Article
Medicine, Research & Experimental
Suet Yen Chong, Olga Zharkova, Siti Maryam J. M. Yatim, Xiaoyuan Wang, Xiong Chang Lim, Chenyuan Huang, Chia Yee Tan, Jianming Jiang, Lei Ye, Michelle Siying Tan, Veronique Angeli, Henri H. Versteeg, Mieke Dewerchin, Peter Carmeliet, Carolyn S. P. Lam, Mark Y. Chan, Dominique P. V. de Kleijn, Jiong-Wei Wang
Summary: The study found that the TF cytoplasmic domain exacerbates post-infarct cardiac injury and adverse LV remodeling by regulating inflammation and angiogenesis. Targeted inhibition of TF cytoplasmic domain-mediated intracellular signaling may ameliorate post-infarct LV remodeling.
Article
Biochemistry & Molecular Biology
Hyungjoo Kim, Seogho Son, Yunhyo Ko, Incheol Shin
Summary: CTGF is overexpressed in TNBC and associated with poor prognosis. It enhances aerobic glycolysis by activating the FAK/Src/NF-κB p65 signaling axis. The study suggests CTGF as a potential therapeutic target in TNBC.
Article
Nanoscience & Nanotechnology
Barbara Blanco-Fernandez, Sergi Rey-Vinolas, Gulsun Bagci, Gerard Rubi-Sans, Jorge Otero, Daniel Navajas, Soledad Perez-Amodio, Elisabeth Engel
Summary: Breast tissue-derived matrices can serve as important biomaterials to replicate the complexity of the tumor extracellular matrix (ECM), with the addition of collagen type I improving the fidelity to breast tumors. These novel bioinks have great potential in bioprinting breast cancer models.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Ying-Ying Liu, Hong-Yi Liu, Tian-Jian Yu, Qin Lu, Fang-Lin Zhang, Guang-Yu Liu, Zhi-Ming Shao, Da-Qiang Li
Summary: This study reveals the importance of MORC2 O-GlcNAcylation in breast cancer progression. MORC2 is O-GlcNAcylated by OGT at threonine 556, and this modification is required for its role in breast cancer cell migration and invasion. TGF-beta 1 induces MORC2 O-GlcNAcylation through enhancing the stability of GFAT, and O-GlcNAcylated MORC2 is necessary for the transcriptional activation of TGF-beta 1 target genes CTGF and SNAIL. These findings provide evidence for targeting MORC2-dependent breast cancer through blocking its O-GlcNAcylation.
CELL DEATH AND DIFFERENTIATION
(2022)
Review
Oncology
Yujian Wu, Mengjie Li, Jiayi Lin, Chenxia Hu
Summary: Breast cancer is the most common type of cancer among women worldwide, and studies have shown that the Hippo signaling pathway and the TEAD family of transcription factors play important roles in breast cancer development.
Article
Immunology
Christoph F. A. Vogel, Gwendal Lazennec, Sarah Y. Kado, Carla Dahlem, Yi He, Alejandro Castaneda, Yasuhiro Ishihara, Christian Vogeley, Andrea Rossi, Thomas Haarmann-Stemmann, Juliann Jugan, Hidetoshi Mori, Alexander D. Borowsky, Michele A. La Merrill, Colleen Sweeney
Summary: AhRR is a potential tumor suppressor that can inhibit the development of mammary tumors, suggesting therapeutic potential for the restoration and expression of AhRR.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Bo Yu, Jun Su, Qiqi Shi, Qing Liu, Jun Ma, Guoqing Ru, Lei Zhang, Jian Zhang, Xichun Hu, Jianming Tang
Summary: This study identifies a new regulatory mechanism for SNIP1, in which it is methylated by KMT5A to initiate oncogenic functions. The study also reveals how SNIP1 methylation promotes breast cancer cell growth, invasion, and lung metastasis, and drives tumorigenesis and metastasis by activating the YAP pathway.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Electrical & Electronic
Arif Mohd. Kamal, Uttam M. Pal, Ashika Nayak, Tejaswi Medisetti, B. S. Arjun, Hardik J. Pandya
Summary: A LED-based time-domain near-infrared spectroscopy system was proposed for rapid and accurate breast cancer diagnosis. Different parameters measured on cancerous and adjacent normal tissues confirmed the effectiveness of the spectroscopy system.
IEEE SENSORS JOURNAL
(2021)
Article
Medicine, Research & Experimental
Cancan Lyu, Yuanchao Ye, Maddison M. Lensing, Kay-Uwe Wagner, Ronald J. Weigel, Songhai Chen
Summary: In HER2(+) breast cancer, overactivation of HER2 leads to aberrant G(i/o)-GPCR signaling, promoting cancer progression and resistance to HER2-targeted therapy. Pharmacologically deactivating GPCR signaling can block tumor growth and enhance therapeutic efficacy.
Article
Multidisciplinary Sciences
Cezanne Miete, Gonzalo P. Solis, Alexey Koval, Martina Bruckner, Vladimir L. Katanaev, Jurgen Behrens, Dominic B. Bernkopf
Summary: This study finds that G alpha i2 can induce the condensation of conductin, leading to the degradation of β-catenin and inhibition of Wnt signaling, thus suppressing the growth of colorectal cancer. Colorectal cancer evades this inhibition by decreasing the expression of G alpha i2 and inactivating mutations, but the G alpha i2-activating drug guanabenz can reduce colorectal cancer growth.
NATURE COMMUNICATIONS
(2022)
Article
Physiology
Abishek Iyer, Tyrone L. R. Humphries, Evan P. Owens, Kong-Nan Zhao, Paul P. Masci, David W. Johnson, David Nikolic-Paterson, Glenda C. Gobe, David P. Fairlie, David A. Vesey
Summary: Activation of PAR2 on HTECs stimulates synthesis and secretion of TF, leading to blood clotting, attenuated by PAR2 antagonism. Thrombin and specific PAR2 activators induce TF synthesis, while peptide activators of PAR1, PAR3, and PAR4 do not. TF secretion is associated with extracellular vesicles.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ali Tahir Sair, Rui Hai Liu
Summary: Breast cancer is a highly aggressive and heterogeneous disease that affects women's lifespan and quality of life. Research has shown that phenolic compounds can control the onset of breast cancer by influencing cell proliferation and apoptosis, particularly the insulin-like growth factor 1 signaling cascade. This review mainly discusses the role of phenolic compounds in regulating the IGF-1 signaling cascade and curbing breast malignancies.
Article
Biochemistry & Molecular Biology
Elzbieta Zarychta, Barbara Ruszkowska-Ciastek
Summary: This article summarizes the roles of angiogenesis, chemotaxis, and coagulation in the development of distant metastases in breast cancer. It highlights that breast cancer is still one of the main causes of morbidity and mortality in women worldwide, but the number of deaths has decreased due to improved diagnostic and therapeutic opportunities. However, metastatic disease remains a therapeutic challenge.
Article
Multidisciplinary Sciences
Radhakrishnan Vishnubalaji, Nehad M. Alajez
Summary: TGF beta signaling in TNBC is complex and involves regulation of protein coding genes and long non-coding RNA. The study provides a comprehensive analysis of the transcriptional landscape in response to TGF beta activation and inhibition, revealing potential targets for TGF beta regulation in TNBC.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Tyrone L. R. Humphries, Kunyu Shen, Abishek Iyer, David W. Johnson, Glenda C. Gobe, David Nikolic-Paterson, David P. Fairlie, David A. Vesey
Summary: Coagulopathies in patients with diabetes and CKD are not fully understood. This study found that glucose availability affects TF synthesis in HTECs through PAR2 activation, and high glucose concentrations enhance this process while inhibiting PAR2, glycolysis, or glycosylation suppresses TF synthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Saravanan Subramaniam, Wolfram Ruf, Markus Bosmann
Summary: Identifying drug targets to mitigate vascular dysfunction, thrombo-inflammation, and thromboembolic complications in COVID-19 is crucial. Understanding the interactions between viral and PAR proteins may lead to potential treatments using PAR1/2 blockers against cytokine release syndrome and COVID-19-associated coagulopathy.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Hematology
Fatemeh Shahneh, Hans Christian Probst, Sabine C. Wiesmann, Noelia A-Gonzalez, Wolfram Ruf, Kerstin Steinbrink, Verena K. Raker, Christian Becker
Summary: This study investigated the role of inflammatory Ly6C(hi) monocytes in deep vein thrombosis, and found that thrombus formation, growth, and resolution can be therapeutically manipulated with a NR4A1 agonist.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Sagarika Chakrabarty, Quyen Bui, Leylla Badeanlou, Kelly Hester, Jerold Chun, Wolfram Ruf, Theodore P. Ciaraldi, Fahumiya Samad
Summary: Sphingosine-1-phosphate (SIP) plays an important role in regulating cell growth, immune cell trafficking, and inflammation. Increased expression of S1PR3 in adipose tissues and the liver is associated with obesity and metabolic dysfunction. S1P-S1PR3 signaling pathway defends against excessive inflammation and steatosis in adipose and liver to maintain metabolic homeostasis.
Article
Cardiac & Cardiovascular Systems
Connie N. Hess, Warren H. Capell, Michael R. Bristow, Wolfram Ruf, Michael Szarek, David A. Morrow, Jose C. Nicolau, Christopher A. Graybill, Debra Marshall, Judith Hsia, Marc P. Bonaca
Summary: The ASPEN-COVID-19 study aims to evaluate a novel therapeutic approach for COVID-19 by targeting tissue factor. The study design includes a randomized phase 2b trial with 160 participants and focuses on D-dimer levels and bleeding events as primary endpoints.
AMERICAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Michael Molitor, Maria T. Bayo-Jimenez, Omar Hahad, Claudius Witzler, Stefanie Finger, Venkata S. Garlapati, Sanela Rajlic, Tanja Knopp, Tabea K. Bieler, Melania Aluia, Johannes Wild, Jeremy Lagrange, Recha Blessing, Steffen Rapp, Andreas Schulz, Hartmut Kleinert, Susanne Karbach, Sebastian Steven, Wolfram Ruf, Philipp Wild, Andreas Daiber, Thomas Muenzel, Philip Wenzel
Summary: The study found that aircraft noise may have a significant impact on the development and deterioration of ischaemic heart disease. Exposure to noise before myocardial infarction (MI) can induce cardiovascular dysfunction and inflammation, leading to worsened cardiac function and increased inflammation in the vascular and cardiac tissues. The findings suggest that reducing environmental noise exposure may improve the clinical outcomes of patients with MI.
CARDIOVASCULAR RESEARCH
(2023)
Article
Hematology
Lennart Beckmann, Jonathan Maeder, Minna Voigtlaender, Felix Klingler, Anita Schulenkorf, Carina Lehr, Judith Regenhardt, Carsten Bokemeyer, Wolfram Ruf, Christina Rolling, Florian Langer
Summary: PACMA-31 regulates monocyte TF production in a concentration-dependent manner, with low concentrations increasing TF production and high concentrations converting TF into a non-coagulant state.
THROMBOSIS RESEARCH
(2022)
Article
Multidisciplinary Sciences
Solveig Hasselwander, Ning Xia, Maximilian Mimmler, Stefanie Ascher, Tanja Knopp, Gisela Reifenberg, Susanne Karbach, Wolfram Ruf, Christoph Reinhardt, Huige Li
Summary: This study reveals the important role of B cells in venous thrombosis, showing that B cell-deficient mice develop larger thrombi due to increased neutrophil numbers and elevated fibrinogen levels. It also demonstrates the contribution of neutrophil extracellular traps in thrombus formation.
Article
Hematology
Asim Cengiz Akbulut, Ryanne A. Arisz, Constance C. F. M. J. Baaten, Gaukhar Baidildinova, Aarazo Barakzie, Rupert Bauersachs, Jur Ten Berg, Wout W. A. van den Broek, H. C. de Boer, Amandine Bonifay, Vanessa Broker, Richard J. Buka, Hugo ten Cate, Arina J. ten Cate-Hoek, S. Cointe, Ciro De Luca, Ilaria De Simone, Rocio Vacik Diaz, Francoise Dignat-George, Kathleen Freson, Giulia Gazzaniga, Eric C. M. van Gorp, Anxhela Habibi, Yvonne M. C. Henskens, Aaron F. J. Iding, Abdullah Khan, Gijsje H. Koenderink, Akhil Konkoth, Romaric Lacroix, Trisha Lahiri, Wilbur Lam, Rachel E. Lamerton, Roberto Lorusso, Qi Luo, Coen Maas, Owen J. T. McCarty, Paola E. J. van der Meijden, Joost C. M. Meijers, Adarsh K. Mohapatra, Neta Nevo, Alejandro Pallares Robles, Philippe Poncelet, Christoph Reinhardt, Wolfram Ruf, Ronald Saraswat, Claudia Schonichen, Roger Schutgens, Paolo Simioni, Stefano Spada, Henri M. H. Spronk, Karlygash Tazhibayeva, Jecko Thachil, Rocio Vacik Diaz, L. Vallier, Alicia Veninga, Peter Verhamme, Chantal Visser, Steve P. Watson, Philip Wenzel, Ruth A. L. Willems, Anne Willers, Pengyu Zhang, Konstantinos Zifkos, Anton Jan van Zonneveld
Summary: The Fourth Maastricht Consensus Conference on Thrombosis covered a wide range of topics, including the role of coagulation proteins in cardiovascular disease, novel mechanisms of thrombosis, strategies to limit bleeding risks, hemostasis in extracorporeal systems, and clinical dilemmas in thrombosis and antithrombotic management. The conference also revisited the coagulopathy associated with COVID-19.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Gastroenterology & Hepatology
Alba Santiago, Amber Hann, Marco Constante, Sara Rahmani, Josie Libertucci, Kyle Jackson, Gaston Rueda, Laura Rossi, Ramachandran Rithwick, Wolfram Ruf, Jon Schertzer, Alberto Caminero, Premysl Bercik, Heather Jean Galipeau, Elena Francisca Verdu
Summary: Emerging evidence suggests that microbial proteolytic activity is implicated in ulcerative colitis (UC), but its role in Crohn's disease (CD) remains unclear. This study investigated the effects of colonizing germ-free mice with CD microbiota and healthy control microbiota. It was found that CD proteolytic microbiota increased colitis severity through a PAR2 pathway. These findings highlight the proinflammatory nature of CD proteolytic microbiota and its role in exacerbating colitis.
Article
Hematology
Monique J. T. Crobach, Rayna J. S. Anijs, Sigrid K. Braekkan, Marianne T. Severinsen, Jens Hammerstrom, Hanne Skille, Soren R. Kristensen, Benedikte Paulsen, Anne Tjonneland, Henri H. Versteeg, Kim Overvad, John-Bjarne Hansen, Inger A. Naess, Suzanne C. Cannegieter
Summary: Patients with cancer have a higher risk of developing venous thromboembolism (VTE), which leads to poorer survival compared to cancer alone. This study aimed to investigate the impact of VTE on cancer patients' survival in a general population. The findings showed that cancer patients with VTE had a 3.4-fold higher risk of death compared to those without VTE, regardless of cancer type.
Article
Hematology
Chantal Kroone, Chris Tieken, Beguem Kocaturk, Madelon Paauwe, Erik J. Blok, Betuel Unlu, Yascha W. van den Berg, Eliana Stanganello, Maaike Y. Kapteijn, Nathalie Swier, Xi Zhang, Danique E. M. Duits, Yazhi Lin, Lisa V. E. Oostenbrink, Rob F. P. van den Akker, Laurent O. Mosnier, Lukas J. Hawinkels, Bart J. M. van Vlijmen, Wolfram Ruf, Peter J. Kuppen, Suzanne C. Cannegieter, Jeroen T. Buijs, Henri H. Versteeg
Summary: Cancer enhances the risk of venous thromboembolism and promotes cancer progression by creating a hypercoagulant microenvironment. Although anticoagulants have been considered as a potential anticancer treatment, their effect on cancer progression remains unclear. The study reveals that breast cancer cells express increased levels of factor VII (FVII), which stimulates epithelial-to-mesenchymal transition (EMT) and metastasis. Surprisingly, liver-derived FVII inhibits metastasis. It suggests that tumor-expressed FVII and liver-derived FVII have opposing effects on EMT and metastasis.
Article
Hematology
Connie N. Hess, Judith Hsia, Ian A. Carroll, Mark R. Nehler, Wolfram Ruf, David A. Morrow, Jose C. Nicolau, Otavio Berwanger, Michael Szarek, Warren H. Capell, Shilpa Johri, Michael S. Pursley, Ryan Gupta, Patrick S. Meehan, Francesco Franchi, Mark B. Effron, Debra Marshall, Christopher A. Graybill, Sophia P. Huebler, Thomas Keuer, Michael R. Bristow, Marc P. Bonaca
Summary: Thrombo-inflammation plays a central role in COVID-19-associated coagulopathy. The novel TF inhibitor rNAPc2 may be a potential therapeutic target for COVID-19, however, its safety and efficacy are still unknown.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Giulia Pontarollo, Bettina Kollar, Amrit Mann, My Phung Khuu, Klytaimnistra Kiouptsi, Franziska Bayer, Ines Brandao, Valeriya V. V. Zinina, Jennifer Hahlbrock, Frano Malinarich, Maximilian Mimmler, Sudhanshu Bhushan, Federico Marini, Wolfram Ruf, Meriem Belheouane, John F. F. Baines, Kristina Endres, Scott M. M. Reba, Verena K. K. Raker, Carsten Deppermann, Christoph Welsch, Markus Bosmann, Natalia Soshnikova, Benoit Chassaing, Mattias Bergentall, Felix Sommer, Fredrik Backhed, Christoph Reinhardt
Summary: The gut microbiota weakens the intestinal barrier by suppressing epithelial neuropilin-1 (NRP1) and Hedgehog (Hh) signaling. Activation of Toll-like receptor-2 (TLR2) by commensal microbiota dampens Hh pathway signaling, resulting in decreased NRP1 protein levels. Conversely, elevated NRP1 levels in germ-free mice are associated with a strengthened gut barrier.
Article
Medicine, Research & Experimental
Venkata Garlapati, Michael Molitor, Thomas Michna, Gregory S. Harms, Stefanie Finger, Rebecca Jung, Jeremy Lagrange, Panagiotis Efentakis, Johannes Wild, Maike Knorr, Susanne Karbach, Sabine Wild, Ksenija Vujacic-Mirski, Thomas Muenzel, Andreas Daiber, Moritz Brandt, Tommaso Gori, Hendrik Milting, Stefan Tenzer, Wolfram Ruf, Philip Wenzel
Summary: Despite advances in MI interventions, adverse cardiac remodeling and fibrosis leading to IHF remain a major cause of death. A profibrotic coagulation signaling pathway involving MAPK could be targeted for improved cardiac function post-MI. Targeted interventions with trametinib in this pathway show promising results in a murine model.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Hematology
Rayna J. S. Anijs, El Houari Laghmani, Betul Unlu, Szymon M. Kielbasa, Hailiang Mei, Suzanne C. Cannegieter, Frederikus A. Klok, Peter J. K. Kuppen, Henri H. Versteeg, Jeroen T. Buijs
Summary: This study aimed to identify novel tumor-expressed miRNAs associated with VTE in colorectal cancer. Through sequencing analysis, 19 differentially regulated tumor-expressed miRNAs were identified, which may provide insights into the biological mechanism and serve as potential predictive biomarkers.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2022)