Article
Dentistry, Oral Surgery & Medicine
Martina Kaurinovic, Konstantina Delli, Ana-Mae E. Jonk, Anouschka Biswana, Carin L. E. Hazenberg, Goda Choi, Marco R. de Groot, Linde M. Morsink, Arjan Vissink, Mar Bellido
Summary: The study aimed to assess the effect of ruxolitinib on the oral mucosa of SR-cGVHD patients with oral involvement. In an observational longitudinal patient study, 53 patients with SR-cGVHD and oral involvement were treated with ruxolitinib. The baseline condition of the oral mucosa was compared to its condition at 4 and 12 weeks after starting ruxolitinib.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Multidisciplinary Sciences
Isobel C. Mouat, Iryna Shanina, Marc S. Horwitz
Summary: ABCs, a unique subset of B cells associated with age, remain elevated and express IFN gamma and TNF during latent viral infection. They persist in the absence of latent virus but with decreased expression of IFN gamma and TNF. Mice without ABCs show defects in anti-viral antibodies and are more susceptible to reactivation of the latent virus.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Corinna L. L. Seidel, Elena Percivalle, Marco Tschaftari, Matthias Weider, Karin Strobel, Ines Willershausen, Christoph Unertl, Helga M. M. Schmetzer, Manuel Weber, Michael Schneider, Benjamin Frey, Udo S. S. Gaipl, Matthias W. W. Beckmann, Lina Goelz
Summary: The study found significantly increased levels of oral cytokines in neonates with orofacial clefts, especially at the first consultation after birth. Furthermore, a significant positive correlation was detected between cleft severity and specific pro-inflammatory mediators.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Eva-Maria Frickel, Christopher A. Hunter
Summary: Toxoplasma gondii is a valuable experimental system for studying how the immune system deals with intracellular infections, particularly in relation to the cytokine IFN-gamma and the strategies pathogens use to evade antimicrobial responses. Its genetic tractability allows for research on the basis of latency and continues to provide insights into host-pathogen interactions.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Microbiology
Tarani Kanta Barman, Rachael Racine, Jesse L. Bonin, Danielle Califano, Sharon L. Salmon, Dennis W. Metzger
Summary: Bacterial co-infections are a common and challenging clinical complication of influenza. This study found that mice lacking both type-I and type-II interferon (IFN) pathways demonstrated minimal lung pathology and increased survival in a pneumococcal-influenza virus superinfection model. Therapeutic neutralization of both type-I and type-II IFN pathways provided optimal protection to superinfected wild-type mice.
Article
Biochemistry & Molecular Biology
Shinri Sato, Eisuke Shimizu, Jingliang He, Mamoru Ogawa, Kazuki Asai, Hiroyuki Yazu, Robert Rusch, Mio Yamane, Fan Yang, Shinji Fukuda, Yutaka Kawakami, Kazuo Tsubota, Yoko Ogawa
Summary: In this study, it was found in a mouse model that gentamicin (GM) significantly suppressed systemic cGVHD phenotypes and ocular manifestations, and reduced inflammatory cell infiltration and fibrosis in cGVHD-targeted organs. Although GM maintained higher levels of regulatory T cells, there were fewer Th17 cells and IL-6-producing macrophages in cGVHD-targeted organs. These findings suggest that orally administered GM may have positive effects in a cGVHD mouse model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Plant Sciences
Alexandre Martel, Tatiana Ruiz-Bedoya, Clare Breit-McNally, Bradley Laflamme, Darrell Desveaux, David S. Guttman
Summary: Natural diversity of plant resistance proteins and pathogen effectors is shaped by ongoing ETS-ETI cycles. The introduction of genetic variation from conspecific organisms in different populations can maintain diversity in both host and pathogen populations.
CURRENT OPINION IN PLANT BIOLOGY
(2021)
Article
Oncology
Juliette Stolze, Marlou Boor, Mette D. Hazenberg, Henk S. Brand, Judith E. Raber-Durlacher, Alexa M. G. A. Laheij
Summary: The study assessed the impact of oral chronic graft-versus-host-disease (cGVHD) symptoms on oral health-related quality of life (OHRQoL). Results showed that OHRQoL was mainly negatively affected by oral pain and sensitivity, rather than the severity of oral mucosal cGVHD. Special attention from healthcare professionals is essential to improve OHRQoL for patients with oral cGVHD.
SUPPORTIVE CARE IN CANCER
(2021)
Review
Oncology
Ori Bar, Sharon Elad, Batia Avni, Jawad Abu-Tair, Bianca Zaharia, Aiham Hanut, Yehuda Zadik
Summary: This study presented new cases of oral VX in chronic graft-versus-host disease (cGVHD) and reviewed relevant literature, identifying 12 patients with OVX. Most patients had oral mucosal lichenoid lesions, but not in close proximity to the VX lesion. It is recommended that clinicians be familiar with the clinical and histological features of OVX to consider it in the differential diagnosis of oral lesions in cGVHD patients.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Multidisciplinary Sciences
Benjamin Ernst, Tahereh Setayesh, Armen Nersesyan, Michael Kundi, Michael Fenech, Claudia Bolognesi, Miroslav Misik, Masood Ghane, Seyed Fazlollah Mousavi, Siegfried Knasmueller
Summary: The consumption of very hot beverages can increase the risk of oral and esophageal cancer, not by damaging genetic material but by increasing cell division rates due to cytotoxic effects occurring at temperatures over 60 degrees Celsius.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Eileen Haring, Robert Zeiser, Petya Apostolova
Summary: Both graft-versus-host disease (GVHD) and inflammatory bowel disease (IBD) are immunologically mediated diseases of the intestine, sharing several key features in their onset and development including intestinal tissue damage and involvement of cytokines.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Surgery
Chunqin Tao, Xiaoxiang Jin, Hengshu Zhang
Summary: Female urethral stricture is a challenging condition, where urethral dilation is commonly used but has complications and high recurrence rate. Recently, dorsal oral mucosa graft urethroplasty has gained attention, showing higher success rates compared to other grafts. However, there is a lack of multicenter, large sample, and long-term follow-up studies, as well as comparative studies between different types of oral mucosa. In summary, dorsal oral mucosa graft urethroplasty is an effective option for treating female urethral stricture, but further research is needed.
FRONTIERS IN SURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Karin Garming Legert, Olle Ringden, Mats Remberger, Johan Torlen, Jonas Mattsson, Goran Dahllof
Summary: The study found that using tacrolimus plus sirolimus as a prophylaxis for graft-versus-host disease following haematopoietic stem cell transplantation did not increase the incidence or severity of oral mucositis, nor did it prolong the healing time compared to cyclosporine plus methotrexate.
Review
Immunology
Victor Tollemar, Karin Legert, Rachael V. V. Sugars
Summary: Chronic Graft-versus-Host Disease (cGVHD) is a common complication after allogenic hematopoietic cell transplantation (HCT). It frequently affects the mouth and can be diagnosed by mucosal lichenoid lesions, salivary gland dysfunction, and limited oral aperture. The pathophysiology of oral cGVHD involves acute and chronic inflammation, dysregulated immunity, and fibrotic healing, which may lead to increased malignant transformation rate.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Juliana Barreto de Albuquerque, Lukas M. Altenburger, Jun Abe, Diego von Werdt, Stefanie Wissmann, Jose Martinez Magdaleno, David Francisco, Geert van Geest, Xenia Ficht, Matteo Iannacone, Remy Bruggmann, Christoph Mueller, Jens Stein
Summary: The study identifies mandibular lymph nodes as sentinel lymphoid organs in intercepting ingested Listeria monocytogenes. Oral uptake of Lm leads to the activation and release of antigen-specific CD8(+) T cells, contributing to rapid clearance of the pathogen. Interestingly, CD8(+) T-EFF generated in the upper GI tract lack gut-seeking phenotype compared to those generated in the lower GI tract.
SCIENCE IMMUNOLOGY
(2022)