Article
Multidisciplinary Sciences
Matthew de Gannes, Sheryl E. Koch, Alvaro Puga, Jack Rubinstein
Summary: Congenital heart disease is the most common congenital abnormality, likely caused by interactions between genetic and environmental factors during heart development. Exposure to toxins early in life may have adverse effects on cardiac function, while continuous exposure to TCDD from fertilization throughout adulthood may lead to different responses in male and female mice.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Heiko Bugger, Nikole J. Byrne, E. Dale Abel
Summary: This article examines the regulation of metabolic pathways in the heart and their role in maintaining myocardial function. It highlights the importance of animal models in studying these pathways.
CIRCULATION RESEARCH
(2022)
Review
Cell Biology
Kavitha S. Rao, Vasumathi Kameswaran, Benoit G. Bruneau
Summary: Congenital heart defects are common birth defects with unknown causes. Recent development of experimental models, including mouse models and human cellular models, have helped to enhance our understanding of the molecular basis of these defects. The development of cardiac organoids also shows promise in creating more anatomically informative human models of congenital heart defects.
GENES & DEVELOPMENT
(2022)
Review
Pharmacology & Pharmacy
Julie Kessler, Perle Totoson, Sylvie Devaux, Johnny Moretto, Daniel Wendling, Celine Demougeot
Summary: Research on animal models of rheumatoid arthritis can help understand the complex link between arthritis and the heart, and identify new therapeutic targets. This review presents data on cardiac disorders in animal models of RA, as well as current knowledge on the pathophysiology and pharmacology of these disorders. Future directions for translational studies in a cardiorheumatic perspective are proposed.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Obstetrics & Gynecology
Shannon L. Son, Lauren L. Hosek, Miranda C. Stein, Amanda A. Allshouse, Anna B. Catino, Arvind K. Hoskoppal, Daniel A. Cox, Kevin J. Whitehead, Ian M. Lindsay, Sean Esplin, Torri D. Metz
Summary: This retrospective longitudinal cohort study found an association between pregnancy and subsequent long-term adverse cardiovascular outcomes in individuals with congenital heart disease. These findings can provide important information for counseling and guidance of individuals with congenital heart disease who are considering pregnancy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Syed Shahyan Bakhtiyar, Sara Sakowitz, Konmal Ali, Nikhil L. Chervu, Arjun Verma, Ming-Sing Si, David D'Alessandro, Peyman Benharash
Summary: The study evaluates the survival rate after heart transplantation in adults with single and biventricular CHD and compares it to that of non-CHD transplant recipients. Single-ventricle physiology is associated with higher short-term mortality, but 10-year conditional survival is similar for biventricular CHD patients and most single-ventricle CHD patients, and notably better for biventricular CHD patients compared to non-CHD heart transplant recipients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Gregory I. Robinson, Fang Ye, Xiangru Lu, Steven R. Laviolette, Qingping Feng
Summary: Maternal exposure to THC during pregnancy induces myocardial hyperplasia and semilunar valve thickening in the fetal heart, resulting in postnatal cardiac dysfunction. These findings suggest that maternal cannabis consumption may lead to developmental abnormalities in the heart and cardiac dysfunction in offspring.
CANNABIS AND CANNABINOID RESEARCH
(2022)
Review
Cell Biology
Logan Meurer, Leonard Ferdman, Beau Belcher, Troy Camarata
Summary: The SIX family of transcription factors play crucial roles in embryonic development and tumorigenesis, controlling gene expression, promoting cell self-renewal and differentiation, and disruptions in their function lead to congenital defects and cancer development. Research in developmental biology and cancer have provided extensive understanding of SIX family functions, with common themes emerging when comparing their roles in embryonic and cancer development. The complementary nature of these two fields highlights how knowledge in one area can facilitate new aspects of experimentation in the other.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jacob C. Scherba, Ravi Karra, Joseph W. Turek, Nenad Bursac
Summary: Human cardiac organoid systems are of great importance for studying the mechanism of early heart development and gaining a better understanding of congenital cardiac disease.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Jayne T. T. Wolfe, Wei He, Min-Su Kim, Huan-Ling Liang, Akankshya Shradhanjali, Hilda Jurkiewicz, Bonnie P. P. Freudinger, Andrew S. S. Greene, John F. F. LaDisa Jr, Lobat Tayebi, Michael E. E. Mitchell, Aoy Tomita-Mitchell, Brandon J. J. Tefft
Summary: Congenital heart disease is a major cause of death related to birth defects, affecting 1 in 100 live births. Induced pluripotent stem cell technology allows for the study of patient-derived cardiomyocytes in vitro. A method to bioengineer these cells into a physiologically accurate cardiac tissue model is needed for disease study and treatment evaluation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Anesthesiology
Viviane G. Nasr, Steven J. Staffa, David F. Vener, ShengXiang Huang, Morgan L. Brown, Mark Twite, Wanda C. Miller-Hance, James A. DiNardo
Summary: This study analyzes the distribution of pediatric cardiac anesthesiologists in different types of procedures and found that the majority of practicing doctors in this field have not completed fellowship training. With increasing patient survival and the retirement of workforce, there will be a continued need for subspecialty training.
ANESTHESIA AND ANALGESIA
(2022)
Article
Cardiac & Cardiovascular Systems
Mohamed F. Elsisy, Joseph A. Dearani, Juan A. Crestanello, Elena A. Ashikhmina, Charlotte S. Van Dorn, Elizabeth H. Stephens
Summary: This study found that delayed sternal closure (DSC) yielded better outcomes for hemodynamic instability and severe coagulopathy after complex congenital heart surgery compared to perioperative sternal reopening.
ANNALS OF THORACIC SURGERY
(2022)
Article
Biology
Chun-Ho Chan, Yin-Yu Lam, Nicodemus Wong, Lin Geng, Jilin Zhang, Virpi Ahola, Aman Zare, Ronald Adolphus Li, Fredrik Lanner, Wendy Keung, Yiu-Fai Cheung
Summary: This study reveals functional abnormalities in cardiomyocytes derived from Tetralogy of Fallot patients with DiGeorge syndrome, including impaired ventricular specification, altered cardiac gene expression, upregulated neural gene expression, and increased arrhythmogenicity. These findings are specific to patients with DiGeorge syndrome and have implications for their clinical outcomes.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biology
Fei Liang, Bo Wang, Juan Geng, Guoling You, Jingjing Fa, Min Zhang, Hunying Sun, Huiwen Chen, Qihua Fu, Xiaoqing Zhang, Zhen Zhang
Summary: Chromosome 4q deletion is common in congenital heart disease patients, and the SORBS2 gene within this interval plays a role in SHF development, with its variants contributing to CHD pathogenesis. Knockdown of SORBS2 in human embryonic stem cells causes cardiomyocyte differentiation defects, which can be rescued by exogenous SHH, and Sorbs2(-/-) mouse mutants exhibit atrial septal anomalies associated with paradoxical thromboembolism.
Article
Obstetrics & Gynecology
Luis D. Pacheco, George Saade, Vineet Shrivastava, Raj Shree, Uri Elkayam
Summary: Pregnancy in individuals with a mechanical heart valve is classified as very high risk, requiring special anticoagulation management to prevent complications and mortality. Adjustments to anticoagulation regimens may be made based on valve type, trimester, individual risk tolerance, and timing of delivery.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Hematology
Terence Gee, Emily Farrar, Yidong Wang, Bingruo Wu, Kevin Hsu, Bin Zhou, Jonathan Butcher
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Kiran A. Vaidya, Matthew P. Donnelly, Terence W. Gee, Marine-Ayan Ibrahim Aibo, Stephen Byers, Jonathan T. Butcher
CARDIOVASCULAR PATHOLOGY
(2020)
Article
Multidisciplinary Sciences
Maria C. Palumbo, Lisa Q. Rong, Jiwon Kim, Pedram Navid, Razia Sultana, Jonathan Butcher, Alberto Redaelli, Mary J. Roman, Richard B. Devereux, Leonard N. Girardi, Mario F. L. Gaudino, Jonathan W. Weinsaft
Article
Biophysics
Huseyin Enes Salman, Maha Alser, Akshay Shekhar, Russell A. Gould, Fatiha M. Benslimane, Jonathan T. Butcher, Huseyin C. Yalcin
Summary: This study investigates disturbed hemodynamics and deteriorated cardiac growth following left atrial ligation (LAL) to explore potential mechanobiological mechanisms for the embryonic development of hypoplastic left heart syndrome (HLHS), highlighting the critical importance of hemodynamic disturbances during heart valve and ventricle development.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Shaohua Wu, Vikas Kumar, Peng Xiao, Mitchell Kuss, Jung Yul Lim, Chittibabu Guda, Jonathan Butcher, Bin Duan
SCIENTIFIC REPORTS
(2020)
Article
Engineering, Biomedical
Terence W. Gee, Jennifer M. Richards, Ablajan Mahmut, Jonathan T. Butcher
Summary: This study utilized a mechanically stressed 3D culture system to replicate valve interstitial cell-induced matrix calcification and investigated the collaborative interactions between valve endothelial cells and interstitial cells in calcific pathogenesis. Results showed that endothelial cells induce pathological remodeling and calcification of interstitial cells through EndMT and paracrine signaling.
Review
Cardiac & Cardiovascular Systems
Katherine Driscoll, Alexander D. Cruz, Jonathan T. Butcher
Summary: Calcific aortic valve disease is on the rise globally, but treatment is limited to prosthetic replacement. With a growing number of younger and more active patients, alternative therapies are needed. There is potential for biologically based diagnostics and treatments to help alleviate or delay disease progression, but a limited understanding of the disease mechanisms hinders progress towards clinical interventions.
CIRCULATION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Michael F. Z. Wang, Madhav Mantri, Shao-Pei Chou, Gaetano J. Scuderi, David W. McKellar, Jonathan T. Butcher, Charles G. Danko, Iwijn De Vlaminck
Summary: Conventional single-cell RNA sequencing analysis relies on genome annotations that may be incomplete or inaccurate especially for understudied organisms. Here the authors present a bioinformatic tool that leverages single-cell data to uncover biologically relevant transcripts beyond the best available genome annotation.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Madhav Mantri, Gaetano J. Scuderi, Roozbeh Abedini-Nassab, Michael F. Z. Wang, David McKellar, Hao Shi, Benjamin Grodner, Jonathan T. Butcher, Iwijn De Vlaminck
Summary: By utilizing single-cell and spatial transcriptomics in chicken hearts, the authors conducted a census of cellular interactions from early to late four-chambered heart stage, identifying a distinct epicardial-mesenchymal cell population with a migratory phenotype.
NATURE COMMUNICATIONS
(2021)
Article
Engineering, Biomedical
Stephanie E. Lindsey, Irene E. Vignon-Clementel, Jonathan T. Butcher
Summary: Mechanical forces play a crucial role in the growth and remodeling of primitive pharyngeal arch arteries into the heart's great vessels. However, the direct correlation between hemodynamics and PAA morphogenesis has been poorly understood. A study using minimally invasive occlusion experiments in avian embryos and 3D anatomical models revealed significant changes in morphology and hemodynamics following vessel occlusion, providing insights into the dynamic vessel adaptation process.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Developmental Biology
David Bassen, Mingkun Wang, Duc Pham, Shuofei Sun, Rashmi Rao, Rishabh Singh, Jonathan Butcher
Summary: This study investigated the influence of compressive and tensile stresses on valve growth and shape maturation, identifying a mechanically activated switch between valve growth and maturation. Compressive stress was found to drive cell proliferation via BMP signaling, while tensile stress promoted valve maturation through MLC2 contractility. The effects of osmotic stress on valve development were shown to be conserved through different stages.
Article
Anatomy & Morphology
Duc H. Pham, Charles R. Dai, Belle Y. Lin, Jonathan T. Butcher
Summary: The study found that the elongation of the fetal semilunar valve occurs through fibrosa-sided endocardial proliferation. Low shear stress induces canonical Wnt signaling in fetal valve endothelium, driving endocardial proliferation, while high shear stress activates Notch signaling to inhibit Wnt signaling. This novel mechanically regulated molecular switch explains how fluid shear stress guides the growth direction of valve endothelium.
DEVELOPMENTAL DYNAMICS
(2022)
Article
Engineering, Biomedical
Nianfang Ma, Daniel Y. Cheung, Jonathan T. Butcher
Summary: In this study, a novel photocrosslinkable composite hydrogel mNCC-MeGel (mNG) was fabricated and evaluated for heart valve applications. Encapsulated HADMSC in mNG showed support for a quiescent fibroblastic phenotype and resistance towards calcification, making it an attractive biomaterial for TEHV. Additionally, mNG was successfully used for 3D bioprinting a tall tubular structure that sustained cell viability, demonstrating its potential for tissue engineering.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Multidisciplinary Sciences
Emily J. Farrar, Emilye Hiriart, Ablajan Mahmut, Bernd Jagla, David S. Peal, David J. Milan, Jonathan T. Butcher, Michel Puceat
Summary: Studies have found that a subset of mouse endocardial cells express Oct4 induced by nuclear factor kappa B (NF kappa B) during the process of transition starting at day 9.5 of embryo development. These cells acquire a chondro-osteogenic fate and in adulthood lead to valve calcification. Genetic deletion of OCT4 can prevent aortic stenosis and valve calcification.
Correction
Engineering, Biomedical
Sraeyes Sridhar, Duc H. Pham, Terence W. Gee, Joanna Hua, Jonathan T. Butcher
CURRENT OPINION IN BIOMEDICAL ENGINEERING
(2021)
