Article
Pharmacology & Pharmacy
Andrew B. Hawkey, Erica Pippen, Bruny Kenou, Zade Holloway, Theodore A. Slotkin, Frederic J. Seidler, Edward D. Levin
Summary: This study demonstrates that developmental exposure to low doses of diazinon has persistent and evolving effects on behavior and neurochemistry in rats, particularly as they enter middle age. The effects of diazinon on locomotor activity diminish with age, but deficits in reference memory and attentional accuracy emerge in middle-aged rats. These long-term behavioral impairments are associated with alterations in dopaminergic function.
Article
Plant Sciences
Di Wu, Juanjuan Wu, Xinying Cheng, Jianrui Qian, Ruiliang Du, Shusheng Tang, Yunhe Lian, Yanjiang Qiao
Summary: This study aimed to evaluate the safety of marigold flavonoids extracted from marigold inflorescence residues. The study included acute oral toxicity, in vitro Ames test, sperm aberration study, bone marrow micronucleus test, subchronic oral toxicity test, and teratogenic potential tests.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Marielly Carvalho, Graziele Alicia Batista Caixeta, Alessandra Ribeiro Sartor Lima, Monatha Nayara Guimaraes Teofilo, Wilson de Melo Cruvinel, Clayson Moura Gomes, Luiz Fernando Froes Fleury, Joelma Abadia Marciano de Paula, Vanessa Cristiane Santana Amaral
Summary: The study evaluated the effects of prenatal treatment with dry extract from the aerial parts of J. pectoralis on maternal and developmental toxicity in Wistar rats. The results showed that oral administration of J. pectoralis dry extract during pregnancy did not induce maternal toxicity or embryotoxic and teratogenic effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Environmental Sciences
Hadeer M. M. Shosha, Hala M. M. Ebaid, Eman A. A. Toraih, Heba M. A. Abdelrazek, Ranwa A. A. Elrayess
Summary: This study evaluated the effects of MSG on placental progesterone receptors and fetal development. The results showed that MSG significantly decreased fetal weights, crown vertebral length, placental weight, and ghrelin expression. Furthermore, it caused incomplete ossification and delayed chondrification in the fetal skeleton and degenerative changes in the liver and kidney tissues.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Environmental Sciences
Minghui Li, Jing Gong, Lixiong Gao, Ting Zou, Jiahui Kang, Haiwei Xu
Summary: Significant progress has been made in toxicology, leading to advances in developmental toxicity assessment. Human organoid models, derived from hESCs and iPSCs, prove to be indispensable in accurately describing toxic effects and predicting in vivo responses. These models are valuable tools for drug discovery and safety assessment.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Chemistry, Multidisciplinary
Thais Leal-Silva, Maysa Rocha Souza, Larissa Lopes Cruz, Rafaianne Queiroz Moraes-Souza, Veronyca Goncalves Paula, Thaigra Sousa Soares, Vanessa Dela Justina, Fernanda Regina Giachini, Debora Cristina Damasceno, Madileine Francely Americo, Gustavo Tadeu Volpato
Summary: This study evaluated the effects of Morinda citrifolia fruit extract on maternal performance and fetal development in rats. The results showed that high doses of the extract can cause maternal hepatotoxicity, anti-implantation effects, and fetal abnormalities.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Fareeha Anwar, Uzma Saleem, Atta-Ur Rehman, Bashir Ahmad, Matheus Froeyen, Muhammad Usman Mirza, Lee Yean Kee, Iskandar Abdullah, Sarfraz Ahmad
Summary: The study demonstrated that SF1 can induce toxic effects in rats at certain doses, affecting various biochemical markers and reproductive functions. However, no fetal abnormalities were observed at the doses given. Therefore, SF1 may have an impact on liver function and the immune system at doses below the LD50, but it can be safely used during pregnancy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zhen Dong, Shu-Sheng Tang, Xiao-Lan Ma, Chang-Hong Li, Zhao-Shan Tang, Zi-Hui Yang, Jian-Guo Zeng
Summary: This study assessed the toxicity of Macleaya cordata extract (MCE) through acute, genotoxic, and chronic toxicity tests. The results showed that MCE is safe within the tested dose range, supporting its use in animal food products.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Environmental Sciences
Fateme Barjasteh-Askari, Simin Nasseri, Ramin Nabizadeh, Aliasghar Najafpoor, Mojtaba Davoudi, Amir-Hossein Mahvi
Summary: This systematic review sheds light on the various aspects of photocatalytic diazinon removal. The most widely used processes with the highest efficacy were ZnO/UV, WO3/UV, TiO2/UV, and TiO2/Vis. The optimal conditions included solution pH in the range of 5-8, catalyst dose below 600 mg/L, diazinon initial concentration below 40 mg/L, and contact time of 20-140 min. Diazinon degradation followed a first-order kinetic model.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Carla Leticia Gediel Rivero-Wendt, Luana Garcia Fernandes, Andreza Negreli dos Santos, Igor Leal Brito, Jeandre Augusto dos Santos Jaques, Edson dos Santos dos Anjos, Carlos Eurico Fernandes
Summary: The study aimed to investigate the effects of Chloramine T on zebrafish embryos, including its lethal effects, changes in AChE activity, and developmental abnormalities. It was found that Chloramine T inhibited AChE activity at concentrations of 64 or 128 mg/L, resulting in delayed hatching and disrupted embryonic development. The study highlights the potential risks of Chloramine T as a disinfectant in fish farms. Overall, the study is rated 8 out of 10 in terms of importance.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2023)
Article
Environmental Sciences
Yuming Chen, Jitong Li, Qixing Zhou, Zhijie Liu, Qiong Li
Summary: Combined toxicity of graphene oxide (GO) and hexavalent chromium (Cr6+) significantly enhanced teratogenicity in zebrafish embryos in a concentration-dependent pattern. The main deformity observed was spinal curvature, with changes in protein secondary structures and disruptions in musculoskeletal system development. Interactions between Cr6+ and GO altered the properties of GO nanoparticles, leading to increased defects and oxidative stress in zebrafish. These findings are important for assessing the ecological risk of graphene family nanomaterials in the natural environment.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Reproductive Biology
Shidong Qiu, Yang Liu, Yuanhang Pan, Yuji Liang, Liyuan Zhou, Xiaobo Wang, Peilu Sun, Suling Teng, Dan Wang, Yanling Mu
Summary: In a developmental and reproduction toxicity study, BA9 showed potential toxicity. The experiment found that body weight gains decreased in F0 rats receiving a dosage of 0.80 mg/kg/day. In the 0.80 mg/kg/day group, a lower fertility index of males was observed and females failed to become pregnant. The number of live fetuses and implantations decreased, while the number of dead fetuses, resorptions, and implantation losses increased in the 0.12 mg/kg/day group.
REPRODUCTIVE TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Emma H. Acosta-Jimenez, Luis A. Zarate-Hernandez, Rosa L. Camacho-Mendoza, Simplicio Gonzalez-Montiel, Jose G. Alvarado-Rodriguez, Carlos Z. Gomez-Castro, Miriam Pescador-Rojas, Amilcar Meneses-Viveros, Julian Cruz-Borbolla
Summary: In this study, a QSTR model was developed to predict the toxicity of carbamate derivatives using a large dataset. The model was rigorously validated and successfully predicted the toxicity by combining structure-based evaluation and physicochemical, structural, and quantum molecular descriptors.
Article
Biochemistry & Molecular Biology
Ekambaram Perumal, Sangavi Eswaran, Reshma Parvin, Satheeswaran Balasubramanian
Summary: The study showed that ferulic acid could mitigate arsenic-induced cardiotoxicity in zebrafish larvae, reducing arsenic content and congenital deformities, such as cardiac malformations. Ferulic acid supplementation reversed abnormal cardiac function and reduced acetylcholinesterase activity induced by arsenic exposure, indicating its protective effects on cardiac malformations.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zhen Dong, Shu-sheng Tang, Xiao-lan Ma, Bin Tan, Zhao-shan Tang, Chang-hong Li, Zi-hui Yang, Jian-guo Zeng
Summary: This study investigated the oral acute toxicity, genotoxicity, and chronic toxicity of MPTA in mice. The results showed that MPTA was safe at the tested doses, but attention should be paid to the potential risk to pregnant animals.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Urology & Nephrology
R. EIMazoudy, N. AbdelHameed, A. ElMasry
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2015)
Article
Environmental Sciences
Reda H. ElMazoudy, Gamal A. Bekhet
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2016)
Article
Plant Sciences
Reda H. Elmazoudy, Azza A. Attia
Article
Pathology
Fatma El-Demerdash, Youssef Dewer, Reda H. ElMazoudy, Azza A. Attia
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
(2013)
Article
Engineering, Environmental
Fatma El-Demerdash, Azza A. Attia, Reda H. Elmazoudy
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING
(2012)
Article
Engineering, Environmental
Reda H. ElMazoudy, Azza A. Attia
JOURNAL OF HAZARDOUS MATERIALS
(2012)
Article
Biochemistry & Molecular Biology
Azia A. Attia, Reda H. ElMazoudy, Nahla S. El-Shenawy
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2012)
Article
Environmental Sciences
Ahmed Alsayyah, Reda ElMazoudy, Mashael Al-Namshan, Meneerah Al-Jafary, Nouf Alaqeel
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2019)
Article
Environmental Sciences
Reda ElMazoudy, Kareman El-Abd, Desouky Mekkawy, Karolyn Kamel
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2020)
Correction
Environmental Sciences
Reda ElMazoudy, Kareman El-Abd, Desouky Mekkawy, Karolyn Kamel
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2020)
Correction
Environmental Sciences
Azza Attia, Heba Ramadan, Reda ElMazoudy, Asmaa Abdelnaser
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Azza Attia, Heba Ramadan, Reda ElMazoudy, Asmaa Abdelnaser
Summary: This study revealed that 26.9 nm citrate-coated AgNPs can access the brain of mice, causing damage to brain conductivity and relative permittivity along with high cellular toxicity. The findings raise concerns about the neurotoxic effects of citrate-coated AgNPs on the brain and suggest further investigation into axonal relevant signal transduction levels in future studies.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Abdelrazeq M. Shehata, Vinod K. Paswan, Youssef A. Attia, Abdel-Moneim Eid Abdel-Moneim, Mohammed Sh. Abougabal, Mohamed Sharaf, Reda Elmazoudy, Wejdan T. Alghafari, Mohamed A. Osman, Mayada R. Farag, Mahmoud Alagawany
Summary: The in ovo technology delivers bioactive compounds to embryos before hatching, improving chicken body weight, feed conversion ratio, and meat yield. Utilizing in ovo stimulation with probiotics and prebiotics can potentially prevent metabolic disorders, poor immunity, and pathogen resistance in the broiler industry.
Article
Biology
Azza Attia, Cecil Matta, Reda ElMazoudy, Hanan Khalifa
Summary: Cisplatin treatment in mice resulted in significant damage to the cerebellar cortex, with alterations in oxidative stress biomarkers and histopathology. The identified mechanism for neurotoxicity involved oxidative stress-induced damage, characterized by changes in cellular nuclei, cytoplasm, and myelinated nerve fibers.
JOURNAL OF BASIC AND APPLIED ZOOLOGY
(2021)
Article
Biology
Azza Attia, Cecil Matta, Reda ElMazoudy, Hanan Khalifa
Summary: Despite its potency in treating malignancies, cisplatin induces cerebellum deficits in mice leading to neuronal histological impairment, primarily through oxidative stress-dependent neurotoxicity.
JOURNAL OF BASIC AND APPLIED ZOOLOGY
(2021)