Article
Biochemistry & Molecular Biology
Yuriko Tanaka, Mayu Onozato, Tetuo Mikami, Terumi Kohwi-Shigematsu, Takeshi Fukushima, Motonari Kondo
Summary: The study found that early signs of Sjogren's Syndrome were observed in SATB1cKO mice, with IFN-dependent IDO expression induction being a crucial early event in the disease. Serum L-KYN could potentially be used as a marker for early SS diagnosis before autoantibodies become detectable.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Kevin MingJie Gao, Mona Motwani, Thomas Tedder, Ann Marshak-Rothstein, Katherine A. Fitzgerald
Summary: Pediatric patients with constitutively active mutations in the cytosolic double-stranded-DNA-sensing adaptor STING develop an autoinflammatory syndrome known as STING-associated vasculopathy. This study found that mice with the same mutations develop lymphocyte-rich bronchus-associated lymphoid tissue in the lungs. Additionally, the study discovered that lung endothelial cells, which are resistant to radiation, play a critical role in the initiation and progression of lung disease.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Urology & Nephrology
Jung Hyun Shin, Bosik Kang, Myung-Soo Choo
Summary: The study found that the features of HLs in IC patients were not associated with subjective symptoms, but inflammatory changes in HLs were a predictive factor for IC recurrence and associated with frequent urgency episodes and smaller bladder capacity.
JOURNAL OF UROLOGY
(2021)
Article
Clinical Neurology
Raphael Bernard-Valnet, David Frieser, Xuan-Hung Nguyen, Leila Khajavi, Clemence Queriault, Sebastien Arthaud, Silvia Melzi, Maxime Fusade-Boyer, Frederick Masson, Matthias Zytnicki, Abdelhadi Saoudi, Yves Dauvilliers, Christelle Peyron, Jan Bauer, Roland S. Liblau
Summary: This study reveals that Pandemrix (R) vaccination may induce narcolepsy through immune cross-reactivity with a self-antigen, leading to an immunopathological process. This process relies on the synergy between CD4 and CD8 T cells.
Article
Chemistry, Medicinal
Yunpeng Shao, Yu Liu, Baixin Shen, Qiao Zhou, Zhongqing Wei
Summary: Interstitial cystitis (IC) is characterized by apoptosis and chronic inflammation in bladder tissue. This study found that echinacoside (ECH) can improve bladder function, reduce inflammatory damage, and decrease apoptosis in IC models. The protective effect of ECH against IC in the bladder may be mediated through modulation of the PPAR gamma/NF-kappa B pathway.
JOURNAL OF MEDICINAL FOOD
(2022)
Article
Multidisciplinary Sciences
Yuan-Ju Lee, Shang-Jen Chang, Hsiu-Ying Lin, En Meng, Jeff S. Chueh, Chi-Shin Tseng
Summary: This follow-up study assessed the long-term effects of pentosan polysulfate sodium (PPS) monotherapy on recurrent urinary tract infections (UTIs). The study found that PPS significantly reduced the recurrence of UTIs and improved the quality of life for women with recurrent UTI during the 2-year follow-up period.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Hekang Du, Meng Kou, Weili Deng, Xueyuan Zhou, Xiaoxiong Zhang, Zhengrong Huang, Bowen Ren, Xingting Cai, Shan Xu, Yu Chen, Lizhu Chen, Chuanben Chen, Hongli Bao, Qi Chen, Daliang Li
Summary: The innate immune system is crucial in combating microbial infection, but abnormal activation of innate immune pathways is a characteristic of various diseases. Therefore, targeted drugs are necessary based on understanding of innate immune signaling pathways. This study showed that a small molecule (DWL-4-140) can selectively regulate STING, resulting in downregulation of DNA-induced interferon responses. DWL-4-140 inhibits the assembly of STING complex and downstream signaling mediators, and it also alleviated lupus in mice. Thus, DWL-4-140 has potential therapeutic applications in autoinflammatory diseases by pharmacologically inhibiting STING.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Zhinoos Taidi, Tommy Zhou, Kate H. Moore, Kylie J. Mansfield, Lu Liu
Summary: Inflammatory conditions of the urinary bladder are associated with urothelial damage and loss of function. The purinergic P2X7 receptor plays a role in such inflammatory conditions and may be a new therapeutic target for bladder inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Min Woo Kim, Jonathan Kipnis
Summary: This study demonstrates that opioid use affects the communication between the central nervous system and the peripheral immune system, leading to changes in T cell and cytokine modulation of brain function, and is associated with withdrawal-induced behavioral dysfunction.
Article
Urology & Nephrology
Lin Zhu, Hanwei Ke, Qi Wang, Kexin Xu
Summary: This study aimed to illustrate the importance of cystoscopy for the diagnosis and prognosis of bladder pain syndrome (BPS) or interstitial cystitis (IC). Through a 4-year follow-up study, it was found that cystoscopy can prevent the misdiagnosis of BPS/IC as other diseases or other diseases as BPS/IC. Classification of BPS/IC can be done based on cystoscopic findings, which is helpful for follow-up treatment.
WORLD JOURNAL OF UROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jin Li, Xianyanling Yi, Jianzhong Ai
Summary: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating disease with a negative impact on quality of life. Diagnoses and treatments are still unsatisfactory, calling for new approaches. This study aims to provide a comprehensive overview of IC/BPS research, promoting progress in diagnosis, treatment, and prognosis. The complexity of IC/BPS and emerging evidence call for further studies to optimize management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Maryam Fatima, Irfan Anjum, Aamir Abdullah, Shaun Zshaan Abid, Muhammad Nasir Hayat Malik
Summary: The study demonstrates the protective effect of boswellic acids on cyclophosphamide-induced cystitis in rats, indicating their potential as therapeutic alternatives for cystitis. Boswellic acids exhibit antioxidant and anti-inflammatory properties, reducing urothelial damage and inflammation.
Article
Multidisciplinary Sciences
Xiaolei Wang, Terrence Tsz-Tai Yuen, Ying Dou, Jingchu Hu, Renhao Li, Zheng Zeng, Xuansheng Lin, Huarui Gong, Celia Hoi-Ching Chan, Chaemin Yoon, Huiping Shuai, Deborah Tip-Yin Ho, Ivan Fan-Ngai Hung, Bao-Zhong Zhang, Hin Chu, Jian-Dong Huang
Summary: Researchers demonstrate the importance of cellular immunity in protecting against SARS-CoV-2 by showing that mice lacking B cells can still develop a robust immune response through vaccination or viral challenge. This study has important implications for understanding the impact of SARS-CoV-2 variants on the immune system.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Krystal Bay-San Lin, Ming-Ping Wu, Yen-Kuang Lin, Yu-Chun Yen, Yao-Chi Chuang, Hung-Yen Chin
Summary: It was found in this study that patients with IC/BPS tend to make lifestyle behavioral changes in terms of diet and personal habits to cope with their symptoms.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Kylie A. Mills, Eliza G. West, Donna J. Sellers, Russ Chess-Williams, Catherine McDermott
Summary: Psychological stress has been associated with the development and exacerbation of overactive bladder symptoms. A study showed that water avoidance stress in mice increased bladder afferent nerve activity, potentially affecting bladder filling sensations and pain perceptions.
SCIENTIFIC REPORTS
(2021)