Article
Gastroenterology & Hepatology
Tharni Vasavan, Sahil Deepak, Indu Asanka Jayawardane, Maristella Lucchini, Catherine Martin, Victoria Geenes, Joel Yang, Anita Lovgren-Sandblom, Paul Townsend Seed, Jenny Chambers, Sophia Stone, Lesia Kurlak, Peter Hendy Dixon, Hanns-Ulrich Marschall, Julia Gorelik, Lucy Chappell, Pam Loughna, Jim Thornton, Fiona Broughton Pipkin, Barrie Hayes-Gill, William Paul Fifer, Catherine Williamson
Summary: Elevated fetal and maternal serum bile acid concentrations in untreated ICP are associated with an abnormal fetal cardiac phenotype characterized by increased NT-proBNP concentration, PR interval length and HRV. UDCA treatment partially attenuates this phenotype.
JOURNAL OF HEPATOLOGY
(2021)
Article
Obstetrics & Gynecology
Richard H. Lee, Mara Greenberg, Torri D. Metz, Christian M. Pettker
Summary: Intrahepatic cholestasis of pregnancy can cause maternal itching symptoms and pose potential risks for the fetus. Regular monitoring of bile acid and liver enzyme levels, medication treatment, and timely antenatal fetal surveillance are recommended.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
J. Fleminger, P. T. Seed, A. Smith, E. Juszczak, P. H. Dixon, J. Chambers, J. Dorling, C. Williamson, J. G. Thornton, L. C. Chappell
Summary: The study found that there was no specific group of women with intrahepatic cholestasis of pregnancy who would benefit from treatment with ursodeoxycholic acid, indicating that its routine use for improvement of bile acid concentration or itch score should be reconsidered.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Review
Obstetrics & Gynecology
Chidera Nneji Obiegbusi, Xiao Jing Dong, Samuel Chigbo Obiegbusi, Xiao Jin, Innocent Kenechukwu Okoene
Summary: This review summarizes the existing evidence on predictors of adverse fetal outcomes in pregnant women diagnosed with intrahepatic cholestasis of pregnancy (ICP). The identified predictors include in vitro fertilization (IVF) pregnancy, multifetal pregnancy, biochemical markers, gestational age of ICP onset, presence of comorbidities, maternal history of ICP, and hepatobiliary disease.
REPRODUCTIVE SCIENCES
(2023)
Article
Medicine, General & Internal
Gal Hershkovitz, Yael Raz, Ilana Goldinger, Ariel Many, Liran Hiersch, Rimon Eli
Summary: Intrahepatic cholestasis of pregnancy (ICP) is characterized by elevated total bile acids (TBA). It is unclear why some fetuses are more prone to the hazardous effect of bile acids (BA) over the others. We aimed to compare TBA levels in umbilical vein and artery to maternal TBA in women with ICP. The study included 18 women and 23 fetuses, and we found that the TBA level in umbilical vein was significantly lower compared to maternal TBA level.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Elena P. Lagon, Marti D. Soffer, Kaitlyn E. James, Keizra Mecklai, Darrick K. Li, Esperance A. Schaefer, Christina M. Duzyj
Summary: This study aimed to investigate the effects of delivery timing on maternal and neonatal outcomes in patients with intrahepatic cholestasis and found that prolonging pregnancy or delaying delivery can reduce neonatal morbidities associated with cholestasis.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2022)
Article
Obstetrics & Gynecology
Xiaomei Huang, Lei Lei, Fan Feng, Yong Shao
Summary: This study investigated the distribution of lipopolysaccharide in the maternal body and its effect on fetal outcomes in mice with intrahepatic cholestasis of pregnancy. The results showed significantly elevated levels of lipopolysaccharide in women with intrahepatic cholestasis of pregnancy, and in vivo fluorescence imaging revealed higher intensity of lipopolysaccharide in mice with intrahepatic cholestasis of pregnancy. Ursodeoxycholic acid and resveratrol treatment effectively reduced lipopolysaccharide levels in pregnant mice with intrahepatic cholestasis of pregnancy.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Obstetrics & Gynecology
Miriam L. Estin, Alexa I. K. Campbell, Virginia Y. Watkins, Sarah K. Dotters-Katz, Carla W. Brady, Jerome J. Federspiel
Summary: This study, using a national database, found that patients with intrahepatic cholestasis of pregnancy delivered earlier but had lower stillbirth rates, which were not affected by gestational age at birth.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Manuel Guerra, Ignacio Montano, Maria T. Haye, Victoria Toro, Nerea Maiz
Summary: This study found differences in fetal cardiac function between patients with and without ICP, with a longer PR interval in fetuses of women with ICP. There was a significant correlation between PR interval and bile acid levels, and administration of UDCA significantly reduced PR interval.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Review
Obstetrics & Gynecology
Rebecca Horgan, Christiana Bitas, Alfred Abuhamad
Summary: This study compared the guidelines for the diagnosis, antepartum surveillance, and timing of delivery of pregnancies complicated by intrahepatic cholestasis of pregnancy published by the Society for Maternal-Fetal Medicine and the Royal College of Obstetricians and Gynaecologists. The two organizations have several key differences in their clinical guidelines, including the criteria for diagnosing intrahepatic cholestasis of pregnancy and the recommended treatments. The Society for Maternal-Fetal Medicine recommends fetal surveillance and specific delivery timing based on bile acid levels, while the Royal College of Obstetricians and Gynaecologists does not recommend additional fetal testing beyond kick count assessment and stratifies delivery timing based on bile acid levels.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Plant Sciences
Shasha Qin, Jingzhuo Tian, Yong Zhao, Lianmei Wang, Jinyu Wang, Suyan Liu, Jing Meng, Fang Wang, Chenyue Liu, Jiayin Han, Chen Pan, Yushi Zhang, Yan Yi, Chunying Li, Meiting Liu, Aihua Liang
Summary: This study aims to systematically elucidate the mechanism by which Gardenia extract ameliorates ANIT-induced cholestatic liver injury.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Medicine, General & Internal
Maciej Majsterek, Magdalena Wierzchowska-Opoka, Inga Makosz, Lena Kreczynska, Zaneta Kimber-Trojnar, Bozena Leszczynska-Gorzelak
Summary: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-related condition characterized by elevated levels of bile acids (BAs) in blood serum and an increased risk of adverse perinatal outcomes. Early diagnosis and prompt management based on BA levels are crucial in reducing fetal complications.
Article
Obstetrics & Gynecology
William M. Hague, Annette Briley, Leonie Callaway, Marloes Dekker Nitert, Jessica Gehlert, Dorothy Graham, Luke Grzeskowiak, Angela Makris, Corey Markus, Philippa Middleton, Michael J. Peek, Antonia Shand, Michael Stark, Jason Waugh
Summary: Intrahepatic cholestasis of pregnancy (ICP) is a liver disease during pregnancy characterized by itching and increased levels of total serum bile acids (TSBA), with an incidence of 0.6-0.7% in Australia. ICP is diagnosed by measuring TSBA and bile pigment in a pregnant woman with itching but no known pre-existing liver disorder. Severe and very severe disease are identified by TSBA levels of ≥40 and ≥100 μmol/L, respectively, with severe cases associated with spontaneous preterm birth and stillbirth in very severe cases. The effectiveness and risks of inducing preterm birth in ICP are still uncertain. Ursodeoxycholic acid is the recommended pharmacotherapy for ICP, improving perinatal outcomes and reducing itching, but its ability to reduce stillbirth has not been proven.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Article
Multidisciplinary Sciences
Dana A. Muin, Martina Kollmann, Jasmin Blatterer, Gregor Hoermann, Peter W. Husslein, Ingrid Lafer, Erwin Petek, Thomas Schwarzbraun
Summary: Investigating cardio-pathogenic variants in singleton fetuses after unexplained intrauterine fetal death revealed that most male fetuses died at a median gestational age of 34 weeks, with a high proportion of variants of uncertain significance in cardio-specific genes.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Przemyslaw Kosinski, Malgorzata Kedzia, Adrianna Mostowska, Pawel Gutaj, Michal Lipa, Ewa Wender-Ozegowska, Adriana Rozy, Joanna Chorostowska-Wynimko, Miroslaw Wielgos, Aleksandra Jezela-Stanek
Summary: The study revealed an increased prevalence of the SERPINA1 PI*Z variant in women with intrahepatic cholestasis, suggesting a possible genetic origin of a higher risk of intrahepatic cholestasis in pregnancy.
FRONTIERS IN GENETICS
(2021)
Review
Pediatrics
Jonas F. Ludvigsson
Summary: Sweden initially chose a different approach to disease prevention and control during the pandemic. The overall excess mortality rate in Sweden was lower than in many other European countries, despite a relatively high number of deaths. The Swedish COVID-19 Commission concluded that earlier and more extensive measures should have been taken, especially during the first wave.
Article
Pediatrics
Maria Ulnes, Henrik Albrektsson, Ketil Stordal, Robert Saalman, Jonas F. Ludvigsson, Karl Marild
Summary: The aim of this study was to examine the clinical follow up of paediatric coeliac disease and the rate of loss of follow up during childhood. The results showed that 14% of the coeliac patients were lost to follow up after an average of 5.3 years since diagnosis. The patients who were lost to follow up were more often boys and had a slightly longer average disease duration.
Article
Public, Environmental & Occupational Health
Sven Cnattingius, Karin Kallen, Anna Sandstrom, Henny Rydberg, Helena Mansson, Olof Stephansson, Thomas Frisell, Jonas F. Ludvigsson
Summary: The Swedish Medical Birth Register (MBR) provides high-quality pregnancy-related information on over 5 million births during five decades. It is an important resource for understanding the health of mothers and offspring in both the short and long term.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Hannes Hagstroem, Jonas F. F. Ludvigsson
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Xiaoying Kang, Shengxin Liu, Bjorn Roelstraete, Hamed Khalili, Jonas F. Ludvigsson
Summary: This study examined the association between type 1 diabetes (T1D) and microscopic colitis (MC). The results showed that the prevalence of T1D was almost 80% higher in MC patients compared to the general population. This association may be related to the consumption of medications associated with MC onset.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Haley M. Zylberberg, Benjamin Lebwohl, Bjorn Roelstraete, Jonas Soederling, Olof Stephansson, Peter H. R. Green, Jonas F. Ludvigsson
Summary: This study aimed to investigate the risk of cardiac birth defects in infants born to mothers with celiac disease (CeD). The results showed no statistically significant association between maternal CeD and the risk of any or cardiac birth defects in the offspring, compared to the general population and non-affected siblings.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Fahim Ebrahimi, Tracey G. Simon, Hannes Hagstrom, Jonas Soderling, Axel Wester, Bjorn Roelstraete, Jonas F. Ludvigsson
Summary: Patients with biopsy-proven NAFLD have a significantly higher risk of developing severe infections requiring hospitalization compared to the general population and their siblings. The risk of infection increases with the severity of NAFLD.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Jonas F. Ludvigsson
Article
Gastroenterology & Hepatology
Asa Everhov, Jonas Soederling, Gustaf Befrits, Hamed Khalili, Gabriella Broems, Martin Neovius, Johan Askling, Jonas F. Halfvarson, Jonas Ludvigsson, Ola Olen, SWIBREG Study Group
Summary: This study assessed the costs of prevalent Crohn's disease (CD) or ulcerative colitis (UC) patients in Sweden from 2007 to 2020, including productivity losses. The study found that in recent years, the costs of patients mainly came from healthcare costs, rather than productivity losses. Particularly, the use of biologics contributed to the increase in healthcare costs.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Public, Environmental & Occupational Health
Patrik Nasr, Erik von Seth, Raphaela Mayerhofer, Nelson Ndegwa, Jonas F. F. Ludvigsson, Hannes Hagstrom
Summary: The incidence rates of non-alcoholic fatty liver disease, alcohol-related cirrhosis, unspecified liver cirrhosis, and liver malignancies have increased in Sweden over the last 15 years. There has also been an increase in mortality rates for several liver diseases. Significant disparities across sex and geographical regions need to be considered when allocating healthcare resources.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Fahim Ebrahimi, Tracey G. Simon, Hannes Hagstrom, Jiangwei Sun, David Bergman, Anders Forss, Bjorn Roelstraete, Lars Engstrand, Jonas F. Ludvigsson
Summary: Antibiotic use may increase the risk of developing nonalcoholic fatty liver disease (NAFLD), especially in individuals without metabolic syndrome. Fluoroquinolones were found to have the highest risk, and the associations remained robust in sibling comparisons.
LIVER INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Jiangwei Sun, Bjorn Roelstraete, Emma Svennberg, Jonas Halfvarson, Johan Sundstrom, Anders Forss, Ola Olen, Jonas F. Ludvigsson
Summary: This study found that patients with inflammatory bowel disease (IBD) have an increased risk of developing arrhythmias. This increased risk persists even 25 years after the diagnosis of IBD.
Article
Medicine, General & Internal
Weiyao Yin, Jonas F. Ludvigsson, Ulrika Aden, Kari Risnes, Martina Persson, Abraham Reichenberg, Michael E. Silverman, Eero Kajantie, Sven Sandin
Summary: This study investigated the association between psychiatric diagnoses in fathers, mothers, and both parents and gestational age. The results showed that both paternal and maternal psychiatric diagnoses were associated with earlier gestational age, and the risk increased when both parents were diagnosed. The risk also increased when fathers and mothers were diagnosed with different psychiatric disorders. These findings suggest that the presence of psychiatric diagnoses in parents impacts gestational age at birth.
Article
Biochemistry & Molecular Biology
Mara Caputo, Ying Xia, Sumit Kumar Anand, Emmelie Cansby, Emma Andersson, Hanns-Ulrich Marschall, Alfred Koenigsrainer, Andreas Peter, Margit Mahlapuu
Summary: Nonalcoholic steatohepatitis (NASH), characterized by liver steatosis, inflammation, and fibrosis, is found to be correlated with the incidence and severity of hepatocellular carcinoma (HCC). MST3 and MST4 are identified to play a critical role in promoting HCC progression, and targeting them may provide a novel strategy for liver cancer treatment.
Letter
Gastroenterology & Hepatology
Kyle Staller, Jonas F. Ludvigsson
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)