期刊
BLOOD
卷 115, 期 2, 页码 261-264出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2009-05-223990
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资金
- Senternovum
- Bill and Melinda Gates Foundation
Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is a treatment option for patients with hematopoietic malignancies that is hampered by treatment-related morbidity and mortality, in part the result of opportunistic infections, a direct consequence of delayed T-cell recovery. Thymic output can be improved by facilitation of thymic immigration, known to require precommitment of CD34(+) cells. We demonstrate that Delta-like ligand-mediated predifferentiation of mobilized CD34(+) cells in vitro results in a population of thymocyte-like cells arrested at a T/natural killer (NK)-cell progenitor stage. On intrahepatic transfer to Rag2(-/-)gamma(-/-)(c) mice, these cells selectively home to the thymus and differentiate toward surface T-cell receptor-alpha beta(+) mature T cells considerably faster than animals transplanted with noncultured CD34(+) cells. This finding creates the opportunity to develop an early T-cell reconstitution therapy to combine with HSCT. ( Blood. 2010; 115:261-264)
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