Article
Biochemistry & Molecular Biology
Hilary R. Keller, Davinna L. Ligons, Can Li, SuJin Hwang, Megan A. Luckey, Praveen Prakhar, Nurcin Liman, Assiatu Crossman, Vanja Lazarevic, Yoo Kyoung Park, Jung-Hyun Park
Summary: The regulatory mechanism of CD103 expression differs between CD4 and CD8 T cells, with the transcription factor Runx3 playing an important but non-essential role. Integrin beta 7 availability is crucial for CD103 surface expression, and forced CD103 expression impairs the generation of MHC-II-restricted TCR transgenic T cells. Overexpression of CD103 does not significantly affect CD4 T cells in peripheral tissues, suggesting they may use CD103-independent pathways for tissue retention.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Matyas Meggyes, Timoteus Feik, David U. Nagy, Beata Polgar, Laszlo Szereday
Summary: This study investigated the immunological consequences of improper placenta development in early-onset preeclampsia. The results showed that early-onset preeclampsia affects maternal immunotolerance against the fetus and alters the Th1 predominance developed by the mother's immune system. Significant differences were also found in the expression patterns of immune checkpoint receptors and ligands between early-onset preeclamptic and healthy pregnant women.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Simona Mutascio, Talia Mota, Lavinia Franchitti, Ashish A. Sharma, Abigail Willemse, Sydney N. Bergstresser, Hong Wang, Maura Statzu, Gregory K. Tharp, Jared Weiler, Rafick-Pierre Sekaly, Steven E. Bosinger, Mirko Paiardini, Guido Silvestri, R. Brad Jones, Deanna A. Kulpa
Summary: Using a primary cell-based in vitro latency model, this study demonstrates that CD8+ T cells can suppress HIV expression and promote latency by inducing specific changes in metabolic and signaling pathways that increase CD4+ T cell survival and stemness. This discovery of CD8-specific mechanisms involved in pro-latency activity may contribute to the development of strategies to eliminate the viral reservoir in individuals with HIV.
Article
Biology
Wei Wei, Yanjun Su
Summary: In this study, researchers used single cell sequencing technology to investigate T cells in non-small-cell lung cancer patients, identifying specific genes related to immune cell function and inferring the function of three types of T cells. The application of this technology helps to understand the mechanism of lung cancer occurrence and development, discover new diagnostic markers and therapeutic targets, and provide a theoretical reference for precise treatment of lung cancer patients in the future.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Cell Biology
Carlos van der Putten, Ester B. M. Remmerswaal, Matty L. Terpstra, Nelly D. van der Bom, Jesper Kers, Ineke J. M. ten Berge, Suzanne E. Geerlings, Rene A. W. van Lier, Frederike J. Bemelman, Michiel C. van Aalderen
Summary: In this study, the researchers aimed to investigate the presence and function of T-RM cells in healthy and allograft kidney tissue by analyzing the phenotype and function of T cells through multichannel flow cytometry. The results showed that kidney tissue samples contained a significant number of CD8 and CD4 T cells that were more actively cycling, expressed specific markers CXCR3 and CXCR6, produced higher levels of IFN gamma, and displayed polyfunctionality compared to circulating T cells.
Article
Immunology
Rouven Wannemacher, Anna Reiss, Karl Rohn, Fred Luehder, Alexander Fluegel, Wolfgang Baumgaertner, Kirsten Huelskoetter
Summary: Theiler's murine encephalomyelitis virus (TMEV) is the causative agent of TMEV-induced demyelinating disease (TMEV-IDD); a well-established animal model for the chronic progressive form of human multiple sclerosis (MS). In susceptible mice with an inadequate immune response, TMEV-IDD is triggered by virus persistence and maintained by a T cell mediated immunopathology. OT-mice are bred on a TMEV-resistant C57BL/6 background and own predominantly chicken ovalbumin (OVA)-specific populations of CD8(+) T cells (OT-I) or CD4(+) T cells (OT-II), respectively.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sherri L. L. Surman, Jeremy Crawford, Pradyot Dash, Susan L. L. Tonkonogy, Paul G. G. Thomas, Julia L. L. Hurwitz
Summary: The microbiome influences the formation of the T cell receptor repertoire, including its impact on immature thymocytes.
Article
Biochemistry & Molecular Biology
Marta Fortunato, Giada Amodio, Silvia Gregori
Summary: Tolerogenic dendritic cells (tolDC) play a central role in immune homeostasis and peripheral tolerance. We developed a protocol to generate genetically engineered tolDC overexpressing IL-10 (DCIL-10) and found that they can modulate cytotoxic CD8(+) T cell responses by reducing proliferation and activation, and inducing anergic CD8(+) T cells without signs of exhaustion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Elise Gressier, Jonas Schulte-Schrepping, Lev Petrov, Sophia Brumhard, Paula Stubbemann, Anna Hiller, Benedikt Obermayer, Jasper Spitzer, Tomislav Kostevc, Paul G. Whitney, Annabell Bachem, Alexandru Odainic, Carolien van de Sandt, Thi H. O. Nguyen, Thomas Ashhurst, Kayla Wilson, Clare V. L. Oates, Linden. J. Gearing, Tina Meischel, Katharina Hochheiser, Marie Greyer, Michele Clarke, Maike Kreutzenbeck, Sarah S. Gabriel, Wolfgang Kastenmueller, Christian Kurts, Sarah L. Londrigan, Axel Kallies, Katherine Kedzierska, Paul J. Hertzog, Eicke Latz, Yu-Chen E. Chen, Kristen J. Radford, Michael Chopin, Jan Schroeder, Florian Kurth, Thomas Gebhardt, Leif E. Sander, Birgit Sawitzki, Joachim L. Schultze, Susanne V. Schmidt, Sammy Bedoui
Summary: Bedoui and colleagues discovered a sequential integration process in APCs that enhances their ability to activate antiviral CD8(+) T cell responses. This process involves the gradual induction of specific transcriptional regulators and co-stimulatory molecules, led by CD4(+) T cell-mediated CD40 stimulation and interferon-alpha/interferon-beta activation. These findings highlight the importance of APC-T cell interactions in antiviral immunity.
Article
Immunology
Amanda M. Honan, Emily N. Vazquez, Zhibin Chen
Summary: The study revealed that CD8(+) T cells can convert to CD4(+) T cells in mice, resulting in a unique population of MHC-I-restricted CD4(+) T cells. This conversion process is influenced by MHC-II expression in lymph node stromal cells and involves a specific transcriptional switch. In vitro expansion of CI-T-reg cells using LNSCs showed potential for therapeutic applications in suppressing inflammatory tissue damage.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Can Cui, Jiawei Wang, Eric Fagerberg, Ping-Min Chen, Kelli A. Connolly, Martina Damo, Julie F. Cheung, Tianyang Mao, Adnan S. Askari, Shuting Chen, Brittany Fitzgerald, Gena G. Foster, Stephanie C. Eisenbarth, Hongyu Zhao, Joseph Craft, Nikhil S. Joshi
Summary: The study found that the enrichment of TFH cell transcriptional signature in lung adenocarcinoma patients is correlated with GC B cell signature and prolonged survival. Interactions between tumor-specific TFH and GC B cells are crucial for tumor control and effector CD8 T cell function.
Article
Immunology
Bram W. van Os, Winnie G. Vos, Laura A. Bosmans, Claudia M. van Tiel, Myrthe den Toom, Linda Beckers, Merel Admiraal, Marten A. Hoeksema, Menno P. de Winther, Esther Lutgens
Summary: Inhibition of CD40L has shown beneficial effects in autoimmune disease and inflammation. CD40L deficiency in T cells reduces CD4(+) T-cell activation and specifically decreases IFN-gamma-producing Th1 cells. CD40L in T cells affects cell death and proliferation. The study also identifies the mediator of CD40L reverse signaling and highlights the importance of both CD40L forward and reverse signaling.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Oncology
Karen Kai-Lin Fang, Jongbok Lee, Ismat Khatri, Yoosu Na, Li Zhang
Summary: The use of allogeneic CAR4-DNTs as adoptive cell therapy for T-cell malignancies is effective. CAR4-DNTs can effectively target T-ALL and PTCL and have superior cytotoxicity compared to empty-vector transduced DNTs.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Cell Biology
Yu-Jung Lu, Palmira Barreira-Silva, Shayla Boyce, Jennifer Powers, Kelly Cavallo, Samuel M. Behar
Summary: CD4 T cells play a crucial role in immunity to tuberculosis by enhancing CD8 effector functions and preventing exhaustion, promoting the survival of infected mice. Vaccines that elicit both CD4 and CD8 T cells are more likely to be successful in generating protective responses against M. tuberculosis infection.
Article
Immunology
Linlu Tian, Yongxia Wu, Hee-Jin Choi, Xiaohui Sui, Xinlei Li, M. Hanief Sofi, Mohamed Faisal Kassir, Xiao Chen, Shikhar Mehrotra, Besim Ogretmen, Xue-Zhong Yu
Summary: The Sphk1/S1P/S1PR1 pathway plays a crucial role in modulating T cell immune responses and mitochondrial activity, providing potential therapeutic targets for GVHD and leukemia.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Letter
Allergy
Andrew J. Takeda, Yu Zhang, Gillian L. Dornan, Braden D. Siempelkamp, Meredith L. Jenkins, Helen F. Matthews, Joshua J. McElwee, Weimin Bi, Filiz O. Seeborg, Helen C. Su, John E. Burke, Carrie L. Lucas
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2017)
Article
Multidisciplinary Sciences
Gillian L. Dornan, Braden D. Siempelkamp, Meredith L. Jenkins, Oscar Vadas, Carrie L. Lucas, John E. Burke
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Multidisciplinary Sciences
Kutay Deniz Atabay, Samuel A. LoCascio, Thom de Hoog, PeterW. Reddien
Article
Biochemistry & Molecular Biology
Moshe Biton, Adam L. Haber, Noga Rogel, Grace Burgin, Semir Beyaz, Alexandra Schnell, Orr Ashenberg, Chien-Wen Su, Christopher Smillie, Karthik Shekhar, Zuojia Chen, Chuan Wu, Jose Ordovas-Montanes, David Alvarez, Rebecca H. Herbst, Mei Zhang, Itay Tirosh, Danielle Dionne, Lan T. Nguyen, Michael E. Xifaras, Alex K. Shalek, Ulrich H. von Andrian, Daniel B. Graham, Orit Rozenblatt-Rosen, Hai Ning Shi, Vijay Kuchroo, Omer H. Yilmaz, Aviv Regev, Ramnik J. Xavier
Article
Immunology
Xavier Michelet, Lydia Dyck, Andrew Hogan, Roisin M. Loftus, Danielle Duquette, Kevin Wei, Semir Beyaz, Ali Tavakkoli, Cathriona Foley, Raymond Donnelly, Cliona O'Farrelly, Mathilde Raverdeau, Ashley Vernon, William Pettee, Donal O'Shea, Barbara S. Nikolajczyk, Kingston H. G. Mills, Michael B. Brenner, David Finlay, Lydia Lynch
Article
Gastroenterology & Hepatology
Yongde Luo, Yaying Yang, Muyun Liu, Dan Wang, Feng Wang, Yawei Bi, Juntao Ji, Suyun Li, Yan Liu, Rong Chen, Haojie Huang, Xiaojie Wang, Agnieszka K. Swidnicka-Siergiejko, Tobias Janowitz, Semir Beyaz, Guoqiang Wang, Sulan Xu, Agnieszka B. Bialkowska, Catherine K. Luo, Christoph L. Pin, Guang Liang, Xiongbin Lu, Maoxin Wu, Kenneth R. Shroyer, Robert A. Wolff, William Plunkett, Baoan Ji, Zhaoshen Li, Ellen Li, Xiaokun Li, Vincent W. Yang, Craig D. Logsdon, James L. Abbruzzese, Weiqin Lu
Article
Biology
Yerbol Z. Kurmangaliyev, Juyoun Yoo, Samuel A. LoCascio, S. Lawrence Zipursky
Article
Genetics & Heredity
Nina N. Brodsky, Oksana Boyarchuk, Tetyana Kovalchuk, Tetyana Hariyan, Andrew Rice, Weizhen Ji, Mustafa Khokha, Saquib Lakhani, Carrie L. Lucas
JOURNAL OF HUMAN GENETICS
(2020)
Article
Immunology
Stephen J. Gaudino, Michael Beaupre, Xun Lin, Preet Joshi, Sonika Rathi, Patrick A. McLaughlin, Cody Kempen, Neil Mehta, Onur Eskiocak, Brian Yueh, Richard S. Blumberg, Adrianus W. M. van der Velden, Kenneth R. Shroyer, Agnieszka B. Bialkowska, Semir Beyaz, Pawan Kumar
Summary: IL-22 signaling in the intestines is positively correlated with Paneth cell differentiation programs, ruling out the involvement of intestinal stem cells.
MUCOSAL IMMUNOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Nina N. Brodsky, Anjali Ramaswamy, Carrie L. Lucas
TRENDS IN MICROBIOLOGY
(2020)
Letter
Cell & Tissue Engineering
Semir Beyaz, Miyeko D. Mana, Omer H. Yilmaz
Review
Immunology
Vanessa Sancho-Shimizu, Petter Brodin, Aurelie Cobat, Catherine M. Biggs, Julie Toubiana, Carrie L. Lucas, Sarah E. Henrickson, Alexandre Belot, Stuart G. Tangye, Joshua D. Milner, Michael Levin, Laurent Abel, Dusan Bogunovic, Jean-Laurent Casanova, Shen-Ying Zhang
Summary: MIS-C, a newly emerging syndrome in children associated with COVID-19, shows heterogeneity resembling KD, possibly triggered by viruses and potentially linked to rare inborn errors of immunity altering the immune response. Discovery of monogenic IEIs underlying MIS-C may pave the way for a new genetic approach to classic KD.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Neurosciences
Alessandro Furlane, Alberto Corona, Sara Boyle, Radhashree Sharma, Rachel Rubino, Jill Habel, Eva Carlotta Gablenze, Jacqueline Giovanniello, Semir Beyaz, Tobias Janowitze, Stephen David Shea, Bo Li
Summary: Obesity is a global pandemic that is associated with many life-threatening diseases. Research shows that neurotensin-expressing neurons in mice play a role in encoding dietary preference for high-energy foods. Activating these neurons promotes obesogenic behaviors, while inhibiting them reduces feeding and hedonic eating. Long-term inactivation leads to weight loss, improved metabolic health, and protection against obesity.
NATURE NEUROSCIENCE
(2022)
Article
Cell Biology
Pierre-Paul Axisa, Tomomi M. Yoshida, Liliana E. Lucca, Herbert G. Kasler, Matthew R. Lincoln, Giang H. Pham, Dante Del Priore, Jean-Marie Carpier, Carrie L. Lucas, Eric Verdin, Tomokazu S. Sumida, David A. Hafler
Summary: Genome-wide association studies have identified numerous susceptibility loci for autoimmune diseases, particularly in genes active in immune cells. In this study, the authors focused on a specific variant of the histone deacetylase 7 (HDAC7) gene and found that it plays a protective role in immune regulation. The findings provide insights into the functional characterization of genetic susceptibility loci and offer potential targets for therapeutic interventions.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Immunology
Jose Ordovas-Montanes, Semir Beyaz, Seth Rakoff-Nahoum, Alex K. Shalek
NATURE REVIEWS IMMUNOLOGY
(2020)