Article
Engineering, Biomedical
Alice Wang, Elizabeth Rourke, Elisabeth Sebesta, Roger Dmochowski
Summary: Overactive bladder and urge urinary incontinence affect millions of people and result in substantial healthcare costs. Concerns over side effects of common medications have led to increased interest in sacral neuromodulation as a potential therapy. The Axonics System is considered safe and effective for treating these conditions, with the added convenience of being rechargeable and MRI safe.
EXPERT REVIEW OF MEDICAL DEVICES
(2021)
Article
Urology & Nephrology
Kristin M. Ebert, Heather Terry, Christina B. Ching, Daniel G. Dajusta, Molly E. Fuchs, Venkata R. Jayanthi, Daryl J. McLeod, Seth A. Alpert
Summary: This study describes and evaluates the efficacy of a more practical, at-home regimen of parasacral transcutaneous electrical nerve stimulation (TENS) for pediatric overactive bladder (OAB). The results showed that nearly half of the medically-refractory OAB pediatric patients reported subjective improvement with this regimen, despite modest objective improvement. Therefore, this regimen may be best used as an adjunct to other therapies.
Article
Urology & Nephrology
H. Henry Lai, Jonathan B. Wiseman, Margaret E. Helmuth, Abigail R. Smith, Cindy L. Amundsen, Anne P. Cameron, Alexander P. Glaser, Whitney K. Hendrickson, Ziya Kirkali, Kimberly Kenton
Summary: The purpose of this study was to characterize patients seeking treatment for urinary urgency with or without urgency urinary incontinence. Participants were followed for 1 year, and their symptoms, psychosocial factors, bowel function, sleep disturbance, physical activity levels, physical function, and quality of life were compared. The results showed that patients with urgency urinary incontinence had more severe symptoms, higher levels of psychosocial symptoms, poorer physical functioning, and worse quality of life compared to patients with urinary urgency-only. The study suggested that urgency urinary incontinence may be a more severe manifestation of urinary urgency.
JOURNAL OF UROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Yunfei Xiao, Shan Yin, Jiahao Wang, Jianwei Cui, Zhenzhen Yang, Jia Wang, Yunjin Bai
Summary: This study aimed to investigate the association between the prevalence of circadian syndrome (CircS) and overactive bladder (OAB). Data from the National Health and Nutrition Examination Survey 2005-2018 were analyzed using three multivariable logistic regression models. The results showed a positive association between the prevalence of CircS and OAB, with a significantly higher prevalence of OAB in individuals with CircS. A positive correlation was also observed between the number of CircS components and the prevalence of OAB when the components were =6. No significant interaction was found in the three models.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Urology & Nephrology
Rufus Cartwright, Larissa Franklin, Kari A. O. Tikkinen, Ilkka Kalliala, Pawel Miotla, Tomasz Rechberger, Ifeoma Offiah, Steve McMahon, Barry O'Reilly, Sabrina Lince, Kirsten Kluivers, Wilke M. Post, Geert Poelmans, Melody R. Palmer, Hunter Wessells, Andrew Wong, Diana Kuh, Mika Kivimaki, Meena Kumari, Massimo Mangino, Tim Spector, Jeremy A. Guggenheim, Benjamin Lehne, N. Maneka G. De Silva, David M. Evans, Debbie Lawlor, Ville Karhunen, Minna Mannikko, Malgorzata Marczak, Phillip R. Bennett, Vik Khullar, Marjo-Riitta Jarvelin, Andrew Walley
Summary: Genome-wide association studies in European women identified new risk loci for stress and urgency urinary incontinence, with differential gene expression between the two types of incontinence observed at the cellular level.
JOURNAL OF UROLOGY
(2021)
Article
Multidisciplinary Sciences
William Gibson, Allyson Jones, Kathleen Hunter, Adrian Wagg
Summary: In older adults with overactive bladder (OAB), urinary urgency induces changes in gait similar to those caused by a distracting task, increasing the risk of falls. This may explain the association between falls and lower urinary tract symptoms in older people. Future research should explore the effects of pharmacological treatment of OAB on gait and dual-task training on gait during urgency.
Article
Urology & Nephrology
Elisabeth M. M. Sebesta, Stephanie Gleicher, Melissa R. R. Kaufman, Roger R. R. Dmochowski, W. Stuart Reynolds
Summary: The study found that overactive bladder was associated with multiple unmet social needs, including housing instability, food insecurity, worry about utilities, lack of transportation, skipping medical appointments, needing legal help, stress in personal relationships, worry about toilet access and plumbing at home, and lack of social supports. This association remained significant after adjusting for multiple covariates, suggesting the importance of considering and addressing these social needs in the management of overactive bladder patients.
JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Teppei Okamoto, Shingo Hatakeyama, Atsushi Imai, Hayato Yamamoto, Tohru Yoneyama, Kazuyuki Mori, Takahiro Yoneyama, Yasuhiro Hashimoto, Shigeyuki Nakaji, Chikara Ohyama
Summary: The study found that individuals reporting daily urinary urgency had lower bacterial diversity in their gut microbiome, lower abundance of Bifidobacterium, and higher abundance of Faecalibacterium compared to non-OAB individuals.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Public, Environmental & Occupational Health
Weilong Lin, Haoxu Wang, Zesong Wu, Wei Zhang, Ming-En Lin
Summary: The study found that exposure to DPHP could increase the risk of OAB in adult females in the United States. However, consistent results were only found in the female group after dividing the participants by gender. Additionally, restricted cubic spline analysis showed a nonlinear dose-response relationship between DPHP and OAB in female participants. Interaction analysis based on age, race, BMI, recreational activity, smoking status, drinking status, hypertension, diabetes, and stroke revealed consistent findings.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Obstetrics & Gynecology
Ilaha Isali, Phillip McClellan, Thomas R. Wong, Clara Sun, Amber Catherine Stout, Fredrick R. Schumacher, Sarah Markt, Chen-Han Wilfred Wu, Kathryn L. Penney, Sherif El-Nashar, Adonis Hijaz, David Sheyn
Summary: This study aimed to analyze differential gene expression between patients with overactive bladder and controls without overactive bladder, and determine the correlations and functional pathways between genes. The systematic review identified 11 up-regulated genes (P2RX2, SMTN, GAP43, TRPM8, CDH1, GJC1, CHRM2, CHRM3, and TRPV4) and 2 down-regulated genes (P2RX3 and P2RX5) in patients with overactive bladder. Gene network analysis revealed their involvement in chemical synaptic transmission, smooth muscle contraction, blood circulation, and response to temperature stimulus. These findings provide potential biomarkers for treatment efficacy and lay the foundation for future gene therapies in clinical settings.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Medicine, General & Internal
Connor McPhail, Robert Carey, Sidharth Nambiar, Nadia Willison, Saghi Bahadori, Pouria Aryan, Tran Nguyen, Fariba Behnia-Willison
Summary: A study in Australia found that percutaneous tibial nerve stimulation (PTNS) can effectively alleviate the symptoms of overactive bladder (OAB) syndrome. For patients with OAB who do not respond to conservative treatment or wish to avoid surgery, PTNS may be an effective second-line treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Carol Emi Bretschneider, Qian Liu, Abigail R. Smith, Ziya Kirkali, Cindy L. Amundsen, Henry Lai, Juila Geynisman-Tan, Anna Kirby, Anne P. Cameron, Margaret E. Helmuth, James W. Griffith, John Eric Jelovsek
Summary: The study described the treatment patterns for women with UU and UUI seeking specialty care over 1 year. Treatment patterns included behavioral therapy, physical therapy, OAB medications, etc., showing diversity in treatment strategies.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Urology & Nephrology
Seyda Toprak Celenay, Yasemin Karaaslan, Enver Ozdemir
Summary: This study investigated the effects of pelvic floor muscle training (PFMT) on sexual dysfunction, sexual satisfaction of partners, urinary symptoms, and pelvic floor muscle strength (PFMS) in women with overactive bladder (OAB). The results showed that PFMT was effective in improving these aspects.
JOURNAL OF SEXUAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Emily R. W. Davidson, Lia Miceli, Katie Propst
Summary: Despite an established treatment algorithm for overactive bladder (OAB), many patients do not progress to the next steps in therapy despite failure of more conservative treatments. This may be due to limited follow-up and lack of knowledge about other treatment options.
JOURNAL OF WOMENS HEALTH
(2022)
Article
Urology & Nephrology
Alexandra Rogers, Stephanie Bragg, Kimberly Ferrante, Chuladatta Thenuwara, David K. L. Peterson
Summary: The novel leadless tibial nerve stimulator, eCoin (R), was evaluated in a pivotal trial for treating refractory urgency urinary incontinence. Results showed that 68% of subjects experienced at least a 50% reduction in urgency urinary incontinence episodes after 48 weeks, with 16% experiencing device-related events.
JOURNAL OF UROLOGY
(2021)
Article
Obstetrics & Gynecology
Aditi Siddharth, Rufus Cartwright, Simon Jackson, Natalia Price
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2020)
Article
Urology & Nephrology
Christopher C. Khoo, David Eldred-Evans, Max Peters, Mariana Bertoncelli Tanaka, Mohamed Noureldin, Saiful Miah, Taimur Shah, Martin J. Connor, Deepika Reddy, Martin Clark, Amish Lakhani, Andrea Rockall, Feargus Hosking-Jervis, Emma Cullen, Manit Arya, David Hrouda, Hasan Qazi, Mathias Winkler, Henry Tam, Hashim U. Ahmed
Article
Obstetrics & Gynecology
Aditi Siddharth, Mohammed J. Hussain, Rufus Cartwright, Simon Jackson, Natalia Price
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2020)
Article
Obstetrics & Gynecology
M. L. Izett-Kay, C. Lumb, R. Cartwright, A. S. Kupelian, A. S. Cutner, S. Jackson, N. Price, A. Vashisht
Summary: Despite the controversy surrounding mesh, women following mesh-augmented prolapse surgery are mainly concerned about pelvic floor symptoms. There is a need for more research on the relationship between pain and prolapse, mesh, and pelvic floor surgery, as well as for providing accessible and evidence-based information for women considering such surgery.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Editorial Material
Obstetrics & Gynecology
R. Cartwright, P. Miotla
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2020)
Editorial Material
Obstetrics & Gynecology
Nikolaus Veit-Rubin, Rufus Cartwright
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Obstetrics & Gynecology
Matthew L. Izett-Kay, Dana Aldabeeb, Anthony S. Kupelian, Rufus Cartwright, Alfred S. Cutner, Simon Jackson, Natalia Price, Arvind Vashisht
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2020)
Editorial Material
Obstetrics & Gynecology
R. M. Tahtinen, R. Cartwright
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Editorial Material
Obstetrics & Gynecology
H. H. Johannessen, R. Cartwright
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Obstetrics & Gynecology
Lunan Ji, Hanan Alshankiti, Christopher Chong, Rufus Cartwright, J. Oliver Daly, Cara L. Grimes, Ladin A. Yurteri-Kaplan
Summary: This case study highlights the work-up and management of a patient experiencing acute kidney injury, urinary retention, and neuropathy following surgery for pelvic organ prolapse and stress urinary incontinence. Four international experts provide their evaluation and approach to this complex case.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2021)
Article
Medicine, General & Internal
Lauri Lavikainen, Gordon H. Guyatt, Yung Lee, Rachel J. Couban, Anna L. Luomaranta, Ville J. Sallinen, Ilkka E. J. Kalliala, Paul J. Karanicolas, Rufus Cartwright, Riikka L. Aaltonen, Kaisa Ahopelto, Karoliina M. Aro, Ines Beilmann-Lehtonen, Marco H. Blanker, Jovita L. Cardenas, Samantha Craigie, Paivi J. Galambosi, Herney A. Garcia-Perdomo, Fang Zhou Ge, Huda A. Gomaa, Linglong Huang, Matthew L. Izett-Kay, Kirsi M. Joronen, Paivi K. Karjalainen, Nadina Khamani, Tuomas P. Kilpelainen, Antti J. Kivela, Tapio Korhonen, Hanna Lampela, Anne K. Mattila, Borna Tadayon Najafabadi, Taina P. Nykanen, Carolina Nysten, Sanna M. Oksjoki, Sanjay Pandanaboyana, Negar Pourjamal, Chathura B. B. Ratnayake, Aleksi R. Raudasoja, Tino Singh, Riikka M. Tahtinen, Robin W. M. Vernooij, Yuting Wang, Yingqi Xiao, Liang Yao, Jari Haukka, Kari A. O. Tikkinen
Summary: This study aims to fill the knowledge gap in baseline risk estimates of VTE and bleeding in general and gynecologic surgeries by conducting a series of systematic reviews and meta-analyses. The primary outcomes will be risk estimates of symptomatic VTE and major bleeding at 4 weeks post-operatively for each procedure stratified by patient risk factors. The findings will inform clinicians and patients about the trade-off between VTE prevention and bleeding in these surgeries.
SYSTEMATIC REVIEWS
(2021)
Article
Obstetrics & Gynecology
Jan A. Deprest, Rufus Cartwright, Hans Peter Dietz, Luiz Gustavo Oliveira Brito, Marianne Koch, Kristina Allen-Brady, Jittima Manonai, Adi Y. Weintraub, John W. F. Chua, Romana Cuffolo, Felice Sorrentino, Laura Cattani, Judith Decoene, Anne-Sophie Page, Natalie Weeg, Glaucia M. Varella Pereira, Marina Gabriela M. C. Mori da Cunha de Carvalho, Katerina Mackova, Lucie Hajkova Hympanova, Pamela Moalli, Oksana Shynlova, Marianna Alperin, Maria Augusta T. Bortolini
Summary: Genetics, vaginal birth, and age are strongly etiologically linked to the development of pelvic organ prolapse (POP), while other factors may contribute to or protect against the risk.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2022)
Review
Health Care Sciences & Services
Aleksi J. Raudasoja, Petra Falkenbach, Robin W. M. Vernooij, Jussi M. J. Mustonen, Arnav Agarwal, Yoshitaka Aoki, Marco H. Blanker, Rufus Cartwright, Herney A. Garcia-Perdomo, Tuomas P. Kilpelainen, Olli Lainiala, Tiina Lamberg, Olli P. O. Nevalainen, Eero Raittio, Patrick O. Richard, Philippe D. Violette, Jorma Komulainen, Raija Sipila, Kari A. O. Tikkinen
Summary: This study aimed to synthesize interventions for de-implementation of low-value practices and provide guidance for future research. The evaluation of the current research revealed limitations and identified potential research gaps in secondary and tertiary care settings and interventions targeted at non-physicians.
IMPLEMENTATION SCIENCE
(2022)
Review
Surgery
Negar Pourjamal, Lauri Lavikainen, Alex L. E. Halme, Rufus Cartwright, Kaisa Ahopelto, Gordon H. Guyatt, Kari A. O. Tikkinen
Review
Surgery
Tino Singh, Lauri Lavikainen, Alex L. E. Halme, Riikka Aaltonen, Arnav Agarwal, Marco H. Blanker, Kostiantyn Bolsunovskyi, Rufus Cartwright, Herney Garcia-Perdomo, Rachel Gutschon, Yung Lee, Negar Pourjamal, Robin W. M. Vernooij, Philippe D. Violette, Jari Haukka, Gordon H. Guyatt, Kari A. O. Tikkinen
Summary: This study provides insights into the timing of venous thromboembolism (VTE) after surgery based on a systematic review and meta-analysis of 22 prospective studies. It reveals that nearly half of VTE events occur during the first week after surgery, while a substantial number occur in the following weeks. These findings are important for guiding the duration of postoperative thromboprophylaxis.
BRITISH JOURNAL OF SURGERY
(2023)