Review
Medicine, Research & Experimental
Deepa Ponnaiyan, C. M. Anitha, P. S. G. Prakash, Sangeetha Subramanian, Roshan R. R. Rughwani, Gayathri Kumar, Sowmya Reddy Nandipati
Summary: Mucormycosis, a life-threatening condition, is a post-COVID-19 side effect that requires early identification and timely treatment. Conventional diagnostic techniques have limitations in early detection, necessitating the use of advanced tools such as nucleic acid diagnostics and PCR. These tools aid in the prevention of adverse outcomes by identifying invasive fungal infections at an early stage.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Immunology
Dolly E. E. Montano, Susann Hartung, Melissa Wich, Rida Ali, Berit Jungnickel, Marie von Lilienfeld-Toal, Kerstin Voigt
Summary: This study reveals the interaction between invasive mucormycosis and human monocytes, providing new insights into the immune response of the host and potential therapies in the future.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Infectious Diseases
Dionysios Neofytos, Carolina Garcia-Vidal, Frederic Lamoth, Christoph Lichtenstern, Alessandro Perrella, Joerg Janne Vehreschild
Summary: The diagnosis and management of invasive aspergillosis in solid organ transplant recipients pose challenges and require specialized attention. Further research is needed to evaluate treatment response criteria and develop comprehensive guidelines for this population.
BMC INFECTIOUS DISEASES
(2021)
Article
Microbiology
S. Imbert, L. Portejoie, E. Pfister, B. Tauzin, M. Revers, J. Uthurriague, M. Hernandez-Grande, M. -E Lafon, C. Jubert, N. Issa, P. -Y Dumas, L. Delhaes
Summary: There has been a significant increase in the use of molecular tools for the diagnosis of invasive aspergillosis (IA) and mucormycosis. However, their detection range may be limited as species diversity and coinfections increase. This study evaluates a molecular workflow based on a new multiplex PCR assay for the diagnosis and species identification of IA and/or mucormycosis. The results show promising sensitivity and the ability to detect multiple species.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Microbiology
Mragnayani Pandey, Immaculata Xess, Gagandeep Singh, Rakesh Kumar, Manoranjan Mahapatra, Viveka P. Jyotsna, Reshu Agarwal, Arnab Ghosh, Azka Iram, Prashant Mani
Summary: Molecular-based approaches, such as panfungal PCR and Mucoralesspecific PCR, may provide valuable adjuncts to standard conventional methods for diagnosing invasive mucormycosis, especially among patients with negative culture results and those on antifungal therapy. The combination of panfungal PCR with Mucoralesspecific PCR, followed by sequencing, could play a significant role in the diagnosis of invasive mucormycosis, particularly in cases where both direct microscopy and culture yield negative results.
JOURNAL OF MEDICAL MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
D. P. Indu, M. L. Kala Yadhav, G. S. Chetana
Summary: This study aimed to determine the serum ferritin levels in COVID-19-associated mucormycosis (CAM) patients and isolate and identify the fungi causing secondary fungal infections. The results showed a significant increase in serum ferritin levels in CAM patients, which can be used as an early marker for screening mucormycosis. Monitoring serum ferritin levels, glycemic control, judicious use of corticosteroids, early diagnosis, and appropriate treatment can aid in the better management of the disease.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Faezeh Tolue Ghasaban, Iman Akhlaghipour, Negin Taghehchian, Amirhosein Maharati, Bahram Memar, Meysam Moghbeli
Summary: Cancer is a major cause of human deaths and a global health challenge. Late diagnosis and lack of efficient and noninvasive diagnostic methods contribute to the high mortality rate among cancer patients. MicroRNAs (miRNAs) have been identified as potential non-invasive tumor markers and therapeutic targets, with miR-185 playing a crucial role in tumor progression through the regulation of multiple signaling pathways.
PROCESS BIOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Kamila Baran, Jacek Kordiak, Slawomir Jablonski, Ewa Brzezianska-Lasota
Summary: This study evaluated the expression levels of CCR6/CCL20 mRNA and non-coding RNAs (ncRNAs) such as miR-150 and linc00673 in NSCLC tissue. It was found that CCL20 mRNA was upregulated while CCR6 mRNA was downregulated in tumor tissue. In addition, the expression levels of miR-150 and linc00673 in serum extracellular vesicles showed associations with tumor staging and histopathological type.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Pamela Houeiss, Rachel Njeim, Hani Tamim, Ahmed F. Hamdy, Tanya S. Azar, William S. Azar, Mohamed Noureldein, Youssef H. Zeidan, Awad Rashid, Sami T. Azar, Assaad A. Eid
Summary: The study aims to assess the potential role of the arachidonic acid metabolite 20-hydroxyeicosatetraenoic acid (20-HETE) in predicting the incidence and progression of diabetic kidney disease (DKD). The results show that urinary 20-HETE levels are correlated with the presence and severity of DKD, and can potentially be used as non-invasive diagnostic and prognostic markers for DKD.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Dermatology
Hyeonji Seo, Ji Yeun Kim, Hyo-Ju Son, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Sung-Han Kim
Summary: Our study suggests that blood PCR can be a useful adjunct test for diagnosing patients with suspected invasive mould infection.
Article
Medicine, General & Internal
Zheng Yingying, Yu Yongji, Cheng Qiuting, Liao Rifang, Zeng Zhuanping
Summary: The study explored has_circ_0071106 as a diagnostic marker for type 2 diabetes in south China and predicted the functional mechanism of this circRNA. It was found that has_circ_0071106 increases the risk of T2DM and may serve as a diagnostic marker for the disease.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Oncology
Dawn P. Liew, Manuel Roehrich, Lisa Loi, Sebastian Adeberg, Mustafa Syed, Ewgenija Gutjahr, Heinz Peter Schlemmer, Frederik L. Giesel, Martin Bendszus, Uwe Haberkorn, Daniel Paech
Summary: The study analysed the correlation between Ga-68-FAPI PET signals and MRI signals in 12 ACC patients. The results showed very weak positive correlations between Ga-68-FAPI PET signals and ceT1w values, and weak negative correlations with T2w values. This indicates that Ga-68-FAPI PET signalling is an independent signal in ACC patients, not just a surrogate marker of MRI sequences.
Review
Immunology
Hila Greenbaum, Bat-El Lugassy Galper, Dean H. Decter, Vered H. Eisenberg
Summary: This study indicates that autoantibodies may be effective non-invasive markers for earlier detection of endometriosis. Current literature suggests that various anti endometrial antibodies may be used for adjunctive diagnosis, with some antibodies being particularly important for early detection in mild endometriosis.
AUTOIMMUNITY REVIEWS
(2021)
Article
Neurosciences
Qi Duan, Yinuo Zhang, Weihao Zhuang, Wenlong Li, Jincai He, Zhen Wang, Haoran Cheng
Summary: This study explores the association between gait domains and Alzheimer's disease (AD) using principal components factor analysis. The results identify three domains of gait performance (rhythm, pace, and variability) that are independently associated with AD. The findings suggest that gait domains may serve as auxiliary diagnostic indices for AD.
Review
Infectious Diseases
Ali Amanati, Omid Reza Zekavat, Hamidreza Foroutan, Omidreza Azh, Ali Tadayon, Ahmad Monabati, Mohammad Hossein Anbardar, Haleh Bozorgi
Summary: Mucormycosis-associated neutropenic enterocolitis is a challenging and life-threatening complication of salvage chemotherapy in leukemic children with disease relapse. Prompt diagnosis and appropriate treatment are crucial, as traditional antibacterial therapy may not be effective in these cases. Surgical intervention and antifungal treatment such as liposomal amphotericin-B may be necessary, but the prognosis remains poor despite aggressive management.
BMC INFECTIOUS DISEASES
(2021)
Letter
Hematology
Stefano Cordella, Angelica Parisotto, Francesca Bettelli, Monica Morselli, Emiliano Barbieri, Stefano Pozzi, Anna Aquilino, Gianluca Repaci, Angela Cuoghi, Paola Bresciani, Andrea Messerotti, Corrado Colasante, Andrea Gilioli, Valeria Pioli, Davide Giusti, Elisabetta Colaci, Luca Cassanelli, Giovanni Ceccherelli, Mirco Bevini, Roberta Malavolti, Donatella Venturelli, Ambra Paolini, Silvia Martinelli, Rossana Maffei, Giovanni Riva, Vincenzo Nasillo, Tommaso Trenti, Patrizia Comoli, Enrico Tagliafico, Rossella Manfredini, Patrizia Barozzi, Leonardo Potenza, Roberto Marasca, Mario Luppi, Fabio Forghieri
ANNALS OF HEMATOLOGY
(2023)
Article
Hematology
Enrico Tiacci, Alessandro Mancini, Monia Marchetti, Gianna Maria D'Elia, Anna Candoni, Alessandro Morotti, Alessandra Romano, Alessandro Gozzetti, Alessandro Broccoli, Luca De Carolis, Riccardo Bruna, Maria Chiara Tisi, Carmine Selleri, Monia Capponi, Daniele Vallisa, Chiara Cattaneo, Matteo Giovanni Della Porta, Alessandro Busca, Brunangelo Falini, Massimo Massaia, Lorenza Bertu, Alessandro Pulsoni, Paolo Rivela, Paolo Corradini, Francesco Passamonti
Summary: Little is known about the course of COVID-19 and the antibody response to infection or vaccination in patients with hairy-cell leukaemia (HCL). In this study of 58 HCL cases, 37 unvaccinated patients developed COVID-19 with a generally favorable outcome, while active leukemia, older age, and comorbidities were associated with a worse course. Seroconversion consistently developed after infection (11 cases) and vaccination (28 cases), except in patients recently treated with anti-CD20 or venetoclax therapy. Vaccination appeared to protect against severe COVID-19 in patients with breakthrough infection.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Hematology
Michelina Dargenio, Massimiliano Bonifacio, Sabina Chiaretti, Antonella Vitale, Nicola Stefano Fracchiolla, Cristina Papayannidis, Fabio Giglio, Prassede Salutari, Ernesta Audisio, Barbara Scappini, Patrizia Zappasodi, Marzia Defina, Fabio Forghieri, Anna Maria Scattolin, Elisabetta Todisco, Monia Lunghi, Fabio Guolo, Maria Ilaria Del Principe, Mario Annunziata, Davide Lazzarotto, Michele Cedrone, Crescenza Pasciolla, Annalisa Imovilli, Ilaria Tanasi, Silvia Trappolini, Marco Cerrano, Roberta La Starza, Mauro Krampera, Nicola Di Renzo, Anna Candoni, Giovanni Pizzolo, Felicetto Ferrara, Robin Foa
Summary: This study analyzed the incidence, characteristics, treatment, and outcome of central nervous system (CNS) relapse in adult acute lymphoblastic leukemia (ALL) patients. The study found that 6.8% of patients experienced a CNS recurrence, with a higher incidence in T-cell ALL than in B-cell ALL. Risk factors for early CNS relapse included T-cell phenotype, hyperleucocytosis, and male gender. Treatment options varied, including chemotherapy, radiotherapy, intrathecal therapy, and novel agents. Allogenic transplant after complete remission showed a significant overall survival benefit. The time to CNS relapse was the strongest predictor of post-relapse survival.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Oncology
Ivana Lagreca, Vincenzo Nasillo, Patrizia Barozzi, Ilaria Castelli, Sabrina Basso, Sara Castellano, Ambra Paolini, Monica Maccaferri, Elisabetta Colaci, Daniela Vallerini, Patrizia Natali, Daria Debbia, Tommaso Pirotti, Anna Maria Ottomano, Rossana Maffei, Francesca Bettelli, Davide Giusti, Andrea Messerotti, Andrea Gilioli, Valeria Pioli, Giovanna Leonardi, Fabio Forghieri, Paola Bresciani, Angela Cuoghi, Monica Morselli, Rossella Manfredini, Giuseppe Longo, Anna Candoni, Roberto Marasca, Leonardo Potenza, Enrico Tagliafico, Tommaso Trenti, Patrizia Comoli, Mario Luppi, Giovanni Riva
Summary: This study sheds light on the dynamics of MM-specific T cells in patients with MGUS/SMM and introduces a new prognostic tool called MaMs T-cell assay, which may serve as an immunologic marker for effective disease control. The findings suggest that this assay can be routinely applied for risk assessment and prognostic evaluation in patients with monoclonal gammopathies.
Review
Oncology
Nicolo Mesini, Stefania Fiorcari, Claudio Giacinto Atene, Rossana Maffei, Leonardo Potenza, Mario Luppi, Roberto Marasca
Summary: In recent decades, the Notch pathway has been recognized as an important regulatory signaling in cell-fate decisions and its alteration has been linked to tumor genesis and progression. The focus of this review is on the activity of Notch2 receptor, which has been found to be mutated in CLL, SMZL, and NMZL. A better understanding of the pathogenic role of Notch2 and the development of targeted therapies are desired.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
L. Maurillo, A. Spagnoli, A. Candoni, C. Papayannidis, E. Borlenghi, D. Lazzarotto, L. Fianchi, M. Sciume, M. E. Zannier, F. Buccisano, M. I. Del Principe, V. Mancini, M. Breccia, R. Fanin, E. Todisco, M. Lunghi, R. Palmieri, N. Fracchiolla, P. Musto, G. Rossi, A. Venditti
Summary: This study compared the efficacy of azacitidine and decitabine in elderly patients with untreated AML. The results showed similar outcomes in terms of complete remission, overall survival, and disease free survival between the two groups.
Article
Oncology
Giovanni Marconi, Anna Candoni, Roberta Di Nicola, Chiara Sartor, Sarah Parisi, Mariachiara Abbenante, Jacopo Nanni, Gianluca Cristiano, Letizia Zannoni, Davide Lazzarotto, Benedetta Giannini, Carmen Baldazzi, Lorenza Bandini, Emanuela Ottaviani, Nicoletta Testoni, Chiara Di Giovanni Bezzi, Rania Abd-alatif, Giulia Ciotti, Renato Fanin, Giovanni Martinelli, Stefania Paolini, Paolo Ricci, Michele Cavo, Cristina Papayannidis, Antonio Curti
Summary: In elderly AML patients, early response and biology-based risk classification can predict survival, but a comprehensive disease model has limitations in stratification. Baseline comorbidity burden may also impact prognosis. Therefore, a comprehensive approach that combines AML biology with tailored interventions to patients' frailty is likely to fully exploit the anti-leukemia potential of novel drugs.
Article
Oncology
Esther Natalie Oliva, Anna Candoni, Prassede Salutari, Giuseppe A. Palumbo, Gianluigi Reda, Giuseppe Ianni, Giovanni Tripepi, Maria Cuzzola, Debora Capelli, Corrado Mammi, Caterina Alati, Maria Concetta Cannata, Pasquale Niscola, Bianca Serio, Pellegrino Musto, Ernesto Vigna, Antonio Volpe, Lorella Maria Antonia Melillo, Maria Teresa Arcadi, Donato Mannina, Maria Elena Zannier, Roberto Latagliata
Summary: Azacitidine (AZA) is a hypomethylating agent used for frontline treatment of acute myeloid leukemia (AML) in patients unfit for intensive chemotherapy. Recent research showed that maintenance therapy with AZA during complete remission improved disease-free survival (DFS) up to 2 and 5 years in AML patients aged >68 years.
Article
Oncology
Marica De Cicco, Ivana Lagreca, Sabrina Basso, Patrizia Barozzi, Stella Muscianisi, Alba Bianco, Giovanni Riva, Sara Di Vincenzo, Chiara Pulvirenti, Davide Sapuppo, Mariangela Siciliano, Vittorio Rosti, Anna Candoni, Marco Zecca, Fabio Forghieri, Mario Luppi, Patrizia Comoli
Summary: This study investigated the feasibility of producing mutated-NPM1-specific cytotoxic T cells (CTLs) for the treatment of NPM1-mutated AML patients. The results showed that mutated-NPM1-specific CTLs with specific cytokine production and high cytotoxicity against patients' leukemia cells could be obtained from both patients and donors. These polyfunctional mutated-NPM1-specific CTLs included both CD8+ and CD4+ T cells with strong lytic capacity.
Letter
Hematology
Gabriele Facchin, Giulia Battaglia, Assunta Sartor, Carla Fili, Maria Elena Zannier, Marta Lisa Battista, Renato Fanin, Anna Candoni
MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES
(2023)
Article
Oncology
Luana Fianchi, Fabio Guolo, Francesco Marchesi, Chiara Cattaneo, Michele Gottardi, Francesco Restuccia, Anna Candoni, Elettra Ortu La Barbera, Rita Fazzi, Crescenza Pasciolla, Olimpia Finizio, Nicola Fracchiolla, Mario Delia, Federica Lessi, Michelina Dargenio, Valentina Bonuomo, Maria Ilaria Del Principe, Patrizia Zappasodi, Marco Picardi, Claudia Basilico, Monica Piedimonte, Paola Minetto, Antonio Giordano, Patrizia Chiusolo, Lucia Prezioso, Caterina Buquicchio, Lorella Maria Antonia Melillo, Daniele Zama, Francesca Farina, Valentina Mancini, Irene Terrenato, Michela Rondoni, Irene Urbino, Mario Tumbarello, Alessandro Busca, Livio Pagano
Summary: This study evaluated the absolute infectious risk in 200 AML patients treated with CPX-351 and found it to have a good safety profile, with an incidence of infectious complications comparable to that of pivotal studies. The only factor significantly associated with mortality was a lack of response to CPX-351 treatment.
Correction
Hematology
V Marasco, A. Piciocchi, A. Candoni, L. Pagano, A. Guidetti, P. Musto
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Review
Medicine, Research & Experimental
Rossana Maffei, Stefania Fiorcari, Claudio Giacinto Atene, Silvia Martinelli, Nicolo Mesini, Flora Pilato, Ivana Lagreca, Patrizia Barozzi, Giovanni Riva, Vincenzo Nasillo, Ambra Paolini, Fabio Forghieri, Leonardo Potenza, Tommaso Trenti, Enrico Tagliafico, Mario Luppi, Roberto Marasca
Summary: Interferon regulatory factor 4 (IRF4) plays a crucial role in regulating B cell development and is associated with B cell malignancies. The complexity of IRF4 functions includes its involvement in different DNA-binding affinity, target motifs, and transcriptional partners.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)