Article
Engineering, Biomedical
Li Hao, Zhao Tianyuan, Yang Zhen, Cao Fuyang, Wu Jiang, Yan Zineng, Ding Zhengang, Liu Shuyun, Hao Chunxiang, Yuan Zhiguo, Guo Quanyi
Summary: This study presents a 3D-printed dual drug-releasing meniscal scaffold for promoting meniscus regeneration. The scaffold was able to enhance cell migration and promote in vivo neomeniscal regeneration, showing potential for clinical treatment of meniscal injury and related degenerative diseases.
Article
Biochemistry & Molecular Biology
Ae-Rang Hwang, Hee-Jung Lee, Suji Kim, Seong-Hee Park, Chang-Hoon Woo
Summary: Inhibition of phosphorylated p90RSK with specific inhibitors, such as FMK or BI-D1870, can suppress PDGF-BB-induced migration and proliferation of vascular smooth muscle cells (VSMCs), reduce phenotypic changes and extracellular matrix accumulation in VSMCs. It can also affect VSMC proliferation by regulating the expression of cyclin D1 and cyclin-dependent kinase-4, and inhibit the decrease of Cdk inhibitor p27 expression induced by PDGF-BB, thereby inhibiting VSMC proliferation in the G0/G1 phase. The use of phosphorylated p90RSK inhibitors can attenuate the PDGF-BB-induced phenotypic switch and neointimal hyperplasia in VSMCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Akira Takaguri, Rena Ishizaka, Shota Maki, Kumi Satoh
Summary: This study reveals the important role of TRIB2 in VSMC proliferation, which is upregulated following vascular injury and PDGF-BB stimulation. The expression of TRIB2 is mediated by ROS/ERK/EGR-1 pathways and plays a critical role in VSMC proliferation via modulation of ERK activity.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
Joo-Hui Han, Hyun-Soo Park, Do-Hyung Lee, Jun-Hwan Jo, Kyung-Sun Heo, Chang-Seon Myung
Summary: The study suggests that PDGF-BB-induced VSMC autophagy is mainly regulated by Erk1/2, independent of the mTOR pathway. Targeting autophagy modulation may be a potential therapeutic strategy for addressing abnormal VSMC proliferation and migration.
Article
Cardiac & Cardiovascular Systems
Jia-Jie Lin, Wei Chen, Miao Gong, Xin Xu, Mei-Yang Du, Si-Fan Wang, Li-Yun Yang, Yu Wang, Ke-Xin Liu, Peng Kong, Bin Li, Kun Liu, Yi-Ming Li, Li-Hua Dong, Shao-Guang Sun
Summary: The research identified multiple lncRNAs involved in regulating VSMC proliferation, with HIF1A-AS2 promoting HASMC proliferation through the miR-30e-5p/CCND2 mRNA axis. These findings reveal potential pathways for treating VSMC proliferative diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Physiology
Siyuan Fan, Cheng Wang, Kai Huang, Minglu Liang
Summary: The study found that myricanol can inhibit the proliferation and migration of Vascular smooth muscle cells (VSMCs) and suppress intimal hyperplasia. This provides a new strategy for the prevention and treatment of coronary atherosclerosis and post-stent stenosis in the future.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Veterinary Sciences
Laura Miguel-Pastor, Katy Satue, Deborah Chicharro, Pau Pelaez, Marta Torres-Torrillas, Jose M. Carrillo, Jose J. Ceron, Joaquin J. Sopena, Monica Rubio
Summary: Feline leukemia virus (FeLV) is a chronic disease that weakens a cat's immune system. Platelet-rich plasma (PRP) and growth factors (GFs) determination offer potential alternative treatment for improving quality of life in FeLV cats. This study aimed to determine the concentration of platelets, red blood cells, white blood cells, and growth factors in whole blood, PRP, and platelet-poor plasma fractions using a standardized protocol.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Cell Biology
Liang-Wei Lin, Shih-Wei Wang, Wei-Chien Huang, Thanh Kieu Huynh, Chao-Yang Lai, Chih-Yuan Ko, Yi-Chin Fong, Jie-Jen Lee, Shun-Fa Yang, Chih-Hsin Tang
Summary: Neovascular age-related macular degeneration (AMD) is a disease characterized by abnormal blood vessel growth in the retina, leading to severe vision loss. The presence of certain markers in the retinas of AMD patients suggests a contribution of endothelial progenitor cells (EPCs) in this pathogenesis. This study explores the potential of melatonin, a hormone produced in the retina, to inhibit EPC angiogenesis in neovascular AMD. The results demonstrate that melatonin can effectively inhibit the formation of EPC blood vessels and shows promise as a potential treatment for neovascular AMD.
Article
Physiology
Wei Yang, Yunbin Chen, Chao Huang, Wenjian Wang, Congfu Huang, Yuanguang Li
Summary: The down-regulation of miR-18a was observed in the sputum and PDGF-BB-treated ASMCs of asthma patients. PDGF-BB promoted ASMCs proliferation and migration, inhibited apoptosis, induced phenotypic transformation, and activated the PI3K/AKT pathway. MiR-18a suppressed PDGF-BB-induced ASMCs proliferation, migration, and phenotypic conversion by inhibiting the PI3K/AKT pathway, thereby attenuating airway remodeling in asthma.
PHYSIOLOGICAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Jing Wang, Xiaoxiang Tian, Chenghui Yan, Hanlin Wu, Yuxin Bu, Jia Li, Dan Liu, Yaling Han
Summary: Phenotypic switching of vascular smooth muscle cells plays a central role in abdominal aortic aneurysm pathology. Knockdown of TCF7L1 inhibits the differentiation of vascular smooth muscle cells. This study suggests potential interventions to prevent AAA by maintaining a normal differentiated smooth muscle cell state, and TCF7L1 may serve as a biomarker for AAA.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Chih-Wei Chiu, Cheng-Ying Hsieh, Chih-Hao Yang, Jie-Heng Tsai, Shih-Yi Huang, Joen-Rong Sheu
Summary: Yohimbine (YOH) inhibits the proliferation and migration of vascular smooth muscle cells (VSMCs) stimulated by PDGF-BB through downregulating the α2B-adrenergic receptor-independent PLC gamma 1 pathway, and reduces neointimal formation in atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Rui Li, Chao Zhang, Fei Xie, Xianming Zhou, Xingjian Hu, Jiawei Shi, Xinling Du, Zhiyong Lin, Nianguo Dong
Summary: Protein phosphatase 2A (PP2A) plays an important role in cardiovascular disease, particularly in atherosclerosis. This study found that the expression and activity of PP2A decreased significantly in atherosclerotic coronary arteries compared to non-atherosclerotic arteries. Inhibition of PP2A worsened atherosclerosis in mice, while deficiency of PP2A in macrophages aggravated atherosclerotic lesions. Mechanistically, PP2A deficiency in macrophages led to an increase in the phosphorylation level of p38, resulting in elevated expression of the scavenger receptor CD36 and enhanced lipid uptake and foam cell formation. These findings indicate that PP2A participates in the pathophysiological process of atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Allergy
Yingying Zhang, Fan Yao, Zhihua Qin
Summary: This study demonstrates that JNJ0966 inhibits the proliferation and extracellular matrix production of airway smooth muscle cells (ASMCs) induced by PDGF-BB through modulating MMP-9, suggesting its potential as a novel therapeutic target for asthma.
ALLERGOLOGIA ET IMMUNOPATHOLOGIA
(2022)
Article
Oncology
Fang-Yun Zhao, Shuang-Lan Xu, Chun-Fang Zhang, Jie Liu, Yue Zhang, Jiao Yang, Xi-Qian Xing
Summary: The study found that PDGF enhances the proliferation and migration of PASMCs by regulating NFATc2, suggesting a potential therapeutic target for PAH treatment.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Pharmacology & Pharmacy
Langtao Wang, Zhen Yang, Sai Wang, Yumei Que, Xi Shu, Fuhua Wu, Gang Liu, Siqi Li, Pingping Hu, Hao Chen, Jian Shi, Xiaoyong Tong
Summary: This study found that the irreversible oxidation of SERCA2 C674 promotes the development of aortic aneurysm by inducing endoplasmic reticulum stress and cell apoptosis. Additionally, ER stress and SERCA2 may be potential therapeutic targets for treating aortic aneurysm.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Immunology
Niels W. C. J. van de Donk, Maarten L. Janmaat, Tuna Mutis, Jeroen J. Lammerts van Bueren, Tahamtan Ahmadi, A. Kate Sasser, Henk M. Lokhorst, Paul W. H. I. Parren
IMMUNOLOGICAL REVIEWS
(2016)
Article
Biochemistry & Molecular Biology
Julia Boshuizen, Louise A. Koopman, Oscar Krijgsman, Aida Shahrabi, Elke Gresnigt-van den Heuvel, Maarten A. Ligtenberg, David W. Vredevoogd, Kristel Kemper, Thomas Kuilman, Ji-Ying Song, Nora Pencheva, Jens Thing Mortensen, Marnix Geukes Foppen, Elisa A. Rozeman, Christian U. Blank, Maarten L. Janmaat, David Satijn, Esther C. W. Breij, Daniel S. Peeper, Paul W. H. I. Parren
Article
Oncology
Marcel N. A. Bijman, Maria P. A. van Berkel, Mirjam Kok, Maarten L. Janmaat, Epie Boven
Article
Pharmacology & Pharmacy
Marcel N. A. Bijman, Cristian A. Hermelink, Maria P. A. van Berkel, Adrie C. Laan, Maarten L. Janmaat, Godefridus J. Peters, Epie Boven
BIOCHEMICAL PHARMACOLOGY
(2008)
Article
Multidisciplinary Sciences
Mario Losen, Aran F. Labrijn, Vivianne H. van Kranen-Mastenbroek, Maarten L. Janmaat, Krista G. Haanstra, Frank J. Beurskens, Tom Vink, Margreet Jonker, Bert A. 't Hart, Marina Mane-Damas, Peter C. Molenaar, Pilar Martinez-Martinez, Eline van der Esch, Janine Schuurman, Marc H. de Baets, Paul W. H. I. Parren
SCIENTIFIC REPORTS
(2017)
Review
Biotechnology & Applied Microbiology
Aran F. Labrijn, Maarten L. Janmaat, Janice M. Reichert, Paul W. H. I. Parren
NATURE REVIEWS DRUG DISCOVERY
(2019)
Article
Oncology
Julia Boshuizen, Nora Pencheva, Oscar Krijgsman, Daniela D'Empaire Altimari, Patricia Garrido Castro, Beaunelle de Bruijn, Maarten A. Ligtenberg, Elke Gresnigt-Van den Heuvel, David W. Vredevoogd, Ji-Ying Song, Nils Visser, Georgi Apriamashvili, Maarten L. Janmaat, Theo S. Plantinga, Patrick Franken, Mischa Houtkamp, Andreas Lingnau, Maria Jure-Kunkel, Daniel S. Peeper
Summary: EnaV effectively targets therapy-resistant tumors, inducing an inflammatory response and immunogenic cell death, as well as promoting memory-like phenotype in cytotoxic T cells in melanoma and lung cancer models. This combination therapy enhances anti-tumor immunity and sensitivity to immune checkpoint blockade.
Article
Medicine, Research & Experimental
Louise A. Koopman, Mikkel G. Terp, Gijs G. Zom, Maarten L. Janmaat, Kirstine Jacobsen, Elke Gresnigt-van den Heuve, Marcel Brandhorst, Ulf Forssmann, Freddy de Bree, Nora Pencheva, Andreas Lingnau, Maria A. Zipeto, Paul W. H. Parren, Esther C. W. Breij, Henrik J. Ditzels
Article
Oncology
ML Janmaat, MI Gallegos-Ruiz, JA Rodriguez, GA Meijer, WL Vervenne, DJ Richel, C Van Groeningen, G Giaccone
JOURNAL OF CLINICAL ONCOLOGY
(2006)
Article
Pharmacology & Pharmacy
ML Janmaat, JA Rodriguez, J Jimeno, FAE Kruyt, G Giaccone
MOLECULAR PHARMACOLOGY
(2005)
Article
Oncology
ML Janmaat, FAE Kruyt, JA Rodriguez, G Giaccone
CLINICAL CANCER RESEARCH
(2003)
Article
Oncology
Dennis Fontijn, Linda J. W. Bosch, Monique C. A. Duyndam, Maria P. A. van Berkel, Maarten L. Janmaat, Epie Boven
Article
Oncology
ML Janmaat, JA Rodriguez, M Gallegos-Ruiz, FAE Kruyt, G Giaccone
INTERNATIONAL JOURNAL OF CANCER
(2006)
Review
Oncology
ML Janmaat, G Giaccone