Article
Biochemistry & Molecular Biology
Naomi C. Bosch, Lena-Marie Martin, Caroline J. Voskens, Carola Berking, Barbara Seliger, Gerold Schuler, Niels Schaft, Jan Doerrie
Summary: NK cells play a crucial role in tumor cell rejection, and activating NK cells along with other immune cells can lead to a more comprehensive cellular response. Dendritic cells are capable of enhancing immune responses by activating NK cells and producing IL-12, while IL-15 serves as an important NK cell activator as well.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Hemavathi Dhandapani, Hascitha Jayakumar, Abirami Seetharaman, Shirley Sunder Singh, Selvaluxmy Ganeshrajah, Nirmala Jagadish, Anil Suri, Rajkumar Thangarajan, Priya Ramanathan
Summary: Dendritic cell-based immunotherapy utilizing recombinant human SPAG9 shows promise in stimulating CD4(+) and CD8(+) T cell responses for cervical cancer patients. The study suggests rhSPAG9 as a strong immunogen for DC-based immunotherapy and highlights the potential of a combinatorial regimen with cisplatin for therapeutic intervention.
CANCER CELL INTERNATIONAL
(2021)
Article
Microbiology
Elisenda Alari-Pahissa, Michelle Ataya, Ilias Moraitis, Miriam Campos-Ruiz, Mireia Altadill, Aura Muntasell, Anna Moles, Miguel Lopez-Botet
Summary: The study reveals that NK cells in combination with anti-EBV antibodies can eliminate the virus attached to the surface of B cells, reducing infection without killing the cells.
Article
Immunology
Gwennaelle C. Monnot, Marcin Wegrecki, Tan-Yun Cheng, Yi-Ling Chen, Brigitte N. Sallee, Reka Chakravarthy, Ioanna Maria Karantza, Shin Yi Tin, Alexandra E. Khaleel, Isha Monga, Laura N. Uwakwe, Alice Tillman, Bin Cheng, Soundos Youssef, Soo Weei Ng, Adam Shahine, Javier A. Garcia-Vilas, Anne-Catrin Uhlemann, Lindsey A. Bordone, Arnold Han, Christine H. Rohde, Graham Ogg, D. Branch Moody, Jamie Rossjohn, Annemieke de Jong
Summary: CD1a presents a range of self-lipid antigens found within the skin. The study identifies CD1a-dependent T cell responses to bacterial membrane phospholipids and suggests a link between PG-based lipid-activated T cells and atopic dermatitis pathogenesis. The expansion of CD4(+) CD1a-(lysyl)PG tetramer(+) T cells in patients with atopic dermatitis supports the involvement of bacteria-associated lipids in the development of this condition.
Article
Immunology
Tae-Shin Kim, Min-Seok Rha, Eui-Cheol Shin
Summary: IL-15 plays a pleiotropic role in NK and CD8(+) T cells and contributes to host protection or immunopathology during infection. This study shows that IFN-gamma more effectively upregulates IL-15 expression in Huh-7 cells compared to IFN-alpha and IFN-beta. IRF1 and Kappa B kinase alpha/beta are involved in the upregulation of IL-15. Additionally, IL-15 on IFN-gamma-treated Huh-7 cells activates NK cells through trans-presentation.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Samantha A. Barnes, Katherine M. Audsley, Hannah V. Newnes, Sonia Fernandez, Emma de Jong, Jason Waithman, Bree Foley
Summary: The study found that IFN alpha 14 and IFN beta are superior activators of NK cell effector function in vitro. It was also shown that NK cells pre-activated with IFN alpha 14 significantly prolonged survival in a preclinical model of leukaemia. These results suggest that further investigation into using IFN alpha 14 to modulate NK cells against leukaemia is promising.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Pauline Rettman, Matthew D. Blunt, Rebecca J. Fulton, Andres F. Vallejo, Leidy Y. Bastidas-Legarda, Laura Espana-Serrano, Marta E. Polak, Aymen Al-Shamkhani, Christelle Retiere, Salim Khakoo
Summary: This study demonstrates the feasibility of a peptide-based KIR-targeting vaccine strategy to activate NK cells and enhance antitumor responses. The DNA vaccine upregulated genes associated with cellular metabolism and downregulated genes related to immune cell maturation. Vaccination led to enhanced antitumor responses against melanoma cells and a tumor model expressing the KIR2DS2 ligand HLA-C*0102.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Xiaolong Wu, Amit Sharma, Johannes Oldenburg, Hans Weiher, Markus Essler, Dirk Skowasch, Ingo G. H. Schmidt-Wolf
Summary: CIK cells are a promising candidate for immunotherapy due to their convenient and relatively inexpensive expansion capability. NKG2D plays a crucial role in CIK cell-mediated antitumor activity, with NKG2D engagement alone being sufficient to activate CIK cells. The role of 2B4 in CIK cells is still unclear, but it provides limited synergy with NKG2D in certain aspects. Additional research is needed to optimize the functional potential of CIK cells for cancer therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ildefonso Sanchez-Cerrillo, Diego Calzada-Fraile, Ana Triguero-Martinez, Marta Calvet-Mirabent, Olga Popova, Cristina Delgado-Arevalo, Mariel Valdivia-Mazeyra, Marta Ramirez-Huesca, Enrique Vazquez de Luis, Alberto Benguria, Teresa Acena-Gonzalo, Roberto Moreno-Vellisca, Magdalena Adrados de Llano, Hortensia de la Fuente, Ilya Tsukalov, Pablo Delgado-Wicke, Elena Fernandez-Ruiz, Emilia Roy-Vallejo, Reyes Tejedor-Lazaro, Almudena Ramiro, Salvador Iborra, Francisco Sanchez-Madrid, Ana Dopazo, Isidoro Gonzalez Alvaro, Santos Castaneda, Enrique Martin-Gayo
Summary: This study reveals the increased proportion of CD16(+) CD56hi NK cell subset and CD64(+) conventional dendritic cells (cDC2) in pSS patients, suggesting their involvement in the progression of the disease. The cDC2 can activate NK cells ex vivo and are found in proximity to NK cells in the salivary glands. The expression of NKG2D ligands on cDC2 from pSS patients is regulated by the IFN signatures associated with the RIG-I/DDX60 pathway. Injection of poly I:C leads to increased proportions of CD64hi RAE-1(+) cDC2 and NKG2D(+) CD11b(+) CD27(+) NK cells in the salivary glands.
Review
Immunology
Matin Ghasemi, Laleh Abbasi, Leila Ghanbari Naeini, Pajman Kokabian, Najmeh Nameh Goshay Fard, Nozar Givtaj
Summary: Every type of cancer tissue is more susceptible to viral infection, which has been utilized as a new anti-cancer therapy using oncolytic viruses (OVs). OVs selectively infect and destroy cancer cells while causing no harm to the host. Research focuses on the interaction between OVs and the host immune system, particularly the role of dendritic cells (DCs) and natural killer (NK) cells in the therapeutic response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Mi He, Bhavesh Soni, Petra C. Schwalie, Tamara Huesser, Caroline Waltzinger, Duvini De Silva, Ylva Prinz, Laura Kruempelmann, Samuele Calabro, Ines Matos, Christine Trumpfheller, Marina Bacac, Pablo Umana, Mitchell P. Levesque, Reinhard Dummer, Maries van den Broek, Stephan Gasser
Summary: TL8-506 in combination with IFN-γ or Poly(I:C) can activate human tumor-associated dendritic cells (DCs), inducing the expression of chemokines and cytokines, and enhancing the immunostimulatory capacity of DCs. This finding provides new insights for the research and development of cancer immunotherapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Teru Hideshima, Daisuke Ogiya, Jiye Liu, Takeshi Harada, Keiji Kurata, Jooeun Bae, Walter Massefski, Kenneth C. Anderson
Summary: IMiDs drugs exhibit significant anti-tumor activity in the treatment of multiple myeloma by directly inhibiting cell growth in the bone marrow environment and promoting immune effector cell function. Studies have shown that IMiDs can enhance NK and T cell cytotoxicity by activating Zap-70.
Article
Multidisciplinary Sciences
Lucia Borriello, Anouchka Coste, Brian Traub, Ved P. Sharma, George S. Karagiannis, Yu Lin, Yarong Wang, Xianjun Ye, Camille L. Duran, Xiaoming Chen, Madeline Friedman, Maria Soledad Sosa, Dan Sun, Erica Dalla, Deepak K. Singh, Maja H. Oktay, Julio A. Aguirre-Ghiso, John S. Condeelis, David Entenberg
Summary: This study utilizes high-resolution intravital imaging to track breast-derived metastatic cells in the lung and finds that macrophages in the primary tumor affect the dissemination and dormancy phenotypes of these cells.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Yan-Xin Niu, Zhao-Xu Xu, Li-Feng Yu, Yong-Ping Lu, Yan Wang, Ce Wu, Yi-Bo Hou, Jia-Ning Li, Shengqiang Huang, Xinyue Song, Xinyu Wang, Jiaqi Wang, Binyu Li, Yingrui Guo, Zhaojin Yu, Lin Zhao, Dong-Xu Yi, Min-Jie Wei
Summary: Fc-fusion proteins, a promising biopharmaceutical product in tumor therapy, have the potential to activate natural killer cells and kill tumor cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Krzysztof T. Krawczyk, Camille Locht, Magdalena Kowalewicz-Kulbat
Summary: This study reveals for the first time that halophilic archaea can activate specific cells in the human immune system, leading to cytokine production and T cell activation. This finding may contribute to understanding the mechanisms by which halotherapy affects immune balance in the human body.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Christine E. Brown, Samantha Bucktrout, Lisa H. Butterfield, Olga Futer, Evanthia Galanis, Adilia Hormigo, Michael Lim, Hideho Okada, Robert Prins, Sara Siebel Marr, Kirk Tanner
Summary: Research and clinical trials on utilizing the immune system to fight brain tumors with specificity and memory have been ongoing for many years. Although progress has been made, obstacles such as the lack of representative animal models and efficient biopsy methods still exist.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Clifford Guy, Diana M. Mitrea, Po-Chien Chou, Jamshid Temirov, Kate M. Vignali, Xueyan Liu, Hui Zhang, Richard Kriwacki, Marcel P. Bruchez, Simon C. Watkins, Creg J. Workman, Dario A. A. Vignali
Summary: This study reveals that the inhibitory receptor LAG3 interferes with TCR signaling and T cell activation by lowering the pH at the immune synapse, providing insights into the mechanism of action of LAG3 in inhibiting T cell function.
Review
Immunology
Paul V. Munson, Juraj Adamik, Lisa H. Butterfield
Summary: Alpha-fetoprotein (AFP) is a fetal glycoprotein produced by hepatocellular carcinoma tumors in humans. It plays an immunosuppressive role in pregnancy, autoimmunity, and cancer by limiting the functionality of natural killer cells, monocytes, and dendritic cells. Recent research has focused on the molecular characteristics of AFP and its impact on cellular metabolism.
TRENDS IN IMMUNOLOGY
(2022)
Article
Oncology
Maria Karasarides, Alexandria P. Cogdill, Paul B. Robbins, Michaela Bowden, Elizabeth M. Burton, Lisa H. Butterfield, Alessandra Cesano, Christian Hammer, Cara L. Haymaker, Christine E. Horak, Heather M. McGee, Anne Monette, Nils-Petter Rudqvist, Christine N. Spencer, Randy F. Sweis, Benjamin G. Vincent, Erik Wennerberg, Jianda Yuan, Roberta Zappasodi, Vanessa M. Hubbard Lucey, Daniel K. Wells, Theresa LaVallee
Summary: This study systematically explores key nodes of immune resistance through the lens of known biological processes, providing support and guidance for future immune resistance research. Integration of multiomic high-dimensional analyses with patient data can help guide effective drug development strategies and improve patient outcomes.
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Immunology
Bratislav M. Janjic, Aditi Kulkarni, Robert L. Ferris, Lazar Vujanovic, Nikola L. Vujanovic
Summary: Research has found that circulating B cells play a role in mediating the immune mechanism against cancer, inducing apoptosis and efficiently killing leukemia and solid tumor cells. This is achieved through the simultaneous activation of multiple plasma membrane-associated TNF superfamily (TNFSF) ligands expressed by B cells. B cells from cancer patients express lower levels of TNFSF ligands, resulting in weaker cytotoxic activity.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Immunology
Janin Chandra, Morten Hansen, Nathalie Labarriere, Ilaria Marigo, Fernando Souza-Fonseca-Guimaraes, Lazar Vujanovic, Yoshinobu Koguchi, Nicolas Jacquelot
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Cindy A. Sander, Elizabeth A. Rush, Jian Shi, Lidia M. R. B. Arantes, Raymond J. Tesi, Mark A. Ross, Michael J. Calderon, Simon C. Watkins, John M. Kirkwood, Robert L. Ferris, Lisa H. Butterfield, Lazar Vujanovic
Summary: TNFR2 is expressed in BRAF-mutant melanoma cells and is involved in solTNF-driven resistance to MAPKi. TNFR2 may serve as a biomarker to identify melanoma patients who can benefit from solTNF-targeting therapies.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Editorial Material
Biochemistry & Molecular Biology
Samantha L. Bucktrout, Nicholas E. Banovich, Lisa H. Butterfield, Cansu Cimen-Bozkus, Josephine R. Giles, Zinaida Good, Daniel Goodman, Vanessa D. Jonsson, Caleb Lareau, Alexander Marson, Denna M. Maurer, Paul Munson, Mike Stubbington, Sarah Taylor, Abbey Cutchin
Summary: This article summarizes a workshop organized by the Parker Institute of Cancer Immunotherapy and 10x Genomics, where researchers and innovators in T cell immunotherapy and single-cell technologies gathered to discuss the attributes of ideal therapeutic T cells and areas for future development. The goal of the workshop was to advance the understanding of T cell research and translate it into effective cancer immunotherapies.
Article
Multidisciplinary Sciences
Juraj Adamik, Paul Munson, Felix J. Hartmann, Alexis J. Combes, Philippe Pierre, Matthew F. Krummel, Sean C. Bendall, Rafael J. Arguello, Lisa H. Butterfield
Summary: Assessing metabolic activity at the single-cell level provides important insights into the immune profiles of human dendritic cells. This study reveals the metabolic differences between immune stimulatory and tolerogenic dendritic cells, and highlights the simultaneous engagement of multiple metabolic pathways in distinct stages of dendritic cell differentiation.
NATURE COMMUNICATIONS
(2022)
Meeting Abstract
Oncology
C. Kuerten, A. Kulkarni, L. Vujanovic, A. Cillo, S. Lang, R. Ferris
Article
Oncology
Xiaoyu Li, Jingjing Li, Yue Zheng, Sandra J. Lee, Jun Zhou, Anita Giobbie-Hurder, Lisa H. Butterfield, Glenn Dranoff, F. Stephen Hodi
Summary: With the successful development of immune checkpoint blockade, the addition of granulocyte-macrophage-CSF (GM-CSF) has been shown to improve efficacy and decrease adverse events. The presence of ICOS+CD4+ or ICOS+CD8+ T cells in the peripheral blood is significantly higher in patients treated with ipilimumab plus GM-CSF compared to those treated with ipilimumab alone. Soluble ICOS splice variants have suppressive effects and can serve as a biomarker for GM-CSF and immune checkpoint blockade-based therapies.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Hematology
Lillian Tran, Bowen Xie, Edwyn Assaf, Ricardo Ferrari, Iraklis I. Pipinos, George P. Casale, Roberto Ivan Mota Alvidrez, Simon Watkins, Ulka Sachdev
Summary: This study found that genes related to ferroptosis are differentially expressed in skeletal muscle affected by PAD. Targeting ferroptosis may be a new therapeutic strategy to reduce PAD myopathy.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Oncology
Ayana T. Ruffin, Housaiyin Li, Lazar Vujanovic, Dan P. Zandberg, Robert L. Ferris, Tullia C. Bruno
Summary: Targeted immunotherapy has improved survival in head and neck squamous cell carcinoma (HNSCC), but new immunotherapies considering the entire HNSCC tumour microenvironment are needed to enhance T cell responses. Recent advancements have provided a comprehensive understanding of the cellular constituents and interactions within the complex HNSCC microenvironment.
NATURE REVIEWS CANCER
(2023)
Review
Immunology
Lisa H. Butterfield, Yana G. Najjar
Summary: The approval of immune checkpoint inhibitors has shifted the treatment paradigm for malignancies. Combination therapies and biomarker studies are important for maximizing clinical efficacy.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Juraj Adamik, Paul V. Munson, Deena M. Maurer, Felix J. Hartmann, Sean C. Bendall, Rafael J. Arguello, Lisa H. Butterfield
Summary: This study analyzed the transcriptomic and immune-metabolic profiles of dendritic cells (DCs) from patients with late-stage melanoma. The results suggest that the metabolic profile of DCs is associated with the immunostimulatory potential of cancer vaccines.
NATURE COMMUNICATIONS
(2023)