Review
Biochemistry & Molecular Biology
Victoria E. de Knegt, Paula L. Hedley, Jorgen K. Kanters, Ida N. Thagaard, Lone Krebs, Michael Christiansen, Ulrik Lausten-Thomsen
Summary: Leptin plays a crucial role in regulating pregnancy-related functions and its dysregulation during pregnancy can lead to pre-eclampsia and restricted fetal growth. The regulatory mechanisms involving leptin in pre-eclampsia are specific to each situation, and the dysregulation of leptin likely affects fetal growth through complex interactions with parallel pregnancy systems throughout pregnancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Rafael Ferraz-Bannitz, Rebeca A. Beraldo, A. Augusto Peluso, Morten Dall, Parizad Babaei, Rayana Cardoso Foglietti, Larissa Marfori Martins, Patricia Moreira Gomes, Julio Sergio Marchini, Vivian Marques Miguel Suen, Luiz C. Conti de Freitas, Luiz Carlos Navegantes, Marco Antonio M. Pretti, Mariana Boroni, Jonas T. Treebak, Marcelo A. Mori, Milton Cesar Foss, Maria Cristina Foss-Freitas
Summary: This study aimed to investigate the benefits of dietary restriction in patients with metabolic syndrome and determine whether it is the calorie or protein restriction that mediates the effects. The findings showed that isocaloric dietary protein restriction can achieve similar clinical outcomes as calorie restriction, making it a more attractive and less drastic dietary strategy for patients with metabolic syndrome and has potential as an adjuvant therapy.
Article
Developmental Biology
J. Y. Chen, M. Chen, X. J. Wu, J. M. Sun, Y. Zhang, Y. F. Li, L. Y. Zhong, B. L. Yu, J. Luo, J. H. Liu
Summary: The study found that the placental vascularization indices (PVIs) at 32-36 weeks of gestation have good value in predicting preeclampsia and fetal growth restriction, while their predictive ability is poor before 32 weeks.
Article
Obstetrics & Gynecology
Vaeochan Govender, Thinagrin D. Naidoo, Serantha Foolchand
Summary: The feasibility of using ductus venosus Doppler (DVD) to time delivery in early-onset fetal growth restriction (FGR) and pre-eclampsia was assessed in this study. The results showed that abnormal DVD was associated with increased perinatal morbidity and mortality, as well as increased risk of placental abruption.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Environmental Sciences
Yu-Feng Zhang, Hua-Long Zhu, Xiao-Feng Xu, Jin Zhang, Qing Ling, Shuang Zhang, Wei Chang, Yong-Wei Xiong, De-Xiang Xu, Hua Wang
Summary: This study investigates the role of placental lipophagy in cadmium-induced fetal growth restriction (FGR) through a case-control study, animal experiments, and primary human placental trophoblast cell cultures. The findings suggest an association between placental lipophagy and FGR. Additionally, exposure to cadmium during pregnancy induces FGR and placental lipophagy. Inhibition of placental lipophagy exacerbates cadmium-induced FGR, while activation of placental lipophagy alleviates FGR. Activation of Atg5-dependent placental lipophagy degrades lipid droplets to produce free cholesterol and promotes placental progesterone synthesis, which can reverse cadmium-induced FGR.
ENVIRONMENTAL POLLUTION
(2023)
Article
Medicine, General & Internal
Yao-Lung Chang, Chin-Chieh Hsu, An-Shine Chao, Shuenn-Dyh Chang, Po-Jen Cheng, Wen-Fang Li
Summary: This study investigates the fetal growth pattern after fetoscopic laser photocoagulation (FLP) in twin-twin transfusion syndrome (TTTS) and the effect of FLP on placental perfusion and intrauterine growth restriction (IUGR) incidence. The results suggest that FLP can decrease body weight discordance (BWD), improve the prognosis of TTTS, and reduce the incidence of IUGR in donor twins.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Natasha de Alwis, Sally Beard, Natalie K. Binder, Natasha Pritchard, Tu'uhevaha J. Kaitu'u-Lino, Susan P. Walker, Owen Stock, Katie Groom, Scott Petersen, Amanda Henry, Joanne M. Said, Sean Seeho, Stefan C. Kane, Stephen Tong, Lisa Hui, Natalie J. Hannan
Summary: Elevated levels of OLAH in the placenta may be associated with placental dysfunction in pregnancies complicated by preterm preeclampsia and fetal growth restriction. Further research is required to understand the role of OLAH in the placenta, and whether these changes are a maternal adaptation or consequence of disease.
Article
Obstetrics & Gynecology
Kelsey McLaughlin, Sebastian R. Hobson, Anjana Ravi Chandran, Swati Agrawal, Rory C. Windrim, W. Tony Parks, Adrian W. Bowman, Ulla Sovio, Gordon C. Smith, John C. Kingdom
Summary: The study established a gestational age-specific reference range for placental growth factor levels and showed that low-molecular-weight heparin therapy can increase circulating placental growth factor levels in patients, prolonging pregnancy and reducing adverse pregnancy outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Acoustics
C. A. Cluver, L. Bergman, J. Bergkvist, H. Imberg, L. Geerts, D. R. Hall, B. W. Mol, S. Tong, S. P. Walker
Summary: This study assessed whether coexisting fetal growth restriction (FGR) influences pregnancy latency and maternal and perinatal outcomes in women with preterm pre-eclampsia. The results showed that FGR is associated with shorter pregnancy latency, more emergency Cesarean deliveries, fewer successful inductions of labor, and increased rates of neonatal morbidity and mortality.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Acoustics
A. Basso, L. Youssef, A. Nakaki, C. Paules, J. Miranda, G. Casu, L. Salazar, E. Gratacos, E. Eixarch, F. Crispi, F. Crovetto
Summary: This study aims to explore the pattern of fetal cortical development in pregnancies complicated by pre-eclampsia (PE), with and without a small-for-gestational-age (SGA) fetus, compared to uncomplicated pregnancies. The results showed that pregnancies with PE, whether with a SGA or AGA fetus, had similar cortical development patterns that were comparable to those observed in small fetuses.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Acoustics
A. C. M. Kluivers, A. Biesbroek, W. Visser, L. Saleh, H. Russcher, A. H. J. Danser, R. I. Neuman
Summary: This study aims to evaluate the levels of placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1), and free PlGF in women with pre-eclampsia (PE) with or without a small-for-gestational-age (SGA) neonate. The findings suggest that diminished PlGF production is an important cause of low free PlGF levels, particularly in pregnancies with early-onset PE and SGA. The upregulation of sFlt-1 occurs synergistically in women with both PE and SGA.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jacopo Troisi, Steven J. K. Symes, Martina Lombardi, Pierpaolo Cavallo, Angelo Colucci, Giovanni Scala, David C. Adair, Maurizio Guida, Sean M. Richards
Summary: Fetal growth restriction (FGR) is a condition that leads to high neonatal mortality and morbidity. The mechanisms behind FGR are not fully understood. In this study, metabolites were extracted from placentas of 493 non-complicated pregnancies using gas chromatography-mass spectrometry (GC-MS). The results showed that certain metabolites were significantly different in placentas of low birth weight (LBW) and small for gestational age (SGA) newborns compared to non-LBW and adequate for gestational age (AGA) newborns. These findings indicate that metabolic pathways related to hypoxia response, amino acid uptake, and inflammation play a role in FGR.
Article
Developmental Biology
A. Arias, J. A. Schander, M. Bariani, F. Correa, A. P. Dominguez Rubio, M. Cella, C. B. Cymeryng, M. L. Wolfson, A. M. Franchi, J. Aisemberg
Summary: Maternal dexamethasone administration during late gestation results in fetal and placental growth restriction, potentially due to altered placental angiogenesis.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Environmental Sciences
Hao Zhang, Yi Zheng, Xiaoyun Liu, Xia Zha, Mabrouk Elsabagh, Yi Ma, Honghua Jiang, Hongrong Wang, Mengzhi Wang
Summary: This study investigated the potential relationship between oxidative stress, autophagy, and apoptosis in pregnant ewes exposed to BPA. The results showed that BPA exposure led to placental insufficiency, fetal growth restriction, autophagy, endoplasmic reticulum stress, mitochondrial dysfunction, oxidative stress, and apoptosis. Additionally, the study revealed that autophagy could alleviate BPA-induced apoptosis, mitochondrial dysfunction, and oxidative stress.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Dayuan Shi, Xinyao Zhou, Luyao Cai, Xing Wei, Luye Zhang, Qianqian Sun, Fenhe Zhou, Luming Sun
Summary: Changes in placental DNA methylation patterns in sFGR may have functional implications for differentially methylated genes and regulatory regions. The study validates the presence of abnormally methylated CYP11A1 gene in the placenta of sFGR.
Article
Acoustics
C. Ghossein-Doha, J. Van Neer, B. Wissink, N. M. Breetveld, L. J. De Windt, A. P. J. Van Dijk, M. J. Van Der Vlugt, M. C. H. Janssen, W. M. Heidema, R. R. Scholten, M. E. A. Spaanderman
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2017)
Article
Acoustics
N. M. Breetveld, C. Ghossein-Doha, S. M. J. Van Kuijk, A. P. Van Dijk, M. J. Van Der Vlugt, W. M. Heidema, J. Van Neer, V. Van Empel, H. -P. Brunner-La Rocca, R. R. Scholten, M. E. A. Spaanderman
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2017)
Review
Pharmacology & Pharmacy
Kelsey McLaughlin, Ralph R. Scholten, John D. Parker, Enrico Ferrazzi, John C. P. Kingdom
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2018)
Review
Peripheral Vascular Disease
Kelsey McLaughlin, Ralph R. Scholten, John C. Kingdom, John S. Floras, John D. Parker
Article
Public, Environmental & Occupational Health
Wieteke M. Heidema, Ralph R. Scholten, Joris van Drongelen, Marc E. A. Spaanderman
JOURNAL OF WOMENS HEALTH
(2019)
Article
Peripheral Vascular Disease
Veronica A. Lopes van Balen, Julia J. Spaan, Tom Cornelis, Wieteke M. Heidema, Ralph R. Scholten, Marc E. A. Spaanderman
MICROVASCULAR RESEARCH
(2018)
Article
Acoustics
W. M. Heidema, J. van Drongelen, M. E. A. Spaanderman, R. R. Scholten
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2019)
Article
Acoustics
N. M. Breetveld, C. Ghossein-Doha, J. van Neer, M. J. J. M. Sengers, L. Geerts, S. M. J. van Kuijk, A. P. van Dijk, M. J. van der Vlugt, W. M. Heidema, H. P. Brunner-La Rocca, R. R. Scholten, M. E. A. Spaanderman
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Nicolette M. Breetveld, Robert-Jan Alers, Lauren Geerts, Sander M. J. van Kuijk, Arie P. van Dijk, Maureen J. van der Vlugt, Wieteke M. Heidema, Jolijn van Neer, Vanessa P. M. van Empel, Hans-Peter Brunner-La Rocca, Ralph R. Scholten, Chahinda Ghossein-Doha, Marc E. A. Spaanderman
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Obstetrics & Gynecology
Eva Stekkinger, Ralph R. Scholten, Wieteke M. Heidema, Marc E. A. Spaanderman
Summary: The prevalence of metabolic syndrome in women with a history of preeclampsia varies according to WHO, IDF, and ATPIII criteria, with substantial agreement among the three definitions. The risk of recurrent preeclampsia differs based on the presence of inter-pregnancy metabolic syndrome according to the different criteria.
HYPERTENSION IN PREGNANCY
(2021)
Article
Acoustics
W. H. Heidema, J. Van Drongelen, M. E. A. Spaanderman, R. R. Scholten
Summary: This study investigates the interaction between body mass index (BMI) and a history of pre-eclampsia (PE) on vascular health. The results indicate that both obesity and PE have negative effects on endothelial function, insulin resistance, and physical fitness. Recognizing and addressing these cardiovascular risk factors is essential for patient education and targeted interventions.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Meeting Abstract
Obstetrics & Gynecology
Veronica A. Lopes van Balen, Julia J. Spaan, Tom Cornelis, Koen D. Reesink, Wieteke M. Heidema, Ralph R. Scholten, Marc E. A. Spaanderman
REPRODUCTIVE SCIENCES
(2016)
Meeting Abstract
Obstetrics & Gynecology
Nicolette M. Breetveld, Chahinda Ghossein-Doha, Marlot J. J. M. Sengers, Sander M. J. van Kuijk, Arie P. van Dijk, Maureen J. van der Vlugt, Wieteke M. Heidema, Jolijn van Neer, Vanessa van Empel, Hans-Peter Brunner-La Rocca, Ralph R. Scholten, Marc E. A. Spaanderman
REPRODUCTIVE SCIENCES
(2016)
Article
Physiology
Yvonne A. W. Hartman, Maria T. E. Hopman, Tim H. Schreuder, Rebecca J. H. M. Verheggen, Ralph R. Scholten, Madelijn H. Oudegeest-Sander, Fleur Poelkens, Andrew J. Maiorana, Louise H. Naylor, Peter H. Willems, Cees J. Tack, Dick H. J. Thijssen, Daniel J. Green
PHYSIOLOGICAL REPORTS
(2018)
Meeting Abstract
Obstetrics & Gynecology
Chahinda Ghossein-Doha, Nicolette M. Breetveld, Salwan Al-Nasiry, Ralph R. Scholten, Wieteke M. Heidema, Arie P. van Dijk, Maureen J. van der Vlugt, Louis L. H. Peeters, Marc E. A. Spaanderman
REPRODUCTIVE SCIENCES
(2015)