Article
Hematology
Mohamed L. Sorror, Barry E. Storer, Amir T. Fathi, Andrew Brunner, Aaron T. Gerds, Mikkael A. Sekeres, Sudipto Mukherjee, Bruno C. Medeiros, Eunice S. Wang, Pankit Vachhani, Paul J. Shami, Esteban Pena, Mahmoud Elsawy, Kehinde Adekola, Selina Luger, Maria R. Baer, David Rizzieri, Tanya M. Wildes, Jamie Koprivnikar, Julie Smith, Mitchell Garrison, Kiarash Kojouri, Wendy Leisenring, Lynn Onstad, Jennifer E. Nyland, Pamela S. Becker, Jeannine S. McCune, Stephanie J. Lee, Brenda M. Sandmaier, Frederick R. Appelbaum, Elihu H. Estey
Summary: The study found that less-intensive induction therapies in older patients with AML were associated with higher mortality risks, but after adjusting for age, physician-assigned KPS, and chance of cure, mortality risks and QOL were similar. Patients receiving less-intensive therapies had shorter lengths of hospitalization. Randomized trials are needed to better assess the value of less-intensive and intensive therapies in older or medically infirm patients.
Editorial Material
Critical Care Medicine
Martin A. C. Manoukian, Rebecca L. Corbett, Bryn E. Mumma, Morgan A. Darrow, Richart W. Harper
Summary: The 70-year-old female patient presented with worsening dyspnea and a complex medical history including diabetes, hypertension, hyperlipidemia, COPD, hypothyroidism, diastolic heart failure, and a significant smoking history. She was transferred to the ED for severe hypoxemia and intubated. Her case highlights the importance of comprehensive management for patients with multiple comorbidities.
Editorial Material
Medicine, General & Internal
Francesco Pata, Giovanni Stamati, Bruno Nardo
Summary: A 70-year-old woman with multiple comorbidities including hypertension, atrial fibrillation, congestive heart failure, and gallstones presented with 3 days of symptoms including nausea, vomiting, and abdominal pain. Imaging showed a thickened gallbladder wall with intraluminal air adherent to the duodenum and a gallstone in the middle ileum with proximal bowel distension. The diagnosis is... and the next step would be...
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Biochemistry & Molecular Biology
Daniela Damiani, Mario Tiribelli
Summary: The prognosis of acute myeloid leukemia (AML) remains unsatisfactory due to poor response to therapy or relapse, which can be attributed to the over-expression of multidrug resistance (MDR) proteins. ABCG2, an efflux transporter responsible for inducing MDR in leukemic cells, has the ability to extrude many antineoplastic drugs, leading to AML resistance and/or relapse. This review focuses on the expression and role of ABCG2, as well as its regulation and potential inhibition to counteract drug resistance and improve outcomes in AML patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Critical Care Medicine
Saki Tomiyasu, Hiroki Kabata, Katsura Emoto, Shuhei Azekawa, Chihaya Maeda, Kyohei Masai, Hiroyuki Yasuda, Koichi Fukunaga
Summary: A 70-year-old woman with a previous diagnosis of pneumonia was referred to our hospital due to persistent cough and lung infiltrates. She had a history of breast cancer surgery 30 years ago but had no other medical history and no smoking history.
Editorial Material
Critical Care Medicine
Michelle B. Herberts, Tucker F. Johnson, Patricio Escalante
Summary: This 70-year-old man presented with recurrent respiratory infections, chronic cough, and blood-tinged sputum. Besides having chronic rhinitis and a low serum IgM level, his family history revealed alpha-1 antitrypsin deficiency in his mother.
Review
Oncology
Dong-Yeop Shin
Summary: The TP53 gene is frequently mutated in various human cancers and is the first tumor suppressor gene discovered. Mutations within the DNA-binding domain of TP53 result in loss of DNA-binding capability of p53 protein. However, the phenotypic landscape of TP53 mutations is complex and presents a significant challenge in developing effective treatment strategies. TP53-mutated AML is associated with poor prognosis and is classified as a distinct subgroup within AML. Current standard treatments are largely ineffective for TP53-mutated AML, and there is an urgent need for novel treatment approaches.
Editorial Material
Cardiac & Cardiovascular Systems
Christopher C. Cheung, Edward P. Gerstenfeld
Summary: This case report discusses the diagnosis of scimitar syndrome in a 79-year-old woman who presented with worsening dyspnea on exertion and new-onset atrial fibrillation.
Article
Medicine, General & Internal
Peter C. Grayson, Cory A. Perugino, Vincent V. Dinculescu, Judith A. Ferry
Summary: This case report describes a 70-year-old man with a history of various diseases who presented with recurrent left pleural effusion. Diagnostic tests were performed to guide treatment decisions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Oncology
Kordelia Barbullushi, Nicolo Rampi, Fabio Serpenti, Mariarita Sciume, Sonia Fabris, Pasquale De Roberto, Nicola Stefano Fracchiolla
Summary: Immunotherapy is revolutionizing the treatment of hematologic diseases. However, in acute myeloid leukemia (AML), the options have been limited to one approved drug, gemtuzumab ozogamicin. This review focuses on the use of vaccines in AML and discusses their biological mechanisms and clinical impact. Various vaccine strategies have been explored, with promising results in terms of toxicity and application in elderly patients. However, the clinical outcomes are still unsatisfactory, and further research is needed to determine the best approach. Vaccines have advantages of being less toxic and more manageable compared to other immunotherapeutic strategies. However, their effectiveness may be limited in active or high-burden disease. Future studies should aim to optimize immunotherapy-based strategies, including the use of vaccines, to achieve long-term disease control in AML.
Article
Medicine, General & Internal
Michael K. Mansour, Joseph D. King, Steven T. Chen, Jay A. Fishman, Rosalynn M. Nazarian
Summary: A 70-year-old man with a history of kidney transplantation presented with rashes during his hospitalization for Covid-19, respiratory failure, and bacteremia. A diagnosis was eventually made.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Multidisciplinary Sciences
Yaping Chang, Gordon H. Guyatt, Trevor Teich, Jamie L. Dawdy, Shaneela Shahid, Jessica K. Altman, Richard M. Stone, Mikkael A. Sekeres, Sudipto Mukherjee, Thomas W. LeBlanc, Gregory A. Abel, Christopher S. Hourigan, Mark R. Litzow, Laura C. Michaelis, Shabbir M. H. Alibhai, Pinkal Desai, Rena Buckstein, Janet MacEachern, Romina Brignardello-Petersen
Summary: The study compared the effectiveness and safety of intensive antileukemic therapy to less-intensive therapy in older adults with acute myeloid leukemia, and found that intensive therapy may lead to longer survival and higher probability of receiving allogeneic hematopoietic stem cell transplantation, but also increase the risk of severe, treatment-emergent adverse events and longer duration of intensive care unit hospitalization.
Article
Medicine, General & Internal
Andrew M. Brunner, Richard A. Newcomb, Yi-Bin Chen, Andrew M. Crabbe
Summary: The text discusses the evaluation of a 49-year-old man with relapsed acute myeloid leukemia, identifying a new FLT3-ITD mutation through molecular genetic profiling. Management decisions were made based on a bone marrow biopsy.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Editorial Material
Critical Care Medicine
Bashaer Gheyath, Alirameen Akram, Raymond Gong, Jason Tovar, Ezra Amsterdam, Sandhya Venugopal
Summary: A 70-year-old male patient presenting with left thigh pain and transient chest discomfort, with a history of cerebrovascular disease, hypertension, and drug abuse. Physical examination revealed tenderness in the left thigh, irregular tachycardia, and otherwise normal findings.
Article
Chemistry, Multidisciplinary
James A. Sommers, Lauren Palys, Nicolas P. Martin, Dylan B. Fast, Mehran Amiri, May Nyman
Summary: The study reveals the differences in solution phase chemistry between zirconium and hafnium, providing molecular level details of their separation process.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
