Article
Radiology, Nuclear Medicine & Medical Imaging
Ahmed Fahmy, Omar Elgebaly, Moustafa Momtaz Elsawy, Samir Orabi
Summary: The study demonstrates that tadalafil can effectively enhance visualization of the posterior urethra in patients with urethral stricture, leading to a higher success rate in opening bladder outlet during voiding. Tadalafil administration was found to be safe with no serious adverse effects reported, providing a non-invasive and cost-effective option for preoperative assessment and patient counseling.
ABDOMINAL RADIOLOGY
(2021)
Article
Urology & Nephrology
Sankalp Goberdhan, Ruben Blachman-Braun, Sirpi Nackeeran, Thomas A. I. I. I. I. I. I. Masterson, Ranjith Ramasamy
Summary: This study evaluated the association of the phosphodiesterase-5 inhibitor tadalafil with major adverse cardiac events (MACE) or venous thromboembolism (VTE) in men with lower urinary tract symptoms (LUTS). The results showed that tadalafil use was associated with a decreased risk of MACE/VTE.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Geriatrics & Gerontology
Lori A. Birder, Amanda S. Wolf-Johnston, Irina Zabbarova, Youko Ikeda, Anne M. Robertson, Ricardo Cardozo, Fatemeh Azari, Anthony J. Kanai, George A. Kuchel, Edwin K. Jackson
Summary: This study found that chronic exposure to hypoxanthine in drinking water caused changes in voiding behavior and bladder structure in adult rats, resembling alterations observed with aging. Increased levels of hypoxanthine were associated with ROS/oxidative stress-induced cellular damage, which may play a key role in the development of age-related LUTS.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Andrology
Bahadir Ermec, Mehmet Gokhan Culha, Gulay Kocak, Lutfi Canat, Alper Otunctemur, Fatih Altunrende
Summary: This study evaluated the effect of vitamin D replacement in patients with LUTS/ED who did not respond to tadalafil treatment. The results showed that after vitamin D replacement, the erectile function and prostate symptom scores of the patients significantly improved.
Review
Gastroenterology & Hepatology
Arman Shafiee, Razman Arabzadeh Bahri, Mohammad Mobin Teymouri Athar, Fatemeh Afsharrezaei, Mostafa Gholami
Summary: Esophageal motility disorders are associated with impaired neuromuscular coordination, and phosphodiesterase 5 (PDE-5) inhibitors have been proposed as a treatment option. This study found that PDE-5 inhibitors significantly reduce lower esophageal sphincter pressure and the amplitude of contractions, without significantly affecting residual pressure. In addition, these inhibitors also have an impact on esophageal contractility and contraction reserve. Therefore, they may potentially improve symptoms and prevent complications in patients with esophageal motility disorders.
BMC GASTROENTEROLOGY
(2023)
Article
Pharmacology & Pharmacy
Damian Nilsson, Russ Chess-Williams, Donna Sellers
Summary: Recent studies suggest that lower urinary tract dysfunction may be caused by changes in local blood flow. Phosphodiesterase-5 inhibitors can improve blood flow to the bladder, although the exact mechanisms are not fully understood. This study aimed to characterize the vascular supply to the bladder and determine the mechanisms of action of the phosphodiesterase-5 inhibitors tadalafil and sildenafil.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Kishor Vasant Otari, Rupesh J. Patil, Chandrashekhar Devidas Upasani
Summary: There is substantial evidence for the modulatory role of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterases (PDEs) in memory and synaptic plasticity. The present study investigated the neuropharmacological effects of tadalafil, which inhibits PDE5 and potentially elevates cGMP levels, in cognitive dysfunction. The results showed that tadalafil attenuated learning and memory deficits induced by scopolamine and diabetes, and co-administration with N-G-nitro-L-arginine methyl ester (L-NAME) further improved cognitive performance.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jin Kono, Masakatsu Ueda, Atsushi Sengiku, Sylvia O. Suadicani, Osamu Ogawa, Hiromitsu Negoro
Summary: The study suggests that urothelial Cx43 mediated ATP signaling and coordination of urothelial activity are essential for proper perception and regulation of responses to bladder distension in the animals' awake, active phase. This research highlights the significant role of Cx43 in bladder function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Alberto Fernando Oliveira Justo, Eliana Cristina de Brito Toscano, Daniela Souza Farias-Itao, Claudia Kimie Suemoto
Summary: Alzheimer's disease (AD) is the leading cause of dementia worldwide, and the deposition of beta-amyloid in the brain is partially responsible for its etiology. Despite extensive research, current treatments for AD are ineffective. This study systematically reviewed the use of phosphodiesterase 5 inhibitors (PDE5i) in rodent models with beta-amyloid accumulation and found that PDE5i was efficient in reducing beta-amyloid levels in the hippocampi and preventing cognitive decline. However, further experimental studies are needed to evaluate the molecular mechanisms of PDE5i in beta-amyloid removal in both male and female animals.
Article
Economics
Sigurd Bjarghov, Hossein Farahmand, Gerard Doorman
Summary: As society becomes more electrified, capacity-based tariffs will become more relevant. Capacity subscription is a new development where consumers are penalised or limited for exceeding their subscribed capacity. Research shows that the costs remain stable for most consumers, with exceptions for those with high peak demand.
Review
Chemistry, Analytical
Piliang Xiang, Yu Yang, Huang Chen, Apeng Chen, Shaorong Liu
Summary: Significant progresses have been made recently in liquid chromatography using <= 5-mu m-i.d. open tubular columns, enabling peak capacities of 2000+, efficiencies of 10+ million plates/m, and millisecond separations. This review article summarizes the latest advancements, procedures for preparing columns, selecting experimental components, and discusses the future prospects of this technique.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Urology & Nephrology
Ching-Hsiang Chiang, Yuan-Hong Jiang, Hann-Chorng Kuo
Summary: This study aimed to evaluate the effectiveness of single and repeat transurethral bladder neck incision (TUI-BN) for female voiding dysfunction caused by bladder outlet obstruction (BNO), and identify predictive factors associated with better treatment outcomes. The results showed that regardless of detrusor underactivity, TUI-BN was effective in treating female voiding dysfunction caused by BNO. Repeat procedures were beneficial in improving self-voiding function, and a high baseline corrected maximum flow rate and the absence of a previous history of suburethral sling were significant predictors of favorable outcomes.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Ching-Hsiang Chiang, Yuan-Hong Jiang, Hann-Chorng Kuo
Summary: This study aimed to assess the efficacy of single and repeat transurethral bladder neck incision (TUI-BN) for female voiding dysfunction caused by bladder outlet obstruction (BNO). The results showed that regardless of the presence of detrusor underactivity (DU), TUI-BN is effective against female voiding dysfunction caused by BNO. Repeat procedures are beneficial and can improve self-voiding function. A high corrected maximum flow rate and the absence of a previous history of suburethral sling can contribute to greater success rates.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Cell Biology
Rakesh C. Kukreja, Rui Wang, Saisudha Koka, Anindita Das, Arun Samidurai, Lei Xi
Summary: This article discusses the potential use of combination therapy with PDE5 inhibitor and HCQ in the treatment of type 2 diabetes (T2D). Previous studies have shown that this combination treatment can reduce blood glucose and lipid levels, improve insulin sensitivity, and reduce myocardial infarction.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Pediatrics
Youko Ikeda
Summary: Research on human and animal models shows that the effective storage and expulsion of urine rely on the coordinated activity of the parasympathetic, sympathetic, and somatic nervous systems. However, congenital neurological or anatomical defects can impact the development of urinary control, leading to various urinary tract-related complications.
PEDIATRIC NEPHROLOGY
(2021)