Article
Oncology
Tima Mohammadi, Daphne P. Guh, Alexander C. T. Tam, Reka E. Pataky, Peter C. Black, Alan So, Larry D. Lynd, Wei Zhang, Annalijn I. Conklin
Summary: In this study, a modeling framework was constructed to evaluate the cost-effectiveness of using a new risk assessment tool (RAT) for biopsy decision-making in men with gray zone prostate-specific antigen (PSA) levels. The RAT based on an existing biomarker's characteristics was found to be a dominant strategy, resulting in cost savings and improved quality-adjusted life years (QALY) compared to the current standard of care (SOC). The findings suggest that implementing a more accurate RAT for biopsy guidance can be cost-effective.
Article
Economics
Lin Wang, Hwanhee Hong, Caleb Alexander, Otis W. Brawley, Channing J. Paller, Jeromie Ballreich
Summary: This study assessed the cost-effectiveness of systemic treatments for metastatic castration-sensitive prostate cancer. The results indicate that abiraterone acetate plus ADT has relatively high cost-effectiveness and is a suitable treatment option for patients.
Article
Medicine, General & Internal
Kevin Duan, Francisco Rodriguez Garza, Hugo Flores, Daniel Palazuelos, Jimena Maza, Luis Alberto Martinez-Juarez, Patrick F. Elliott, Elena Moreno Lazaro, Natan Enriquez Rios, Gustavo Nigenda, Lindsay Palazuelos, Ryan K. McBain
Summary: CESPEC is a cost-effective community-based model of diabetes care for patients in rural Mexico, providing more health-adjusted years at a lower cost compared to usual care.
Article
Public, Environmental & Occupational Health
Shu Su, William Cw Wong, Zhuoru Zou, Dan Dan Cheng, Jason J. Ong, Polin Chan, Fanpu Ji, Man-Fung Yuen, Guihua Zhuang, Wai-Kay Seto, Lei Zhang
Summary: This study evaluated the cost-effectiveness of implementing universal hepatitis B virus (HBV) screening in China and identified the optimal screening strategy. The findings suggest that implementing the five-test universal screening strategy in the 18-70 age group within the next 10 years is the most cost-effective approach and can contribute to the prevention of HBV-related deaths.
LANCET GLOBAL HEALTH
(2022)
Article
Economics
Shaobo Long, Hongxia Pei, Hao Tian, Fangfang Li
Summary: Investment has played a significant role in driving economic growth in China, but the growth rate of fixed asset investment in the country has shown a downward trend in recent years. Identifying the main influencing factors of China's investment is crucial for formulating stable investment policies.Using the nonlinear autoregressive distributed lag (NARDL) model, this study found that economic policy uncertainty, capital cost, and raw material cost have asymmetrical impacts on China's fixed asset investment.
ECONOMIC ANALYSIS AND POLICY
(2021)
Article
Business, Finance
Jinjing Liu, Hong Wang
Summary: This paper examines the impact of economic policy uncertainty (EPU) on the cost of capital in China. The results suggest that an increase in EPU leads to a significantly higher cost of capital, mainly through increasing the cost of equity. There is no significant difference between the impact on state-owned enterprises (SOEs) and private firms, but a stronger impact on large firms than small firms is found. Further analysis shows that the stronger impact on large firms only occurs in private firms.
INTERNATIONAL REVIEW OF FINANCIAL ANALYSIS
(2022)
Article
Environmental Sciences
Daiyou Xiao, Jinxia Su, Bakhtawer Ayub
Summary: As a result of the COVID-19 pandemic, commodity prices have experienced significant drops, and the study suggests that economic policy uncertainty plays a significant role in influencing commodity markets, especially in high-volatility regimes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Dan Su, Bin Wu, Lizheng Shi
Summary: The study demonstrated that genomic test-directed olaparib is a cost-effective option for treating metastatic castration-resistant prostate cancer patients with multiple loss-of-function alterations in DNA repair genes. The incremental cost-effectiveness ratio (ICER) showed that olaparib treatment led to quality-adjusted life year (QALY) gains and cost savings compared to standard care, making it a preferred option for eligible patients. Subgroup and sensitivity analyses supported the robustness of the results.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Dongying Sun, Miao Zhang, Donghwi Jung
Summary: Water resource shortage and pollution are critical issues in China, and regulating the water consumption and sewage discharge of industrial enterprises is an effective solution.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Public, Environmental & Occupational Health
Daniela Angulo, Maria Fernanda Cortes, Ivan Mura, Raha Akhavan-Tabatabaei
Summary: This study proposes a differential equation model to predict the costs and effectiveness of cervical cancer public health policies, including vaccination and screening. The results identify 8 dominant policies, with the best one costing 6.3 million Colombian Pesos per averted DALY. The model allows for customization with country-specific data and enables detailed analysis of cost and effectiveness.
Article
Medicine, General & Internal
Mengxi Du, Christina F. Griecci, Frederick Cudhea, Heesun Eom, John B. Wong, Parke Wilde, David D. Kim, Dominique S. Michaud, Y. Claire Wang, Dariush Mozaffarian, Fang Fang Zhang
Summary: Menu calorie labelling in the USA is associated with lower obesity-related cancer burdens, reduced healthcare costs, and cost savings. Policymakers should prioritize nutrition policies for cancer prevention in the USA.
Review
Oncology
David Cantarero-Prieto, Javier Lera, Paloma Lanza-Leon, Marina Barreda-Gutierrez, Vicente Guillem-Porta, Luis Castelo-Branco, Jose M. Martin-Moreno
Summary: Prostate cancer is a common and impactful disease for men, with no clear consensus on the most effective treatment strategy. This article analyzes data from OECD countries to characterize the economic burden and cost-effectiveness of different treatment strategies for localized prostate cancer.
Article
Public, Environmental & Occupational Health
Akashdeep Singh Chauhan, Deepshikha Sharma, Abha Mehndiratta, Nidhi Gupta, Basant Garg, Amneet P. Kumar, Shankar Prinja
Summary: This study assessed the accuracy of results generated from adaptive HTA approaches for economic evaluation specific to the Indian context. The findings showed significant variations in adapted cost estimates while quality-adjusted life-years did not differ much. There is a need to interpret findings from aHTA methods with caution and develop more robust approaches for cost adjustment in the future.
Article
Medicine, General & Internal
Susie Huntington, Krishnan Puri Sudhir, Verena Schneider, Alex Sargent, Katy Turner, Emma J. Crosbie, Elisabeth J. Adams
Summary: This study compares the costs and effects of three sampling strategies for HPV primary screening, and finds that self-sampling could be a less expensive alternative to clinician-collected sampling, and can expand the reach of cervical screening to under-screened women.
Article
Immunology
Bernardo Sousa-Pinto, Kimberly G. Blumenthal, Eric Macy, Ana Margarida Pereira, Luis Filipe Azevedo, Luis Delgado, Joao Almeida Fonseca
Summary: The study projected that penicillin allergy testing is cost-saving in both inpatient and outpatient settings, with potential average savings in United States dollars for patients. Probabilistic sensitivity analysis showed that testing was the less costly option in 75% of simulations, supporting policies promoting widespread testing of patients with a penicillin allergy label.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Gerontology
Shabnam Haghzare, Elaine Stasiulis, Ghazaleh Delfi, Hodan Mohamud, Mark J. Rapoport, Gary Naglie, Alex Mihailidis, Jennifer L. Campos
Summary: This study aimed to assess the views of people with dementia on automated vehicles (AVs) and their hesitancies regarding their use. The results showed that while people with dementia might prefer fully automated AVs and had motivations to use them, they also had hesitations about AV use, including concerns about AV cost, their own abilities, and driving conditions.
Article
Critical Care Medicine
Christopher J. Yarnell, Alistair Johnson, Tariq Dam, Annemijn Jonkman, Kuan Liu, Hannah Wunsch, Laurent Brochard, Leo Anthony Celi, Harm-Jan De Grooth, Paul Elbers, Sangeeta Mehta, Laveena Munshi, Robert A. Fowler, Lillian Sung, George Tomlinson
Summary: Based on the study of the probability of invasive ventilation within 3 hours of meeting physiologic thresholds, it was found that the probability of invasive ventilation was low and associated with patient race/ethnicity.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Oncology
Helen Yang, Valerie S. Kim, Narhari Timilshina, Henriette Breunis, Urban Emmenegger, Richard Gregg, Aaron Hansen, George Tomlinson, Shabbir M. H. Alibhai
Summary: This study evaluated the effects of treatment on physical function (PF) and quality of life (QoL) in older men with metastatic castration-resistant prostate cancer (mCRPC). The results showed that although chemotherapy had some negative effects on PF and QoL, the differences were not significant compared to other common treatments. However, due to the small sample size, limited follow-up time, and attrition, further research is needed to study the impact of radium-223 treatment on PF and QoL outcomes in this setting.
JOURNAL OF GERIATRIC ONCOLOGY
(2023)
Review
Critical Care Medicine
Jose Dianti, Idunn S. Morris, Martin Urner, Marcello Schmidt, George Tomlinson, Marcelo B. P. Amato, Lluis Blanch, Gordon Rubenfeld, Ewan C. Goligher
Summary: ICU clinicians heavily rely on bedside physiological measurements for clinical decisions, but testing hypotheses through mathematical models of the relationship between physiology and outcomes presents methodological challenges. These models can be influenced by researchers' assumptions and beliefs, requiring careful consideration of measurement errors, confounding factors, coupling, and causality direction. This paper outlines the challenges in analyzing and interpreting these models, providing potential solutions.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Hematology
Peter Olupot-Olupot, George Tomlinson, Thomas N. Williams, Leon Tshilolo, Brigida Santos, Luke R. Smart, Kathryn McElhinney, Thad A. Howard, Banu Aygun, Susan E. Stuber, Adam Lane, Teresa S. Latham, Russell E. Ware
Summary: The REACH study provides hydroxyurea at maximum tolerated dose for children with sickle cell anemia in sub-Saharan Africa, and it not only reduces SCA-related clinical events but also decreases malaria incidence by around 50%. The study analyzed the associations between hydroxyurea and lower malaria rates, through recording infections in clinical sites across Angola, Democratic Republic of Congo, Kenya, and Uganda. The results showed that ANC and splenomegaly were significant factors associated with malaria risk, and hydroxyurea treatment at MTD led to lower malaria incidence through incompletely defined mechanisms.
Article
Cardiac & Cardiovascular Systems
Mark B. B. Badrov, Daniel A. A. Keir, George Tomlinson, Catherine F. F. Notarius, Philip J. J. Millar, Derek S. S. Kimmerly, J. Kevin Shoemaker, Evan Keys, John S. S. Floras
Summary: This study compared patients with heart failure and healthy controls to identify factors that contribute to augmented muscle sympathetic nerve activity. The results showed that in heart failure patients, muscle sympathetic nerve activity was proportional to heart rate and body mass index, but not related to age, blood pressure, or drug therapy. This study has important implications for personalized therapy.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Oncology
Emily Vettese, Farha Sherani, Allison A. King, Lolie Yu, Catherine Aftandilian, Christina Baggott, Vibhuti Agarwal, Ramamoorthy Nagasubramanian, Kara M. Kelly, David R. Freyer, Etan Orgel, Scott M. Bradfield, Wade Kyono, Michael Roth, Lisa M. Klesges, Melissa Beauchemin, Allison Grimes, George Tomlinson, L. Lee Dupuis, Lillian Sung
Summary: The study aimed to describe the adaptation process and specific adaptation decisions related to symptom management care pathways based on clinical practice guidelines. The findings showed that most care pathways were adopted or adapted. The adaptation process was accomplished over a relatively short timeframe. Future research should focus on evaluating care pathway compliance and determining the impact of care pathway-consistent care on patient outcomes.
Article
Anesthesiology
Alina Beliavsky, Barry Johnston, Qixuan Li, George Tomlinson, Rupert Kaul, John Granton
Summary: The study aimed to compare the incidence and nature of secondary infections between critically ill patients with COVID-19 viral pneumonia and seasonal influenza, and explore the association between secondary infections and clinical outcomes. The study found no significant difference in the incidence of secondary infections between COVID-19 and influenza patients, but secondary infections in COVID-19 patients were associated with worse clinical outcomes and increased healthcare resource use.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2023)
Article
Hematology
Irina Amitai, Kim Roos, Iran Rashedi, Yidi Jiang, Kathryn Mangoff, Gail Klein, Nicholas Forward, Douglas Stewart, Pierre Laneuville, Isabelle Bence-Bruckler, Joy Mangel, George Tomlinson, Neil L. Berinstein
Summary: A combination therapy of maveropepimut-S, pembrolizumab, and low-dose cyclophosphamide was found to be effective and safe in patients with relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL). Patients with CD20+/PD-L1 expression had higher response rates and longer progression-free survival and duration of response. This treatment regimen had important clinical implications for a challenging patient population.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Article
Oncology
Ronald Chow, Jean J. Mathews, Emily YiQin Cheng, Samantha Lo, Joanne Wong, Sorayya Alam, Breffni Hannon, Gary Rodin, Rinat Nissim, Sarah Hales, Dio Kavalieratos, Kieran L. Quinn, George Tomlinson, Camilla Zimmermann
Summary: This study examined the effectiveness of interventions offering support for caregivers of patients with advanced cancer on caregiver quality of life (QOL) and mental health outcomes. The findings suggest that interventions targeting caregivers, dyads, or patients and families can lead to improvements in caregiver QOL and mental health.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Narhari Timilshina, Antonio Finelli, George Tomlinson, Beate Sander, Shabbir M. H. Alibhai
Summary: This study used validated quality indicators (QIs) to examine the quality of care in active surveillance (AS) for prostate cancer at the population level. It found wide variations in compliance with process QIs based on patient age and physician volume, and significant variations in outcome QIs based on patient age group.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2023)
Article
Multidisciplinary Sciences
Efthymios Papadopoulos, Andy Kin On Wong, Sharon Hiu Ching Law, Lindsey Ze Jing Zhang, Henriette Breunis, Urban Emmenegger, Shabbir M. H. Alibhai
Summary: This study comprehensively assessed sarcopenia in men with metastatic castrate-resistant prostate cancer by using CT scans and measures of muscle function. The results showed that baseline sarcopenia predicts radiographic progression and overall mortality, and may also predict severe treatment toxicity and emergency room visits.
Article
Hematology
Aniket Bankar, Wing C. Chan, Ning Liu, Matthew Cheung, Shabbir Alibhai, Vikas Gupta
Summary: This population-based study found a high prevalence of frailty in patients with myeloproliferative neoplasms (MPN), including essential thrombocythemia, polycythemia vera, and myelofibrosis, even in patients with younger age or minimal comorbidities. Frailty was independently associated with worse overall survival, regardless of age or comorbidities.
Article
Oncology
Deborah Tomlinson, L. Lee Dupuis, David Dix, Nicole Crellin-Parsons, Sadie Cook, Ketan Kulkarni, Tal Schechter, George A. Tomlinson, Lillian Sung
Summary: The study evaluated the reliability and validity of a symptom assessment tool for pediatric patients receiving cancer treatments. The results showed that the tool is reliable, valid, and responsive in children aged 4-18 years.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
William Dale, Heidi D. Klepin, Grant R. Williams, Shabbir M. H. Alibhai, Cristiane Bergerot, Karlynn Brintzenhofeszoc, Judith O. Hopkins, Minaxi P. Jhawer, Vani Katheria, Kah Poh Loh, Lisa M. Lowenstein, June M. Mckoy, Vanita Noronha, Tanyanika Phillips, Ashley E. Rosko, Tracy Ruegg, Melody K. Schiaffino, John F. Simmons, Ishwaria Subbiah, William P. Tew, Tracy L. Webb, Mary Whitehead, Mark R. Somerfield, Supriya G. Mohile
Summary: The purpose of this article is to update the ASCO guideline on the practical assessment and management of age-associated vulnerabilities in older patients undergoing systemic cancer therapy. The panel recommends the use of geriatric assessments to identify vulnerabilities or impairments in older adults with cancer and to guide their care plan. The Practical Geriatric Assessment is one option for this purpose.
JOURNAL OF CLINICAL ONCOLOGY
(2023)