Review
Environmental Sciences
Shiqi Lin, Jiajia Li, Xiaojin Yan, Lijun Pei, Xuejun Shang
Summary: This systematic review and meta-analysis examined the association between prenatal maternal pesticide exposure and the risk of preterm birth and length of gestational age. The results indicated that a ten-fold increase in pesticide concentrations may be associated with a higher risk of preterm birth and a shortened gestational age.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Pediatrics
Michelle Romijn, Paula Dhiman, Martijn J. J. Finken, Anton H. van Kaam, Trixie A. Katz, Joost Rotteveel, Ewoud Schuit, Gary S. Collins, Wes Onland, Heloise Torchin
Summary: This study systematically reviews and assesses the accuracy of prediction models for bronchopulmonary dysplasia (BPD) at 36 weeks of postmenstrual age. A total of 65 studies were reviewed, including 158 development models and 108 externally validated models. Although these models perform satisfactorily, they all have a high risk of bias due to limitations in the analysis part. Methodologic improvement and complete reporting are needed before they can be considered for use in clinical practice. Future research should aim to validate and update existing models.
JOURNAL OF PEDIATRICS
(2023)
Article
Environmental Sciences
Yuhao Wu, Junke Wang, Yuexin Wei, Jiadong Chen, Lian Kang, Chunlan Long, Shengde Wu, Lianju Shen, Guanghui Wei
Summary: Based on current evidence, maternal exposure to metals and phthalates may increase the risk for preterm birth.
ENVIRONMENTAL POLLUTION
(2022)
Review
Obstetrics & Gynecology
Clara Q. Wu, Kelly Nichols, Matthew Carwana, Nicholas Cormier, Christina Maratta
Summary: This study conducted a systematic review and meta-analysis to evaluate the impact of recurrent pregnancy loss (RPL) on the risk of preterm birth (PTB) in subsequent pregnancies. The results showed that women with a history of RPL had significantly higher odds of delivering preterm infants in subsequent pregnancies, and the risk of PTB increased with the number of pregnancy losses.
FERTILITY AND STERILITY
(2022)
Review
Environmental Sciences
Kristen M. Rappazzo, Jennifer L. Nichols, R. Byron Rice, Thomas J. Luben
Summary: This systematic review summarized epidemiologic studies on the relationship between ozone exposure during early pregnancy and preterm birth. Results showed that increased ozone exposure during early pregnancy is associated with preterm birth across studies, with high heterogeneity observed in effect estimates for both exposure periods.
ENVIRONMENTAL RESEARCH
(2021)
Review
Environmental Sciences
Qi Zhong, Hui-li Liu, Hong Fu, Qin-shan Niu, Hua-bing Wu, Fen Huang
Summary: The evidence on the relationship between prenatal phthalates exposure and preterm birth is uncertain, with most associations not being statistically significant. Heterogeneity was mainly found in studies conducted in China and matrix collected at the first trimester of pregnancy. A multicenter cohort study with a consistent approach is recommended to unravel the complex associations of prenatal phthalates exposure with birth outcomes.
Review
Environmental Sciences
Zengli Yu, Xiaoan Zhang, Junxi Zhang, Yang Feng, Han Zhang, Zhongxiao Wan, Chenglong Xiao, Huanhuan Zhang, Qiong Wang, Cunrui Huang
Summary: This study reviewed the long-term and short-term effects of particulate matter exposure on preterm birth. The results showed that both long-term and short-term exposure to particulate matter increased the risk of preterm birth.
ENVIRONMENTAL RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
X. D. Yao, L. J. Zhu, J. Yin, J. Wen
Summary: The COVID-19 pandemic is associated with a decreased risk of preterm birth compared to the prepandemic period, although the reduction is only significant for very preterm birth.
Review
Nutrition & Dietetics
Ramon Serra, Reyna Penailillo, Lara J. Monteiro, Max Monckeberg, Macarena Pena, Lia Moyano, Camila Brunner, Georgina Vega, Mahesh Choolani, Sebastian E. Illanes
Summary: Supplementation with omega 3 fatty acids during pregnancy does not significantly reduce the risk of preterm birth or early preterm birth according to the results of this review. Further studies are needed to determine the impact of omega 3 supplementation during pregnancy on fetal outcomes.
Article
Multidisciplinary Sciences
Rachel K. Robinson, Kati Heinonen, Polina Girchenko, Marius Lahti-Pulkkinen, Eero Kajantie, Petteri Hovi, Aulikki Lano, Sture Andersson, Johan G. Eriksson, Dieter Wolke, Sakari Lemola, Katri Raikkonen
Summary: The study found that preterm and term born adults did not differ in optimism, but preterm individuals scored higher in pessimism. Additionally, preterm individuals with higher birth weight may have more optimistic life orientations.
Review
Pediatrics
Pauline E. van Beek, Peter Andriessen, Wes Onland, Ewoud Schuit
Summary: This study summarized prognostic models for predicting mortality in very preterm infants, assessing their quality and finding high risk of bias in the majority of models due to inadequate analysis. Internal validation was lacking in 41% of models and external validation in 96%. Meta-analyses showed good C-statistics for certain prediction scores.
Review
Nutrition & Dietetics
Mangesh Deshmukh, Sanjay Patole
Summary: Probiotics have been shown to reduce the risk of necrotizing enterocolitis, late onset sepsis, and all-cause mortality in preterm neonates. Implementing routine probiotic supplementation can significantly improve outcomes in these vulnerable infants.
ADVANCES IN NUTRITION
(2021)
Review
Immunology
Xian-Ling Cao, Xuan-You Zhou, Nai-Xin Xu, Song-Chang Chen, Chen-Ming Xu
Summary: This study conducted a systematic review and meta-analysis to investigate the relationship between IL-4 and IL-10 gene polymorphisms and preterm birth (PTB). The findings suggest that the over-dominant gene model AA + GG vs. AG of IL-10-1082A/G (rs1800896) polymorphism may be associated with genetic susceptibility to PTB and may have a protective function against PTB risk. However, no clear association was found between IL-4-590C/T (rs2243250), IL-10-592A/C (rs1800872), and IL-10-819T/C (rs1800871) polymorphisms and PTB. Further research is needed to confirm these findings due to the limitations of the included studies and the risk of publication bias.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pediatrics
Vincent D. Gaertner, Janine Thomann, Dirk Bassler, Christoph M. Ruegger
Summary: Surfactant nebulization (SN) shows promise as a safe alternative for administering surfactant to preterm infants with respiratory distress syndrome. SN significantly reduces the intubation rate at 72 hours post-birth, particularly in specific subgroups such as infants with gestational age >28 weeks, using a pneumatically driven nebulizer, and receiving >= 200 mg/kg animal-derived surfactant. No differences in neonatal morbidities or mortality were found between SN and standard care.
Review
Obstetrics & Gynecology
Liam McAuliffe, Ashad Issah, Rosanna Diacci, Kimberley. P. P. Williams, Anne-Marie Aubin, Jason Phung, Carol Wang, Alexander Maouris, Sebastian Leathersich, Panos Maouris, Craig. E. E. Pennell
Summary: This study compared the efficacy of the Shirodkar and McDonald cerclage techniques in preventing preterm birth. The results showed that the Shirodkar technique significantly reduced the rate of preterm birth before 37 weeks compared to the McDonald technique, with other positive effects as well. However, the overall quality of studies in this field is low, and further large, well-designed randomized controlled trials are needed to address this important question.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Acoustics
S. Ruiz-Martinez, J. L. Delgado, C. Paules, A. Cavallaro, C. De Paco, J. Villar, A. Papageorghiou, D. Oros
Summary: This study identified nine clinical phenotypes of small-for-gestational-age (SGA) fetuses that are associated with different patterns of adverse perinatal outcomes. The findings suggest that considering clinical characteristics in addition to ultrasound findings could improve risk stratification and decision-making for managing SGA fetuses.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Review
Acoustics
F. G. Sileo, J. Zollner, F. D'Antonio, S. Islam, A. T. Papageorghiou, A. Khalil
Summary: Fetuses with prenatal diagnosis of intracranial hemorrhage are at high risk of perinatal mortality and adverse neurodevelopmental outcomes, with around 28% needing postnatal shunt placement or surgery and approximately one-third being diagnosed with cerebral palsy. Despite some cases experiencing mild to severe neurodevelopmental delay, about half of the fetuses achieve normal neurodevelopmental outcomes.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Acoustics
J. Allotey, R. Whittle, K. I. E. Snell, M. Smuk, R. Townsend, P. von Dadelszen, A. E. P. Heazell, L. Magee, G. C. S. Smith, J. Sandall, B. Thilaganathan, J. Zamora, R. D. Riley, A. Khalil, S. Thangaratinam
Summary: This study externally validated published prediction models for stillbirth using individual participant data (IPD) meta-analysis. The results showed that these models had generally poor and uncertain predictive performance, with limited evidence to support their clinical application. The study highlighted methodological shortcomings in the development of these models and called for further research to validate and improve them.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Brenda Eskenazi, Stephen Rauch, Enrico Iurlaro, Robert B. Gunier, Albertina Rego, Michael G. Gravett, Paolo Ivo Cavoretto, Philippe Deruelle, Perla K. Garcia-May, Mohak Mhatre, Mustapha Ado Usman, Mohamed Elbahnasawy, Saturday Etuk, Raffaele Napolitano, Sonia Deantoni, Becky Liu, Federico Prefumo, Valeria Savasi, Patricia F. Marques, Eric Baafi, Ghulam Zainab, Ricardo Nieto, Berta Serrano, Muhammad Baffah Aminu, Jorge Arturo Cardona-Perez, Rachel Craik, Adele Winsey, Gabriela Tavchioska, Babagana Bako, Daniel Oros, Caroline Benski, Hadiza Galadanci, Monica Savorani, Manuela Oberto, Loic Sentilhes, Milagros Risso, Ken Takahashi, Carmen Vecciarelli, Satoru Ikenoue, Anil K. Pandey, Constanza P. Soto Conti, Irene Cetin, Vincent Bizor Nachinab, Ernawati Ernawati, Eduardo A. Duro, Alexey Kholin, Michelle L. Firlit, Sarah Rae Easter, Joanna Sichitiu, Yetunde John-Akinola, Roberto Casale, Hellas Cena, Josephine Agyeman-Duah, Paola Roggero, Ana Langer, Zulfiqar A. Bhutta, Stephen H. Kennedy, Jose Villar, Aris T. Papageorghiou
Summary: This study found that diabetes mellitus and overweight or obesity are risk factors for COVID-19 in pregnancy, and gestational diabetes mellitus is associated with the disease, especially among women requiring insulin. Therefore, women with these comorbidities should be vaccinated.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Letter
Obstetrics & Gynecology
Ana Sofia Cerdeira, Joe O'Sullivan, Eric O. Ohuma, Tim James, Aris T. Papageorghiou, Marian Knight, Manu Vatish
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Sam Ali, Michael G. Kawooya, Josaphat Byamugisha, Isaac M. Kakibogo, Esther A. Biira, Adia N. Kagimu, Diederick E. Grobbee, David Zakus, Aris T. Papageorghiou, Kerstin Klipstein-Grobusch, Marcus J. Rijken
Summary: This study investigated the prevalence of abnormal Doppler measurements in umbilical artery, uterine artery, middle cerebral artery, and cerebroplacental ratio in women receiving routine antenatal care in Uganda. The findings suggest that fetuses with cerebral blood flow redistribution are at higher risk of stillbirth and perinatal complications.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Neurosciences
Roberto Frenquelli, Marc Ratcliff, Jimena Villar de Onis, Michelle Fernandes, Fernando C. Barros, Jane E. Hirst, Aris T. Papageorghiou, Stephen H. Kennedy, Jose Villar
Summary: Complex perinatal syndromes have diverse contexts of complexity and interaction that determine the growth and development of individuals in the short and long term. Understanding these processes requires longitudinal, interdisciplinary research and integration into clinical practice.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Immunology
Cristiane de Freitas Paganoti, Rafaela Alkmin da Costa, Aris T. Papageorghiou, Fabricio da Silva Costa, Silvana Maria Quintana, Luciana Graziela de Godoi, Nataly Adriana Jimenez Monroy, Agatha Sacramento Rodrigues, Rossana Pulcineli Vieira Francisco
Summary: This study found that COVID-19 vaccination plays an important role in reducing the severity of COVID-19 infection among hospitalized pregnant and postpartum women, reducing the risk of intensive care unit admission, intubation, and death.
Article
Peripheral Vascular Disease
Wenlu Ye, Kyle Steenland, Ashlinn Quinn, Jiawen Liao, Kalpana Balakrishnan, Ghislaine Rosa, Florien Ndagijimana, Jean de Dieu Ntivuguruzwa, Lisa M. Thompson, John P. McCracken, Anaite Diaz-Artiga, Joshua P. Rosenthal, Aris Papageorghiou, Victor G. Davila-Roman, Ajay Pillarisetti, Michael Johnson, Jiantong Wang, Laura Nicolaou, William Checkley, Jennifer L. Peel, Thomas F. Clasen
Summary: Approximately 3 to 4 billion people worldwide are exposed to household air pollution, which has been associated with increased blood pressure (BP) in pregnant women in some studies. This study recruited 3195 pregnant women in four countries and found that using gas stoves did not significantly affect gestational blood pressure.
Editorial Material
Acoustics
M. Alsharid, L. Drukker, H. Sharma, J. A. Noble, A. T. Papageorghiou
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Acoustics
L. Drukker, H. Sharma, J. N. Karim, R. Droste, J. A. Noble, A. T. Papageorghiou
Summary: This study utilized deep-learning-based video analysis to investigate the clinical workflow of sonographers during second-trimester anomaly scans. The results revealed wide variation in the number and sequence of structures obtained during routine scans.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Health Care Sciences & Services
Angela Koech, Peris Muoga Musitia, Grace Mkanjala Mwashigadi, Mai-Lei Woo Kinshella, Marianne Vidler, Marleen Temmerman, Rachel Craik, Peter von Dadelszen, J. Alison Noble, Aris T. Papageorghiou
Summary: This study evaluates the feasibility and acceptability of the TraCer device in an appropriate setting and finds that it is highly acceptable to pregnant women, their families, and health care workers. Its introduction is predicted to reduce anxiety, increase antenatal care attendance, and save time and cost. However, some participants express hesitancy and suggest the need for further testing.
JMIR HUMAN FACTORS
(2022)
Article
Obstetrics & Gynecology
E. Kalafat, B. Liu, I. Barratt, R. Bhate, A. Papageorghiou, A. Khalil
Summary: This study investigated the perinatal outcomes of dichorionic twin pregnancies complicated by selective fetal growth restriction (sFGR). The umbilical artery Z-scores were found to be associated with both intrauterine death and adverse perinatal outcomes.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Diego F. Wyszynski, Aris T. Papageorghiou, Cheryl Renz, Torri D. Metz, Sonia Hernandez-Diaz
Summary: This study aims to assess the relative risk of obstetric, neonatal, and infant outcomes associated with the use of drugs specifically indicated for COVID-19 treatment compared with other drug treatment strategies. The COVID-PR is a noninterventional, postmarketing cohort study designed to evaluate the safety profile of each studied drug and its potential effects on neonatal outcomes.
Article
Engineering, Biomedical
Bing Zhang, Yang Wang, Caifu Ding, Ziqing Deng, Linwei Li, Zesheng Qin, Zhao Ding, Lifeng Bian, Chen Yang
Summary: Medical image segmentation is crucial in diagnostic and clinical research. This article proposes a Multi-Scale Feature Pyramid Fusion Network (MS-Net) that combines Multi-Scale Attention Module (MSAM) and Stacked Feature Pyramid Module (SFPM) to improve the accuracy of segmentation. Experimental results show that the proposed MS-Net achieves better segmentation results on different datasets.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2023)