Article
Oncology
Edoardo Zanchetta, Chiara Maura Ciniselli, Annalisa Bardelli, Chiara Colombo, Silvia Stacchiotti, Giacomo Giulio Baldi, Salvatore Provenzano, Rossella Bertulli, Federica Bini, Alessandra Casale, Francesca Gabriella Greco, Andrea Ferrari, Paolo Verderio, Marco Fiore, Alessandro Gronchi, Paolo Giovanni Casali, Carlo Morosi, Elena Palassini
Summary: Changes in volume and MRI T2-weighted intensity play significant roles in evaluating the efficacy of MTX-VA treatment in patients with DF. Reduction in T2-signal intensity seems to better reflect symptomatic improvement, while high T2-signal intensity at baseline may be associated with further disease progression.
Article
Biochemistry & Molecular Biology
Jian-Chun Li, Wei-Feng Dai, Dan Liu, Zhi-Jun Zhang, Ming-Yan Jiang, Kai-Rui Rao, Rong-Tao Li, Hong-Mei Li
Summary: Forty-three quinolizidine alkaloids, including twelve new compounds, were isolated from Sophora alopecuroides seeds. Some of the compounds showed anti-inflammatory and cytotoxic activities.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Fangqing Zhang, Bing-Tao Ren, Yuqiao Zhou, Yangbin Liu, Xiaoming Feng
Summary: cis-Hydroindole scaffolds are commonly found in natural products, pharmaceuticals, and organocatalysts. This study developed an efficient and enantioselective method for the synthesis of cis-hydroindoles using a chiral N,N'-dioxide/Mg(OTf)(2) complex catalyzed inverse-electron-demand Diels-Alder reaction. The reaction yielded a series of substituted cis-hydroindole derivatives with multiple stereocenters and functional groups in high yields and enantioselectivities. Additionally, the enantioselective total synthesis of (+)-minovincine was achieved to demonstrate the synthetic potential of this method.
Article
Medicine, General & Internal
Pei Zhang, Yang Du, Hua Bai, Zhijie Wang, Jianchun Duan, Xin Wang, Jia Zhong, Rui Wan, Jiachen Xu, Xiran He, Di Wang, Kailun Fei, Ruofei Yu, Jie Tian, Jie Wang
Summary: Histone deacetylase inhibitor tucidinostat can alter the tumor microenvironment, promote CD8(+) T cell migration and infiltration, and enhance M1 polarization of macrophages, thereby enhancing immune therapeutic efficacy.
Article
Biochemistry & Molecular Biology
Qin Zhang, Yan-Hui Zan, Han-Gao Yang, Meng-Yue Yang, Fang-Shen Liu, Sheng-Ge Li, Xiao-Hui Peng, Bin Lin, Zhan-Lin Li, Da-Hong Li, Hui-Ming Hua
Summary: The study isolated over 20 alkaloids from Peganum harmala L., with 3-(4-hydroxyphenyl)quinoline showing potent antiproliferative activity against HepG-2 cell lines.
Review
Biochemistry & Molecular Biology
Arun Kanakkanthara, John H. Miller
Summary: Understanding the regulation of beta III-tubulin expression and its functions in different cancers is crucial for assessing its prognostic value and developing therapeutic strategies. Targeting tumors overexpressing beta III-tubulin with emerging therapeutic strategies is a key focus of current research.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Chemistry, Medicinal
Yang Xu, Xiuli Wang, Kuiru Sa, Hua Li, Lixia Chen
Summary: Sophora flavescens is a traditional Chinese medicine with roots containing various alkaloids. This study identified new and known alkaloids in the roots, determined their compound structures, and examined their inhibitory effects on the growth of MCF-7 cells. Compound 12 exhibited significant inhibitory effects and could potentially target human Rho GTPase activating protein 5 variant and human arachidonate 12-lipoxygenase (12S-type) for its anti-tumor activity.
Review
Food Science & Technology
Laleh Arzi, Reyhane Hoshyar
Summary: Saffron and its carotenoids have demonstrated anti-metastatic potential by inhibiting cell migration, invasion, angiogenesis, and affecting cell-cell adhesion through various mechanisms. Among them, crocin exhibits stronger anti-metastatic potency compared to saffron extract and crocetin.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Oncology
Xiaoyu Zhang, Jiayun Wang, Lin Zhu, Xuezhen Wang, Feifei Meng, Lei Xia, Hairong Zhang
Summary: Stigmasterol, a phytosterol derived from various herbaceous plants, has shown various pharmacological effects such as anti-inflammation, anti-diabetes, anti-oxidation, and cholesterol-lowering. It is particularly promising as a therapeutic agent for malignant tumors due to its significant anti-tumor bioactivity. Stigmasterol has been found to induce apoptosis, inhibit proliferation, metastasis and invasion, and induce autophagy in tumor cells. Mechanistic studies have revealed that stigmasterol triggers apoptosis through regulating the PI3K/Akt signaling pathway and mitochondrial reactive oxygen species, while its anti-proliferative activity is dependent on its modulation of cyclin proteins and cyclin-dependent kinase (CDK). The current understanding of stigmasterol's anti-tumor effect is limited, and there is a lack of systematic review on its underlying mechanisms.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Xingxun Bao, Jinhua Hu, Yan Zhao, Ruixue Jia, Hairong Zhang, Lei Xia
Summary: Saffron, a natural floral glycoside ester compound called crocin, has been widely recognized for its significant anti-tumor effects. Crocin exhibits multiple therapeutic effects, including anti-inflammatory, antioxidant, anti-hyperlipidemic, and anti-stone effects. It has shown promising results in various malignant tumors, such as gastric cancer, liver cancer, cervical cancer, breast cancer, and colorectal cancer. This review summarizes recent studies on the anti-tumor effects of crocin and explores its mechanisms, aiming to develop innovative approaches for malignancy treatment and anti-tumor drug exploration.
Review
Biochemistry & Molecular Biology
Md. Ahsan Habib, Md. Mobinul Islam, Md. Mukul Islam, Md. Mohidul Hasan, Kwang-Hyun Baek
Summary: Alkaloids in Nicotiana have antioxidant and antimicrobial properties, and are used in pharmaceuticals for cancer treatment. Nicotiana is also used to genetically engineer various anti-cancer molecules. The main alkaloids found in Nicotiana include nicotine, nornicotine, anatabine, and anabasine. Certain alkaloids in Nicotiana, such as beta-carboline and Kynurenines, show anti-tumor effects, particularly in colon and breast cancers. Manipulating biosynthesis pathways in Nicotiana can result in increased synthesis of different anti-tumor molecules or their derivatives or precursors.
Review
Immunology
Jingyao Tu, Hang Liang, Chunya Li, Yongbiao Huang, Ziqi Wang, Xinyi Chen, Xianglin Yuan
Summary: Tumor immunotherapy has become a focus of research and treatment due to its effectiveness and fewer side effects compared to traditional treatments. However, the abnormal angiogenesis state of tumors can affect the efficacy of immunotherapy. The application of anti-angiogenesis drugs to normalize tumor vessels has shown promise in improving the effectiveness of immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Analytical
Zhenhui Ren, Huixia Zhang, Liu Yang, Zile Wang, Jincheng Xiong, Pimiao Zheng, Jianyi Wang, Haiyang Jiang
Summary: In this study, a high-performance and broad-spectrum antibody was produced for the detection of ester-type Aconitum alkaloids (AAs), the main medicinal ingredients of Aconitum L. herbs. The monoclonal antibody obtained exhibited broad-spectrum recognition specificity of 15 ester-type AAs and had high sensitivity. The developed immunoassay method allowed for rapid and sensitive detection of toxic ester-type AAs in Aconitum L. herbs.
ANALYTICA CHIMICA ACTA
(2022)
Review
Oncology
Manru Huang, Caiyan Liu, Yingying Shao, Shiyue Zhou, Gaoyong Hu, Shuangshuang Yin, Weiling Pu, Haiyang Yu
Summary: This review summarizes several natural products with anti-tumor effects related to mitosis, and discusses their advantages and disadvantages, as well as strategies to address the disadvantages. It provides important references for drug development in cancer treatment.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Oncology
Karama Asleh, Dongsheng Tu, Dongxia Gao, Vivien Bramwell, Mark N. Levine, Kathleen Pritchard, Lois E. Shepherd, Torsten O. Nielsen
Summary: The nestin/INPP4B IHC panel can identify women with basal breast cancers who benefit from nonanthracycline chemotherapy but not endocrine adjuvant treatments. These biomarkers are associated with high grade, younger age, estrogen receptor negativity, triple-negative, core basal, and PAM50 basal-like subtypes.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Kathrin Heinrich, Lisa Miller-Phillips, Frank Ziemann, Korbinian Hasselmann, Katharina Ruehlmann, Madeleine Flach, Dorottya Biro, Michael von Bergwelt-Baildon, Julian Holch, Tobias Herold, Louisa von Baumgarten, Philip A. Greif, Irmela Jeremias, Rachel Wuerstlein, Jozefina Casuscelli, Christine Spitzweg, Max Seidensticker, Bernhard Renz, Stefanie Corradini, Philipp Baumeister, Elisabetta Goni, Amanda Tufman, Andreas Jung, Joerg Kumbrink, Thomas Kirchner, Frederick Klauschen, Klaus H. Metzeler, Volker Heinemann, C. Benedikt Westphalen
Summary: This study retrospectively analyzed the first 1000 cases of the University of Munich Molecular Tumor Board (MTB) precision oncology program. The results showed that patients with breast and biliary tract cancers were more likely to have actionable genetic variants. However, only 17% of patients implemented the treatment recommendations from the tumor board, highlighting the importance of meticulous follow-up and broad access to innovative therapies for these patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Letter
Oncology
Franziska Wachter, Katherine A. Janeway
PEDIATRIC BLOOD & CANCER
(2023)
Article
Hematology
Maike Roas, Binje Vick, Marc-Andre Kasper, Marina Able, Harald Polzer, Marcus Gerlach, Elisabeth Kremmer, Judith S. Hecker, Saskia Schmitt, Andreas Stengl, Verena Waller, Natascha Hohmann, Moreno Festini, Alexander Ludwig, Lisa Rohrbacher, Tobias Herold, Marion Subklewe, Katharina S. Goetze, Christian P. R. Hackenberger, Dominik Schumacher, Jonas Helma-Smets, Irmela Jeremias, Heinrich Leonhardt, Karsten Spiekermann
Summary: A novel FLT3-targeting ADC, 20D9-ADC, has been developed and characterized, demonstrating potent cytotoxicity to AML cells both in vitro and in vivo. The combination of 20D9-ADC with TKI midostaurin shows strong synergy, reducing aggressive AML cells below the detection limit.
Letter
Hematology
Maryam Ghalandary, Yuqiao Gao, Diana Amend, Ginte Kutkaite, Binje Vick, Karsten Spiekermann, Maja Rothenberg-Thurley, Klaus H. Metzeler, Anetta Marcinek, Marion Subklewe, Michael P. Menden, Vindi Jurinovic, Ehsan Bahrami, Irmela Jeremias
Article
Oncology
Fengbiao Zhou, Nesrine Aroua, Yi Liu, Christian Rohde, Jingdong Cheng, Anna-Katharina Wirth, Daria Fijalkowska, Stefanie Goellner, Michelle Lotze, Haiyang Yun, Xiaobing Yu, Caroline Pabst, Tim Sauer, Thomas Oellerich, Hubert Serve, Christoph Roellig, Martin Bornhaeuser, Christian Thiede, Claudia Baldus, Michaela Frye, Simon Raffel, Jeroen Krijgsveld, Irmela Jeremias, Roland Beckmann, Andreas Trumpp, Carsten Mueller-Tidow
Summary: The dynamic 2'-O-methylation of ribosomal RNA regulates leukemia stem cell activity in acute myeloid leukemia. The methylation pattern is associated with AML development stage and stem cell gene expression. Enhanced 2'-O-methylation redirects ribosome translation and controls AML stem cell self-renewal.
Article
Physiology
Kai Foerster, Hanna Marchi, Sophia Stoecklen, Olaf Dietrich, Harald Ehrhardt, Mark O. Welipultz, Andreas W. Flemmer, Benjamin Schubert, A. Marcus Mall, Birgit Ertl-Wagner, Anne Hillgendroff
Summary: This study developed a novel scoring system using MRI to assess lung structural changes in neonatal chronic lung disease. It showed high reproducibility and disease specificity, and has the potential to be used as a quantifiable endpoint in clinical trials and disease monitoring.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Medicine, Research & Experimental
Michela Carlet, Karin Schmelz, Jenny Vergalli, Tobias Herold, Daniela Senft, Vindi Jurinovic, Thomas Hoffmann, Jutta Proba, Nina Weichert, Christian Junghanss, Mareike Roth, Georg Eschenburg, Malwine Barz, Guenter Henze, Cornelia Eckert, Angelika Eggert, Johannes Zuber, Patrick Hundsdoerfer, Irmela Jeremias
Summary: In this study, researchers found that Smac mimetics (SM) could enhance the sensitivity of relapsed/refractory acute lymphoblastic leukemia (r/r ALL) cells to chemotherapy drugs. They also identified a crucial role of inhibitor of apoptosis proteins (IAP) in r/r ALL, suggesting that IAP could be a potential therapeutic target for r/r ALL.
EMBO MOLECULAR MEDICINE
(2023)
Article
Obstetrics & Gynecology
George Daskalakis, Vasilios Pergialiotis, Magnus Domelloef, Harald Ehrhardt, Gian Carlo Di Renzo, Esin Koc, Ariadne Malamitsi-Puchner, Marian Kacerovsky, Neena Modi, Andrew Shennan, Diogo Ayres-de-Campos, Elko Gliozheni, Kristiina Rull, Thorsten Braun, Artur Beke, Katarzyna Kosinska-Kaczynska, Ana Luisa Areia, Simona Vladareanu, Tanja Premru Srsen, Thomas Schmitz, Bo Jacobsson
Summary: Corticosteroids should be given to pregnant women between 24 and 33 weeks of gestation, when preterm birth is expected within the next seven days, as they have been proven to reduce neonatal mortality and morbidity. In some cases, this period can be extended up to 34(+6) weeks. It is recommended to administer the corticosteroids within 7 days of delivery, even with a single dose, to improve neurodevelopmental outcome. Betamethasone or dexamethasone can be used as corticosteroids.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Judith Behnke, Vanessa Estreich, Frank Oehmke, Bernd Axel Neubauer, Anita Windhorst, Harald Ehrhardt
Summary: Nutritional supply is crucial for the growth and development of very-low-birthweight infants, and our study confirms the effectiveness of rapid enteral feeding in reducing long-term complications. Our findings show that the standardized protocol (STENA) for enteral feeding not only reduces the need for parenteral nutrition but also improves somatic growth and reduces the requirement for mechanical ventilation. Additionally, the benefits of STENA on head circumference persist until the age of 2 years.
Article
Immunology
Anita C. Windhorst, Motaharehsadat Heydarian, Maren Schwarz, Prajakta Oak, Kai Foerster, Marion Frankenberger, Erika Gonzalez Rodriguez, Xin Zhang, Harald Ehrhardt, Christoph Huebener, Andreas W. Flemmer, Hamid Hossain, Tobias Stoeger, Christian Schulz, Anne Hilgendorff
Summary: In this study, the researchers investigated the early changes in innate immunity associated with the development of bronchopulmonary dysplasia (BPD) in preterm infants. They found that the abundance of different monocyte subtypes differed between preterm and term neonates at birth, and specific monocyte subtypes were associated with the development of BPD. The study also identified a cytokine and growth factor expression profile that corresponded to the disease-dependent regulation of monocyte abundances. Gene expression analysis revealed that genes involved in inflammatory pathways were overrepresented in predicting BPD.
FRONTIERS IN IMMUNOLOGY
(2023)
Correction
Immunology
Anita C. Windhorst, Motaharehsadat Heydarian, Maren Schwarz, Prajakta Oak, Kai Foerster, Marion Frankenberger, Erika Gonzalez Rodriguez, Xin Zhang, Harald Ehrhardt, Christoph Huebener, Andreas W. Flemmer, Hamid Hossain, Tobias Stoeger, Christian Schulz, Anne Hilgendorff
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pediatrics
Rahel Schuler, Lea Woitschitzky, Carola Eiben, Judith Beck, Alena Jaegers, Anita Windhorst, Birgit Kampschulte, Jutta Petzinger, Markus Waitz, Monique Oude Reimer-van Kilsdonk, Bernd A. Neubauer, Klaus-Peter Zimmer, Harald Ehrhardt, Burkhard Brosig, Walter A. Mihatsch
Summary: This study aims to evaluate the effects of family-centered care on preterm infants and their families. The study will be conducted in a hospital in Germany and will recruit preterm infants with a gestational age of 32 + 0 weeks or less and a birth weight of 1500 g or less, along with their parents. The study will be conducted in multiple phases, implementing family-centered care through improvements in the NICU environment, staff training, parental education, and psychosocial support. Outcome measures include the developmental outcomes and survival rate of preterm infants, parental skills and satisfaction, and staff satisfaction.
Article
Medicine, General & Internal
Harald Ehrhardt, Adrien M. Aubert, Ulrika Aden, Elizabeth S. Draper, Anna Gudmundsdottir, Heili Varendi, Tom Weber, Michael Zemlin, Rolf F. Maier, Jennifer Zeitlin
Summary: This study found no association between Apgar scores and long-term outcomes in infants born extremely preterm (EPT). This may be due to high interobserver variability in Apgar scoring, poorer response to resuscitation after birth among EPT infants, and the influence of more deleterious exposures in the neonatal intensive care unit or socioeconomic factors on outcomes during the first 5 years of life.
Article
Medicine, General & Internal
Franziska Wachter, Yana Pikman, Jacob Bledsoe, Malika Kapadia, Susanne Baumeister, Jared Rowe, Akiko Shimamura, Andrew E. Place, Susan Prockop, Jennifer Whangbo, Leslie Lehmann, John Horan, Jessica Pollard
Summary: This study presents a comprehensive treatment approach, including a second hematopoietic cell transplantation and innovative targeted therapies, for the treatment of recurrent pediatric MDS.
CLINICAL CASE REPORTS
(2023)
Article
Respiratory System
Birte Staude, Silvia Gschwendtner, Tina Frodermann, Frank Oehmke, Thomas Kohl, Susanne Kublik, Michael Schloter, Harald Ehrhardt
Summary: This prospective observational cohort study examined the bacterial signatures in the amniotic fluid (AF) of intact pregnancies and preterm deliveries, and their variations between different severity stages of bronchopulmonary dysplasia (BPD). The results showed distinct and diverse intrauterine 16S rRNA gene patterns in preterm infants, indicating the potential to identify at-risk infants and emphasizing the prenatal impact on the origins of BPD.
RESPIRATORY RESEARCH
(2023)