Article
Oncology
J. Ripoll, M. Ramos, J. Montano, J. Pons, A. Ameijide, P. Franch
Summary: Survival rates for bladder cancer vary significantly by stage, with a high percentage of non-invasive cases. Age and histology play a role in predicting survival outcomes.
Article
Environmental Sciences
Mohd Nasrullah Nik Ab Kadir, Suhaily Mohd Hairon, Najib Majdi Yaacob, Azizah Ab Manan, Nabihah Ali
Summary: Bladder cancer in Malaysia is predominantly found in men with an average age of diagnosis at 64.9 years old. The overall five-year observed survival rate was 36.9%, with the highest rate at stage I. As the cancer advances to stage IV, the survival rate drastically decreases to 12.2%. The study suggests the need to enhance cancer control programs for improving survival outcomes.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Oncology
Dong Wook Shin, Jaeman Bae, Johyun Ha, Kyu-Won Jung
Summary: The study presents 5-year relative conditional survival probabilities for ovarian cancer patients from 1997-2016. The results showed that the conditional survival rates increased with each year survived, but even after 5 years, the excess mortality did not reach 'no excess mortality' level. Patients with poorer initial prognoses showed the largest improvements in conditional survival rates.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Dong Wook Shin, Jaeman Bae, Johyun Ha, Kyu Won Jung
Summary: This study investigated conditional relative survival (CRS) among cervical cancer patients and found that patients with poorer initial survival estimates showed the largest increases in CRS over time. The probability of surviving an additional 5 years conditioned on time already survived increased gradually, providing patients with more information for follow-up care and future life decisions.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2021)
Review
Cell Biology
Hui-Jin Li, Xue Gong, Zheng-Kun Li, Wei Qin, Chun-Xia He, Lu Xing, Xin Zhou, Dong Zhao, Hui-Ling Cao
Summary: Bladder cancer is characterized by dysregulated lncRNAs, which play key roles in tumorigenesis, progression, and prognosis. These lncRNAs can serve as potential diagnostic and prognostic biomarkers for bladder cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Jedrzej Borowczak, Krzysztof Szczerbowski, Mateusz Maniewski, Marek Zdrenka, Piotr Slupski, Paulina Antosik, Sylwia Kolodziejska, Marta Sekielska-Domanowska, Mariusz Dubiel, Magdalena Bodnar, Lukasz Szylberg
Summary: This article investigates the prognostic role of cyclin-dependent kinase 9 expression in urothelial carcinoma. The results show that high CDK9 expression is associated with a better prognosis, tumor grade, stage, and invasiveness, contradicting previous findings. CDK9 may play a crucial role in the early stages of urothelial carcinoma.
Article
Multidisciplinary Sciences
Jeffrey S. Damrauer, Wolfgang Beckabir, Jeff Klomp, Mi Zhou, Elizabeth R. Plimack, Matthew D. Galsky, Petros Grivas, Noah M. Hahn, Peter H. O'Donnell, Gopa Iyer, David Quinn, Benjamin G. Vincent, Diane Zipursky Quale, Sara E. Wobker, Katherine A. Hoadley, William Y. Kim, Matthew Milowsky
Summary: UC-GENOME is a genomic analysis study on metastatic urothelial carcinoma, which identified features associated with benefit to chemotherapy and immune checkpoint inhibition, and developed a computational model for predicting immune checkpoint inhibitor response. This study provides a foundation for better understanding the biology of urothelial carcinoma.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Jian-Guo Chen, Hai-Zhen Chen, Jian Zhu, Ai-Guo Shen, Xiang-Yang Sun, Donald Maxwell Parkin
Summary: This study traced cancer cases hospitalized in Nantong Tumor Hospital from 2002 to 2017 and compared the effects of incidence date truncation and delayed reporting on survival estimates between hospital-based registries and population-based registries. The results showed that survival rates calculated based on hospital-based registries were lower than those based on population-based registries, and delayed reporting was also found in population-based registries. Therefore, controlling delayed reporting and maximizing data completeness are crucial for evaluating cancer patient survival rates.
FRONTIERS IN ONCOLOGY
(2023)
Article
Nutrition & Dietetics
Ola Hysaj, Nena Karavasiloglou, Manuela Limam, Miriam Wanner, Dimitri Korol, Sabine Rohrmann
Summary: In Switzerland, there is a seasonal variation in sunlight, with winter being associated with vitamin D deficiency. A study found that being diagnosed with cancer in summer and/or autumn was associated with better survival rates, possibly due to the seasonal variation of sun-induced vitamin D.
Article
Oncology
Dong Wook Shin, Kyu-Won Jung, Johyun Ha, Jaeman Bae
Summary: The objective of this study was to estimate the 5-year conditional relative survival rates of endometrial cancer in Korea, taking into account the time already survived. The study found that the survival rates improved with increased time elapsed from diagnosis. Older patients, those with non-endometrioid histology, and those with more advanced disease showed the greatest improvements in survival rates.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Yi-An Liao, Chun-Ju Chiang, Wen-Chung Lee, Bo-Zhi Zhuang, Chung-Hsin Chen, Yeong-Shiau Pu
Summary: This study investigated the association between extranodal extension (ENE) and prognosis in Taiwanese bladder cancer patients with pathological nodal disease treated with radical cystectomy. The presence of ENE significantly reduced overall survival (OS) and cancer-specific survival (CSS) in these patients, with adjuvant chemotherapy showing better survival outcomes.
Article
Genetics & Heredity
Huiyuan Xiao, Wen Huang, Yanlei Li, Rongxin Zhang, Long Yang
Summary: The study showed that higher expression of TTN-AS1 was associated with poorer DFS in BC patients, especially in those who underwent Re-TURBT. Knocking down TTN-AS1 could inhibit the proliferation and invasion abilities of BC cells. ATF2 may act as a downstream target of TTN-AS1 in BC, and high expression of ATF2 is also related to adverse DFS in patients.
FRONTIERS IN GENETICS
(2021)
Article
Multidisciplinary Sciences
Ningshu Lin, Luyan Chen, Yunni Zhang, Yi Yang, Lei Zhang, Lei Chen, Peng Zhang, Huiming Su, Min Yin
Summary: KIF4A overexpression is associated with bladder cancer and activation of immunocytes. High expression of KIF4A is correlated with decreased CD8(+) tumor-infiltrating lymphocytes and worse prognosis in patients. KIF4A promotes tumor growth, especially in immune-competent mice.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Hubert Kamecki, Malgorzata Debowska, Jan Poleszczuk, Tomasz Demkow, Artur Przewor, Lukasz Nyk, Roman Sosnowski
Summary: Bladder cancer patients diagnosed incidentally tend to have improved survival, especially if the bladder lesion was first visualized with an ultrasound. However, the improved survival might be caused by overdiagnosis of low-grade cancer. This study provides important evidence for the discussion on the role of screening for bladder cancer.
Article
Oncology
Zhao Kang, Qian Dou, Ting Huang, Maoting Tu, Yongping Zhong, Mei Wang, Tao Li
Summary: The study evaluated the predictive role and value of an angiogenesis-associated long non-coding RNA signature in patients with bladder cancer, as well as the role of LINC02321 in the progression of this malignancy. Six angiogenesis-associated lncRNAs were identified as candidates for the prognostic signature, and LINC02321 was found to promote the malignant progression of bladder cancer via the VEGFA signaling pathway. These findings provide insights into the prognostic prediction and potential therapeutic targets for bladder cancer.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Oncology
Danny R. Youlden, David M. Roder, Rick Walker, Natalie K. Bradford, Joanne F. Aitken
Summary: This study aimed to investigate the risk of second primary cancers among adolescent and young adult (AYA) cancer survivors. The results showed that out of 34,431 eligible patients, 3086 cases of second primary cancers were observed, with an overall relative risk of 1.59 compared to the general population. Melanoma and female breast cancer were the most common types of second primary cancers in the study cohort. The relative risk of second primary cancers among AYA patients was inversely associated with age and highest immediately after the first diagnosis.
JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY
(2023)
Article
Obstetrics & Gynecology
Penelope Fotheringham, Nadom Safi, Zhouyang Li, Antoinette Anazodo, Marc Remond, Andrew Hayen, David Currow, David Roder, Nada Hamad, Michael Nicholl, Adrienne Gordon, Jane Frawley, Elizabeth A. Sullivan
Summary: This study aimed to describe the incidence and perinatal outcomes of pregnancy-associated gynecological cancer (PAGC). The incidence of PAGC was 14.6 per 100,000 deliveries and did not change over time. Women with PAGC had increased odds of severe maternal morbidity and their babies had a higher rate of preterm birth and severe neonatal complications.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Surgery
Mia Shepherdson, Daniel Kilburn, Shahid Ullah, Timothy Price, Christos S. Karapetis, Peter Nguyen, Amanda Townsend, Robert Padbury, Cynthia Piantadosi, Guy Maddern, Scott Carruthers, David Roder, Michael Sorich, Amitesh C. Roy
Summary: A retrospective study of colorectal cancer cases with liver-only metastasis from the South Australian Colorectal Cancer Registry revealed that surgical resection of liver metastasis and primary tumor improved patients' overall survival. Further research is needed on the use of targeted treatments in patients undergoing liver resection.
ANZ JOURNAL OF SURGERY
(2023)
Article
Geriatrics & Gerontology
Maria C. Inacio, Luke Collier, Tracy Air, Kailash Thapaliya, Maria Crotty, Helena Williams, Steve L. Wesselingh, Andrew Kellie, David Roder, Adrienne Lewis, Gillian Harvey, Janet K. Sluggett, Monica Cations, Tiffany K. Gill, Jyoti Khadka, Gillian E. Caughey
Summary: The study examines the use and trends of primary care, allied health, geriatric, pain, and palliative care services by permanent residential aged care (PRAC) residents and the older Australian population. The results show that the utilization of most services increased over time for both cohorts, but preventive and management care was still low. PRAC residents have low access to pain, palliative, and geriatric medicine services, which may not meet their needs.
AUSTRALASIAN JOURNAL ON AGEING
(2023)
Article
Oncology
David Banham, David Roder, Sandra Thompson, Anna Williamson, Freddie Bray, David Currow
Summary: This study examines the potential of more frequent contact with general practitioners (GPs) in ensuring early-stage cancer diagnosis among older Aboriginal Australians. The results show that frequent GP contact is associated with a higher likelihood of a local-stage diagnosis among Aboriginal people.
CANCER CAUSES & CONTROL
(2023)
Article
Obstetrics & Gynecology
Nadom Safi, Zhuoyang Li, Antoinette Anazodo, Marc Remond, Andrew Hayen, David Currow, David Roder, Nada Hamad, Michael Nicholl, Adrienne Gordon, Jane Frawley, Penelope Fotheringham, Elizabeth Sullivan
Summary: This study investigated the obstetric management and outcomes of women with pregnancy-associated cancer (PAC) and their babies. The results showed that women with PAC are more likely to have serious maternal complications, and their babies are more likely to be born preterm and experience poorer perinatal outcomes.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Orthopedics
Sindhrani Dars, Elizabeth Buckley, Kerri Beckmann, David Roder, Helen Banwell
Summary: Australian podiatrists have reached a consensus on the management strategies for Chemotherapy Induced Peripheral Neuropathy (CIPN) through a survey. The survey results provide clinical recommendations for the identification, diagnosis, assessment, and management of CIPN.
JOURNAL OF FOOT AND ANKLE RESEARCH
(2023)
Article
Oncology
Kazzem Gheybi, Elizabeth Buckley, Agnes Vitry, David Roder
Summary: This study found that older age is associated with decreased likelihood of colorectal cancer treatment. Comorbidities also have a role in reducing treatment rates. Different comorbidity types have different effects on treatment modalities.
Article
Public, Environmental & Occupational Health
David Roder, David Banham, Jacob George, Shelley Rushton, Tracey O'Brien
Summary: This study conducted a detailed analysis of liver cancer risk by linking liver cancer registration data from the New South Wales Cancer Registry with additional data from the Australian Bureau of Statistics. The results indicate that liver cancer disproportionately affects socially and economically disadvantaged populations.
Article
Public, Environmental & Occupational Health
David Banham, Jonathan Karnon, Alex Brown, David Roder, John Lynch
Summary: This study uses the FLYLAD measure to quantify disparities in cancer burden between Aboriginal and non-Aboriginal populations in South Australia. The results show that Aboriginal people have a higher cancer burden, mainly due to younger age at diagnosis and higher premature cancer mortality. The use of FLYLAD provides important insights for evaluating cancer control initiatives, particularly those focused on early detection and treatment of cancer.
POPULATION HEALTH METRICS
(2023)
Article
Oncology
Ming Li, Antoinette Anazodo, Luciano Dalla-Pozza, Paola Kabalan Baeza, David Roder, David Currow
Summary: This study investigated the impact of age on treatment and survival in acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). The results showed that children received shorter and less diverse treatments for ALL compared to adolescents and young adults. The 5-year disease-specific survival rate for ALL was 84%, and children had a lower risk of death from ALL. The 5-year survival rate for AML was 73%, with no age differences. Children receiving multiple treatments for ALL had a higher risk of mortality.
EUROPEAN JOURNAL OF CANCER CARE
(2023)
Article
Oncology
Tenaw Tiruye, David Roder, Liesel M. FitzGerald, Michael O'Callaghan, Kim Moretti, Kerri Beckmann
Summary: This study compared the usefulness of different admission-based comorbidity indices in men with non-metastatic prostate cancer. The results showed only slight differences in predictive accuracy among the indices, with the Charlson Comorbidity Index (CCI) having a slightly better prognostic value than the others.
CANCER EPIDEMIOLOGY
(2023)
Meeting Abstract
Oncology
Tharani Krishnan, Shahid Ullah, Cynthia Piantadosi, Christos Stelios Karapetis, Amanda Rose Townsend, Amitesh Roy, Barbara Geerinckx, Guy Maddern, David Roder, Rob Padbury, Timothy Price
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Tenaw Tiruye, Kerry Ettridge, Michael O'Callaghan, Kim Moretti, Alex Jay, Braden Higgs, Kerry Santoro, Ganessan Kichenadasse, David Roder, Kerri Beckmann
Summary: This study describes the development of the Prostate Cancer Outcomes Report Card, which provides information on different treatment approaches for prostate cancer. Through consumer engagement and feedback, the report was designed to meet the needs of users and provide simple and easily understandable evidence. The report aims to help prostate cancer survivors better understand the risks and benefits of treatment, and facilitate communication and shared decision making between patients and providers.
EUROPEAN JOURNAL OF CANCER CARE
(2023)
Meeting Abstract
Oncology
Mrunal Hiwase, Tenaw Tiruye, Ashna Khalid, Ming Li, David Roder, Rick Catterwell, Kerri Beckmann
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2023)