Article
Pharmacology & Pharmacy
Samir Senapati, Ahmed Adel Ali Youssef, Corinne Sweeney, Chuntian Cai, Narendar Dudhipala, Soumyajit Majumdar
Summary: Cannabidiol (CBD), a non-psychoactive cannabinoid, has therapeutic potential in various diseases. This study evaluated the effect of CBD on intraocular pressure (IOP) in a rabbit model and found that topical application of CBD nanoemulsion reduced IOP, supporting its potential as a therapeutic option for inflammation-based ocular diseases.
Article
Parasitology
Sylvester Sunday Obeta, Simon Azubuike Ubah, Charles Ejike Ejiofor, Oluwa Adikpe Agbonu, Philemon Kwinjoh Columbus, Kenneth Owoicho Abah, Alapa Baba Ikpe, Abayomi Samuel Bankole, Prisca Adaoma Ezinwo, Joy Iyojo Itodo, Issac Oluwatobi Akefe, Charles Amaechi Uba, Samuel Mailafia
Summary: The clinical effect of Trypanosoma congolense infection on Dutch belted rabbits was investigated. The results showed a decrease in packed cell volume and the presence of parasitaemia in infected rabbits. The study suggests that the use of haematinics and anti-pyrexia treatments as part of disease management for rabbits would be useful.
PARASITOLOGY RESEARCH
(2023)
Article
Multidisciplinary Sciences
Daniel C. De Souza, Nicolas Hebert, Erica B. Esrick, M. Felicia Ciuculescu, Natasha M. Archer, Myriam Armant, Etienne Audureau, Christian Brendel, Giuseppe Di Caprio, Frederic Galacteros, Donghui Liu, Amanda Mccabe, Emily Morris, Ethan Schonbrun, Dillon Williams, David K. Wood, David A. Williams, Pablo Bartolucci, John M. Higgins
Summary: This study reports the results of exploratory single-cell analysis in patients treated with BCL11A gene silencing and hydroxyurea. Gene therapy can reverse the switch from fetal to adult hemoglobin, increase fetal hemoglobin expression, decrease sickle hemoglobin expression, and enhance the resistance of red blood cells to polymerization under low oxygen tension.
NATURE COMMUNICATIONS
(2023)
Article
Developmental Biology
Howard M. Solomon, Stacia Murzyn, Joyce Rendemonti, Sharon Chapman, Shih-Hsun Cheng, Beat M. Jucker, Dinesh Stanislaus, Andrew Gehman, Hasan Alsaid
Summary: This study aimed to compare alizarin red stain and micro-CT images for examining fetal rabbit skeletons, and determine if the results were consistent regardless of the method used. The results showed that micro-CT imaging is a realistic and robust alternative to staining for analyzing fetal rabbit skeletons in developmental toxicity studies.
BIRTH DEFECTS RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Matthew Booth, Nancy Powell, Clare Corfield, Julian M. French
Summary: Automated staining methods for bone and cartilage in fetal animals are commonly used, but have difficulty producing consistent staining in mouse fetuses. A modified staining protocol using methanol and glacial acetic acid has been successfully employed for regulatory prenatal developmental toxicity studies in mice.
BIOTECHNIC & HISTOCHEMISTRY
(2022)
Article
Pediatrics
Pascale Bach, Marie Cassart, Myriam Chami, Catherine Garel, Michel Panuel
Summary: This study discusses guidelines from the Fetal Imaging Task Force of the European Society of Paediatric Radiology for indications, protocols, and reporting of ultra-low-dose fetal CT. Ultra-low-dose fetal CT is a useful complementary tool that can significantly improve prenatal diagnostic accuracy in select cases.
PEDIATRIC RADIOLOGY
(2023)
Article
Ophthalmology
Dennis Brooks, Monica Anayatzin Linares-Alba, Rodrigo Garcia-Santisteban, Enli Xie, Glenwood Gum, Linda L. Manza, Lucila Servitje-Azcarraga, Diego G. Santisteban, Gustavo Adolfo Garcia-Sanchez
Summary: The study found that after subconjunctival injection in Dutch belted rabbits, the proprietary liposomal sirolimus (LS) could quickly diffuse into the posterior intraocular tissues without reaching detectable levels in aqueous humor or serum. Peak levels of LS in the posterior intraocular tissues occurred at 6 hours, and remained present after 3 weeks.
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
(2022)
Article
Pathology
JoAnn C. L. Schuh, Dana L. Holve, Karen E. Mundwiler
Summary: The International Committee for Classification of Corneal Dystrophies categorized corneal dystrophies in humans using anatomic, genotypic, and clinicopathologic phenotypic features. A review of the veterinary literature confirmed that corneal dystrophy is imprecisely applied to any corneal opacity and to multiple poorly characterized histologic abnormalities of the cornea in animals. Sporadic corneal dystrophy in DB rabbits appears to be a potential animal model of TBCD.
TOXICOLOGIC PATHOLOGY
(2021)
Article
Veterinary Sciences
Masoud Sahimirad, Hassan Gilianpour, Mohammadreza Paryani, Bijan Radmehr, Abbas Veshkini
Summary: The current study aimed to determine the onset of vertebral ossification, ribs, and sternum in partridge embryos using staining techniques. The results showed that ossification of ribs and sternum began after vertebral ossification, indicating a progressive process in the thoracic region of the embryos.
EGYPTIAN JOURNAL OF VETERINARY SCIENCE
(2021)