Article
Multidisciplinary Sciences
Anteneh Omer, Dejene Hailu, Gezahegn Nigusse, Afework Mulugeta
Summary: This study found that the prevalence of anemia among children aged 6-59 months in Ethiopia is 44.7%. Microcytic hypochromic anemia with high red cell distribution width is the most common type, primarily affecting children under the age of two. Normocytic normochromic anemia is significantly more prevalent among children aged 24-59 months, while macrocytic anemia is not related to age.
Article
Medical Laboratory Technology
Fan Zhang, Jing Yang, Yang Wang, Manyi Cai, Juan Ouyang, JunXun Li
Summary: This study aimed to develop a machine learning algorithm to differentiate between iron deficiency anemia (IDA) and thalassemia trait (TT). Laboratory data from 798 patients with microcytic hypochromic anemia (MHA) were collected, and the performance of six existing discriminant formulas was compared. The random forest model was chosen as the discriminant algorithm, and a webpage tool was developed to assist healthcare providers in rural areas.
CLINICA CHIMICA ACTA
(2023)
Article
Biochemistry & Molecular Biology
Lidia Romero-Cortadellas, Gonzalo Hernandez, Xenia Ferrer-Cortes, Laura Zalba-Jadraque, Jose Luis Fuster, Mar Bermudez-Cortes, Ana Maria Galera-Minarro, Santiago Perez-Montero, Cristian Tornador, Mayka Sanchez
Summary: DMT1, encoded by SLC11A2 gene, plays a crucial role in iron homeostasis. Mutations in SLC11A2 can lead to AHMIO1, a rare form of anemia with iron overload. This study reports two novel cases of AHMIO1, one with a new SLC11A2 splicing variant and the other with a previously reported DMT1 G75R mutation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Hajime Yasuda, Taku Hatano, Tadahiro Honda, Miyuki Tsutsui, Nobutaka Hattori, Miki Ando, Norio Komatsu
Summary: Vitamin B6 deficiency can cause anemia, characterized by microcytic, hypochromic, and sideroblastic features. Levodopa/carbidopa therapy can lead to VB6 deficiency anemia. This case report describes a 75-year-old Parkinson's disease patient who developed severe VB6 deficiency anemia due to levodopa/carbidopa intestinal gel therapy, and was successfully treated with oral supplementation of pyridoxal phosphate hydrate. VB6 deficiency anemia can be easily mistaken for myelodysplastic syndrome, emphasizing the importance of accurate diagnosis for patients receiving levodopa/carbidopa therapy.
Article
Genetics & Heredity
Xiuqin Bao, Jicheng Wang, Danqing Qin, Cuize Yao, Jie Liang, Kailing Liang, Yukun Zeng, Li Du
Summary: This study used SMRT sequencing to detect rare and complex variants in the a-globin locus in Chinese population. Four novel large deletions were observed, and the results were confirmed. The study demonstrates that SMRT sequencing is a better method to identify major gene variations compared to traditional methods, and has potential for wide clinical applications.
Article
Fisheries
Zhu-Xiang Jiang, Meher un Nissa, Zao-Zao Guo, Ya-Bing Zhang, Guo-Dong Zheng, Shu-Ming Zou
Summary: The study on grass carp gene mutations induced by ENU revealed that mutations in the TOLLIP gene can suppress inflammation and enhance resistance to viruses, which may be beneficial for future breeding strategies focusing on disease resistance.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Muhamed Focak, Maja Mitrasinovic-Brulic, Damir Suljevic
Summary: Gentamicin (GM) is an antibiotic used for bacterial infections. Aronia melanocarpa extract (AME), known as black chokeberry, has a moderate beneficial effect against GM-induced nephropathy.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Pathology
Mostafa Kotb, Marwa Abdelaziz, Yasmine Abdelmeguid, Ahmed Hassan, Nagwa Mashali, Yasser Saad-Eldin
Summary: Gastroduodenal intussusception, the invagination of a portion of the stomach into the duodenum, predominantly occurs in adults but can also occur in young children like the 2-year-old girl in this case report. This condition may be associated with anemia, especially in cases where there is a gastric mucosal prolapse polyp.
FETAL AND PEDIATRIC PATHOLOGY
(2021)
Article
Medicine, General & Internal
Dan Ou, Yuan Zhou, Jibo Zhang, Chao Wang, Lihua Zhou, Bo Wen, Dan Peng
Summary: Thalassemia trait (TT) and iron deficiency anemia (IDA) are common disorders of hypochromic microcytic anemia (HMA). The Green and King Index showed the highest sensitivity (82%) and Area Under Curve (0.86), as well as the highest Youden's Index (63%), making it the most reliable index for distinguishing TT and IDA.
ACTA MEDICA MEDITERRANEA
(2021)
Article
Environmental Sciences
Chun Pan, Minghao Yan, Haibo Jin, Hongqian Guo, Xiaodong Han
Summary: The study found that microcystins play an important role in human hematological parameters, potentially leading to microcytic anemia, and identified the related signaling pathway for the first time.
ENVIRONMENTAL POLLUTION
(2021)
Article
Medicine, General & Internal
Febe Renjitha Suman, Ravi Teja, Jesu Magdalene, Tejaswita Bisht, Suresh Varadharajan, Uma Lakshmi, Jayalakshmi Balasubramanian
Summary: This study aimed to detect beta (13) thalassemia heterozygous state in antenatal women and create a validated flag in the software for filtering samples for high-performance liquid chromatography (HPLC), as well as establishing a model for thalassemia prevention. The results showed that Sehgal index and Mentzer index were suitable screening indices, and the implementation of an alert flag in the software helped to avoid missing samples for HPLC. Spouse testing of women with beta thalassemia trait achieved a rate of 55.81%. A screening program model was designed, indicating the success of the antenatal screening program.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Malavika Shankar, Nicole Gousy, Tutul Chowdhury
Summary: Sickle cell disease variants can present as life-threatening complications or milder symptoms. Early investigation of these symptoms may reduce the risk of severe complications.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Donel, Ruza Prima Rustam, Dhini Aiyulie Novri, Maya Savira
Summary: Pregnant women experience a twofold increase in iron requirements due to increased blood volume without expansion of plasma volume, making them susceptible to iron deficiency anemia. This study showed that 3-month iron tablet supplementation significantly increased hemoglobin levels in pregnant women with microcytic hypochromic anemia.
MAJALAH KEDOKTERAN BANDUNG
(2021)
Article
Medicine, General & Internal
Yi-Kai Fu, Hsueng-Mei Liu, Li-Hsuan Lee, Ying-Ju Chen, Sheng-Hsuan Chien, Jeong-Shi Lin, Wen-Chun Chen, Ming-Hsuan Cheng, Po-Heng Lin, Jheng-You Lai, Chyong-Mei Chen, Chun-Yu Liu
Summary: A new classifier combining indices and machine-learning techniques was developed to discriminate thalassemia and non-thalassemia microcytic anemia, showing better performance than other indices.
Article
Plant Sciences
Min Gao, Zejun Zhang, Yiming Zhang, Minghui Li, Xiaoyan Che, Xiuming Cui, Mei Wang, Yin Xiong
Summary: This study demonstrated that steamed Panax notoginseng can ameliorate renal anemia by promoting overall hematopoiesis and inhibiting the progress of renal injury in mice.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Chloe Latour, Celine Besson-Fournier, Delphine Meynard, Laura Silvestri, Ophelie Gourbeyre, Patricia Aguilar-Martinez, Paul J. Schmidt, Mark D. Fleming, Marie-Paule Roth, Helene Coppin
Article
Genetics & Heredity
Haifa H. Jabara, Steven E. Boyden, Janet Chou, Narayanaswamy Ramesh, Michel J. Massaad, Halli Benson, Wayne Bainter, David Fraulino, Fedik Rahimov, Colin Sieff, Zhi-Jian Liu, Salem H. Alshemmari, Basel K. Al-Ramadi, Hasan Al-Dhekri, Rand Arnaout, Mohammad Abu-Shukair, Anant Vatsayan, Eli Silver, Sanjay Ahuja, E. Graham Davies, Martha Sola-Visner, Toshiro K. Ohsumi, Nancy C. Andrews, Luigi D. Notarangelo, Mark D. Fleming, Waleed Al-Herz, Louis M. Kunkel, Raif S. Geha
Article
Hematology
Daniel A. Lichtenstein, Andrew W. Crispin, Anoop K. Sendamarai, Dean R. Campagna, Klaus Schmitz-Abe, Cristovao M. Sousa, Martin D. Kafina, Paul J. Schmidt, Charlotte M. Niemeyer, John Porter, Alison May, Mrinal M. Patnaik, Matthew M. Heeney, Alec Kimmelman, Sylvia S. Bottomley, Barry H. Paw, Kyriacos Markianos, Mark D. Fleming
Letter
Hematology
Baris Boyraz, Courtney M. Bellomo, Mark D. Fleming, Corey S. Cutler, Suneet Agarwal
Article
Oncology
Esther A. Obeng, Ryan J. Chappell, Michael Seiler, Michelle C. Chen, Dean R. Campagna, Paul J. Schmidt, Rebekka K. Schneider, Allegra M. Lord, Lili Wang, Rutendo G. Gambe, Marie E. McConkey, Abdullah M. Ali, Azra Raza, Lihua Yu, Silvia Buonamici, Peter G. Smith, Ann Mullally, Catherine J. Wu, Mark D. Fleming, Benjamin L. Eberts
Article
Oncology
Kim Cattivelli, Dean R. Campagna, Klaus Schmitz-Abe, MatthewM. Heeney, Hassan M. Yaish, Amy E. Caruso Brown, Susan Kearney, Kelly Walkovich, Kyriacos Markianos, Mark D. Fleming, Ellis J. Neufeld
PEDIATRIC BLOOD & CANCER
(2017)
Article
Medicine, Research & Experimental
Raphael Carapito, Martina Konantz, Catherine Paillard, Zhichao Miao, Angelique Pichot, Magalie S. Leduc, Yaping Yang, Katie L. Bergstrom, Donald H. Mahoney, Deborah L. Shardy, Ghada Alsaleh, Lydie Naegely, Aline Kolmer, Nicodeme Paul, Antoine Hanauer, Veronique Rolli, Joelle S. Mueller, Elisa Alghisi, Loic Sauteur, Cecile Macquin, Aurore Morlon, Consuelo Sebastia Sancho, Patrizia Amati-Bonneau, Vincent Procaccio, Anne-Laure Mosca-Boidron, Nathalie Marle, Nael Osmani, Olivier Lefebvre, Jacky G. Goetz, Sule Unal, Nurten A. Akarsu, Mirjana Radosavljevic, Marie-Pierre Chenard, Fanny Rialland, Audrey Grain, Marie-Christine Bene, Marion Eveillard, Marie Vincent, Julien Guy, Laurence Faivre, Christel Thauvin-Robinet, Julien Thevenon, Kasiani Myers, Mark D. Fleming, Akiko Shimamura, Elodie Bottollier-Lemallaz, Eric Westhof, Claudia Lengerke, Bertrand Isidor, Seiamak Bahram
JOURNAL OF CLINICAL INVESTIGATION
(2017)
Article
Multidisciplinary Sciences
Anthony T. Nguyen, Miguel A. Prado, Paul J. Schmidt, Anoop K. Sendamarai, Joshua T. Wilson-Grady, Mingwei Min, Dean R. Campagna, Geng Tian, Yuan Shi, Verena Dederer, Mona Kawan, Nathalie Kuehnle, Joao A. Paulo, Yu Yao, Mitchell J. Weiss, Monica J. Justice, Steven P. Gygi, Mark D. Fleming, Daniel Finley
Article
Hematology
Paul J. Schmidt, Kaifeng Liu, Gary Visner, Kevin Fitzgerald, Shannon Fishman, Tim Racie, Julia L. Hettinger, James S. Butler, Mark D. Fleming
AMERICAN JOURNAL OF HEMATOLOGY
(2018)
Editorial Material
Hematology
John M. Gansner, Elissa Furutani, Dean R. Campagna, Mark D. Fleming, Akiko Shimamura
AMERICAN JOURNAL OF HEMATOLOGY
(2018)
Article
Hematology
Inga Hofmann, Mitchell J. Geer, Timo Vogtle, Andrew Crispin, Dean R. Campagna, Alastair Barr, Monica L. Calicchio, Silke Heising, Johanna P. van Geffen, Marijke J. E. Kuijpers, Johan W. M. Heemskerk, Johannes A. Eble, Klaus Schmitz-Abe, Esther A. Obeng, Michael Douglas, Kathleen Freson, Corinne Pondarre, Remi Favier, Gavin E. Jarvis, Kyriacos Markianos, Ernest Turro, Willem H. Ouwehand, Alexandra Mazharian, Mark D. Fleming, Yotis A. Senis
Letter
Hematology
Matthew M. Heeney, Dongjing Guo, Luigia De Falco, Dean R. Campagna, Gordana Olbina, Paige P. -C. Kao, Klaus Schmitz-Abe, Fedik Rahimov, Patrick Gutschow, Keith Westerman, Vaughn Ostland, Tracy Jackson, Robert E. Klaassen, Kyriacos Markianos, Karin E. Finberg, Achille Iolascon, Mark Westerman, Wendy B. London, Mark D. Fleming
Review
Hematology
Sarah Ducamp, Mark D. Fleming
Article
Hematology
Juliana Xavier-Ferrucio, Vanessa Scanlon, Xiuqi Li, Ping-Xia Zhang, Larisa Lozovatsky, Nadia Ayala-Lopez, Toma Tebaldi, Stephanie Halene, Chang Cao, Mark D. Fleming, Karin E. Finberg, Diane S. Krause
Letter
Oncology
Jamie Heather Oakley, Dean R. Campagna, Liang Sun, Shira Rockowitz, Piotr Sliz, Jeanne Boudreaux, Gary Woods, Mark D. Fleming
PEDIATRIC BLOOD & CANCER
(2022)