Article
Neurosciences
Bowen Hu, Qinghua He, Jiang Qiu, Xu Lei, Hong Chen, Tingyong Feng
Summary: To succeed, taking risks wisely is crucial, which depends on individual ability to exploit risk. A study using voxel-based morphometry (VBM) revealed that the ability to exploit risk was correlated with gray matter volumes in the orbitofrontal cortex and dorsolateral prefrontal cortex. The findings suggest that precise valuation, adaptive learning, and self-control play a role in the ability to exploit risk.
Article
Neurosciences
Hikaru Takeuchi, Ryosuke Kimura, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Izumi Matsudaira, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Sugiko Hanawa, Kunio Iizuka, Atsushi Sekiguchi, Tsuyoshi Araki, Carlos Makoto Miyauchi, Shigeyuki Ikeda, Kohei Sakaki, Kelssy H. Dos S. Kawata, Takayuki Nozawa, Susumu Yokota, Daniele Magistro, Tadashi Imanishi, Ryuta Kawashima
Summary: This study found associations between the genetic risk of BD and creativity, mood disturbance, as well as prefrontal cortical structures.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Rossella Oliva, Sanja Budisavljevic, Umberto Castiello, Chiara Begliomini
Summary: Binge-eating is characterized by higher trait impulsivity and greater gray matter volume in the left middle frontal gyrus among normal-weight individuals. These findings provide new insights into the neurobiological roots of binge-eating in non-clinical populations and highlight the association of this behavior with brain morphometric changes in prefrontal regions.
Article
Psychology, Developmental
Livia Nascimento Rabelo, Jose Pablo Goncalves Queiroz, Carla Cristina Miranda Castro, Sayonara Pereira Silva, Laura Damasceno Campos, Larissa Camila Silva, Ezequiel Batista Nascimento, Veronica Martinez-Cerdeno, Felipe Porto Fiuza
Summary: This study investigated the changes in glia/neuron ratios (GNR) in patches of the dorsolateral prefrontal cortex (DL-PFC) of children with autism spectrum disorder (ASD). The analysis of high-resolution digital images of postmortem human brains revealed a reduced GNR in the ASD DL-PFC overall, and a lower GNR in layers II-III compared to layers V-VI within the patches. These findings provide new insights into the altered neurodevelopmental programs in ASD.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Psychiatry
Rishi Gupta, Mamta Sood, Uma Sharma, Rachna Bhargava, N. R. Jagannathan, R. K. Chadda
Summary: Neurochemical dysfunction in select brain areas directly correlates with impairment in cognitive functions seen in patients with bipolar disorder in euthymic phase.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Neurosciences
Hiroki Tanaka, Qiulu Shou, Toko Kiyonari, Tetsuya Matsuda, Masamichi Sakagami, Haruto Takagishi
Summary: The study suggests that gray matter volume in the dorsolateral prefrontal cortex is associated with prosocial behavior, but the direction of this relationship is controversial. The concept of default prosociality preference moderates this relationship.
Article
Psychiatry
Eman M. Khedr, Khaled Elbeh, Mostafa Saber, Zeinab Abdelrady, Ahmed Abdelwarith
Summary: This study compared the effectiveness of low frequency repetitive transcranial magnetic stimulation over different brain regions for the treatment of obsessive-compulsive disorder (OCD). The results showed that both active treatment groups outperformed the sham group in improving OCD symptoms. Patients with shorter illness duration, lower baseline scores, and fewer comorbidities responded better to the treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Neurosciences
Lin Song, Xiaodong Han, Yuanjing Li, Xiaolei Han, Mingqing Zhao, Chunyan Li, Pin Wang, Jiafeng Wang, Yi Dong, Lin Cong, Xiaojuan Han, Tingting Hou, Keke Liu, Yongxiang Wang, Chengxuan Qiu, Yifeng Du
Summary: The KIBRA rs17070145 C-allele is associated with a reduced likelihood of olfactory impairment among older adults, partly mediated through left thalamic gray matter volume.
Article
Neuroimaging
Kai G. Ringwald, Tina Meller, Simon Schmitt, Till F. M. Andlauer, Frederike Stein, Katharina Brosch, Julia-Katharina Pfarr, Olaf Steinstraeter, Susanne Meinert, Hannah Lemke, Lena Waltemate, Katharina Thiel, Dominik Grotegerd, Verena Enneking, Melissa Klug, Andreas Jansen, Andreas J. Forstner, Fabian Streit, Stephanie H. Witt, Marcella Rietschel, Bertram Mueller-Myhsok, Markus M. Noethen, Udo Dannlowski, Axel Krug, Igor Nenadic, Tilo Kircher
Summary: This study found that early genetic and environmental risk factors do not interact with current stressful life events on brain morphology in healthy subjects. Additionally, recent stressful life events are negatively correlated with grey matter volume in the left medial orbitofrontal cortex.
NEUROIMAGE-CLINICAL
(2021)
Article
Neuroimaging
Shuang Zheng, Ximei Chen, Weijun Liu, Ziang Li, Mingyue Xiao, Yong Liu, Hong Chen
Summary: This study used voxel-based morphometry (VBM) to investigate the association between brain GMV and loneliness in 462 young adults. The results revealed that individuals with higher loneliness tended to have greater GMV in the right dorsolateral prefrontal cortex (DLPFC). The study also found that the relationship between DLPFC GMV and loneliness was mediated by interpersonal self-support traits (ISS).
BRAIN IMAGING AND BEHAVIOR
(2023)
Review
Neurosciences
Jiashu Wang, Bo Zhang, Shi Liang, Jian Li
Summary: The reinforcement history significantly influences human value-based choices, with prior costs and rewards biasing subsequent decisions within the mental accounting framework. Neurologically, activities in the ventral striatum recalibrate the reference point based on prior gains and losses, while functional connectivity between the dorsolateral prefrontal cortex and medial orbitofrontal cortex affects individual susceptibility to prior outcomes.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Clinical Neurology
Valeria Tretyak, Dylan E. Kirsch, Sepeadeh Radpour, Wade A. Weber, Kim Fromme, Stephen M. Strakowski, Elizabeth T. C. Lippard
Summary: This study found that there are differences in subjective response to alcohol between individuals with bipolar disorder and typically developing individuals, which are associated with variations in gray matter volume in the OFC. Individuals with bipolar disorder and typically developing individuals exhibit differences in subjective response and drinking patterns, which are related to OFC biology.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Xiaoyu Jia, Lei Hao, Li He, Ping Li, Minglan Liu, Yuchi Zhang, Jiang Qiu
Summary: The growth mindset refers to beliefs in the malleable nature of intelligence and plays a significant role in motivation and achievement. This study utilized voxel-based morphometry to investigate the relationship between growth mindset and gray matter volume (GMV) in healthy adults. Whole-brain correlation analyses revealed a positive association between growth mindset scores and regional GMV in the medial orbitofrontal cortex (mOFC) after controlling for age, sex, and total intracranial volume. This finding remained robust even after adjusting for intelligence quotient, highlighting the relevance of the mOFC in reward processing, supporting the social-cognitive theory of motivation in the context of growth mindset.
Article
Clinical Neurology
Yuan Cao, Hongsheng Xie, Huan Sun, Hongqi Xiao, Xipeng Long, Changjian Qiu, Zhiyun Jia
Summary: A meta-analysis was conducted to explore the common and distinct gray matter volume (GMV) alterations in young adults with borderline personality disorder (BPD) and major depressive disorder (MDD). Results showed that BPD was associated with GMV reduction in the prefrontal cortex, medial temporal network, and insula, while MDD was associated with GMV alteration in the visual and sensorimotor networks. Differences in GMV between the two disorders were observed in the orbitofrontal cortex, cingulate cortex, insula, and cerebellum.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Kai G. Ringwald, Julia-Katharina Pfarr, Simon Schmitt, Frederike Stein, Katharina Brosch, Tina Meller, Jonathan Andrae, Ronja Zech, Olaf Steinstraeter, Susanne Meinert, Lena Waltemate, Hannah Lemke, Katharina Thiel, Alexandra Winter, Nils Opel, Janik Goltermann, Andreas Jansen, Udo Dannlowski, Axel Krug, Igor Nenadic, Tilo Kircher
Summary: This study tested the interactions between recent stressful life events, childhood abuse, and brain structure in a large group of major depressive disorder patients. The results showed that childhood abuse and recent stressful life events interacted in individuals with major depressive disorder but not in healthy individuals.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Correction
Clinical Neurology
Ozgun Ozalay, Burcu Aksoy, Sebnem Tunay, Fatma Simsek, Swati Chandhoke, Omer Kitis, Cagdas Eker, Ali Saffet Gonul
PSYCHIATRY RESEARCH-NEUROIMAGING
(2016)
Article
Clinical Neurology
Ozgun Ozalay, Burcu Aksoy, Sebnem Tunay, Fatma Simsek, Swati Chandhoki, Omer Kitis, Cagdas Eker, Ali Saffet Gonul
PSYCHIATRY RESEARCH-NEUROIMAGING
(2016)
Article
Psychiatry
Ece Durmusoglu, Onur Ugurlu, Sebnem Akan, Fatma Simsek, Gozde Kizilates, Omer Kitis, Burcu Aksoy Ozkul, Cagdas Eker, Kerry L. Coburn, Ali Saffet Gonul
COMPREHENSIVE PSYCHIATRY
(2018)
Article
Clinical Neurology
Ozgun Ozalay, Cem Calli, Omer Kitis, M. Cagdas Eker, Ozlem Donat Eker, Erol Ozan, Kerry Coburn, Ali Saffet Gonul
JOURNAL OF AFFECTIVE DISORDERS
(2013)
Article
Neurosciences
Sonja M. C. de Zwarte, Rachel M. Brouwer, Ingrid Agartz, Martin Alda, Andre Aleman, Kathryn I. Alpert, Carrie E. Bearden, Alessandro Bertolino, Catherine Bois, Aurora Bonvino, Elvira Bramon, Elizabeth E. L. Buimer, Wiepke Cahn, Dara M. Cannon, Tyrone D. Cannon, Xavier Caseras, Josefina Castro-Fornieles, Qiang Chen, Yoonho Chung, Elena De la Serna, Annabella Di Giorgio, Gaelle E. Doucet, Mehmet Cagdas Eker, Susanne Erk, Scott C. Fears, Sonya F. Foley, Sophia Frangou, Andrew Frankland, Janice M. Fullerton, David C. Glahn, Vina M. Goghari, Aaron L. Goldman, Ali Saffet Gonul, Oliver Gruber, Lieuwe de Haan, Tomas Hajek, Emma L. Hawkins, Andreas Heinz, Manon H. J. Hillegers, Hilleke E. Hulshoff Pol, Christina M. Hultman, Martin Ingvar, Viktoria Johansson, Erik G. Jonsson, Fergus Kane, Matthew J. Kempton, Marinka M. G. Koenis, Miloslav Kopecek, Lydia Krabbendam, Bernd Kraemer, Stephen M. Lawrie, Rhoshel K. Lenroot, Machteld Marcelis, Jan-Bernard C. Marsman, Venkata S. Mattay, Colm McDonald, Andreas Meyer-Lindenberg, Stijn Michielse, Philip B. Mitchell, Dolores Moreno, Robin M. Murray, Benson Mwangi, Pablo Najt, Emma Neilson, Jason Newport, Jim van Os, Bronwyn Overs, Aysegul Ozerdem, Marco M. Picchioni, Anja Richter, Gloria Roberts, Aybala Saricicek Aydogan, Peter R. Schofield, Fatma Simsek, Jair C. Soares, Gisela Sugranyes, Timothea Toulopoulou, Giulia Tronchin, Henrik Walter, Lei Wang, Daniel R. Weinberger, Heather C. Whalley, Nefize Yalin, Ole A. Andreassen, Christopher R. K. Ching, Theo G. M. van Erp, Jessica A. Turner, Neda Jahanshad, Paul M. Thompson, Rene S. Kahn, Neeltje E. M. van Haren
BIOLOGICAL PSYCHIATRY
(2019)
Article
Neurosciences
Sonja M. C. de Zwarte, Rachel M. Brouwer, Ingrid Agartz, Martin Alda, Silvia Alonso-Lana, Carrie E. Bearden, Alessandro Bertolino, Aurora Bonvino, Elvira Bramon, Elizabeth E. L. Buimer, Wiepke Cahn, Erick J. Canales-Rodriguez, Dara M. Cannon, Tyrone D. Cannon, Xavier Caseras, Josefina Castro-Fornieles, Qiang Chen, Yoonho Chung, Elena de la Serna, Caterina del Mar Bonnin, Caroline Demro, Annabella Di Giorgio, Gaelle E. Doucet, Mehmet Cagdas Eker, Susanne Erk, Mar Fatjo-Vilas, Scott C. Fears, Sonya F. Foley, Sophia Frangou, Janice M. Fullerton, David C. Glahn, Vina M. Goghari, Jose M. Goikolea, Aaron L. Goldman, Ali Saffet Gonul, Oliver Gruber, Tomas Hajek, Emma L. Hawkins, Andreas Heinz, Ceren Hidiroglu Ongun, Manon H. J. Hillegers, Josselin Houenou, Hilleke E. Hulshoff Pol, Christina M. Hultman, Martin Ingvar, Viktoria Johansson, Erik G. Jonsson, Fergus Kane, Matthew J. Kempton, Marinka M. G. Koenis, Miloslav Kopecek, Bernd Kraemer, Stephen M. Lawrie, Rhoshel K. Lenroot, Machteld Marcelis, Venkata S. Mattay, Colm McDonald, Andreas Meyer-Lindenberg, Stijn Michielse, Philip B. Mitchell, Dolores Moreno, Robin M. Murray, Benson Mwangi, Leila Nabulsi, Jason Newport, Cheryl A. Olman, Jim van Os, Bronwyn J. Overs, Aysegul Ozerdem, Giulio Pergola, Marco M. Picchioni, Camille Piguet, Edith Pomarol-Clotet, Joaquim Radua, Ian S. Ramsay, Anja Richter, Gloria Roberts, Raymond Salvador, Aybala Saricicek Aydogan, Salvador Sarro, Peter R. Schofield, Esma M. Simsek, Fatma Simsek, Jair C. Soares, Scott R. Sponheim, Gisela Sugranyes, Timothea Toulopoulou, Giulia Tronchin, Eduard Vieta, Henrik Walter, Daniel R. Weinberger, Heather C. Whalley, Mon-Ju Wu, Nefize Yalin, Ole A. Andreassen, Christopher R. K. Ching, Sophia I. Thomopoulos, Theo G. M. van Erp, Neda Jahanshad, Paul M. Thompson, Rene S. Kahn, Neeltje E. M. van Haren
Summary: First-degree relatives of patients diagnosed with schizophrenia show widespread thinner cortex, while relatives of patients diagnosed with bipolar disorder show widespread larger cortical surface area. Both groups have lower IQ scores compared to controls, with schizophrenia relatives showing more pronounced brain abnormalities and bipolar disorder relatives showing weaker effects after adjusting for IQ or educational attainment.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Hande Yildirim-Celik, Seda Eroglu, Kaya Oguz, Gulser Karakoc-Tugrul, Yigit Erdogan, Damla Isman-Haznedaroglu, Cagdas Eker, Ali Saffet Gonul
Summary: The study found that emotional contextual features play a role in facial emotion recognition, but this effect is not related to depression. Depressive patients have slower reaction times in recognizing facial emotions, possibly due to cognitive impairments.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Kaan Keskin, Mehmet Cagdas Eker, Ali Saffet Gonul, Georg Northoff
Summary: This study aims to investigate the relationship between self-focus and emotion regulation in major depressive disorder (MDD) by examining the global brain activity in specific regions associated with the self. The results show that MDD patients exhibit abnormal emotion regulation, especially in the regulation of negative emotions. Additionally, there is increased global brain activity in regions related to the mental and exteroceptive self in MDD patients. These findings support the hypothesis that increased self-focus in MDD contributes to abnormal regulation of negative emotions.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Neurosciences
Hilal Subasi, Damla Isman-Haznedaroglu, Seda Eroglu, Yigit Erdogan, Mehmet Cagdas Eker, Ali Saffet Gonul
Summary: This study presents a case of psychiatric symptoms following flow diverter stent placement. The patient underwent cranial MRI, MRA, CTA, neuropsychological tests, LSRP, and WURS-25. Results showed personality changes and psychiatric symptoms occurred after the stent placement and persisted for two and a half years.
Article
Neurosciences
Burcu Ozkul, Cemre Candemir, Kaya Oguz, Seda Eroglu-Koc, Gozde Kizilates-Evin, Onur Ugurlu, Yigit Erdogan, Defne Dakota Mull, Mehmet Cagdas Eker, Omer Kitis, Ali Saffet Gonul
Summary: Group support plays a role in brain functioning, and the loss of social group support leads to reduced brain activity. Being part of a social group and receiving support enhances cognitive functioning, while the loss of group support activates brain regions associated with attention and survival.
Article
Psychiatry
Melek Hande Bulut Demir, Rahime Kaya, Ozgun Ozalay, Damla Isman Haznedaroglu, Yigit Erdogan, Omer Kitis, Tezan Bildik, Ali Saffet Gonul, Mehmet Cagdas Eker
Summary: The objective of this study was to explore the effects of sexual abuse on limbic and prefrontal cortex structures in adolescents. The findings showed that children with a history of sexual abuse had thinner prefrontal cortex, larger amygdala and hippocampus, and aberrations in threat detection, orientation, and response circuit. These adaptations may be beneficial in a dangerous environment in the short term.
SCANDINAVIAN JOURNAL OF CHILD AND ADOLESCENT PSYCHIATRY AND PSYCHOLOGY
(2023)
Article
Clinical Neurology
Nazan Dolapoglu, Banu Pinar Sarer Yurekli, Mehmet Cagdas Eker, Hayriye Elbi
Summary: The study showed a significantly higher frequency of metabolic syndrome in euthymic bipolar patients compared to the control group, although there was no significant difference in serum AgRP levels between the patient and control groups. Furthermore, there was no significant difference in serum AgRP levels between bipolar patients with metabolic syndrome and those without in both study groups.
NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
(2021)
Proceedings Paper
Engineering, Biomedical
Ozkan Cigdem, Refik Soyak, Burhan Aydeniz, Kaya Oguz, Hasan Demirel, Omer Kitis, Cagdas Eker, Ali Saffet Gonul, Devrim Unay
2019 MEDICAL TECHNOLOGIES CONGRESS (TIPTEKNO)
(2019)
Meeting Abstract
Neurosciences
Sonja de Zwarte, Rachel Brouwer, Manon Hillegers, Wiepke Cahn, Hilleke Hulshoff Pol, Rene Kahn, Kathryn Alpert, Lei Wang, Elvira Bramon, Fergus Kane, Robin Murray, Tomas Hajek, Martin Alda, Gloria Roberts, Philip Mitchell, Peter Schofield, Janice Fullerton, Anja Richter, Oliver Gruber, Aurora Bonvino, Alessandro Bertolino, Annabella Di Giorgio, Xavier Caseras, Ali Saffet Gonul, Mehmet Cagdas Eker, Fatma Simsek, Scott Fears, Carrie Bearden, David Glahn, Theo van Erp, Paul Thompson, Ole Andreassen, Jessica Turner, Neeltje van Haren
BIOLOGICAL PSYCHIATRY
(2017)