Article
Cell Biology
Lingye Zhang, Anni Zhou, Shengtao Zhu, Li Min, Si Liu, Peng Li, Shutian Zhang
Summary: This review summarizes the biological functions and molecular mechanisms of ARHGAP26 in different tumors, proposes the potential clinical value of ARHGAP26 in cancer treatment, and discusses current issues that need to be addressed.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Genetics & Heredity
Margaret F. Lippincott, Wanxue Xu, Abigail A. Smith, Xinyu Miao, Agathe Lafont, Omar Shennib, Gordon J. Farley, Riwa Sabbagh, Angela Delaney, Maria Stamou, Lacey Plummer, Kathryn Salnikov, Neoklis A. Georgopoulos, Veronica Mericq, Richard Quinton, Frederic Tran Mau-Them, Sophie Nambot, Asma Hamad, Helen Brittain, Rebecca S. Tooze, Eduardo Calpena, Andrew O. M. Wilkie, Marjolaine Willems, William F. Crowley, Ravikumar Balasubramanian, Nathalie Lamarche-Vane, Erica E. Davis, Stephanie B. Seminara
Summary: This study identified ARHGAP35 as a new autosomal dominant genetic driver for idiopathic hypogonadotropic hypogonadism (IHH) and ARHGAP5 as a candidate gene for IHH. These observations suggest a novel role for the p190 RhoGAP proteins in GnRH neuronal development and integrity.
GENETICS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Vanessa Aline Bernusso, Karla P. Vieira, Adriana S. S. Duarte, Caroline Honaiser Lescano, Fabiola Zakia Monica, Cristina Pontes Vicente, Erich Vinicius De Paula, Sara Teresinha Olalla Saad, Mariana Lazarini
Summary: The RhoGAP protein ARHGAP21 plays a critical role in megakaryocytic differentiation and platelet function by regulating cytoskeletal rearrangement. Silencing of ARHGAP21 affects microtubule stability and cell spreading, while haploinsufficiency of Arhgap21 leads to enhanced platelet activation and thrombus formation. These findings suggest that ARHGAP21 may be a key protein in the control of platelet production and function.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Lijian Shao, Na Yoon Paik, Mark A. Sanborn, Thilinie Bandara, Anjali Vijaykumar, Kilian Sottoriva, Jalees Rehman, Cesar Nombela-Arrieta, Kostandin V. Pajcini
Summary: Notch signaling is crucial for the emergence and development of definitive hematopoietic stem cells (HSCs) in the embryo and fetal liver. This study reveals endothelial Jagged1 (Jag1) as a critical factor in early fetal liver vascular development but not essential for fetal HSC expansion. Jag1 is expressed in various hematopoietic cells in the fetal liver, including HSCs, but lost in adult bone marrow HSCs. Deletion of hematopoietic Jag1 does not impact fetal liver development, but results in a significant transplantation defect in fetal liver HSCs.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell & Tissue Engineering
Silvia Preciado, Sandra Muntion, Fermin Sanchez-Guijo
Summary: This review summarizes the potential of mesenchymal stromal cells to improve hematopoietic function through the secretion of extracellular vesicles after allogenic hematopoietic stem cell transplantation. It also discusses the advantages of EVs over MSCs, as well as the challenges and uncertainties that need to be addressed for their clinical application.
Review
Oncology
Wenping Song, Jinhua Chen, Shuolei Li, Ding Li, Yongna Zhang, Hanqiong Zhou, Weijiang Yu, Baoxia He, Wenzhou Zhang, Liang Li
Summary: The study focuses on summarizing the role of ARHGAP9 gene in tumorigenesis and development as a potential therapeutic target for cancer treatment. The research found that the genetic/epigenetic variations and abnormal expression of ARHGAP9 gene are closely associated with various diseases, particularly cancer. ARHGAP9 can inactivate Rho GTPases and regulate cancer cellular events through signaling pathways. The study also assessed the potential of ARHGAP9 as a predictive biomarker and druggable target for cancer treatment through patent review. Overall, the characterization of ARHGAP9 is crucial for understanding its importance in different stages of cancer progression and therapy.
RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY
(2022)
Article
Oncology
Chih-Cheng Chen, Chia-Chen Hsu, Sung-Lin Chen, Po-Han Lin, Ju-Pei Chen, Yi-Ru Pan, Cih-En Huang, Ying-Ju Chen, Yi-Yang Chen, Yu-Ying Wu, Muh-Hwa Yang
Summary: The BET inhibitor JQ1 abrogates amoeboid movement of DLBCL cells through restrained RAS signaling and MYC-mediated suppression of GTP-RhoA activity, while also increasing IQGAP3 expression, impacting the prognosis of specific DLBCL patients. Inhibitors targeting both BET and RAS activities effectively suppress DLBCL dissemination in vivo, suggesting their potential synergistic therapeutic effect for specific DLBCL subtypes.
Article
Oncology
Xi Wang, Yiqun Jia, Liling Wen, Wenxin Mu, Xianrui Wu, Tao Liu, Xiangqi Liu, Juan Fang, Yizhao Luan, Ping Chen, Jinlong Gao, Ky-Anh Nguyen, Jun Cui, Gucheng Zeng, Ping Lan, Qianming Chen, Bin Cheng, Zhi Wang
Summary: The study reveals that the periodontal pathogen P. gingivalis can promote colorectal tumorigenesis by recruiting myeloid cells and creating a proinflammatory tumor microenvironment.
Article
Microbiology
Meichen Zhu, Yankun Liu, Xuewei Yang, Lirong Zhu, Yanmei Shen, Shipeng Duan, Jinkui Yang
Summary: This study investigated the functions of two Rho-GAPs and two PAKs in the nematode-trapping fungus Arthrobotrys oligospora using bioinformatics analysis and reverse genetics. The results revealed that these proteins play crucial roles in sporulation and trap formation.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Lu Han, Ran Zhao, Jingyi Yang, Yingling Zu, Yanyan Liu, Jian Zhou, Linlin Li, Zhenghua Huang, Jishuai Zhang, Quanli Gao, Yongping Song, Keshu Zhou
Summary: This article reports a case of successful allogeneic hematopoietic stem cell transplantation (allo-HSCT) using CAR-T cell therapy as a conditioning regimen for a relapsed/refractory acute lymphoblastic leukemia patient. Despite the occurrence of acute graft versus host disease, the patient remained in complete remission.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yanshu Zhang, Takao Kitagawa, Makoto Furutani-Seiki, Shige H. Yoshimura
Summary: This study utilized high-speed atomic force microscopy (HS-AFM) and other techniques to examine the structure and dynamics of intracellular actin architecture in normal and YAP-knockout cells. The results showed that YAP influences the density, dynamics, and elasticity of actin filaments in cells, as well as the migration and activity of ARHGAP18, leading to changes in cell architecture and motility.
Article
Biochemistry & Molecular Biology
Yanshu Zhang, Takao Kitagawa, Makoto Furutani-Seiki, Shige H. Yoshimura
Summary: YAP controls the intracellular actin architecture and mechano-responses by regulating Rho GTPase activity and protein translocation at the cell edge.
Article
Cell & Tissue Engineering
Huangfan Xie, Zhongjie Sun, Xiong Xiao, Defang Liu, Hailong Qi, Guoxiong Tian, Miao Chen, Ligong Chen, Xuncheng Su
Summary: Transient inhibition of the JNK pathway can increase the frequency of HSCs in cord blood and promote their quiescence, leading to the enhancement of HSC number and engraftment potential. These findings have the potential to improve HSC collection and transplantation.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Wenfei Ji, Lili Zhang, Hongjun Zhu
Summary: This study found that GATA5 and ARHGAP9 are lowly expressed in lung adenocarcinoma and are positively correlated. Further experiments demonstrated that GATA5 can successfully activate ARHGAP9, which significantly inhibits the proliferation, invasion, and migration of lung adenocarcinoma cells. Additionally, the silencing of GATA5 reversed the inhibitory effect of upregulated ARHGAP9 on the malignant progression of lung adenocarcinoma cells.
Review
Oncology
Shahzaib Maqbool, Muhammad Nadeem, Ahmad Shahroz, Kiran Naimat, Imran Khan, Hassaan Tahir, Abdur Rehman, Faiz Anwer, Raheel Iftikhar, Ka Yiu Lee
Summary: Engraftment syndrome (ES) is a common non-infectious complication in hematopoietic stem cell transplants, characterized by fever, diarrhea, and skin rash. ES has a high incidence and is often treated with intravenous methylprednisolone.
Article
Hematology
Diamantis G. Konstantinidis, Katie M. Giger, Mary Risinger, Suvarnamala Pushkaran, Ping Zhou, Phillip Dexheimer, Satwica Yerneni, Paul Andreassen, Ursula Klingmueller, James Palis, Yi Zheng, Theodosia A. Kalfa
Article
Developmental Biology
David M. Barry, Ke Xu, Stryder M. Meadows, Yi Zheng, Pieter R. Norden, George E. Davis, Ondine Cleaver
Review
Pharmacology & Pharmacy
Yuan Lin, Yi Zheng
EXPERT OPINION ON DRUG DISCOVERY
(2015)
Article
Biochemistry & Molecular Biology
Chris R. Evelyn, Jacek Biesiada, Xin Duan, Hong Tang, Xun Shang, Ruben Papoian, William L. Seibel, Sandra Nelson, Jaroslaw Meller, Yi Zheng
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Neurosciences
Juan Li, Lei Zhang, Zhenzhong Chen, Minjuan Xie, Lu Huang, Jinhua Xue, Yutong Liu, Nuyun Liu, Fukun Guo, Yi Zheng, Jiming Kong, Lin Zhang, Lu Zhang
NEUROBIOLOGY OF DISEASE
(2015)
Article
Multidisciplinary Sciences
Inuk Zandvakili, Ashley Kuenzi Davis, Guodong Hu, Yi Zheng
Article
Multidisciplinary Sciences
Kyung Hee Chang, Ramesh C. Nayak, Swarnava Roy, Ajay Perumbeti, Ashley M. Wellendorf, Katie Y. Bezold, Megan Pirman, Sarah E. Hill, Joseph Starnes, Anastacia Loberg, Xuan Zhou, Tadashi Inagami, Yi Zheng, Punam Malik, Jose A. Cancelas
NATURE COMMUNICATIONS
(2015)
Article
Multidisciplinary Sciences
Constantinos M. Mikelis, May Simaan, Koji Ando, Shigetomo Fukuhara, Atsuko Sakurai, Panomwat Amornphimoltham, Andrius Masedunskas, Roberto Weigert, Triantafyllos Chavakis, Ralf H. Adams, Stefan Offermanns, Naoki Mochizuki, Yi Zheng, J. Silvio Gutkind
NATURE COMMUNICATIONS
(2015)
Article
Allergy
Jun-Qi Yang, Khalid W. Kalim, Yuan Li, Shuangmin Zhang, Ashwini Hinge, Marie-Dominique Filippi, Yi Zheng, Fukun Guo
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2016)
Article
Oncology
Yajie Zhu, Jitao Zhou, Hongwei Xia, Xiangzheng Chen, Meng Qiu, Juan Huang, Surui Liu, Qiulin Tang, Nan Lang, Zhen Liu, Ming Liu, Yi Zheng, Feng Bi
INTERNATIONAL JOURNAL OF ONCOLOGY
(2014)
Article
Immunology
Shuangmin Zhang, Diamantis G. Konstantinidis, Jun-Qi Yang, Benjamin Mizukawa, Khalid Kalim, Richard A. Lang, Theodosia A. Kalfa, Yi Zheng, Fukun Guo
JOURNAL OF IMMUNOLOGY
(2014)
Letter
Oncology
F. Guo, J. Li, S. Zhang, W. Du, S. Amarachintha, J. Sipple, J. Phelan, H. L. Grimes, Y. Zheng, Q. Pang
Article
Biochemistry & Molecular Biology
Salvatore Fabbiano, Mauricio Menacho-Marquez, Maria A. Sevilla, Julian Albarran-Juarez, Yi Zheng, Stefan Offermanns, Maria J. Montero, Xose R. Bustelo
MOLECULAR AND CELLULAR BIOLOGY
(2014)
Review
Biochemistry & Molecular Biology
Zheng Zhang, Ming Liu, Yi Zheng
Summary: The future of regenerative medicine hinges on understanding the role of stem cells in tissue generation and restoration. Rho GTPases play a crucial role in regulating various cellular processes related to cell dynamics, and their implications in cancer stem cells open up new possibilities for cancer therapy.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2021)
Article
Oncology
Kee-Beom Kim, Dong-Wook Kim, Youngchul Kim, Jun Tang, Nicole Kirk, Yongyu Gan, Bongjun Kim, Bingliang Fang, Jae-ll Park, Yi Zheng, Kwon-Sik Park
Summary: This study characterizes the activity of the WNT pathway in small cell lung cancer (SCLC) and identifies the key role of the WNT5A-RHOA axis in SCLC progression. It provides potential targets for therapeutic interventions and biomarkers to improve patient treatment.