Article
Allergy
Rebecca A. Marsh, Kyle Hebert, Soyoung Kim, Christopher C. Dvorak, Victor M. Aquino, K. Scott Baker, Deepak Chellapandian, Blachy Davila Saldana, Christine N. Duncan, Michael J. Eckrich, George E. Georges, Timothy S. Olson, Michael A. Pulsipher, Shalini Shenoy, Elizabeth Stenger, Mark Vander Lugt, Lolie C. Yu, Andrew R. Gennery, Mary Eapen
Summary: Allogeneic hematopoietic cell transplantation for hemophagocytic lymphohistiocytosis (HLH) disorders is associated with substantial morbidity and mortality. The study found that conditioning regimens using flu/melphalan and flu/melphalan/thiotepa had better outcomes compared to other regimens in terms of post-transplant complications and survival rates in HLH patients.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Oncology
Lingbo He, Yini Wang, Dina Suolitiken, Ruoxi Zhang, Menghan Liu, Zhengjie Hua, Shuyan Yao, Heshan Zou, Zhao Wang
Summary: Allogenic hematopoietic stem cell transplantation (HSCT) is a promising method to cure adult-onset primary hemophagocytic lymphohistiocytosis (pHLH) with a 5-year probability of survival reaching 60%. Achieving complete response (CR) before HSCT contributes to a better outcome for patients. Haploidentical HSCT (haplo-HSCT) is safe and effective for adult pHLH patients, and donors with monoallelic mutations in pHLH-related genes but normal cytotoxic functions are reliable.
HEMATOLOGICAL ONCOLOGY
(2022)
Article
Hematology
Mahasweta Gooptu, Haesook T. Kim, Eric Jacobsen, David C. Fisher, Ann LaCasce, Vincent T. Ho, Corey S. Cutler, John Koreth, Robert J. Soiffer, Joseph H. Antin, Nancy Berliner, Sarah Nikiforow
Summary: Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome that can be fatal if not diagnosed and treated early. Allogeneic hematopoietic stem cell transplantation (HSCT) is a potential curative option for primary and relapsed/refractory HLH cases. This study analyzed the outcomes of adult HLH patients who underwent HSCT with a reduced intensity platform and early administration of alemtuzumab at a cancer institute. The results showed high overall survival and progression-free survival rates, suggesting that HSCT with a reduced intensity regimen can effectively treat HLH in adults.
Article
Hematology
Dietrich W. Beelen, Matthias Stelljes, Peter Remenyi, Eva-Maria Wagner-Drouet, Peter Dreger, Wolfgang Bethge, Fabio Ciceri, Friedrich Stoelzel, Christian Junghanss, Helene Labussiere-Wallet, Kerstin Schaefer-Eckart, Goetz U. Grigoleit, Christof Scheid, Francesca Patriarca, Alessandro Rambaldi, Dietger Niederwieser, Inken Hilgendorf, Domenico Russo, Gerard Socie, Ernst Holler, Bertram Glass, Jochen Casper, Gerald Wulf, Nadezda Basara, Maria Bieniaszewska, Gernot Stuhler, Mareike Verbeek, Ursula La Rocca, Juergen Finke, Fabio Benedetti, Uwe Pichlmeier, Anja Klein, Joachim Baumgart, Miroslaw Markiewicz
Summary: In older or comorbid patients with acute myeloid leukemia or myelodysplastic syndrome undergoing allogeneic hematopoietic cell transplantation, treosulfan-based conditioning regimen shows better event-free survival and overall survival compared to a widely applied reduced-intensity conditioning busulfan regimen.
AMERICAN JOURNAL OF HEMATOLOGY
(2022)
Review
Immunology
Asim Saha, Bruce R. Blazar
Summary: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment option for hematological malignancies. However, conventional allo-HSCT methods have adverse effects and can lead to graft-versus-host-disease. Recent developments in targeted radiotherapy and antibody-based conditioning show promise in improving the outcomes of allo-HSCT.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mette Jorgensen, Jens C. Norgaard, Emma E. Ilett, Ramtin Z. Marandi, Marc Noguera-Julian, Roger Paredes, Daniel D. Murray, Jens Lundgren, Cameron Ross MacPherson, Henrik Sengelov
Summary: This study examines the impact of allogeneic hematopoietic stem cell transplantation (aHSCT) on the taxonomic features and metabolic functions of gut bacteria in patients with malignant hematologic disorders. The results show that there is a decrease in bacterial diversity and metabolic functions post-transplant, especially in the myeloablative group.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Suguru Uemura, Daiichiro Hasegawa, Kenji Kishimoto, Tomoko Fujikawa, Sayaka Nakamura, Aiko Kozaki, Atsuro Saito, Toshiaki Ishida, Takeshi Mori, Kayo Ozaki, Yoshiyuki Kosaka
Summary: This study examined the association between conditioning intensity and height growth in pediatric patients who underwent allo-HSCT. The results showed significant differences in height SDS between MAC and RIC groups at 2 and 3 years after allo-HSCT. Multivariate logistic regression analysis indicated that MAC regimen was associated with an increased risk of short stature at 3 years after allo-HSCT.
Article
Hematology
Oscar B. Lahoud, Sean M. Devlin, Molly A. Maloy, Lindsey E. Roeker, Parastoo B. Dahi, Doris M. Ponce, Boglarka Gyurkocza, Guenther Koehne, James W. Young, Hugo R. Castro-Malaspina, Juliet N. Barker, Esperanza B. Papadopoulos, Ann A. Jakubowski, Andrew D. Zelenetz, Anthony R. Mato, Sergio A. Giralt, Miguel A. Perales, Craig S. Sauter
Summary: This study demonstrates that allogeneic hematopoietic stem cell transplantation (HSCT) can potentially cure patients with chronic lymphocytic leukemia (CLL), with favorable progression-free survival (PFS) and overall survival (OS) rates. The impact of novel agents on HSCT outcomes was found to be negligible. Reduced intensity conditioning (RIC) HSCT may be a successful treatment option for CLL patients with Richter's transformation and poor-risk CLL patients.
Article
Biophysics
Alexandros Spyridonidis, Myriam Labopin, Tobias Gedde-Dahl, Arnold Ganser, Matthias Stelljes, Charles Craddock, Eva Maria Wagner-Drouet, Jurjen Versluis, Thomas Schroeder, Igor Wolfgang Blau, Gerald. G. Wulf, Peter Dreger, Gitte Olesen, Henrik Sengeloev, Nicolaus Kroger, Victoria Potter, Edouard Forcade, Jakob Passweg, Regis Peffault de Latour, Johan Maertens, Keith M. O. Wilson, Jean Henri Bourhis, Juergen Finke, Eolia Brissot, Ali Bazarbachi, Sebastian Giebel, Bipin P. Savani, Arnon Nagler, Fabio Ciceri, Mohamad Mohty
Summary: This study confirms the effectiveness of the recently developed transplant conditioning intensity (TCI) score in predicting mortality and relapse rates in hematopoietic cell transplantation.
BONE MARROW TRANSPLANTATION
(2023)
Review
Biophysics
Adeel Masood, Ahsan Wahab, Qamar Iqbal, James Davis, Hamid Ehsan, Hamza Hashmi
Summary: Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening disorder of the immune system. While familial HLH is more common in children, secondary HLH is more commonly seen in adults and is associated with various underlying conditions. Allogeneic hematopoietic stem cell transplant (allo-HSCT) appears to have reasonable efficacy and acceptable safety for treating adolescent and adult patients with HLH, based on retrospective studies analyzed in this systematic review.
BONE MARROW TRANSPLANTATION
(2022)
Article
Hematology
Shlomo Elias, Samantha Brown, Sean M. Devlin, Juliet N. Barker, Christina Cho, David J. Chung, Parastoo B. Dahi, Sergio Giralt, Boglarka Gyurkocza, Ann A. Jakubowski, Oscar B. Lahoud, Heather Landau, Richard J. Lin, Esperanza B. Papadopoulos, Ioannis Politikos, Doris M. Ponce, Michael Scordo, Brian C. Shaffer, Gunjan L. Shah, Roni Tamari, James W. Young, Miguel-Angel Perales, Roni Shouval
Summary: Comorbidity assessment is important before allogeneic haematopoietic cell transplantation (allo-HCT) to estimate non-relapse mortality (NRM) risk. The Simplified Comorbidity Index (SCI), which includes a small number of comorbidities and older age, has been shown to predict NRM. In this study, we validated the SCI in patients receiving reduced-intensity conditioning followed by allo-HCT from HLA-matched donors. Higher SCI scores were associated with increased NRM risk and reduced overall survival. These findings suggest that the SCI is a reliable tool for risk stratification in allo-HCT candidates.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Oncology
Ellen K. Chang, Dayana Chanson, Jennifer Berano Teh, Aleksi Iukuridze, Kelly Peng, Stephen J. Forman, Ryotaro Nakamura, F. Lennie Wong, LiYing Cai, Saro H. Armenian
Summary: The incidence of de novo atrial fibrillation (AF) after allogeneic hematopoietic cell transplantation (HCT) is relatively high, with independent risk factors including age, donor relationship, dyslipidemia, and pre-HCT cardiac parameters. The development of AF is associated with poor survival outcomes, and preventive strategies should focus on these risk factors.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Hematology
Naveed Ali, Ashish Arunkumar Sharma, Ana Carolina Pires de Rezende, Folashade Otegbeye, Bilal Muhammad Latif, Mariana Nassif Kerbauy, Brenda W. Cooper, Gabriela Sanchez, Leland Metheny, Saswat K. Bal, Roberto Sakuraba, Benjamin K. Tomlinson, Kirsten M. Boughan, Lucila Kerbauy, Ehsan Malek, Andreza Feitosa Ribeiro, Molly Gallogly, David Mansur, Gisele Pereira, Eduardo Weltman, Rafick-Pierre Sekaly, Marcos de Lima, Paolo F. Caimi, Nelson Hamerschlak
Summary: This study evaluated the efficacy of intensified fludarabine/busulfan (Flu/Bu) reduced-intensity conditioning (RIC) regimen with targeted marrow irradiation (TMI) in high-risk hematologic malignancies patients. The results showed that this approach was feasible with low transplantation-related mortality in medically frail patients with advanced malignancies.
TRANSPLANTATION AND CELLULAR THERAPY
(2022)
Article
Hematology
Kimimori Kamijo, Yoshimitsu Shimomura, Akihito Shinohara, Shohei Mizuno, Minoru Kanaya, Yoshiaki Usui, Sung-Won Kim, Takahide Ara, Ishikazu Mizuno, Takuro Kuriyama, Hideyuki Nakazawa, Ken-ichi Matsuoka, Shigeru Kusumoto, Nobuo Maseki, Masaki Yamaguchi, Takashi Ashida, Makoto Onizuka, Takahiro Fukuda, Yoshiko Atsuta, Eisei Kondo
Summary: By comparing the effects of Flu/Bu2 and Flu/Bu4 on patients with non-Hodgkin lymphoma undergoing allogeneic hematopoietic cell transplantation, the study found that Flu/Bu4 was associated with higher nonrelapse mortality and lower 5-year overall survival compared to Flu/Bu2.
ANNALS OF HEMATOLOGY
(2023)
Article
Cell & Tissue Engineering
Yue Song, Qingxia Yin, Jingshi Wang, Zhao Wang
Summary: LAHS, a common type in secondary HLH, may have a better prognosis after removing the trigger of HLH. In this study, autologous transplantation in LAHS significantly improved the prognosis and provided LAHS with a similar prognosis as high-risk lymphoma without HLH.
CELL TRANSPLANTATION
(2021)
Article
Statistics & Probability
Mi-Ok Kim, Mai Zhou
Article
Mathematical & Computational Biology
Hang J. Kim, Bo Lu, Edward J. Nehus, Mi-Ok Kim
STATISTICS IN MEDICINE
(2019)
Article
Oncology
Leanne C. Sayles, Marcus R. Breese, Amanda L. Koehne, Stanley G. Leung, Alex G. Lee, Heng-Yi Liu, Aviv Spillinger, Avanthi T. Shah, Bogdan Tanasa, Krystal Straessler, Florette K. Hazard, Sheri L. Spunt, Neyssa Marina, Grace E. Kim, Soo-Jin Cho, Raffi S. Avedian, David G. Mohler, Mi-Ok Kim, Steven G. DuBois, Douglas S. Hawkins, E. Alejandro Sweet-Cordero
Article
Gastroenterology & Hepatology
Chenthan Krishnakumar, Cortney R. Ballengee, Chunyan Liu, Mi-Ok Kim, Susan S. Baker, Robert N. Baldassano, Stanley A. Cohen, Wallace V. Crandall, Lee A. Denson, Marla C. Dubinsky, Jonathan Evans, Ranjana Gokhale, Anne Griffiths, Stephen L. Guthery, Maria Oliva-Hemker, Melvin B. Heyman, David Keljo, Richard Kellermayer, Neal S. Leleiko, David R. Mack, James F. Markowitz, Dedrick E. Moulton, Joshua D. Noe, Anthony R. Otley, Ashish S. Patel, Marian Pfefferkorn, Shervin Rabizadeh, Joel R. Rosh, Scott Snapper, Thomas D. Walters, David Ziring, Kajari Mondal, Michael D. Kappelman, Jeffrey S. Hyams, Subra Kugathasan
INFLAMMATORY BOWEL DISEASES
(2019)
Article
Immunology
Yael Haberman, Melanie Schirmer, Phillip J. Dexheimer, Rebekah Karns, Tzipi Braun, Mi-Ok Kim, Thomas D. Walters, Robert N. Baldassano, Joshua D. Noe, Joel Rosh, James Markowitz, Wallace V. Crandall, David R. Mack, Anne M. Griffiths, Melvin B. Heyman, Susan S. Baker, Richard Kellermayer, Dedrick Moulton, Ashish S. Patel, Ajay S. Gulati, Steven J. Steiner, Neal LeLeiko, Anthony Otley, Maria Oliva-Hemker, David Ziring, Barbara S. Kirschner, David J. Keljo, Stephen L. Guthery, Stanley A. Cohen, Scott Snapper, Jonathan Evans, Marla Dubinsky, Bruce Aronow, Jeffrey S. Hyams, Subra Kugathasan, Curtis Huttenhower, Ramnik J. Xavier, Lee A. Denson
MUCOSAL IMMUNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Jonathan S. Fletcher, Mitchell G. Springer, Kwangmin Choi, Edwin Jousma, Tilat A. Rizvi, Eva Dombi, Mi-Ok Kim, Jianqiang Wu, Nancy Ratner
Article
Immunology
Matthew L. Hedberg, Noah D. Peyser, Julie E. Bauman, William E. Gooding, Hua Li, Neil E. Bhola, Tian Ran Zhu, Yan Zeng, Toni M. Brand, Mi-Ok Kim, Richard C. K. Jordan, Scott VandenBerg, Victor Olivas, Trever G. Bivona, Simion I. Chiosea, Lin Wang, Gordon B. Mills, Jonas T. Johnson, Umamaheswar Duvvuri, Robert L. Ferris, Patrick Ha, Daniel E. Johnson, Jennifer R. Grandis
JOURNAL OF EXPERIMENTAL MEDICINE
(2019)
Article
Health Care Sciences & Services
Shan-Yu Liu, Chunyan Liu, Eddie Nehus, Maurizio Macaluso, Bo Lu, Mi-Ok Kim
STATISTICAL METHODS IN MEDICAL RESEARCH
(2020)
Article
Oncology
Yosuke Kasai, Kenzo Hirose, Carlos U. Corvera, Grace E. Kim, Thomas A. Hope, Brandon E. Shih, Nusrat Harun, Mi-Ok Kim, Robert S. Warren, Emily K. Bergsland, Eric K. Nakakura
JOURNAL OF SURGICAL ONCOLOGY
(2020)
Article
Mathematical & Computational Biology
Seonjin Kim, Hyunkeun Ryan Cho, Mi-Ok Kim
Summary: The study proposes a nonparametric bivariate varying coefficient generalized linear model to predict future mean response trajectories by utilizing a combination of kernel and spline methods. The research also develops a new bootstrap approach for statistical inference and applies the methodology to the Framingham Heart Study.
STATISTICS IN MEDICINE
(2021)
Article
Mathematical & Computational Biology
Ying Sheng, Yifei Sun, Chiung-Yu Huang, Mi-Ok Kim
Summary: This paper presents a unified framework for combining individual-level data and external aggregate data under the Cox model to improve estimation efficiency. Various forms of external aggregated information are summarized and a penalized empirical likelihood approach is proposed. Empirical studies demonstrate the proposed methods outperform competitors in terms of estimation efficiency and variable selection.
STATISTICS IN MEDICINE
(2021)
Article
Oncology
Zoya Qureshy, Hua Li, Yan Zeng, Jose Rivera, Ning Cheng, Christopher N. Peterson, Mi-Ok Kim, William R. Ryan, Patrick K. Ha, Julie E. Bauman, Steven J. Wang, Steven R. Long, Daniel E. Johnson, Jennifer R. Grandis
Summary: The study found that ruxolitinib has inhibitory effects on the active STAT3 levels, cell growth, and colony formation of HNSCC cell lines. For patient-derived xenografts (PDX) from HNSCC patients who received a short course of neoadjuvant ruxolitinib in a clinical trial, ruxolitinib had an impact on tumor growth and STAT3 activation.
CLINICAL CANCER RESEARCH
(2022)
Article
Hematology
Anya L. Levinson, Karensa Tjoa, Benjamin Huang, Lauren K. Meyer, Mi-Ok Kim, Samuel W. Brady, Jinghui Zhang, Kevin Shannon, Anica M. Wandler
Summary: The study reveals that JDP2 overexpression acts as a mechanism of adaptive glucocorticoid resistance in T-ALL and interacts with KDM6A inactivation. This finding sheds light on the additional mechanisms of glucocorticoid resistance and offers potential targets for therapy.
Article
Mathematical & Computational Biology
Huaqing Jin, Mi-Ok Kim, Aaron Scheffler, Fei Jiang
Summary: Interest in incorporating historical data in clinical trials has increased due to rising costs. However, existing historical control borrowing adaptive designs can lead to distributional imbalance, threatening the internal validity of the trial. In this article, we propose a Bayesian design that borrows and updates treatment allocation ratios based on the similarity between current and historical control data, addressing this issue.
STATISTICS IN MEDICINE
(2023)
Article
Mathematical & Computational Biology
Yunxiang Huang, Chiung-Yu Huang, Mi-Ok Kim
Summary: In this article, a penalized likelihood approach is proposed to simultaneously select and synthesize consistent external aggregate information, avoiding bias. The proposed approach allows for incorporating external information from heterogeneous study populations as long as the conditional distribution of the dependent variable is the same.
STATISTICS IN MEDICINE
(2023)