Article
Environmental Sciences
Martin Ferencik, Jana Blahova, Jana Schovankova, Zuzana Siroka, Zdenka Svobodova, Vit Kodes, Karla Stepankova, Pavla Lakdawala
Summary: Anticonvulsant drugs enter the aquatic environment through wastewater and have an impact on aquatic biota. This study aimed to identify the presence and concentrations of anticonvulsant drugs in water samples from the Elbe River in the Czech Republic and evaluate their correlation with flow rates. The results indicate that these drugs are present in the surface water of the Elbe River and their concentrations are higher further away from the source.
Review
Psychology, Clinical
Aarti Gupta, Pallavi Joshi, Gargi Bhattacharya, Melissa Lehman, Melissa Funaro, Deena J. Tampi, Rajesh R. Tampi
Summary: This systematic review identified four RCTs evaluating the use of anticonvulsants among older adults, with perioperative gabapentin showing a reduction in postoperative delirium after spinal surgery, but not in other types of surgeries. Perioperative pregabalin did not reduce delirium incidence after THA in older adults.
INTERNATIONAL PSYCHOGERIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Michaela Shishmanova-Doseva, Lyudmil Peychev, Lyubka Yoanidu, Yordanka Uzunova, Milena Atanasova, Katerina Georgieva, Jana Tchekalarova
Summary: Treatment with TPM and LCM can reduce the number of motor seizures in SE. SE decreases SOD activity and GSH levels while increasing CAT activity, MDA, and IL-1 beta levels. A higher dose of LCM can restore SOD activity to control level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Clinical Neurology
Rebecca Knight, Anja Wittkowski, Rebecca Louise Bromley
Summary: Recent research has shown that exposure to certain newer antiseizure medications (ASMs) such as lamotrigine and levetiracetam during pregnancy does not appear to have a significant impact on child neurodevelopment. However, due to limitations in study quality and data availability, further research is needed to fully understand the effects of other ASMs on child neurodevelopment.
Article
Biochemistry & Molecular Biology
Dannielle Zierath, Stephanie Mizuno, Melissa Barker-Haliski
Summary: This study investigated the effects of monotherapy on drug-resistant epilepsy and found that early and repeated administration of antiseizure medications, regardless of their different effects on sodium channel states, promotes the development of pharmacoresistant chronic seizures. This suggests that inappropriate use of monotherapy in newly diagnosed epilepsy patients may be one driver of future drug resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Timo Jendrik Faustmann, Franco Corvace, Pedro M. Faustmann, Fatme Seval Ismail
Summary: Despite the potential glial toxicity of LTG and TPM, both drugs reduced inflammatory activity, suggesting potential positive effects on the neuroinflammatory components of the pathogenesis of epilepsy and bipolar disorder.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Spencer C. Greene, Kimberly Wyatt, Alexis L. Cates, Sarah Weiss
Summary: This retrospective study analyzed cases of fatal outcomes associated with oral anticonvulsant use reported to the AAPCC National Poison Data System from 2000 to 2019. The majority of fatalities were suicides, and fatal adverse reactions and therapeutic errors were most commonly associated with phenytoin use, disproportionately affecting elderly patients.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2023)
Article
Clinical Neurology
Leanne M. M. Lehmann, Melissa Barker-Haliski
Summary: This study established the anticonvulsant profile of mechanistically distinct antiseizure medicines (ASMs) in the 6-Hz seizure test in PSEN2-knockout (KO) mice. The results provide valuable information for seizure management in early-onset Alzheimer's disease (EOAD) patients.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Juri-Alexander Witt, Guido Widman, Niels Hansen, Randi von Wrede, Christian E. Elger, Christoph Helmstaedter
Summary: This retrospective study found that rapid titration of topiramate significantly impairs executive function, while the traditional titration scheme also leads to cognitive impairments. Therefore, it is recommended to use a faster titration rate and perform repeated cognitive assessments when administering topiramate to epilepsy patients.
Article
Clinical Neurology
Christopher Rohde, Ole Kohler-Forsberg, Andrew A. A. Nierenberg, Soren Dinesen Ostergaard
Summary: This study found that treatment with antipsychotics and valproate was associated with an increased risk of diabetes mellitus in patients with bipolar disorder, while treatment with lithium and lamotrigine did not show a significant risk increase. These findings suggest the need for caution when using antipsychotics and valproate in the treatment of bipolar disorder in a real-world clinical setting.
Article
Genetics & Heredity
Kohei Hamanaka, Keita Miyoshi, Jia-Hui Sun, Keisuke Hamada, Takao Komatsubara, Ken Saida, Naomi Tsuchida, Yuri Uchiyama, Atsushi Fujita, Takeshi Mizuguchi, Benedicte Gerard, Allan Bayat, Berardo Rinaldi, Mitsuhiro Kato, Jun Tohyama, Kazuhiro Ogata, Yun Stone Shi, Kuniaki Saito, Satoko Miyatake, Naomichi Matsumoto
Summary: A gain-of-function variant in the GRIA3 gene was found to cause a distinct neurodevelopmental disorder phenotype compared to loss-of-function variants. Drugs that suppress glutamatergic neurotransmission may improve the symptoms of this phenotype. This study is significant for the clinical management of GRIA3-related NDDs.
Article
Biochemistry & Molecular Biology
Sanja Petrovic, Milena Kovacevic, Sandra Vezmar Kovacevic, Branislava Miljkovic
Summary: Analysis of data on drug-induced liver injury (DILI) in elderly patients treated with newer antiseizure medications (ASMs) revealed that certain drugs may pose a risk of liver injury in this population. Further research is needed to validate these findings.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Peter Kamerman
Summary: The purpose of this study was to determine whether the rescheduling of gabapentinoids in England in April 2019 resulted in changes in prescribing behavior by general practitioners. The findings showed that there were no significant changes in the number of prescriptions or average dose for gabapentin and pregabalin after the rescheduling.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Engineering, Biomedical
Yuhling Wang, Vassiliy Tsytsarev, Lun-De Liao
Summary: The study of epileptic seizures is closely related to neurovascular coupling. Laser speckle contrast imaging can provide information about cerebral blood flow in the area of epileptic activity, and combined with electrocorticography, it can evaluate the effectiveness of drugs in epileptic seizures and provide spatial and temporal information.
APL BIOENGINEERING
(2023)
Article
Clinical Neurology
Haris Hakeem, Wei Feng, Zhibin Chen, Jiun Choong, Martin J. Brodie, Si-Lei Fong, Kheng-Seang Lim, Junhong Wu, Xuefeng Wang, Nicholas Lawn, Guanzhong Ni, Xiang Gao, Mijuan Luo, Ziyi Chen, Zongyuan Ge, Patrick Kwan
Summary: This study developed and validated a deep learning model to predict treatment success with the first ASM for individual patients based on clinical information. The transformer model outperformed other machine learning models in predicting treatment success. Key clinical variables for predicted outcomes included number of pretreatment seizures, presence of psychiatric disorders, electroencephalography, and brain imaging findings.