Article
Oncology
Marco Rossi, Emanuela Altomare, Cirino Botta, Maria Eugenia Gallo Cantafio, Sarai Sarvide, Daniele Caracciolo, Caterina Riillo, Marco Gaspari, Domenico Taverna, Francesco Conforti, Paola Critelli, Bernardo Bertucci, Michelangelo Iannone, Nicoletta Polera, Domenica Scumaci, Mariamena Arbitrio, Nicola Amodio, Maria Teresa Di Martino, Bruno Paiva, Pierosandro Tagliaferri, Pierfrancesco Tassone
Summary: The study demonstrated that miR-21 plays a crucial role in Th17-mediated tumor growth and bone disease in multiple myeloma, with inhibition of miR-21 leading to reduced pathology. Early inhibition of miR-21 in T cells (miR-21i-T cells) was found to impair Th17 differentiation, thereby decreasing MM cell proliferation and osteoclast activity.
Article
Immunology
Wenyi Yang, Binhui Zhou, Qi Liu, Taozhen Liu, Huijie Wang, Pei Zhang, Liaoxun Lu, Lichen Zhang, Fanghui Zhang, Rong Huang, Jitong Zhou, Tianzhu Chao, Yanrong Gu, Songhua Lee, Hui Wang, Yinming Liang, Le He
Summary: This study identified a mouse line carrying a missense mutation of Sgpl1, which successfully modeled a human disease after treatment with Imiquimod. The mutation caused similar pathologies as Sgpl1 knock-out mice in multiple organs but greatly preserved the lifespan. The study also revealed an enrichment of IL17a producing V gamma 6(+) cells in the skin, which contributed to severe skin pathology.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Minodora Dobreanu, Doina Ramona Manu, Ion Bogdan Manescu, Manuela Rozalia Gabor, Adina Hutanu, Laura Barcutean, Rodica Balasa
Summary: The study found that T cell subtypes in multiple sclerosis patients demonstrated variations in ex vivo cell survival and proliferation, as well as differential resistance to cladribine. This experimental model shows promise in predicting individual responsiveness of MS patients to cladribine and other DMDs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
M. Hope Robinson, Nancy Y. Villa, David L. Jaye, Ajay K. Nooka, Alyssa Duffy, Samuel S. McCachren, Julia Manalo, Jeffrey M. Switchenko, Sierra Barnes, Sayalee Potdar, Maryam I. Azeem, Ava A. Horvat, Vaunita C. Parihar, Jingjing Gong, Yan Liang, Geoffrey H. Smith, Vikas A. Gupta, Lawrence H. Boise, Jonathan L. Kaufman, Craig C. Hofmeister, Nisha S. Joseph, Sagar Lonial, Kavita M. Dhodapkar, Madhav V. Dhodapkar
Summary: This study investigates the mechanisms underlying immune infiltration in human multiple myeloma (MM) and its precursor monoclonal gammopathy of undetermined significance (MGUS) using high-dimensional spatial analyses and in vitro and in vivo modeling. The results suggest that MM exhibits clustered tumor growth and spatial heterogeneity with the coexistence of T cell-rich and T cell-sparse regions, as well as areas of T cell exclusion. T cell entry into MM clusters is regulated by agonistic signals and CD2-CD58 interactions, and CLEC9A+ DCs play a role in marking the portals of entry for T cell infiltration.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, Research & Experimental
Byeongho Jung, Gerardo Ferrer, Pui Yan Chiu, Rukhsana Aslam, Anita Ng, Florencia Palacios, Michael Wysota, Martina Cardillo, Jonathan E. Kolitz, Steven L. Allen, Jacqueline C. Barrientos, Kanti R. Rai, Nicholas Chiorazzi, Barbara Sherry
Summary: Chronic lymphocytic leukemia (CLL) patients with higher levels of IL-17A(+) and IL-17F(+) CD4(+) T cells and increased expression of miR155 in Th17 cells have better outcomes. CLL cells directly regulate miR155 levels in T cells, thereby affecting Th17 differentiation. CLL cells promote IL-17A(+) and IL-17F(+) T cell generation through an miR155-dependent mechanism. This mechanism is associated with clinical prognosis in CLL.
Article
Oncology
Wen-Hsuan Chang, Thuy-Tien Thi Nguyen, Chia-Hsin Hsu, Kirsten L. Bryant, Hong Jin Kim, Haoqiang Ying, Jon W. Erickson, Channing J. Der, Richard A. Cerione, Marc A. Antonyak
Summary: KRAS mutations lead to the production of exosomes enriched with the cell survival protein Survivin, which enhance cancer cell survival and resistance to chemotherapy drugs. Targeting Survivin within these exosomes could potentially serve as a therapeutic strategy for KRAS-dependent cancers.
Article
Immunology
Urmi Roy, Romulo S. de Oliveira, Eric J. C. Galvez, Achim Gronow, Marijana Basic, Laura Garcia Perez, Nicola Gagliani, Andre Bleich, Samuel Huber, Till Strowig
Summary: The study reveals that segmented filamentous bacteria (SFB) not only induce Th17 cells but also distinct IL-17A negative CD4+ T cell populations in the intestine, some of which produce IL-22 upon restimulation and during enteric infections. These cells, presumably Th22 cells, develop independently of intestinal Th17 cells and produce a different set of cytokines compared to Th17 cells. This suggests that aside from Th17, SFB can also induce CD4+ T cell populations that serve as an immediate source of IL-22 during intestinal inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Florianne M. J. Hafkamp, Esther W. M. Taanman-Kueter, Toni M. M. van Capel, Tom Groot Kormelink, Esther C. de Jong
Summary: This study investigated the effects of Vitamin D3 on the differentiation of specific human T cells. The results showed that Vitamin D3 can restrict the development of Th17 cells, promote the development of regulatory T cells, and reduce the production of specific cytokines by dendritic cells. This provides potential for the use of Vitamin D3 as an adjuvant in the treatment of autoimmune disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Rene Reitermaier, Thomas Krausgruber, Nikolaus Fortelny, Tanya Ayub, Pablo Augusto Vieyra-Garcia, Philip Kienzl, Peter Wolf, Anke Scharrer, Christian Fiala, Marita Kolz, Manuela Hiess, Martin Vierhapper, Christopher Schuster, Andreas Spittler, Christof Worda, Wolfgang Weninger, Christoph Bock, Rene Reitermaier, Adelheid Elbe-Buerger
Summary: Single-cell analyses identified a naive T cell population expressing specific T cell receptors enriched in fetal skin and intestine. These cells may contribute to early skin development and fetal immune defense, showing fundamental differences in immune surveillance between fetal and adult human skin.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Review
Oncology
Patricia Maiso, Pedro Mogollon, Enrique M. Ocio, Mercedes Garayoa
Summary: Multiple myeloma is a cancer of plasma cells that accumulate in the bone marrow, and the interaction between mesenchymal stromal cells and myeloma cells appears to play a crucial role in the progression of the disease. Structural and functional differences between mesenchymal stromal cells from healthy donors and myeloma patients have been identified, suggesting a significant contribution to the pathophysiology of multiple myeloma.
Article
Immunology
Sara M. Parigi, Srustidhar Das, Annika Frede, Rebeca F. Cardoso, Kumar Parijat Tripathi, Cristian Donas, Yue O. O. Hu, Per Antonson, Lars Engstrand, Jan-Ake Gustafsson, Eduardo J. Villablanca
Summary: The gastrointestinal microenvironment, dominated by dietary compounds and commensal bacteria, plays a crucial role in regulating intestinal CD4(+)T helper (Th) cell differentiation. The study shows that LXR modulates ROR gamma t(+)Treg and Th17 cells in the mesenteric lymph node (MLN) through distinct mechanisms. LXR activation leads to a decrease in MLN Th17 and ROR gamma t(+)Tregs, while LXR deficiency results in an increase in these cell populations.
MUCOSAL IMMUNOLOGY
(2021)
Article
Toxicology
Jinding Pu, Juan Xu, Lu Chen, Hongbin Zhou, Weitao Cao, Binwei Hao, Naijian Li, Jianxiong Wu, JinZhen Zheng, Wei Hong, Bing Li, Pixin Ran
Summary: Research has shown that biomass smoke exposure may induce Th17 responses through activation of dendritic cells and lead to the development of chronic obstructive pulmonary disease in a rat model. By studying the role of antigen-presenting cells and the effect of biomass-related particulate matter, it was found that biomass smoke activates lung dendritic cells via the Toll-like receptor 2 pathway.
TOXICOLOGY LETTERS
(2021)
Article
Immunology
Lena Michaelis, Marcel Tress, Hanna-Christine Loew, Johanna Klees, Christian Klameth, Anna Lange, Anne Griesshammer, Andrea Schaefer, Sarah Menz, Alex Steimle, Klaus Schulze-Osthoff, Julia-Stefanie Frick
Summary: Intestinal commensal bacteria play a significant role in regulating the development of Th17 cells, with potential implications for autoimmune diseases. The atypical nuclear I kappa B protein I kappa B zeta may be involved in this process. Different gut commensals with varying immunogenicity levels can affect the expression of I kappa B zeta in dendritic cells and influence the immune response, indicating potential therapeutic implications for autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
H. Hackstein, A. Kalina, B. Dorn, I. S. Keil, N. Baal, G. Michel, C. Brendel, A. Neubauer, T. Jakob, G. Bein
Summary: Extracorporeal photopheresis (ECP) acts through antigen-presenting dendritic cells (DC) and is influenced by CD11c(+) DC, demonstrating antigen specificity and showing the critical importance of CD11c(+) DC for ECP activity.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Tetsuya Hirata, Yoichiro Harada, Koichiro M. Hirosawa, Yuko Tokoro, Kenichi G. N. Suzuki, Yasuhiko Kizuka
Summary: Small extracellular vesicles (sEVs) secreted from cancer cells are crucial in cancer metastasis and malignancy by transferring biomolecules and modifying future metastatic sites. This study investigates the enzyme activity of glycosyltransferases, specifically N-acetylglucosaminyltransferase-V (GnT-V), in cancer-derived sEVs. The results show that cleaved GnT-V is selectively enriched in non-exosomal sEVs and can be transferred to recipient cells, leading to the remodeling of N-glycan structures in recipient cells.