期刊
BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS
卷 99, 期 3, 页码 160-169出版社
WILEY
DOI: 10.1002/bdrc.21039
关键词
cardiac progenitors; cardiac tissue engineering; heart regeneration; zebrafish; mouse
资金
- National Basic Research Program of China [2010CB529503, 2012CB944501]
- Natural Science Foundation of China [31271549, 31221002]
Although cardiac stem cells (CSCs) and tissue engineering are very promising for cardiac regenerative medicine, studies with model organisms for heart regeneration will provide alternative therapeutic targets and opportunities. Here, we present a review on heart regeneration, with a particular focus on the most recent work in mouse and zebrafish. We attempt to summarize the recent progresses and bottlenecks of CSCs and tissue engineering for heart regeneration; and emphasize what we have learned from mouse and zebrafish regenerative models on discovering crucial genetic and epigenetic factors for stimulating heart regeneration; and speculate the potential application of these regenerative factors for heart failure. A brief perspective highlights several important and promising research directions in this exciting field. Birth Defects Research (Part C) 99:160-169, 2013. (c) 2013 Wiley Periodicals, Inc.
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