Article
Urology & Nephrology
Mark N. Brook, Holly Ni Raghallaigh, Koveela Govindasami, Tokhir Dadaev, Reshma Rageevakumar, Diana Keating, Nafisa Hussain, Andrea Osborne, Artitaya Lophatananon, Kenneth R. Muir, Zsofia Kote-Jarai, Rosalind A. Eeles
Summary: A family history of prostate cancer is associated with an increased risk of developing the disease. This study examines how the number, degree, and age of relatives with prostate cancer are related to overall survival and prostate cancer-specific survival in prostate cancer patients.
Article
Genetics & Heredity
Xiaodong Lu, Ka-wing Fong, Fang Wang, Galina Gritsina, Sylvan C. Baca, Jacob E. Berchuck, Jenny Ross, Eva Corey, Navdeep Chandel, William J. Catalona, Ximing Yang, Matthew L. Freedman, Jonathan C. Zhao, Jindan Yu, Lourdes T. Brea, Sandor Spisak, CoIm Morrissey
Summary: The study reveals that HOXB13 suppresses lipogenic transcriptional program in prostate cancer through HDAC3 recruitment, which inhibits tumor metastasis. Loss or mutation of HOXB13 leads to lipid accumulation in PCa cells, promoting cell motility and tumor metastasis. This study provides important insights into the roles of HOXB13 in prostate cancer progression and metastasis.
Article
Oncology
Duy T. Nguyen, Wei Yang, Arun Renganathan, Cody Weimholt, Duminduni H. Angappulige, Thanh Nguyen, Robert W. Sprung, Gerald L. Andriole, Eric H. Kim, Nupam P. Mahajan, Kiran Mahajan
Summary: This study reveals that HOXB13 exacerbates the antagonism of androgen receptor (AR) in castration-resistant prostate cancers (CRPC), and identifies a novel lysine 13 (K13) acetylation in HOXB13. Acetylated K13-HOXB13 serves as a clinical biomarker for the development of CRPC and promotes the expression of lineage, diagnostic, CRPC-promoting, and angiogenesis genes. The HOXB13 target ACK1 could be a potential therapeutic target for inhibiting CRPC growth.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Radhika A. Patel, Erolcan Sayar, Ilsa Coleman, Martine P. Roudier, Brian Hanratty, Jin-Yih Low, Neha Jaiswal, Azra Ajkunic, Ruth Dumpit, Caner Ercan, Nina Salama, Valerie P. O'Brien, William B. Isaacs, Jonathan Epstein, Angelo M. De Marzo, Bruce J. Trock, Jun Luo, W. Nathaniel Brennen, Maria Tretiakova, Funda Vakar-Lopez, Lawrence D. True, David W. Goodrich, Eva Corey, Colm Morrissey, Peter S. Nelson, Paula J. Hurley, Roman Gulati, Michael C. Haffner
Summary: This study investigated the expression pattern of HOXB13 in prostate development and cancer progression. HOXB13 was found to be more highly expressed in localized prostate cancers and retained in advanced metastatic prostate cancers. The expression of HOXB13 was reduced in tumors with evidence of lineage plasticity, but most androgen receptor-negative castration-resistant prostate cancers and neuroendocrine prostate cancers still had detectable levels of HOXB13. HOXB13 showed greater sensitivity in detecting advanced metastatic prostate cancers compared to the commonly used marker NKX3.1. HOXB13 immunohistochemistry had high sensitivity and specificity for confirming the prostatic origin of tumors in clinical samples.
JOURNAL OF PATHOLOGY
(2023)
Review
Oncology
Amy Finch, Roderick Clark, Danny Vesprini, Justin Lorentz, Raymond H. Kim, Emily Thain, Neil Fleshner, Mohammad R. Akbari, Cezary Cybulski, Steven A. Narod
Summary: Most criteria for genetic testing for prostate cancer susceptibility require a prior diagnosis of prostate cancer, but advances in the field may improve outcomes and offer screening and prevention for high-risk individuals. Understanding the value of genetic testing and the impact of germline pathogenic variants on treatment for different stages of prostate cancer is important.
NPJ PRECISION ONCOLOGY
(2022)
Article
Medicine, General & Internal
Hyo Geun Choi, Woo Jin Bang, Jung Ki Jo, Cheol Young Oh, Myungsun Shim, Jin Seon Cho
Summary: This study found that a family history of prostate cancer in fathers posed a higher risk for patients compared to a family history in brothers. Additionally, age and hyperlipidemia were significant predictors of prostate cancer development.
Article
Urology & Nephrology
Burcu F. Darst, Raymond Hughley, Aaron Pfennig, Ujani Hazra, Caoqi Fan, Peggy Wan, Xin Sheng, Lucy Xia, Caroline Andrews, Fei Chen, Sonja Berndt, Zsofia Kote-Jarai, Koveela Govindasami, Jeannette T. Bensen, Sue A. Ingles, Benjamin A. Rybicki, Barbara Nemesure, Esther M. John, Jay H. Fowke, Chad D. Huff, Sara S. Strom, William B. Isaacs, Jong Y. Park, Wei Zheng, Elaine A. Ostrander, Patrick C. Walsh, John Carpten, Thomas A. Sellers, Kosj Yamoah, Adam B. Murphy, Maureen Sanderson, Dana C. Crawford, Susan M. Gapstur, William S. Bush, Melinda C. Aldrich, Olivier Cussenot, Gyorgy Petrovics, Jennifer Cullen, Christine Neslund-Dudas, Rick A. Kittles, Jianfeng Xu, Mariana C. Stern, Anand P. Chokkalingam, Luc Multigner, Marie-Elise Parent, Florence Menegaux, Geraldine Cancel-Tassin, Adam S. Kibel, Eric A. Klein, Phyllis J. Goodman, Janet L. Stanford, Bettina F. Drake, Jennifer J. Hu, Peter E. Clark, Pascal Blanchet, Graham Casey, Anselm J. M. Hennis, Alexander Lubwama, Ian M. Thompson, Robin J. Leach, Susan M. Gundell, Loreall Pooler, James L. Mohler, Elizabeth T. H. Fontham, Gary J. Smith, Jack A. Taylor, Laurent Brureau, William J. Blot, Richard Biritwum, Evelyn Tay, Ann Truelove, Shelley Niwa, Yao Tettey, Rohit Varma, Roberta McKean-Cowdin, Mina Torres, Mohamed Jalloh, Serigne Magueye Gueye, Lamine Niang, Olufemi Ogunbiyi, Michael Oladimeji Idowu, Olufemi Popoola, Akindele O. Adebiyi, Oseremen Aisuodionoe-Shadrach, Maxwell Nwegbu, Ben Adusei, Sunny Mante, Afua Darkwa-Abrahams, Edward D. Yeboah, James E. Mensah, Andrew Anthony Adjei, Halimatou Diop, Michael B. Cook, Stephen J. Chanock, Stephen Watya, Rosalind A. Eeles, Charleston W. K. Chiang, Joseph Lachance, Timothy R. Rebbeck, David Conti, Christopher A. Haiman
Summary: A specific germline deletion variant in HOXB13 (X285K) was found to be associated with an increased risk of prostate cancer in men of West African ancestry. This variant was more strongly associated with aggressive and advanced disease. Understanding who carries this variant can inform prostate cancer screening in men of West African ancestry.
Article
Multidisciplinary Sciences
Shuji Ito, Xiaoxi Liu, Yuki Ishikawa, David D. Conti, Nao Otomo, Zsofia Kote-Jarai, Hiroyuki Suetsugu, Rosalind A. Eeles, Yoshinao Koike, Keiko Hikino, Soichiro Yoshino, Kohei Tomizuka, Momoko Horikoshi, Kaoru Ito, Yuji Uchio, Yukihide Momozawa, Michiaki Kubo, Shiro BioBank Japan Project, Yoichiro Kamatani, Koichi Matsuda, Christopher A. Haiman, Shiro Ikegawa, Hidewaki Nakagawa, Chikashi Terao
Summary: Leveraging large-scale genetic data and advanced analytical methods, the prediction of mortality risk in prostate cancer shows potential.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
QiongFei Zheng, Qinli Ying, ZhengJu Ren, Qin Zhang, DongLiang Lu, HongBai Wang, WuRan Wei
Summary: Family history of prostate cancer in first-degree relatives is associated with an increased risk of breast cancer, with consistent results in subgroup analysis. Compared with no family history of prostate cancer, history of prostate cancer in first-degree relatives is associated with a slight risk of ovarian cancer. Having a family history of prostate cancer among siblings may increase the risk of ovarian cancer by 17%, while no significant association was found between family history of prostate cancer among parents and the risk of ovarian cancer.
Article
Biotechnology & Applied Microbiology
Yixin Zhang, James B. Meigs, Ching-Ti Liu, Josee Dupuis, Chloe Sarnowski
Summary: Considering family history may enhance the accuracy and power of CC-GWAS in detecting disease-associated genetic variants. The methods incorporating family history showed higher power than CC-GWAS, especially in older age groups. These methods detected known genetic variants and increased their significance in real data applications, demonstrating the importance of including family history in genetic association studies.
Article
Multidisciplinary Sciences
Weerachai Jaratlerdsiri, Jue Jiang, Tingting Gong, Sean M. Patrick, Cali Willet, Tracy Chew, Ruth J. Lyons, Anne-Maree Haynes, Gabriela Pasqualim, Melanie Louw, James G. Kench, Raymond Campbell, Lisa G. Horvath, Eva K. F. Chan, David C. Wedge, Rosemarie Sadsad, Ilma Simoni Brum, Shingai B. A. Mutambirwa, Phillip D. Stricker, M. S. Riana Bornman, Vanessa M. Hayes
Summary: Prostate cancer shows significant geo-ethnic disparity, with African ancestry being a major risk factor. Whole-genome sequencing revealed specific somatic variants and mutational subtypes associated with African ancestry, providing insights into the differences in evolutionary trajectories and mutational processes between ethnic groups.
Article
Endocrinology & Metabolism
Rachel A. Sabol, Elisa M. Ledet, Ellen Jaeger, Whitley Hatton, Marcus Moses, Anjali Lankford, Alexa Zaheria, Pedro Barata, Jodi L. Layton, Brian E. Lewis, Oliver Sartor
Summary: In men with a personal history of prostate cancer, germline pathogenic/likely pathogenic variants were associated with first degree relatives with breast or ovarian cancer, but not with a family history of prostate cancer.
Article
Oncology
Yonghong Chen, Catherine R. Dufour, Lingwei Han, Ting Li, Hui Xia, Vincent Giguere
Summary: Dysregulation of mTOR signaling is critical in promoting prostate cancer growth. This study reveals that mTOR interacts with and phosphorylates HOXB13, leading to the regulation of a specific gene program with oncogenic implications in prostate cancer. These findings uncover a previously unknown molecular cascade and provide a potential therapeutic avenue for advanced prostate cancer management.
MOLECULAR CANCER RESEARCH
(2023)
Article
Oncology
Stella Koutros, Kathy L. Decker, Dalsu Baris, Larissa A. Pardo, Alison Johnson, G. M. Monawar Hosain, Nathaniel Rothman, Margaret R. Karagas, Molly R. Schwenn, Debra T. Silverman
Summary: Twin studies suggest a familial aggregation of bladder cancer, with individuals having a first-degree relative with bladder cancer having nearly double the risk of developing bladder cancer. Additionally, a family history of female genital cancer, melanoma, and tobacco-associated cancer also increased the risk of bladder cancer.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Siyuan Cheng, Shu Yang, Yingli Shi, Runhua Shi, Yunshin Yeh, Xiuping Yu
Summary: HOX gene-encoded homeobox proteins control body patterning during embryonic development; specific expression pattern of HOX genes may correspond to tissue identity. Our study found that NEPCa tumors lose their prostate identities but do not gain new tissue identities, indicating their anaplastic nature. Additionally, treatment with all trans retinoic acid (ATRA) can potentially revert reduced HOXB13 expression in NEPCa cells, suggesting ATRA as a therapeutic agent for NEPCa tumors.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Petros D. Grivas, Sumana Devata, Rami Khoriaty, Philip S. Boonstra, Joshua Ruch, Kevin McDonnell, Leonel Hernandez-Aya, Joshua Wilfong, Jeffrey Smerage, Michael G. Ison, Joseph N. S. Eisenberg, Maria Silveira, Kathleen A. Cooney, Francis P. Worden
JOURNAL OF CANCER EDUCATION
(2017)
Meeting Abstract
Urology & Nephrology
Dharam Kaushik, Wasim Chowdhury, Ping Wu, Teresa Johnson-Pais, Yidong Chen, Michael A. Liss, Ronald Rodriguez
JOURNAL OF UROLOGY
(2017)
Article
Urology & Nephrology
Deepak K. Pruthi, Hanzhang Wang, Arpan Satsangi, Miguel Cajipe, Kevan Iffrig, Georges M. Haider, Taylor Hicks, Edward Y. Sako, Michael A. Liss, Wasim H. Chowdhury, Ronald Rodriguez, Dharam Kaushik
CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL
(2018)
Article
Endocrinology & Metabolism
Jennifer L. Beebe-Dimmer, Kimberly A. Zuhlke, Anna M. Johnson, Daniel Liesman, Kathleen A. Cooney
Article
Oncology
Naseruddin Hoti, Tamara Jane Johnson, Wasim H. Chowdhury, Ronald Rodriguez
Meeting Abstract
Oncology
Dharam Kaushik, Hanzhang Wang, Keith A. Ashcraft, Alia Nazarullah, Michael A. Liss, Deepak Pruthi, Ahmed Mansour, Cooper B. Tye, Wasim Chowdhury, Dean Bacich, Denise O'Keefe, Ronald Rodriguez
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Article
Endocrinology & Metabolism
Samantha Greenberg, Stacey Slager, Brock O' Neil, Kathleen Cooney, Benjamin Maughan, Nicole Stopa, Vickie Venne, Susan Zickmund, Sarah Colonna
Article
Oncology
Miguel Cajipe, Hanzhang Wang, Ahmed Elshabrawy, Dharam Kaushik, Michael Liss, Robert Svatek, Shenghui Wu, Wasim H. Chowdhury, Chethan Ramamurthy, Ahmed M. Mansour
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2020)
Article
Medical Laboratory Technology
Dharam Kaushik, Keith A. Ashcraft, Hanzhang Wang, Karthigayan Shanmugasundaram, Pankil K. Shah, Gabriela Gonzalez, Alia Nazarullah, Cooper B. Tye, Michael A. Liss, Deepak K. Pruthi, Ahmed M. Mansour, Wasim Chowdhury, Dean Bacich, Hao Zhang, Amanda L. Watson, Karen Block, Denise O'Keefe, Ronald Rodriguez
TRANSLATIONAL RESEARCH
(2020)
Article
Oncology
Jianfeng Xu, Zhuqing Shi, Jun Wei, Rong Na, W. Kyle Resurreccion, Chi-Hsiung Wang, Chris Sample, Misop Han, S. Lilly Zheng, Kathleen A. Cooney, Brian T. Helfand, William B. Isaacs
Summary: This study simultaneously assessed the associations between germline mutations in DNA repair genes and KLK3 gene and prostate cancer progression. The results showed that both types of mutations were significantly associated with an increased risk of prostate cancer progression, providing important information for genetic testing and guidelines for prostate cancer.
PROSTATE CANCER AND PROSTATIC DISEASES
(2022)
Article
Oncology
Matthew R. Trendowski, Christopher Sample, Tara Baird, Azita Sadeghpour, David Moon, Julie J. Ruterbusch, Jennifer L. Beebe-Dimmer, Kathleen A. Cooney
Summary: This study focused on genetic variants in Black men with early-onset prostate cancer. The findings suggest that variants in DNA damage repair genes and HOXB13 may be important risk factors for prostate cancer in this population, especially in those with a family history of cancer.
JCO PRECISION ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yanjun Gao, Shanhui Liu, Qi Guo, Su Zhang, Youli Zhao, Hanzhang Wang, Tianbao Li, Yuwen Gong, Yuhan Wang, Tao Zhang, Zhilong Dong, Dean Bacich, Wasim H. Chowdhury, Ronald Rodriguez, Zhiping Wang
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2019)
Meeting Abstract
Urology & Nephrology
Deepak Pruthi, Hanzhang Wang, Michael Liss, Wasim Chowdhury, Ronald Rodriguez, Dharam Kaushik
JOURNAL OF UROLOGY
(2018)
Meeting Abstract
Urology & Nephrology
Juan Herrera, Geraldine Klein, Wasim Chowdhury, Hanzhang Wang, Ahmed Mansour, Dharam Kaushik, Robert Svatek
JOURNAL OF UROLOGY
(2018)
Meeting Abstract
Urology & Nephrology
Kris Miguel Cajipe, Hanzhang Wang, Wasim Chowdhury, Robert Svatek, Dharam Kaushik, Ahmed Mansour
JOURNAL OF UROLOGY
(2018)