期刊
BLOOD
卷 117, 期 6, 页码 1917-1927出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2010-09-307140
关键词
-
类别
资金
- Inserm
- Spanish Ministry of Science
- French Minister of Education
- CNRS
- Institut Curie
- Agence Nationale pour la Recherche
- Association pour la recherche sur le Cancer
- Belgian InterUniversity Attraction Pole
- Canceropole Ile-de-France
- Institut National du Cancer
- Universite Paris Descartes
Chronic lymphocytic leukemia (CLL) is characterized by a clonal accumulation of mature neoplastic B cells that are resistant to apoptosis. Aiolos, a member of the Ikaros family of zinc-finger transcription factors, plays an important role in the control of mature B lymphocyte differentiation and maturation. In this study, we showed that Aiolos expression is up-regulated in B-CLL cells. This overexpression does not implicate isoform imbalance or disturb Aiolos subcellular localization. The chromatin status at the Aiolos promoter in CLL is defined by the demethylation of DNA and an enrichment of euchromatin associated histone markers, such as the dimethylation of the lysine 4 on histone H3. These epigenetic modifications should allow its upstream effectors, such as nuclear factor-kappa B, constitutively activated in CLL, to gain access to promoter, resulting up-regulation of Aiolos. To determine the consequences of Aiolos deregulation in CLL, we analyzed the effects of Aiolos overexpression or down-regulation on apoptosis. Aiolos is involved in cell survival by regulating the expression of some Bcl-2 family members. Our results strongly suggest that Aiolos deregulation by epigenetic modifications may be a hallmark of CLL. (Blood. 2011; 117(6): 1917-1927)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据