Article
Radiology, Nuclear Medicine & Medical Imaging
Zungho Zun, Kushal Kapse, Marni Jacobs, Sudeepta Basu, Mariam Said, Nicole Andersen, Jonathan Murnick, Taeun Chang, Adre du Plessis, Catherine Limperopoulos
Summary: This study longitudinally assessed cerebral blood flow in very preterm infants during the ex utero third trimester, showing significant increases in all regions with advancing postmenstrual age, particularly in the cerebellum. Lower CBF was associated with intraventricular hemorrhage and medically managed patent ductus arteriosus in preterm infants.
Article
Medicine, General & Internal
Teresa Janevic, Kimberly B. Glazer, Luciana Vieira, Ellerie Weber, Joanne Stone, Toni Stern, Angela Bianco, Brian Wagner, Siobhan M. Dolan, Elizabeth A. Howell
Summary: This study found no evidence for increased racial/ethnic disparities in preterm birth in New York City during the early stages of the COVID-19 pandemic, regardless of whether women tested positive or negative for SARS-CoV-2.
Article
Pediatrics
Dustin D. Flannery, Erika M. Edwards, Karen M. Puopolo, Jeffrey D. Horbar
Summary: This study investigated the epidemiology and microbiology of early-onset sepsis (EOS) among very preterm infants from 2018 to 2019. The findings revealed an incidence rate of 13.5 per 1000 very preterm births, with Escherichia coli and group B Streptococcus being the most common pathogens. Infected infants had longer hospital stays and lower survival rates, emphasizing the need for novel preventive strategies.
Article
Clinical Neurology
Xi Chen, Xiaoli Zhang, Wenhua Li, Wendong Li, Yong Wang, Shan Zhang, Changlian Zhu
Summary: Preterm births with different etiologies are associated with varying neonatal complications, but no differences in neurodevelopmental outcomes were observed at 12 months of corrected age.
FRONTIERS IN NEUROLOGY
(2021)
Article
Pediatrics
Dustin D. Flannery, Erika M. Edwards, Sarah A. Coggins, Jeffrey D. Horbar, Karen M. Puopolo
Summary: This study examines the epidemiology, microbiology, and outcomes of late-onset sepsis among very preterm infants in the United States. The findings reveal a significant proportion of infants suffering from late-onset sepsis, particularly those born at the lowest gestational ages. Infected infants have higher mortality rates and survivors are at increased risk of technology-dependent chronic morbidities.
Article
Medicine, General & Internal
Charlotte Greer, Sarah L. Harris, Richard Troughton, Philip D. Adamson, John Horwood, Chris Frampton, Brian A. Darlow
Summary: Being born preterm and at very low birth weight is associated with increased cardiopulmonary disorders in childhood and potential late cardiac effects, including right ventricular remodeling and occult pulmonary hypertension as survivors age. In a population-based study, young adults born PT at VLBW exhibited smaller RV dimensions compared to normal-weight term-born controls, with slightly reduced RV function detected using strain imaging. Birth weight and gestational age were related to these differences, highlighting the potential importance of echocardiographic strain imaging in detecting RV function disparities in this population.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Matthias W. Wagner, Delvin So, Ting Guo, Lauren Erdman, Min Sheng, S. Ufkes, Ruth E. Grunau, Anne Synnes, Helen M. Branson, Vann Chau, Manohar M. Shroff, Birgit B. Ertl-Wagner, Steven P. Miller
Summary: This study aims to predict adverse neurodevelopmental outcomes in very preterm neonates. By using brain MRI and extracting radiomic features, it was found that radiomic features outperformed clinical variables in predicting motor outcomes, and combining the two improved predictive performance.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Avinash S. Patil, Chad A. Grotegut, Nilesh W. Gaikwad, Shelley D. Dowden, David M. Haas
Summary: Plasma levels of DOC and 16 alpha-OHP in early gestation, combined with patient demographic and clinical data, can predict significant neonatal morbidity, neonatal length of stay, and the risk for very preterm delivery. Validation studies are needed to confirm these findings. Early identification of pregnancies at risk for preterm delivery and neonatal morbidity can lead to timely multidisciplinary care and improved perinatal outcomes.
Article
Pediatrics
Raimund Pechlaner, Anna Posod, Xiaoke Yin, Sean Anthony Burnap, Sophia Julia Kiechl, Manuel Mayr, Stefan Kiechl, Ursula Kiechl-Kohlendorfer
Summary: The study found that very preterm-born preschoolers have reduced levels of platelet activation markers, potentially persisting up to preschool age. Further research is needed to explore the clinical implications of these findings.
PEDIATRIC RESEARCH
(2021)
Article
Multidisciplinary Sciences
Mareike Grotheer, David Bloom, John Kruper, Adam Richie-Halford, Stephanie Zika, Vicente A. Aguilera Gonzalez, Jason D. Yeatman, Kalanit Grill-Spector, Ariel Rokem
Summary: The study evaluated a cross-sectional sample of newborns and found that white matter myelin grows faster before birth than after birth. The delayed myelin growth in preterm infants can be explained by the time they spent developing in utero and ex utero. These results suggest that myelinates faster in utero than ex utero, which may explain the lower myelin content and long-term developmental consequences in individuals born preterm.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Obstetrics & Gynecology
Diane Korb, Francois Goffinet, Loic Sentilhes, Gilles Kayem, Marie Victoire Senat, Elie Azria, Thomas Schmitz
Summary: This study assessed the survival of very preterm twins to discharge without severe neonatal morbidity based on the planned mode of delivery. The results showed that planned cesarean delivery was not associated with higher survival rates compared to planned vaginal delivery. This suggests that very preterm delivery should not automatically be an indication for planned cesarean in twin pregnancies.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Pediatrics
Mathilde Letouzey, Laurence Foix-L'Helias, Heloise Torchin, Ayoub Mitha, Andrei S. Morgan, Jennifer Zeitlin, Gilles Kayem, Emeline Maisonneuve, Pierre Delorme, Babak Khoshnood, Monique Kaminski, Pierre-Yves Ancel, Pascal Boileau, Elsa Lorthe
Summary: The study found that the risk of late-onset sepsis in very preterm infants differs according to the cause of preterm birth, with infants born after hypertensive disorders or fetal growth restriction having a higher risk compared to those born after preterm labor. Antenatal factors, particularly the various causes leading to preterm birth, should be considered to better prevent and manage neonatal infectious morbidity and inform parents.
PEDIATRIC RESEARCH
(2021)
Review
Medicine, General & Internal
Sahar Sharif, Sam J. Oddie, Paul T. Heath, William McGuire
Summary: This review aims to evaluate the effectiveness of enteral supplementation with prebiotic oligosaccharides on the risk of necrotising enterocolitis, and associated morbidity and mortality, in very preterm or very low birth weight infants.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Environmental Sciences
Jie Wang, Xiucui Luo, Jing Pan, Xiaoyan Dong, Xiujuan Tian, Zhihua Tu, Weina Ju, Meijiao Zhang, Mei Zhong, Charles De Chen, Michael Flory, Yong Wang, W. Ted Brown, Nanbert Zhong
Summary: Spontaneous preterm birth is a syndrome with clinical and genetic heterogeneity, with genetic and epigenetic defects associated with premature uterine contractions being the focus of this study. Through a multiomic approach, genetic variations in the TTN gene and transcriptomic variations in genes related to uterine muscle contraction were identified as being closely associated with premature uterine contractions in spontaneous preterm birth.
ENVIRONMENT INTERNATIONAL
(2021)
Review
Pediatrics
Megan Dibble, Jin Zhe Ang, Liam Mariga, Eleanor J. Molloy, Arun L. W. Bokde
Summary: White matter abnormalities, as measured by diffusion tensor imaging, are more significant in very preterm infants compared to moderate-late preterm infants and full-term controls at term-equivalent age. These microstructural changes may contribute to the increased risk of neurodevelopmental disability in preterm infants later in life, making diffusion tensor imaging a potentially useful prognostic tool.
JOURNAL OF PEDIATRICS
(2021)
Article
Health Care Sciences & Services
Sung Wook Kim, Lazaros Andronis, Anna-Veera Seppanen, Adrien M. Aubert, Henrique Barros, Elizabeth S. Draper, Mariane Sentenac, Jennifer Zeitlin, Stavros Petrou
Summary: This study aims to describe the health-related quality of life outcomes of children born very preterm and extremely preterm at five years of age, and explores the mediation effects of bronchopulmonary dysplasia and severe non-respiratory neonatal morbidity on those outcomes. The results suggest that extremely preterm birth and complications such as bronchopulmonary dysplasia and severe non-respiratory morbidity significantly impair health-related quality of life.
QUALITY OF LIFE RESEARCH
(2023)
Article
Urology & Nephrology
Chandana Guha, Anita van Zwieten, Rabia Khalid, Siah Kim, Amanda Walker, Anna Francis, Madeleine Didsbury, Armando Teixeira-Pinto, Belinda Barton, Chanel Prestidge, Emily Lancsar, Fiona Mackie, Joseph Kwon, Kirsten Howard, Kylie-Ann Mallitt, Martin Howell, Allison Jaure, Alison Hayes, Rakhee Raghunandan, Stavros Petrou, Suncica Lah, Steven McTaggart, Jonathan C. Craig, Germaine Wong
Summary: This multi-center longitudinal cohort study aimed to assess the trajectories of health-related quality of life (HRQoL) in children with chronic kidney disease (CKD) over time. The results showed that the HRQoL scores differed between children with different CKD stages, and the transition from dialysis to transplantation was significantly associated with the improvement in HRQoL. Children with CKD stage 1-5 and transplant recipients at baseline had stable HRQoL over time.
KIDNEY INTERNATIONAL
(2023)
Article
Economics
Corneliu Bolbocean, Sylvia van der Pal, Stef van Buuren, Peter J. Anderson, Peter Bartmann, Nicole Baumann, Jeanie L. Y. Cheong, Brian A. Darlow, Lex W. Doyle, Kari Anne Evensen, John Horwood, Marit S. Indredavik, Samantha Johnson, Neil Marlow, Marina Mendonca, Yanyan Ni, Dieter Wolke, Lianne Woodward, Erik Verrips, Stavros Petrou
Summary: This study aims to examine the associations between VP/VLBW status and preference-based health-related quality-of-life outcomes in early adulthood. The results showed that VP/VLBW status is associated with lower overall health-related quality of life, particularly in terms of physical and cognitive functioning. Further studies are needed to estimate the effects of VP/VLBW status on health-related quality-of-life outcomes in mid and late adulthood.
Article
Obstetrics & Gynecology
Melissa Amyx, Jennifer Zeitlin, Beatrice Blondel, Camille Le Ray
Summary: This study aimed to evaluate the association between gestational weight gain (GWG) and intrapartum obstetric interventions (oxytocin administration and cesarean section). The study found that excessive GWG was associated with oxytocin use and cesarean section, while inadequate GWG was also associated with oxytocin use. This suggests that maintaining a healthy GWG is important for normal labor progression.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Obstetrics & Gynecology
Anne Ego, Isabelle Monier, Antoine Vilotitch, Gilles Kayem, Christophe Vayssiere, Eric Verspyck, Jennifer Zeitlin
Summary: Standardised longitudinal reporting of growth monitoring information did not improve antenatal detection of infants who are small for gestational age (SGA) compared to usual care.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Mariane Sentenac, Sabrina Twilhaar, Valerie Benhammou, Andrei S. S. Morgan, Samantha Johnson, Anna Chaimani, Jennifer Zeitlin
Summary: Meta-analyses of studies on the impact of very preterm birth on cognition found a marked IQ deficit among VPT children compared to term-born peers, but with unexplained heterogeneity in effect size. An umbrella review was conducted to examine the design and methodology of primary studies, revealing that methodological heterogeneity mainly influenced the choice of cognitive test used.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Editorial Material
Public, Environmental & Occupational Health
Jennifer Zeitlin
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Orthopedics
S. Petrou, M. E. Png, D. Metcalfe
Summary: Economic evaluation provides a framework for assessing costs and consequences of alternative interventions, and decision-analytic models are commonly used in healthcare for this purpose. This article discusses key issues in interpreting evidence from decision-analytic modeling-based economic evaluations of orthopedic interventions, providing guidance for readers, reviewers, and decision-makers.
BONE & JOINT JOURNAL
(2023)
Article
Pediatrics
Rym El Rafei, Rolf Felix Maier, Pierre Henri Jarreau, Mikael Norman, Henrique Barros, Patrick Van Reempts, Arno Van Heijst, Pernille Pedersen, Marina Cuttini, Samantha Johnson, Raquel Costa, Michael Zemlin, Elizabeth S. Draper, Jennifer Zeitlin
Summary: This study aimed to investigate whether extrauterine growth restriction (EUGR) during neonatal hospitalisation in extremely preterm infants is associated with cerebral palsy (CP) and cognitive and motor abilities at 5 years of age. The findings suggested that severe EUGR among extremely preterm infants was associated with decreased IQ at 5 years of age.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Pediatrics
Xinyang Hua, Stavros Petrou, Victoria Coathup, Claire Carson, Jennifer J. Kurinczuk, Maria A. Quigley, Elaine Boyle, Samantha Johnson, Alison Macfarlane, Oliver Rivero-Arias
Summary: This study aimed to investigate the association between gestational age at birth and hospital admission costs from birth to 8 years of age. The study found that both birth admission and subsequent admission hospital costs decreased with increasing gestational age at birth. Differences in hospital admission costs between gestational age groups diminished with increasing age, particularly after the first 2 years following birth. Extremely preterm and very preterm children still had higher average hospital admission costs during the eighth year of life compared with children born at 40 weeks. Extremely preterm children had the highest 8-year cumulative hospital admission costs per child.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Obstetrics & Gynecology
Olivia Anselem, Francois Goffinet, Pierre-Henri Jarreau, Jennifer Zeitlin, Isabelle Monier
Summary: This study in France investigated the management and survival of very preterm singletons born because of fetal growth restriction (FGR) with or without maternal hypertensive disorders. The results showed that the proportion of terminations of pregnancy (TOP) was higher when FGR was associated with hypertensive disorders, while the proportion of stillbirths was higher in isolated FGR.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Article
Obstetrics & Gynecology
Victoire Pauphilet, Francois Goffinet, Diane Korb, Jennifer Zeitlin, Heloise Torchin, Thomas Schmitz
Summary: This study evaluated the rate of mother-child separation in twin pregnancies delivered in maternity units offering an appropriate level of neonatal care. The study found that the rate of mother-child separation was 2.1%, and it differed by level of care in the maternity units.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Cell Biology
Aicha Sassi, Maxime Fredon, Alexia K. Cotte, Camille Fuselier, Christophe Schneider, Laurent Martiny, David Monchaud, Leila Chekir-Ghedira, Virginie Aires, Dominique Delmas
Summary: Despite progress in treatments, melanoma incidence and mortality have increased. Chrysin, a natural polyphenol, shows potential as a therapeutic strategy due to its modulation of tumorigenesis and resistance mechanisms. This study reveals a link between chrysin-induced antitumoral effects, DNA damage pathway activation, and reduced angiogenesis in melanoma cells. The disruption of key protein actors in tumor growth by chrysin suggests its potential as a new therapeutic strategy in melanoma treatment.
Article
Clinical Neurology
May Ee Png, Matthew L. Costa, Stavros Petrou, Juul Achten, Ruth Knight, Julie Bruce, David J. Keene
Summary: This study estimates the financial cost and pain medication use associated with neuropathic pain after lower limb fracture surgery. It found that healthcare costs were higher among patients with chronic neuropathic pain and opioids, rather than neuropathic pain medications, were commonly prescribed contrary to clinical guidelines.
BRITISH JOURNAL OF PAIN
(2023)
Editorial Material
Public, Environmental & Occupational Health
Alice Hocquette, Jennifer Zeitlin
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)