offner, A. Scheliga, G. Nowakowski, F. Re, L. M. Fogliatto, P. Scheinberg, I. Flinn, C. Moreira, M. Czuczman, S. Kalambakas, P. Fustier, C. Wu, J. P. Leonard
Meeting Abstract
Oncology
John G. Gribben, Koji Izutsu, Nathan Hale Fowler, Xiaonan Hong, Huilai Zhang, Fritz Offner, Adriana A. S. Scheliga, Grzegorz S. Nowakowski, Antonio Pinto, Francesca Re, Laura Maria Fogliatto, Phillip Scheinberg, Ian Flinn, Claudia Moreira, Stacey Anastasia Kalambakas, Pierre Fustier, Chengqing (Alan) Wu, John Paul Leonard
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Meeting Abstract
Biophysics
Fernando Barroso Duarte, Talyta Ellen de Jesus dos Santos, Anna Thawanny, Gadelha Moura, Yhasmine Delles Oliveira Garcia, Vaneuza Araujo Moreira Funke, Virgilio Antonio Rensi Colturato, Nelson Hamerschlak, Luiz Fernando Lopes, Maria Cristina Martins de Almeida Macedo, Afonso Celso Vigorito, Rodolfo Daniel de Almeida Soares, Alessandra Paz, Mariana Stevenazzi, Lilian Diaz, Abrahao Elias Hallack Neto, Gustavo Bettarello, Breno Moreno de Gusmao, Marco Aurelio Salvino, Rodolfo Froes Calixto, Maria Claudia Rodrigues Moreira, Gustavo Machado Teixeira, Cinthya Correa da Silva, Anderson Joao Simioni, Phillip Scheinberg, Neysimelia Costa Vilela, Romelia Pinheiro Goncalves Lemes
BONE MARROW TRANSPLANTATION
(2019)
Letter
Hematology
Catherine Lai, Vishal Ranpura, Colin Wu, Matthew J. Olnes, Ankur R. Parikh, Aarthi Shenoy, Julie Thompson, Barbara Weinstein, Phillip Scheinberg, A. John Barrett, Ronan Desmond, Neal S. Young, Christopher S. Hourigan
Meeting Abstract
Hematology
J. Gribben, M. Trneny, K. Izutsu, N. H. Fowler, X. Hong, J. Zhu, H. Zhang, F. Offner, A. Scheliga, G. Nowakowski, A. Pinto, F. Re, L. M. Fogliatto, P. Scheinberg, I. Flinn, C. Moreira, D. Liu, S. Kalambakas, P. Fustier, C. Wu, J. P. Leonard
BRITISH JOURNAL OF HAEMATOLOGY
(2019)
Correction
Medicine, General & Internal
P. Scheinberg, O. Nunez, B. Weinstein, P. Scheinberg, A. Biancotto, C. O. Wu, N. S. Young
NEW ENGLAND JOURNAL OF MEDICINE
(2018)