Article
Immunology
Qi Xu, Ming Shi, Lu Ding, Yu Xia, Liang Luo, Xiaofang Lu, Xiaoying Zhang, David Y. B. Deng
Summary: This study found that P-selectin induces the formation of NETs through the PSGL-1 and downstream Syk/Ca2+/PAD4 signaling pathway, playing an important role in acute pancreatitis. Inhibiting the P-selectin pathway may be a promising strategy for the treatment of AP.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Joao L. Pereira, Patricia Cavaco, Ricardo C. da Silva, Ivette Pacheco-Leyva, Stefan Mereiter, Ricardo Pinto, Celso A. Reis, Nuno R. dos Santos
Summary: PSGL-1, a membrane-bound glycoprotein expressed in lymphoid and myeloid cells, plays a role in T cell trafficking and homing, and has been linked to lymphoid malignancies. The expression of PSGL-1 promotes T cell lymphoma development and dissemination to various organs.
TRANSLATIONAL ONCOLOGY
(2021)
Review
Immunology
Silvere D. Zaongo, Yanqiu Liu, Vijay Harypursat, Fangzhou Song, Huan Xia, Ping Ma, Yaokai Chen
Summary: Antiretroviral therapy (ART) is the only currently effective method to treat HIV-1 infection, but may be toxic to vital organs. Therefore, considering HIV-1 restriction factors from the innate immune system to explore novel therapeutic approaches is seen as a promising strategy by researchers.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dandan Huang, Qihan Ding, Shenbao Chen, Shouqin Lu, Yan Zhang, Mian Long
Summary: E-selectins negatively regulate neutrophil transmigration by altering endothelial plasticity, downregulating cortactin and Arp2/3 activation, and enhancing VE-cadherin adhesive function. The findings also highlight the overlapping functions of redundant P-selectins in neutrophil adhesion and transmigration, contributing to better understanding of actin remodeling and junctional integrity in endothelial cells mediating leukocyte TEM.
Article
Oncology
Julia M. DeRogatis, Karla M. Viramontes, Emily N. Neubert, Monique L. Henriquez, Christian F. Guerrero-Juarez, Roberto Tinoco
Summary: Therapeutically targeting PSGL-1 can reinvigorate antitumor immunity by enhancing effector T-cell responses and reducing regulatory T cells, thus delaying tumor growth in a melanoma mouse model.
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Linda Li, Qihan Ding, Jin Zhou, Yi Wu, Mingkun Zhang, Xingming Guo, Mian Long, Shouqin Lu
Summary: The interactions between selectins and CD44 at the molecular level were investigated using experimental measurements and simulation predictions. Different binding kinetics and microstructural mechanisms were observed for E-selectin-CD44, P-selectin-CD44, and L-selectin-CD44 interactions, providing insights into the functional differences of selectin-CD44 interactions. These results were supported by molecular docking and molecular dynamics simulations, demonstrating the specificity and strength of each selectin-CD44 interaction.
Review
Oncology
Hans-Ake Fabricius, Sarah Starzonek, Tobias Lange
Summary: Platelets, as the smallest cells in the blood stream, play crucial roles in hemostasis, inflammation, immunity, and tissue repair. In malignancies, platelets are also involved in promoting metastasis and resistance to anti-tumor treatment. The complex interaction between platelets and cancer cells is still not fully understood, although various surface molecules and transduction mechanisms have been identified.
FRONTIERS IN ONCOLOGY
(2021)
Article
Plant Sciences
Siya Wu, Jian Liu, Ya Zhang, Jianxi Song, Zhongshan Zhang, Yue Yang, Mingjiang Wu, Haibin Tong
Summary: This study determined the structural characteristics of SFF-32, a fucoidan fraction from S. fusiforme, and its antagonistic effect against P-selectin mediated function. It was found that SFF-32 inhibited P-selectin-mediated function by blocking the interaction between P-selectin and its physiological ligand PSGL-1, suggesting its potential as an anti-inflammatory lead compound.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biophysics
Yuncheng Man, Erdem Kucukal, Shichen Liu, Ran An, Utku Goreke, William J. Wulftange, Zoe Sekyonda, Allison Bode, Jane A. Little, Deepa Manwani, Evi X. Stavrou, Umut A. Gurkan
Summary: Neutrophil recruitment to the inflamed endothelium is crucial in the development of vaso-occlusive crisis in sickle cell disease (SCD). However, there is no standardized approach for assessing neutrophil recruitment to the inflamed endothelium for personalized risk stratification and therapeutic response prediction in SCD. This study presents a microfluidic device functionalized with E-selectin as a strategy to assess neutrophil binding under physiologic flow in normoxia and hypoxia in SCD. The findings provide mechanistic insight into neutrophil-endothelial interactions under hypoxia and offer a clinically feasible means for assessing neutrophil binding to E-selectin using clinical whole blood samples, which can guide therapeutic decisions for SCD patients.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Endocrinology & Metabolism
Wanqing Xie, Tingting Huang, Yunlu Guo, Yueman Zhang, Weijie Chen, Yan Li, Chen Chen, Peiying Li
Summary: Neutrophils play critical roles in the evolving of brain injuries following ischemic stroke. CAMP represents an important mediator that could promote post-stroke angiogenesis and neurological recovery in the late phase after stroke. CAMP peptide treatment could enhance angiogenesis-related gene expression and attenuate neurological deficits after stroke.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Hematology
Silvia D'Ambrosi, R. Jonas Nilsson, Thomas Wurdinger
Summary: The nucleic acid content of platelets was previously thought to be solely determined by their progenitor cells, but recent research shows that other mediators like cancer cells can influence platelet RNA repertoire. This transfer of RNA from cancer cells to platelets could serve as a novel source of potential biomarkers for early cancer detection and treatment monitoring.
Article
Multidisciplinary Sciences
Jeffrey W. Brown, Koushik K. Das, Vasilios Kalas, Kiron M. Das, Jason C. Mills
Summary: The epitope recognized by mAb Das-1 was identified as 3'-Sulfo-Lewis A/C, which is broadly reexpressed in gastrointestinal epithelia and other organs during metaplastic and carcinomatous transformation, and can be detected using immunohistochemistry and ELISA. These findings provide new avenues for tumor risk stratification in various gastrointestinal lesions.
Article
Hematology
Stuart Wallis, Nina Wolska, Hanna Englert, Mareike Posner, Abhishek Upadhyay, Thomas Renne, Ian Eggleston, Stefan Bagby, Giordano Pula
Summary: In this study, Efb(68-87) was identified as a novel selective platelet-binding peptide that directly binds to P-selectin and inhibits interactions between platelets and leukocytes leading to PLAs and NETs formation. This peptide has the potential to become a selective inhibitor of the proinflammatory activity of platelets, which play a key role in thromboinflammation.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Cell Biology
Vinaya Phatak, Yannick von Grabowiecki, Justyna Janus, Leah Officer, Caron Behan, Lydia Aschauer, Lucia Pinon, Hannah Mackay, Sara Zanivan, Jim C. Norman, Michael Kelly, John Le Quesne, Patricia A. J. Muller
Summary: Mutant p53 protein can facilitate the cell membrane recycling of P-gp through RCP, leading to chemoresistance. Cells without RCP or mutant p53 show increased sensitivity to cisplatin and etoposide.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Kaitlin Garofano, Kameron Rashid, Michael Smith, Christine Brantner, Sumanun Suwunnakorn, David Diemert, Olivia Gordon, Anelia Horvath, Sikandar Khan, Anastas Popratiloff, Johng Rhim, Alfateh Sidahmed, Sanjay B. Maggirwar, Travis J. O'Brien, Minoli A. Perera, Norman H. Lee
Summary: Platelets play a crucial role in cancer and thrombosis, and the interaction between prostate cancer cells and platelets has been found to promote cancer cell invasion and resistance to apoptosis. Various signaling proteins and their ligands have been identified to be involved in this process, with some of them showing abnormal expression levels in prostate cancer patients.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Takako Hirata, Takashi Usui, Shio Kobayashi, Tsuneyo Mimori
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2015)
Article
Cell Biology
Daisuke Nagakubo, Osamu Yoshie, Takako Hirata
CELLULAR IMMUNOLOGY
(2016)
Article
Cell Biology
Masanori Matsumoto, Takako Hirata
CELLULAR IMMUNOLOGY
(2016)
Article
Multidisciplinary Sciences
Kana Hasegawa, Satomi Tanaka, Fumihiro Fujiki, Soyoko Morimoto, Katsuhiko Nakano, Hiroko Kinoshita, Atsushi Okumura, Yuka Fujioka, Rika Urakawa, Hiroko Nakajima, Naoya Tatsumi, Jun Nakata, Satoshi Takashima, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Yusuke Oji, Eiji Miyoshi, Takako Hirata, Atsushi Kumanogoh, Haruo Sugiyama, Naoki Hosen
Article
Immunology
Hiroki Satooka, Daisuke Nagakubo, Tomomi Sato, Takako Hirata
JOURNAL OF IMMUNOLOGY
(2017)
Article
Immunology
Kazuhiko Matsuo, Daisuke Nagakubo, Shinya Yamamoto, Akiko Shigeta, Shuta Tomida, Mitsugu Fujita, Takako Hirata, Ikuo Tsunoda, Takashi Nakayama, Osamu Yoshie
JOURNAL OF IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Rana Mashud, Akira Nomachi, Akihide Hayakawa, Koji Kubouchi, Sally Danno, Takako Hirata, Kazuhiko Matsuo, Takashi Nakayama, Ryosuke Satoh, Reiko Sugiura, Manabu Abe, Kenji Sakimura, Shigeharu Wakana, Hiroyuki Ohsaki, Shingo Kamoshida, Hideyuki Mukai
SCIENTIFIC REPORTS
(2017)
Article
Immunology
Takako Hirata, Akira Nomachi, Kazuo Tohya, Masayuki Miyasaka, Sachiko Tsukita, Takeshi Watanabe, Shuh Narumiya
INTERNATIONAL IMMUNOLOGY
(2012)
Article
Multidisciplinary Sciences
Akira Nomachi, Masanori Yoshinaga, Jaron Liu, Pakorn Kanchanawong, Kiyoshi Tohyama, Dean Thumkeo, Takeshi Watanabe, Shuh Narumiya, Takako Hirata
Article
Multidisciplinary Sciences
Chengcan Yao, Takako Hirata, Kitipong Soontrapa, Xiaojun Ma, Hiroshi Takemori, Shuh Narumiya
NATURE COMMUNICATIONS
(2013)
Correction
Multidisciplinary Sciences
Chengcan Yao, Takako Hirata, Kitipong Soontrapa, Xiaojun Ma, Hiroshi Takemori, Shuh Narumiya
NATURE COMMUNICATIONS
(2013)
Article
Multidisciplinary Sciences
D. Thumkeo, Y. Katsura, Y. Nishimura, P. Kanchanawong, K. Tohyama, T. Ishizaki, S. Kitajima, C. Takahashi, T. Hirata, N. Watanabe, M. F. Krummel, S. Narumiya
Article
Multidisciplinary Sciences
Hiroki Satooka, Hirohito Ishigaki, Kagefumi Todo, Koji Terada, Yasutoshi Agata, Yasushi Itoh, Kazumasa Ogasawara, Takako Hirata
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Makoto Matsui, Daisuke Nagakubo, Hiroki Satooka, Takako Hirata
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Immunology
Tomomi Sato, Hiroki Satooka, Satoko Ichioka, Yoshihiro Maruo, Takako Hirata
INTERNATIONAL IMMUNOLOGY
(2020)