Article
Radiology, Nuclear Medicine & Medical Imaging
Samantha Rossano, Takuya Toyonaga, Eric Berg, Isabella Lorence, Krista Fowles, Nabeel Nabulsi, Jim Ropchan, Songye Li, Yunpeng Ye, Zachary Felchner, David Kukis, Yiyun Huang, Helene Benveniste, Alice F. Tarantal, Stephanie Groman, Richard E. Carson
Summary: This study assessed synaptic density changes in the developing fetal brain using positron emission tomography (PET) radioligands. The results showed an increase in SV2A concentration during the third trimester, with lower levels in cortical regions. Furthermore, the post-mortem quantification of SV2A density correlated significantly with the PET measurements.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Reproductive Biology
Helen Booler, Anthony M. Delise, Erik Nimz, Diana Shefchek, C. Marc Luetjens
Summary: In this study, the potential impact of intravitreal RTH258 on pre- and postnatal development in the offspring of cynomolgus monkeys was assessed. Results showed that RTH258 had no impact on pregnancy or parturition, embryo-fetal development, or survival, growth, and postnatal development of offspring when administered via repeated intravitreal administration.
REPRODUCTIVE TOXICOLOGY
(2023)
Article
Veterinary Sciences
Tinika N. Johns, Joseph J. Wakshlag, Alexander V. Lyubimov, Alexander Zakharov, Wesley M. Burnside
Summary: This study aimed to analyze the pharmacokinetics of oral CBD and CBDA-rich hemp oil in juvenile macaques. The results showed that the serum concentrations of CBD and CBDA were low, indicating that the doses and frequency used in this study may be insufficient for a therapeutic effect. Further clinical studies are needed to determine the appropriate therapeutic dose for macaques.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Joseph D. Bozzay, Patrick F. Walker, Rex E. Atwood, Robert W. DeSpain, William J. Parker, Daniel S. Chertow, John A. Mares, Crystal L. Leonhardt, Eric A. Elster, Matthew J. Bradley
Summary: The study developed a prolonged critical care environment with sedation and ventilation support, and investigated the corresponding NHP biologic and inflammatory markers. The results showed that the inflammatory response of NHPs was not significantly altered by sedation and mechanical ventilation, but short-term ventilation had effects on the pulmonary system of NHPs.
Article
Cell Biology
C. J. Little, W. J. Haynes, L. Huang, C. M. Daffada, K. B. Wolfe, E. Perrin, J. A. Simpson, J. A. Kropp Schmidt, H. M. Hinkle, L. T. Keding, R. T. Behrens, D. T. Evans, D. B. Kaufman, J. A. Thomson, T. G. Golos, M. E. Brown
Summary: Engraftment of rhesus macaque hematopoietic tissues in immune-deficient mice yields a robust BLT/NeoThy-type primatized mouse model for studying nonhuman primate hematopoiesis and immune function in vivo.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ken Mizuta, Yoshitaka Katou, Baku Nakakita, Aoi Kishine, Yoshiaki Nosaka, Saki Saito, Chizuru Iwatani, Hideaki Tsuchiya, Ikuo Kawamoto, Masataka Nakaya, Tomoyuki Tsukiyama, Masahiro Nagano, Yoji Kojima, Tomonori Nakamura, Yukihiro Yabuta, Akihito Horie, Masaki Mandai, Hiroshi Ohta, Mitinori Saitou
Summary: This study demonstrates the ex vivo reconstitution of fetal oocyte development in humans and monkeys, providing a critical step forward for in vitro oogenesis in humans and uncovering important characteristics of fetal oocyte development in primates. The cytological and transcriptomic progressions of fetal oocyte development in vitro closely recapitulate those in vivo, revealing species-specific and conserved programs driving this process.
Article
Multidisciplinary Sciences
Sara C. Johnston, Keersten M. Ricks, Alexandra Jay, Jo Lynne Raymond, Franco Rossi, Xiankun Zeng, Jennifer Scruggs, David Dyer, Ondraya Frick, Jeffrey W. Koehler, Paul A. Kuehnert, Tamara L. Clements, Charles J. Shoemaker, Susan R. Coyne, Korey L. Delp, Joshua Moore, Kerry Berrier, Heather Esham, Joshua Shamblin, Willie Sifford, Jimmy Fiallos, Leslie Klosterman, Stephen Stevens, Lauren White, Philip Bowling, Terrence Garcia, Christopher Jensen, Jeanean Ghering, David Nyakiti, Stephanie Bellanca, Brian Kearney, Wendy Giles, Nazira Alli, Fabian Paz, Kristen Akers, Denise Danner, James Barth, Joshua A. Johnson, Matthew Durant, Ruth Kim, Jay W. Hooper, Jeffrey M. Smith, Jeffrey R. Kugelman, Brett F. Beitzel, Kathleen M. Gibson, Margaret L. M. Pitt, Timothy D. Minogue, Aysegul Nalca
Summary: Airborne transmission of SARS-CoV-2 is found to be a prevalent route of human exposure. In a study comparing African green monkeys, rhesus macaques, and cynomolgus macaques exposed to the virus, respiratory abnormalities and viral shedding were observed in all animals. Fever was noted in cynomolgus macaques, while African green monkeys and rhesus macaques experienced thrombocytopenia. The findings suggest that macaques, in addition to African green monkeys, can serve as successful natural transmission models for evaluating medical countermeasures.
Article
Neurosciences
Nakul Aggarwal, Jason F. Moody, Douglas C. Dean III, Do P. M. Tromp, Steve R. Kecskemeti, Jonathan A. Oler, Andy L. Alexander, Ned H. Kalin
Summary: The study investigates the early white matter (WM) growth in nonhuman primates by imaging 34 rhesus monkeys longitudinally during the first year of life. The results show a rapid WM development in the initial 10 weeks followed by a decline in growth rates, with distinct gradients observed in WM maturation. Individual differences in WM microstructure at 3 weeks of age were found to be significantly related to those at 1 year of age.
Article
Pharmacology & Pharmacy
Andre Tadeu Gotardo, Luciana Lucinio Lippi, Kalan Bastos Violin, Estela Maris Andrade Forell Bevilacqua, Silvana Lima Gorniak
Summary: Ipomoea carnea is a toxic plant containing calystegines and swainsonine, which inhibit key cellular enzymes and cause cell death. This study aimed to determine the teratogenic effects of exposure to I. carnea on fetuses, with results showing deleterious effects on mothers and fetuses, particularly in postnatal evaluation.
Review
Toxicology
Ann-Kathrin Loerracher, Thomas Braunbeck
Summary: There is a strong trend towards using zebrafish embryos as translational models in ecotoxicological and toxicological testing strategies, leading to an increasing need to understand their biotransformation capacity. However, there is still insufficient research on the expression patterns and activities of CYP isoforms in juvenile and adult zebrafish. Studies have shown qualitative similarities but quantitative differences in metabolic activities between zebrafish embryos and later developmental stages, highlighting the importance of further research to assess metabolic profiles and capacities of CYP isoforms in zebrafish.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Gastroenterology & Hepatology
Michael J. Nash, Evgenia Dobrinskikh, Rachel C. Janssen, Mark A. Lovell, Deborah A. Schady, Claire Levek, Kenneth L. Jones, Angelo D'Alessandro, Paul Kievit, Kjersti M. Aagaard, Carrie E. McCurdy, Maureen Gannon, Jacob E. Friedman, Stephanie R. Wesolowski
Summary: Maternal consumption of a Western-style diet during pregnancy can lead to hepatic injury and steatosis in fetal offspring, and postweaning exposure to a Western-style diet can worsen this effect. These effects include the occurrence of liver fibrosis and endoplasmic reticulum stress, making the development of pediatric NAFLD more severe.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Ivo Jelicic, Katarina Vukojevic, Anita Racetin, Davor Caric, Merica Glavina Durdov, Mirna Saraga-Babic, Natalija Filipovic
Summary: This study investigated the expression of Pannexins in the human kidney during development and in patients with type 2 diabetes mellitus. The results showed that Panx1 expression in the early stages of kidney development is associated with cellular differentiation, migration, and positioning. Additionally, glomerular Panx1 expression may serve as a potential indicator of worsening renal function in diabetic patients.
Review
Genetics & Heredity
Miranda Li, Alyssa Brokaw, Anna M. Furuta, Brahm Coler, Veronica Obregon-Perko, Ann Chahroudi, Hsuan-Yuan Wang, Sallie R. Permar, Charlotte E. Hotchkiss, Thaddeus G. Golos, Lakshmi Rajagopal, Kristina M. Adams Waldorf
Summary: A wide range of pathogens can harm fetuses and cause malformations. Human cytomegalovirus is currently the leading infectious cause of congenital malformations. Different infectious diseases can result in congenital malformations, permanent organ damage, and other consequences.
FRONTIERS IN GENETICS
(2021)
Article
Reproductive Biology
Zachary K. Seekford, Lydia K. Wooldridge, Nicholas W. Dias, Claire L. Timlin, Alvaro F. Sales, Savannah L. Speckhart, Ky G. Pohler, Rebecca R. Cockrum, Vitor R. G. Mercadante, Alan D. Ealy
Summary: Supplementing IL6 during in vitro embryo development has a positive impact on the developmental trajectory of the embryo and fetus, resulting in pregnancies that more closely resemble those generated through timed artificial insemination.
Article
Plant Sciences
Fernanda C. R. Dias, Sergio L. P. Matta, Graziela D. A. Lima, Ana Claudia F. Souza, Tatiana P. Menezes, Fabiana C. S. A. Melo, Wagner C. Otoni, Mariana Machado Neves, Marcos L. M. Gomes
Summary: The hydroalcoholic extract of tetraploid P. glomerata root altered sperm and testicular parameters, compromising embryonic development after implantation.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)