Article
Nanoscience & Nanotechnology
Peng Zhao, Jun Wang, Behnaz Karkheiran, Samira Alesaeidi, Ehsan Nourbakhsh, Mohammad Saeed Kahrizi, Asal Mir
Summary: This study developed a new nano-liposome that can modulate the tumor microenvironment and enhance the efficacy of immune checkpoint inhibitors, leading to improved anti-tumor immune response.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Biology
Chuanjie Qin, Nazakat Hussain Memon, Quan Gong, Qinchao Shi, Qingfa Yang
Summary: The interaction of CXC chemokine ligand 12/CXC receptor 4 ligand/receptor in the immune system plays a crucial role in response against bacterial infection in vertebrates. The study on Pelteobagrus vachellii revealed a 24-hour variation in the expression of CXCR4 and CXCL12 genes, highlighting the importance of understanding the immune rhythm in teleosts.
CHRONOBIOLOGY INTERNATIONAL
(2021)
Article
Oncology
Sung-Tai Wei, Jung-Ying Chiang, Hwai-Lee Wang, Fu-Ju Lei, Yen-Chih Huang, Chi-Chung Wang, Der-Yang Cho, Chia-Hung Hsieh
Summary: Hypoxic tumor microenvironment (HTM) promotes a more aggressive and malignant state in glioblastoma. In this study, the researchers found that CXCL14, regulated by HIF and activated IGF-1R signaling pathway, plays a role in HTM-mediated glioblastoma progression. Targeting CXCL14 with siRNA nanoparticles can inhibit glioblastoma growth and extend survival time.
Article
Genetics & Heredity
Xinyu Wei, Shuang Tao, Huilan Mao, Haitao Zhu, Lingyu Mao, Wenhao Pei, Xiuru Shi, Yingxiang Shi, Shiwen Zhang, Yulun Wu, Ke Wei, Jing Wang, Siyan Pang, Wenrui Wang, Changjie Chen, Qingling Yang
Summary: This study found that lncRNA NEAT1 is highly expressed in BC cells and exosomes. NEAT1 promotes migration and paclitaxel resistance in BC cells, while downregulation of NEAT1 reduces drug resistance. In addition, downregulation of NEAT1 decreases migration and proliferation of BC cells by inhibiting CXCL12 expression and reducing miR-133b adsorption. This study reveals that exosomal lncRNA NEAT1 derived from SKBR3/PR cells in the tumor microenvironment can induce paclitaxel resistance, cell migration, and growth, and may serve as a new target for clinical treatment of BC.
Article
Immunology
Linda M. Sircy, Malia Harrison-Chau, Camille Leite Novis, Andrew Baessler, Jacklyn Nguyen, J. Scott Hale
Summary: This study analyzed effector and memory CD4+ T cell differentiation in mice following protein vaccination, revealing that cells displayed memory differentiation post vaccination. Challenges with virus increased cell plasticity, leading to the generation of Tfh and memory Tfh cells in response to protein immunization.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Cell Biology
Andrew D. Hildreth, Eddie T. Padilla, Rana Yakhshi Tafti, Akshara R. Legala, Timothy E. O'Sullivan
Summary: Using single-cell transcriptomic analysis, the study reveals the liver-resident cell connectome and signalome during acute liver injury. The results identify Il12b as a central regulator of liver injury-associated changes in gene expression. It is found that Interleukin (IL)-12 produced by conventional type 1 dendritic cells (cDC1s) is required for protection during acute injury through activation of interferon (IFN)-g production by liver-resident type 1 innate lymphoid cells (ILC1s). The study also uncovers the role of cDC1-intrinsic cGAS-STING signaling in initiating early protective immune responses via IL-12 production.
Review
Immunology
Di Yu, Lucy S. K. Walker, Zheng Liu, Michelle A. Linterman, Zhanguo Li
Summary: Yu et al. review the crucial roles of follicular helper T cells in humoral immunity, including sustaining germinal center B cell responses, regulating antibody affinity maturation and memory formation, and mediating pathogenic autoimmune responses. Understanding the regulation of follicular helper T cell generation and function is important for disease prevention and treatment, as well as vaccine development and enhancement.
Article
Medicine, Research & Experimental
Keywan Mortezaee
Summary: Myeloid-derived suppressor cells (MDSCs) are a group of immature immune cells that significantly increase in cancer patients, releasing factors that impact tumor-related events such as metastasis and immune evasion, and can serve as an indicator of tumor prognosis. They can be targeted in combination with current immunotherapies to enhance the immune system's response against tumors.
Article
Toxicology
Sweta Ghosh, Mayukh Banerjee, Bodduluri Haribabu, Venkatakrishna Rao Jala
Summary: Environmental chemicals like iAs can increase oxidative stress in the body, disrupting gut homeostasis, but gut microbiota are essential to protect against its toxicity, with microbial metabolites such as UroA potentially providing protection against environmental hazards by reducing oxidative stress and enhancing gut barrier function.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Engineering, Biomedical
Niranjan G. Kotla, Rajbir Singh, Becca Baby, Swetha Rasala, Jawad Rasool, Sean O. Hynes, Darrell Martin, Laurence J. Egan, Praveen K. Vemula, Venkatakrishna R. Jala, Yury Rochev, Abhay Pandit
Summary: Delivering drugs directly to inflamed intestinal sites to treat inflammatory bowel disease (IBD) is a challenge, but the development of targeted carrier systems such as IT-NCs shows promising therapeutic potential in improving treatment efficacy.
Article
Dermatology
Di Yin, Jiaqing Hao, Rong Jin, Yanmei Yi, Sobha R. Bodduluri, Yuan Hua, Ajay Anand, Yibin Deng, Bodduluri Haribabu, Nejat K. Egilmez, Edward R. Sauter, Bing Li
Summary: Depilatory creams can cause skin inflammation in people with sensitive skin, but the reasons for their increased sensitivity are unknown. This study shows that epidermal fatty acid-binding protein (E-FABP) plays a critical role in promoting depilatory-induced acute skin inflammation in mouse models. The activation of multiple signaling pathways in keratinocytes by depilatory creams leads to the inflammatory response.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Niranjan G. Kotla, Isma Liza Mohd Isa, Swetha Rasala, Secil Demir, Rajbir Singh, Becca Baby, Samantha K. Swamy, Peter Dockery, Venkatakrishna R. Jala, Yury Rochev, Abhay Pandit
Summary: The pathogenesis of ulcerative colitis is linked to superficial mucosal damage and dysregulated barrier functions, with traditional treatment strategies focusing on maintaining disease remission levels. Restoring barrier functionality through mucosal healing or physical barrier protection is essential for disease management.
Meeting Abstract
Biochemistry & Molecular Biology
Sweta Ghosh, Mayukh Banerjee, Haribabu Bodduluri, Venkatakrishna Rao Jala
Article
Biochemistry & Molecular Biology
Tiziana Schioppa, Hoang Oanh Nguyen, Valentina Salvi, Norma Maugeri, Fabrizio Facchinetti, Gino Villetti, Maurizio Civelli, Carolina Gaudenzi, Mauro Passari, Francesca Sozio, Ilaria Barbazza, Nicola Tamassia, Marco A. Cassatella, Annalisa Del Prete, Daniela Bosisio, Laura Tiberio
Summary: Neutrophils are important in respiratory diseases, and tanimilast can modulate their activity to reduce tissue damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Sara Monaci, Federica Coppola, Daniela Rossi, Gaia Giuntini, Irene Filippi, Giuseppe Marotta, Silvano Sozzani, Fabio Carraro, Antonella Naldini
Summary: Hypoxia-induced autophagy in dendritic cells is regulated by PI3Ks, especially Vps34. The study highlights the role of autophagy in maintaining DC homeostasis and inflammatory response levels.
Review
Biochemistry & Molecular Biology
Cinzia Fionda, Gianluca Scarno, Helena Stabile, Rosa Molfetta, Chiara Di Censo, Angela Gismondi, Rossella Paolini, Silvano Sozzani, Angela Santoni, Giuseppe Sciume
Summary: Colorectal cancer is a common malignancy globally, with NK cells and ILC playing crucial roles in the disease prognosis and outcome. Their cytotoxic functions are key in controlling CRC metastasis, and understanding their molecular mechanisms holds significance for CRC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Siddharth Mehra, Supriya Srinivasan, Samara Singh, Zhiqun Zhou, Vanessa Garrido, Iago De Castro Silva, Tulasigeri M. Totiger, Austin R. Dosch, Xizi Dai, Rajinder K. Dawra, Venkatakrishna Rao Jala, Chanjuan Shi, Jashodeep Datta, Michael VanSaun, Nipun Merchant, Nagaraj Nagathihalli
Summary: Heavy alcohol consumption is the main risk factor for chronic pancreatitis, and there is limited treatment and prevention strategies for alcoholic chronic pancreatitis (ACP). This study demonstrates that urolithin A (Uro A), a gut-derived microbial metabolite, can attenuate the severity of ACP through suppression of the PI3K/AKT/mTOR signaling pathway, providing a potential therapeutic approach for patients with ACP.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Immunology
Sweta Ghosh, Bhagavatula Moorthy, Bodduluri Haribabu, Venkatakrishna Rao Jala
Summary: The study suggests that CYP1A1 expression is crucial for the enhanced gut barrier functions and protective activities against colitis mediated by UroA. It is speculated that CYP1A1 may play critical, yet unknown roles beyond xenobiotic metabolism in maintaining gut homeostasis in IBD pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Elisa Gardiman, Francisco Bianchetto-Aguilera, Sara Gasperini, Laura Tiberio, Matteo Scandola, Virginia Lotti, Davide Gibellini, Valentina Salvi, Daniela Bosisio, Marco A. A. Cassatella, Nicola Tamassia
Summary: COVID-19 disease is characterized by dysregulation of the innate immune system. This study demonstrates that single-strand RNAs from the SARS-CoV-2 genome can activate human neutrophils via the TLR8 pathway, potentially contributing to the pathogenesis of severe COVID-19.
Article
Oncology
Francesca Sozio, Tiziana Schioppa, Mattia Laffranchi, Valentina Salvi, Nicola Tamassia, Francisco M. Bianchetto-Aguilera, Laura Tiberio, Raffaella Bonecchi, Daniela Bosisio, Marc Parmentier, Barbara Bottazzi, Roberto Leone, Eleonora Russo, Giovanni Bernardini, Stefano Garofalo, Cristina Limatola, Angela Gismondi, Giuseppe Sciume, Alberto Mantovani, Annalisa Del Prete, Silvano Sozzani
Summary: Patterns of receptors play a crucial role in regulating the homing of leukocytes. A study reveals that the CCRL2/chemerin/CMKLR1 axis acts as a selective pathway for the homing of NK cells to the lung. Inactivation of CCRL2 or its ligand chemerin promotes lung tumor growth by affecting the recruitment of NK cells, while other receptors identified in lung-infiltrating NK cells are dispensable for this process.
CANCER IMMUNOLOGY RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Subir Kumar Juin, Rosemary Ouseph, Dibson Dibe Gondim, Venkatakrishna Rao Jala, Utpal Sen
Summary: Diabetic nephropathy (DN) is still the main cause of morbidity and mortality in diabetes patients. Gasotransmitters, including nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S), play a vital role in the development and progression of DN. Aberrant levels of gasotransmitters have been observed in patients with diabetes, and gasotransmitter donors show potential in ameliorating diabetic renal dysfunction. This review provides an overview of the physiological relevance of gasotransmitters and their interaction with other factors in the severity modulation of DN, highlighting the possible therapeutic interventions.
Review
Pharmacology & Pharmacy
Hoang Oanh Nguyen, Laura Tiberio, Fabrizio Facchinetti, Giulia Ripari, Valentina Violi, Gino Villetti, Valentina Salvi, Daniela Bosisio
Summary: Inhibitors of phosphodiesterase-4 (PDE4) have broad-spectrum anti-inflammatory effects by modulating the activation status of dendritic cells (DCs) and inducing immunomodulatory DCs. This fine-tuning is distinct from the effects of traditional anti-inflammatory drugs and may have important implications in the treatment of respiratory disorders.
Meeting Abstract
Cell & Tissue Engineering
F. Bifari, S. Dolci, L. Mannino, A. Campanelli, E. Bottani, I. Karkossa, E. Setten, S. Gianoli, M. Di Chio, F. Ciarpella, G. Busetto, A. Pezzotta, A. Castagna, G. Pruonto, L. Binaschi, A. Amenta, M. Scupoli, C. Cavallini, F. Boschi, A. Doherty, G. Malpeli, E. Rossi, N. Martinelli, S. Ferretti, Z. Malik, M. Sandri, A. Pistocchi, K. Schubert, M. Endrizzi, P. Bossolasco, G. Fumagalli, M. Locati, I. Decimo