IMiD immunomodulatory compounds block C/EBP  translation through eIF4E down-regulation resulting in inhibition of MM

Targeting the translational machinery as a novel treatment strategy for hematologic malignancies

(2010) P. R. Hagner et al.   BLOOD

Dexamethasone Synergizes with Lenalidomide to Inhibit Multiple Myeloma Tumor Growth, But Reduces Lenalidomide-Induced Immunomodulation of T and NK Cell Function

(2010) A. K. Gandhi et al.   CURRENT CANCER DRUG TARGETS

Recent advances of IMiDs in cancer therapy

(2010) Shirong Li et al.   CURRENT OPINION IN ONCOLOGY

Immunomodulatory derivatives induce PU.1 down-regulation, myeloid maturation arrest, and neutropenia

(2009) R. Pal et al.   BLOOD

Immunomodulatory drugs reorganize cytoskeleton by modulating Rho GTPases

(2009) Y. Xu et al.   BLOOD

C/EBP  regulates transcription factors critical for proliferation and survival of multiple myeloma cells

(2009) R. Pal et al.   BLOOD

Pomalidomide and Lenalidomide Induce p21WAF-1 Expression in Both Lymphoma and Multiple Myeloma through a LSD1-Mediated Epigenetic Mechanism

(2009) L. Escoubet-Lozach et al.   CANCER RESEARCH

Lenalidomide Oral Monotherapy Produces Durable Responses in Relapsed or Refractory Indolent Non-Hodgkin's Lymphoma

(2009) Thomas E. Witzig et al.   JOURNAL OF CLINICAL ONCOLOGY

Pomalidomide (CC4047) Plus Low-Dose Dexamethasone As Therapy for Relapsed Multiple Myeloma

(2009) Martha Q. Lacy et al.   JOURNAL OF CLINICAL ONCOLOGY

Mechanism of action of immunomodulatory drugs (IMiDS) in multiple myeloma

(2009) H Quach et al.   LEUKEMIA

Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia

(2008) A. Ferrajoli et al.   BLOOD

KD5170, a novel mercaptoketone-based histone deacetylase inhibitor, exerts antimyeloma effects by DNA damage and mitochondrial signaling

(2008) Rentian Feng et al.   MOLECULAR CANCER THERAPEUTICS

IRF4 addiction in multiple myeloma

(2008) Arthur L. Shaffer et al.   NATURE

Translationally regulated C/EBPβ isoform expression upregulates metastatic genes in hormone-independent prostate cancer cells

(2008) Myoung H. Kim et al.   PROSTATE