期刊
BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS
卷 96, 期 2, 页码 109-120出版社
WILEY
DOI: 10.1002/bdrc.21012
关键词
digital atlases; embryo development; image processing; in toto microscopy imaging
资金
- Spanish Ministry of Science and Innovation [TEC2010-21619-C04-03, TEC2011-28972-C02-02]
- CDTI-CENIT (AMIT)
- INNPACTO (PRECISION)
- Comunidad de Madrid (ARTEMIS)
- French Program ANR
- French Program ARC
- European Regional Development Funds (FEDER)
- FP6 New Emerging Science and Technology EC Program
- FP7 Health program
Digital atlases of animal development provide a quantitative description of morphogenesis, opening the path toward processes modeling. Prototypic atlases offer a data integration framework where to gather information from cohorts of individuals with phenotypic variability. Relevant information for further theoretical reconstruction includes measurements in time and space for cell behaviors and gene expression. The latter as well as data integration in a prototypic model, rely on image processing strategies. Developing the tools to integrate and analyze biological multidimensional data are highly relevant for assessing chemical toxicity or performing drugs preclinical testing. This article surveys some of the most prominent efforts to assemble these prototypes, categorizes them according to salient criteria and discusses the key questions in the field and the future challenges toward the reconstruction of multiscale dynamics in model organisms. Birth Defects Research (Part C) 96:109120, 2012. (c) 2012 Wiley Periodicals, Inc.
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