期刊
BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS
卷 96, 期 4, 页码 325-333出版社
WILEY-BLACKWELL
DOI: 10.1002/bdrc.21024
关键词
fetal wounds; fibrosis; ECM; CXCR3
资金
- National Institute of General Medical Science of the National Institutes of Health (USA) [GM063569]
- NIH/NIGM-FASEB-MARC
The adverse physiological and psychological effects of scars formation after healing of wounds are broad and a major medical problem for patients. In utero, fetal wounds heal in a regenerative manner, though the mechanisms are unknown. Differences in fetal scarless regeneration and adult repair can provide key insight into reduction of scarring therapy. Understanding the cellular and extracellular matrix alterations in excessive adult scarring in comparison to fetal scarless healing may have important implications. Herein, we propose that matrix can be controlled via cellular therapy to resemble a fetal-like matrix that will result in reduced scarring. Birth Defects Research (Part C) 96:325333, 2012. (C) 2013 Wiley Periodicals, Inc.
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