Article
Reproductive Biology
D. V. Bonato, E. B. Ferreira, D. N. Gomes, F. G. C. Bonato, R. G. Droher, F. Morotti, M. M. Seneda
Summary: Two experiments were conducted in high milk-producing Holstein cows to evaluate the repeatability of antral follicle count (AFC) during ovulation synchronization protocol and investigate the follicular dynamics and Doppler ultrasonography. The results showed that AFC has high repeatability and cows with low AFC exhibited larger preovulatory follicles, greater perfusion in corpus luteum, and higher progesterone levels.
Article
Biochemistry & Molecular Biology
Magdalena Szymanska, Ketan Shrestha, Eliezer Girsh, Avi Harlev, Iris Eisenberg, Tal Imbar, Rina Meidan
Summary: Granulosa-lutein cells (GLCs) from PCOS women exhibit reduced levels of HIF-1 alpha and EDN2, with microRNA-210 playing a key role in regulating this process. The disrupted hypoxic response in the GLCs of periovulatory follicles in PCOS may contribute to ovulation failure and reduced fertility in this syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Reproductive Biology
R. Nunez Favre, M. F. Garcia, M. H. Ratto, R. Rearte, M. C. Stornelli, R. L. de la Sota, M. A. Stornelli
Summary: The study found that subcutaneous administration of cat seminal plasma induced ovulation in queens, and purified llama beta-NGF showed some ovulation-inducing effect in a small percentage of individuals. These findings improve the understanding of queen's reproductive physiology and offer a potential physiological alternative for inducing ovulation in queens.
Article
Reproductive Biology
Rafael Aragunde Vieytes, Carolina Vinoles Gil, Gustavo D. A. Gastal, Daniel Cavestany
Summary: This study aimed to assess the effect of administering eCG on Day 5 or 7 of a fixed-time artificial insemination protocol in anestrous suckled beef cows. The results showed that administering eCG on Day 5 accelerated ovulation of a larger follicle, resulting in a larger corpus luteum and higher progesterone concentrations, and significantly improved the conception rate.
Article
Agriculture, Dairy & Animal Science
Bartlomiej Maria Jaskowski, Hartwig Bostedt, Marek Gehrke, Jedrzej Maria Jaskowski
Summary: The study shows that recipients with a cavitary corpus luteum have higher progesterone levels and pregnancy rates during embryo transfer. Therefore, the presence of a cavity inside the corpus luteum should not be a reason to exclude recipients from embryo transfer.
Review
Agriculture, Dairy & Animal Science
Massimo Zerani, Angela Polisca, Cristiano Boiti, Margherita Maranesi
Summary: Corpora lutea are temporary endocrine structures that secrete progesterone, essential for a healthy pregnancy. Research using the pseudopregnant rabbit model has shed light on the multifactorial mechanisms regulating CL lifespan, providing valuable insights for overcoming reproductive challenges in mammalian species.
Article
Veterinary Sciences
Ludimila Cardoso Zoccal Janini, Maria Isabela Azeredo Silva, Guilherme Rizzoto, Carlos Eduardo Fonseca-Alves, Beatriz Lippe de Camillo, Viviana Helena Vallejo Aristizabal, Natalia Felix Negreiros, Luiz Fernando Cintra Corona, Eduardo Hara, Victor Hugo Mendonca, Heitor Vinicius Mendonca, Rafael Silva Cipriano
Summary: Prostaglandin F-2 alpha (PGF(2 alpha)) is commonly used to manipulate the oestrous cycle in mares, but it has adverse side effects. Acupuncture has been studied as an alternative to reduce the PGF(2 alpha) dose. This study analyzed the reproductive performance of mares receiving different doses at the Bai Hui acupoint and found that both 5mg and 2.5mg doses were viable alternatives to intramuscular administration.
EQUINE VETERINARY EDUCATION
(2023)
Article
Cell Biology
Yong Shi, Yanjie Guo, Jiayi Zhou, Guanshen Cui, Jung-Chien Cheng, Ying Wu, Yong-Liang Zhao, Lanlan Fang, Xiao Han, Yun-Gui Yang, Yingpu Sun
Summary: We profiled the transcriptomic atlas of developing rat ovaries using scRNA-seq and spatial transcriptomic sequencing, revealing four components of developing granulosa cells and their differential transcriptional regulatory networks. We identified new growth signals from oocytes to cumulus cells and observed three cumulus sequential phases during follicle development. This study provides a new research dimension for temporal and spatial analysis of ovary development and valuable data resources for understanding the mechanisms of mammalian ovary development.
CELL PROLIFERATION
(2023)
Article
Medicine, General & Internal
Raquel Silveira da Cunha Araujo, Sabina Bastos Maia, Juliane Dornelas Lucio, Moises Diogo de Lima, Helizabet Salomao Abdalla Ayroza Ribeiro, Paulo Augusto Ayroza Galvao Ribeiro
Summary: In patients with unilateral ovarian endometriomas, the lateral compartment was the most affected, with dense adhesions around the left ovarian fossa being common. Left-sided ovarian endometriomas were more prevalent, and the posterior and anterior compartments also showed frequent lesions.
Article
Agriculture, Dairy & Animal Science
S. G. Umana Sedo, C. C. Figueiredo, T. D. Gonzalez, G. A. Duarte, M. B. Ugarte Marin, C. A. Crawford, K. G. Pohler, R. C. Chebel, T. R. Bilby, R. S. Bisinotto
Summary: The objective of this study was to evaluate the effects of two analogs of PGF(2 alpha), cloprostenol and dinoprost, as well as the effects of one injection versus two injections on luteolysis, follicle diameter, hormonal concentrations, and time to ovulation in dairy heifers. The results showed that cloprostenol induced luteolysis faster compared to dinoprost, but treatment did not affect the time to ovulation.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Veterinary Sciences
Ilaria Colombo, Giorgia Podico, Alba Rudolf -Vegas, Stefan Bauersachs, Igor F. Canisso
Summary: The aim of this study was to determine the progesterone concentration and luteal tissue area in non-pregnant mares, pregnant mares, and mares that failed to conceive. The results showed that there was no significant difference in progesterone concentration and luteal tissue area between pregnant and non-pregnant mares.
JOURNAL OF EQUINE VETERINARY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Cecily Bishop, Vimal Selvaraj, David H. Townson, Joy L. Pate, Milo C. Wiltbank
Summary: The corpus luteum (CL) forms from the cellular remnants of the follicle and produces progesterone required for successful pregnancy. The CL and the embryo have a symbiotic relationship, both relying on each other for survival. The Northeast Multistate Project has contributed to our understanding of the regulation and function of the CL in cattle, providing valuable insights for improving fertility.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Patricio Ponce-Barajas, Marcos G. Colazo, Amir Behrouzi, Todd O. Ree, John P. Kastelic, Divakar J. Ambrose
Summary: Poor reproductive efficiency in dairy cows is common due to low estrus detection, suboptimal fertility, and high embryonic losses. Synchronized ovulation protocols eliminate estrus detection and enable timed insemination. Using porcine luteinizing hormone to synchronize ovulation significantly increased pregnancy per artificial insemination and altered intrafollicular protein milieu without affecting blood progesterone concentrations in cows.
Article
Agriculture, Dairy & Animal Science
Maria Camila Lopez-Duarte, Camila Londono, Sergio Lasso, Daniella Heredia, Morgan Brown, Nicolas DiLorenzo, Ky Pohler, Angela Gonella
Summary: During cell death, DNA is fragmented and enters the bloodstream as cell-free DNA (cfDNA). We hypothesized that cfDNA concentrations would increase when inducing luteolysis through the use of a prostaglandin F-2α (PGF2α) analog. The results showed a significant increase in cfDNA concentrations after luteolysis induction, indicating that cfDNA could be used as a biomarker for luteolysis in plasma.
REPRODUCTION IN DOMESTIC ANIMALS
(2023)
Article
Food Science & Technology
Dainan Yu, Xun Jiang, Wenjing Ge, Bo Qiao, Dalei Zhang, Hui Liu, Haibin Kuang
Summary: This study found that acrylamide exposure during early- and mid-pregnancy had negative effects on luteal function, including decreased levels of serum progesterone and estradiol, reduced numbers and relative areas of ovarian corpora lutea, dysregulation of ovarian angiogenesis, increased oxidative stress, and induced apoptosis of ovarian cells.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Genetics & Heredity
Paola Vigano, Marco Reschini, Marta Ciaffaglione, Veronica Cuce, Maira Casalechi, Laura Benaglia, Paolo Vercellini, Edgardo Somigliana
Summary: This study aimed to compare the factors underlying infertility in women with endometriosis. The results showed that there were no significant differences in fertilization rate, embryo quality, and clinical pregnancy rate between women with and without endometriosis. Therefore, conventional IVF can still be used in endometriosis patients unless there is a male factor involved.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Environmental Sciences
Lidia Caporossi, Paola Vigano, Enrico Paci, Silvia Capanna, Alessandra Alteri, Daniela Pigini, Giovanna Tranfo, Bruno Papaleo
Summary: Male infertility is a significant public health concern, and the potential link between exposure to plasticizers like phthalates and bisphenol A and this condition is a topic of debate. A study was conducted with 155 infertility cases and 211 controls to investigate this issue. The results showed higher urinary concentrations of phthalates in cases compared to controls, but no significant difference in BPA levels. However, no clear quantitative correlation between specific plasticizers and sperm parameters was identified, calling for further research on the risks associated with exposure to these chemicals.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Review
Obstetrics & Gynecology
Edgardo Somigliana, Fabio Parazzini, Alice Goisis, Giovanna Esposito, Letizia Li Piani, Francesca Filippi, Paola Vigano
Summary: The article calls for more research on infertile couples to understand their intended number of children and the rate of return after the first IVF treatment. This could potentially impact clinical practice by improving chances of conceiving a second child and identifying barriers to non-return or a gap between intended and realized number of children. However, the current evidence is insufficient to recommend any interventions.
HUMAN REPRODUCTION
(2023)
Article
Oncology
Luca Giannella, Giovanni Delli Carpini, Jacopo Di Giuseppe, Giorgio Bogani, Francesco Sopracordevole, Nicolo Clemente, Giorgio Giorda, Rosa Pasqualina De Vincenzo, Maria Teresa Evangelista, Barbara Gardella, Mattia Dominoni, Ermelinda Monti, Chiara Alessi, Lara Alessandrini, Alessio Pagan, Marta Caretto, Alessandro Ghelardi, Andrea Amadori, Massimo Origoni, Maggiorino Barbero, Francesco Raspagliesi, Tommaso Simoncini, Paolo Vercellini, Giovanni Scambia, Andrea Ciavattini
Summary: This study examined the impact of HPV status on the prognosis of early stage cervical glandular lesions. The results showed that HPV status did not affect the recurrence rate, but most adenocarcinomas were positive for high-risk HPV.
Editorial Material
Biochemistry & Molecular Biology
Paola Vigano, Maira Casalechi, Paolo Vercellini, Edgardo Somigliana
Article
Obstetrics & Gynecology
Giovanna Esposito, Fabio Parazzini, Paola Vigano, Matteo Franchi, Sonia Cipriani, Francesco Fedele, Giovanni Corrao, Edgardo Somigliana
Summary: Limited evidence exists on the role of medically assisted reproduction (MAR) in achieving desired family size. This study aimed to assess the probability and mode of conception of a second live birth based on the mode of conception of the first child. The findings showed that women who used MAR for their first child were more likely to use MAR again for a second child.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Review
Obstetrics & Gynecology
Giulia Emily Cetera, Camilla Erminia Maria Merli, Giussy Barbara, Carlotta Caia, Paolo Vercellini
Summary: This review aims to identify central sensitization questionnaires used in clinical endometriosis studies and analyze the strengths and weaknesses of each questionnaire. The Central Sensitization Inventory (CSI) is the most frequently used questionnaire, validated in patients with endometriosis. However, there is ongoing debate about the construct validity of these questionnaires and the need for a gold standard diagnostic tool for central sensitization.
REPRODUCTIVE SCIENCES
(2023)
Review
Public, Environmental & Occupational Health
Giulia Emily Cetera, Camilla Erminia Maria Merli, Federica Facchin, Paola Vigano, Elisa Pesce, Francesca Caprara, Paolo Vercellini
Summary: Approximately 25-33% of women with endometriosis do not have an adequate response to first-line hormonal treatment for resolution of painful symptoms. The concept of progesterone resistance has been proposed but is controversial. A broader perspective of endometriosis is emerging, questioning whether the lack of response is due to altered signaling pathways or other pain contributors.
Article
Obstetrics & Gynecology
Alessandra Chine, Marco Reschini, Gianfranco Fornelli, Ludovica Basili, Andrea Busnelli, Paola Vigano, Ludovico Muzii, Edgardo Somigliana
Summary: Low ovarian reserve, indicated by anti-Mullerian hormone (AMH) or antral follicle count (AFC), does not increase the risk of miscarriage in young women conceiving with ART.
HUMAN REPRODUCTION OPEN
(2023)
Review
Obstetrics & Gynecology
Paolo Vercellini, Veronica Bandini, Laura Buggio, Giussy Barbara, Nicola Berlanda, Dhouha Dridi, Maria Pina Frattaruolo, Edgardo Somigliana
Summary: This study aimed to investigate a cost-saving measure for the treatment of endometriosis by using a non-standard dosing regimen of a 3.75 mg depot formulation of triptorelin. The extended-interval dosing regimen, with injections every 6 weeks instead of every 4 weeks, reduced the cost by one-third without compromising pain relief.
HUMAN REPRODUCTION OPEN
(2023)
Article
Obstetrics & Gynecology
Paolo Vercellini, Veronica Bandini, Paola Vigano, Giorgia Di Stefano, Camilla Erminia Maria Merli, Edgardo Somigliana
Summary: Repetitive ovulation and menstruation provided an advantage in the Palaeolithic era, but societal changes have created a mismatch between genetic adaptation and environment, leading to an increased risk of estrogen-related diseases.
HUMAN REPRODUCTION
(2023)
Review
Obstetrics & Gynecology
Paolo Vercellini, Veronica Bandini, Paola Vigano, Deborah Ambruoso, Giulia Emily Cetera, Edgardo Somigliana
Summary: According to epidemiological data, the incidence of endometriosis increases rapidly around the age of 25. The delay in diagnosis is usually between 5 and 8 years in adult women and over 10 years in adolescents. Ovulation and menstruation, which are inflammatory events, may contribute to the early development of endometriosis and adenomyosis. Therefore, secondary prevention targeting severely symptomatic adolescents is crucial for reducing suffering, limiting lesion progression, and preserving future reproductive potential.
HUMAN REPRODUCTION
(2023)
