Review
Immunology
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. T. Spicer, Nirupama D. D. Verma, Suzanne J. Hodgkinson, Bruce M. M. Hall
Summary: The immune response to an allograft can activate lymphocytes that cause rejection. The activation of T regulatory cells can reduce allograft rejection and induce immune tolerance. Activated T regulatory cells can be distinguished by various markers. A more detailed characterization of these cells may help reduce non-specific immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Nirupama D. Verma, Andrew D. Lam, Christopher Chiu, Giang T. Tran, Bruce M. Hall, Suzanne J. Hodgkinson
Summary: The study found significant shifts in CD4(+) T cell subpopulations in multiple sclerosis (MS) patients, with reduced resting Treg, increased activated Treg, and increased effector CD4(+) cells. Additionally, some MS patients showed reduced CCR6(+)Th17-like Treg, which may contribute to the activity of MS.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Agnese Fiori, Stefanie Uhlig, Harald Kluter, Karen Bieback
Summary: Mesenchymal stromal cells (MSC) have immunomodulatory effects on various immune cells. In this study, human adipose tissue-derived MSC (ASC) were found to inhibit CD4 + T cell proliferation, induce Treg cells, and modulate cytokine secretion, suggesting a potential role in immune regulation. These findings highlight the complex interplay between ASC and CD4 + T cells.
Article
Immunology
Ying Pan, Huiping Wang, Furun An, Fan Wu, Qianshan Tao, Yingwei Li, Yanjie Ruan, Zhimin Zhai
Summary: This study found that higher levels of circulating Tregs, especially one week after CD19 CAR-T cell infusion, served as a poor predictor for CD19 CAR-T therapy in R/R B-ALL patients, indicating a significant association with treatment efficacy and prognosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Jessica G. Lee, Kathleen E. Jaeger, Yoichi Seki, Yi Wei Lim, Christina Cunha, Aleksandra Vuchkovska, Alexander J. Nelson, Anya Nikolai, Dan Kim, Michael Nishimura, Katherine L. Knight, Paula White, Makio Iwashima
Summary: The study reveals that a subset of CD14(+) monocytes can generate regulatory Foxp3(+) T-bet(+) T cells from umbilical cord blood, which suppress T-cell proliferation and ameliorate graft-versus-host disease. Additionally, adult peripheral blood monocytes are capable of inducing Foxp3(+) T cells, but their induction is inhibited by lymphoid cells from adult peripheral blood in neonates. This suggests a novel immunoregulatory role of monocytes in generating regulatory T cells with implications for both neonates and adults.
Review
Immunology
Shareni Jeyamogan, Joseph R. Leventhal, James M. Mathew, Zheng Jenny Zhang
Summary: Solid organ transplantation (SOT) and vascularized composite allotransplantation (VCA) are the gold-standard treatments for end-stage organ failure and complex tissue defects. However, ischemia reperfusion injury (IRI) is a major factor that can negatively impact transplant outcomes. CD4+CD25+FOXP3+ regulatory T cells (Tregs) have immunomodulatory potential and can prevent and mitigate IRI. Increasing the number of Tregs and targeted delivery can improve the outcomes of SOT and VCA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jingnan Liao, Yuan Li, Xiaofeng Li, Xian Su, Jing Peng, Na Xiao, Xiangxiu Fan, Huijun Chen, Guangxiu Lu, Ge Lin, Lamei Cheng, Fei Gong
Summary: The study found that pre-pregnancy blood Treg levels were significantly lower in URPL patients than in controls, and that Treg levels predicted subsequent miscarriages. There were no significant differences among other blood cell types between the two groups.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Nicolas Sailliet, Hoa-Le Mai, Amandine Dupuy, Gaelle Tilly, Cynthia Fourgeux, Martin Braud, Magali Giral, Jean-Michel Robert, Nicolas Degauque, Richard Danger, Jeremie Poschmann, Sophie Brouard
Summary: In this study, single cell transcriptomics were used to characterize in vitro induced GZMB+ regulatory B cells (Bregs), showing differential gene expression involved in proliferation, apoptosis, metabolism, and antigen presentation. Compared to total B cells, Bregs exhibited strong inhibition of T cell genes associated with proliferation, activation, inflammation, and apoptosis. Lymphotoxin alpha (LTA) was identified as a new and potent Breg ligand implicated in Breg suppressive properties.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Johanna Veldman, Jessica Rodrigues Placa, Lauren Chong, Miente Martijn Terpstra, Mirjam Mastik, Leon C. van Kempen, Klaas Kok, Tomohiro Aoki, Christian Steidl, Anke van den Berg, Lydia Visser, Arjan Diepstra
Summary: In classical Hodgkin lymphoma, CD4+CD26- T cells are an important T cell population that is antigen-experienced, polyclonal, and exhausted. This finding is significant for understanding the immune characteristics of the disease and the therapeutic response to immune checkpoint inhibitors.
Article
Pathology
Mai Takeuchi, Hiroaki Miyoshi, Yuichiro Semba, Kyohei Yamada, Kazutaka Nakashima, Kensaku Sato, Takuya Furuta, Mayuko Moritsubo, Yusuke Ogura, Ken Tanaka, Teppei Imamoto, Fumiko Arakawa, Kei Kohno, Koichi Ohshima
Summary: By using digital spatial profiling, this study revealed the significant role of CD4(+) T cell rosettes in the tumor microenvironment of classic Hodgkin lymphoma (CHL). The expression of immune checkpoint molecules was found to be higher in CD4(+) T cell rosettes compared to other CD4(+) T cells.
Article
Rheumatology
Mostafa Kamal, Hala Gabr, Somaya Anwar, Samah Bastawy, Lamiaa Salah
Summary: This study assessed the percentage of circulating CD4(+)CD25(+)Foxp3(+) Treg cells in SLE patients and found a significant decrease compared to healthy controls. The percentage of Treg cells also showed negative correlations with disease activity and damage index.+
Article
Biochemistry & Molecular Biology
Mohammad Fayyad-Kazan, Redouane Rouas, Makram Merimi, Mehdi Najar, Bassam Badran, Philippe Lewalle, Hussein Fayyad-Kazan
Summary: CD4(+)CD25(+) FOXP3(+) regulatory T cells are important in suppressing immune reactions, but difficult to distinguish from conventional CD4(+) T cells. This study identifies differentially transcribed genes between Tregs and conventional T cells using qRT-PCR and bioinformatics analysis, providing new molecular targets for understanding Tregs' function and isolation.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
(2023)
Article
Cardiac & Cardiovascular Systems
Jessica Handke, Laura Kummer, Markus A. Weigand, Jan Larmann
Summary: The study found that preoperative expansion of Tregs can mitigate the destabilization of atherosclerotic plaques induced by surgical stress. This suggests that therapeutic expansion of Tregs prior to major surgery may help prevent cardiovascular events associated with non-cardiac surgery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cell Biology
Ling Wang, Wei Chen, Fu-Biao Kang, Ya-Hui Zhang, Li-Li Qi, Ying-Ze Zhang
Summary: Hip fracture patients experience immunological changes, with blood transfusion potentially helping to rebalance the immune response and improve prognosis.
Article
Hematology
Alex F. Herrera, Joycelynne Palmer, Vikram Adhikarla, Dave Yamauchi, Erasmus K. Poku, James Bading, Paul Yazaki, Savita Dandapani, Matthew Mei, Robert Chen, Thai Cao, Nicole Karras, Pamela McTague, Auayporn Nademanee, Leslie Popplewell, Firoozeh Sahebi, John E. Shively, Jennifer Simpson, D. Lynne Smith, Joo Song, Ricardo Spielberger, Ni-Chun Tsai, Sandra H. Thomas, Stephen J. Forman, David Colcher, Anna M. Wu, Jeffrey Wong, Eileen Smith
Summary: In this study, the addition of 90Y-antiCD25 (aTac) to BEAM AHCT for high-risk relapsed or refractory classical Hodgkin lymphoma (HL) patients was shown to be safe and effective, with favorable outcomes observed in terms of toxicity, engraftment, and overall survival. Further evaluation of this approach in a phase 2 trial is ongoing to assess its efficacy.
Article
Hematology
Lindsay S. Hall, Charlotte S. Lennon, Andrew M. Hall, Stanislaw J. Urbaniak, Mark A. Vickers, Robert N. Barker
Review
Cell Biology
Giorgio Ottaviano, Robert Chiesa, Tobias Feuchtinger, Mark A. Vickers, Anne Dickinson, Andrew R. Gennery, Paul Veys, Stephen Todryk
Letter
Hematology
Sajida Kazi, Abhinav Mathur, Gwen Wilkie, Kirsty Cheal, Richard Battle, Neil McGowan, Neil Fraser, Emily Hargreaves, David Turner, John D. M. Campbell, Marc Turner, Mark A. Vickers
Article
Hematology
Huan Cao, Andreas Neerincx, Bernard de Bono, Ursula Lakner, Catherine Huntington, John Elvin, Emma Gudgin, Clare Pridans, Mark A. Vickers, Brian Huntly, John Trowsdale, Alexander D. Barrow
Summary: The monoclonal antibody A9E8 specific for Siglec-15 stains myeloid leukaemia cell lines and blasts from AML patients, but shows minimal expression on healthy donor cells, indicating therapeutic potential for AML treatment. Additionally, after binding, A9E8 is rapidly internalised into K562 cells, suggesting an efficient mechanism for targeted therapy.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Immunology
Charlotte S. Lennon, Huan Cao, Andrew M. Hall, Mark A. Vickers, Robert N. Barker
Summary: Non-immune cells, specifically red blood cells, play a role in regulating the activation state of human B cells by inhibiting their activation through contact and involving sialic acids and the CD22 receptor. This novel mechanism may contribute to suppressing inappropriate responsiveness of healthy B cells in the bloodstream.
Article
Multidisciplinary Sciences
Huan Cao, Aristotelis Antonopoulos, Sadie Henderson, Heather Wassall, John Brewin, Alanna Masson, Jenna Shepherd, Gabriela Konieczny, Bhinal Patel, Maria-Louise Williams, Adam Davie, Megan A. Forrester, Lindsay Hall, Beverley Minter, Dimitris Tampakis, Michael Moss, Charlotte Lennon, Wendy Pickford, Lars Erwig, Beverley Robertson, Anne Dell, Gordon D. Brown, Heather M. Wilson, David C. Rees, Stuart M. Haslam, J. Alexandra Rowe, Robert N. Barker, Mark A. Vickers
Summary: The surface-exposed high mannose N-glycans on diseased or oxidized red blood cells bind to mannose receptor CD206 on phagocytes, mediating phagocytosis in sickle cell disease and malaria. This recognition of surface N-linked high mannose glycans as a response to cellular stress is a common molecular mechanism in the pathogenesis of sickle cell disease and resistance to severe malaria in individuals with sickle cell trait.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Rachel S. Cooper, Aleksandra Kowalczuk, Gwen Wilkie, Mark A. Vickers, Marc L. Turner, John D. M. Campbell, Alasdair R. Fraser
Summary: Adoptive immunotherapy using EBV-specific T cells has the potential to cure EBV-related malignancies. Improved GMP-compliant processes for T cell manufacture and phenotyping, optimized LCL-mediated production, and flow cytometry analysis showed enhanced central memory T cell retention and expansion. Simplified t-SNE analysis visualized complex flow cytometric data and cytokine profiling characterized T cell differentiation status throughout the culture process.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Review
Gastroenterology & Hepatology
Abhinav Mathur, Mairi H. McLean, Huan Cao, Mark A. Vickers
Summary: This article discusses the mechanisms and management of functional hyposplenism, emphasizing the importance of early recognition and treatment of serious infections.
DIGESTIVE DISEASES
(2022)
Editorial Material
Immunology
Huan Cao, Mark A. Vickers
Summary: Plasmodium falciparum evades adaptive immunity in erythrocytes, but the innate immune system can recognize infected cells through the expression of high-mannose glycans induced by oxidative stress caused by parasite replication. These glycans act as pathogen associated molecular patterns, stimulating phagocytosis in the spleen, with enhanced responses in individuals with the sickle cell allele.
TRENDS IN IMMUNOLOGY
(2021)
Article
Immunology
Wakunyambo Maboshe, Helen M. Macdonald, Heather Wassall, William D. Fraser, Jonathan C. Y. Tang, Shona Fielding, Robert N. Barker, Mark A. Vickers, Anthony Ormerod, Frank Thies
Summary: Seasonal variations in immune markers have been reported, but the specific contributions of sunlight and vitamin D variability on these changes remain unclear. A study involving daily low dose vitamin D supplementation found no significant impact on the nTregs population, indicating that environmental factors may influence immune responses independently of vitamin D status. However, vitamin D was able to attenuate the seasonal changes in T cell-produced IFN-gamma, suggesting a potential role in modulating inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Huan Cao, Abhinav Mathur, Charlotte Robertson, Aristotelis Antonopoulos, Sadie Henderson, Louis-Pierre Girard, Jin Hien Wong, Adam Davie, Sonja Wright, John Brewin, David C. Rees, Anne Dell, Stuart M. Haslam, Mark A. Vickers
Summary: Red blood cells lose their plasma membrane as they age, a process mediated by a molecule called high-mannose glycans. These glycans are recognized by specific cells in the spleen and lead to extravascular hemolysis. Research has found that patients with certain diseases or those who have undergone splenectomy exhibit significantly higher levels of these glycans on the surface of their red blood cells.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Medicine, General & Internal
Rekha Gurung, Charlotte Robertson, Mark A. Vickers
Meeting Abstract
Cell & Tissue Engineering
R. Cooper, L. Milne, L. M. Smith, M. Barnett, G. J. Graham, M. Vickers, M. Turner, J. Campbell, A. R. Fraser
Meeting Abstract
Cell & Tissue Engineering
R. Cooper, G. Wilkie, K. Samuel, L. McMillan, M. Vickers, M. Turner, J. Campbell, A. R. Fraser
Correction
Medicine, General & Internal
Abhinav Mathur, Shehan Samaranayake, Neill P. F. Storrar, Mark A. Vickers
BMJ-BRITISH MEDICAL JOURNAL
(2019)