期刊
BIPOLAR DISORDERS
卷 14, 期 3, 页码 271-282出版社
WILEY
DOI: 10.1111/j.1399-5618.2012.01009.x
关键词
bipolar disorder; clinical classifications; depression; epidemiology
资金
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
- NIAAA, National Institutes of Health (NIH)
- NIH [DA019606, DA020783, DA023200, MH076051, R01AA08159, R01DA018652, K05AA00161, MH 57910, MH 62185]
- Alicia Koplowitz Foundation
- American Foundation for Suicide Prevention
- New York State Psychiatric Institute
- CIBER de Salud Mental, Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III [CIBER07/09, CIBERSAM]
- Fundacion Alicia Koplowitz
- Centro de Investigacion Biomedica en Red de Salud Mental (CIBERSAM)
- AstraZeneca
- Bristol-Myers Squibb
- Caja Navarra
- Comunidad de Madrid
- Fundacion Mutua Madrilena
- Instituto de Salud Carlos III
- CIBERSAM
- NARSAD
- Spanish Ministry of Education
- Spanish Ministry of Science and Innovation
- Spanish Ministry of Health
- Stanley Foundation
- Eli Lilly Co
- Janssen
- Almirall
- European 7th Framework Program
- GlaxoSmithKline
- Janssen-Cilag
- Novartis
- Organon
- Otsuka
- Pfizer
- Sanofi-aventis
- Seny Foundation
- Servier
- Spanish Ministry of Health, the Spanish Ministry of Science and Innovation (CIBERSAM)
- Stanley Medical Research Institute
Moreno C, Hasin DS, Arango C, Oquendo MA, Vieta E, Liu S, Grant BF, Blanco C. Depression in bipolar disorder versus major depressive disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Bipolar Disord 2012: 14: 271282. (C) 2012 The Authors. Journal compilation (C) 2012 John Wiley & Sons A/S. Objectives: To compare the clinical features and course of major depressive episodes (MDEs) occurring in subjects with bipolar I disorder (BD-I), bipolar II disorder (BD-II), and major depressive disorder (MDD). Methods: Data were drawn from the National Epidemiologic Survey on Alcohol and Related Conditions (2001-2002), a nationally representative face-to-face survey of more than 43000 adults in the USA, including 5695 subjects with lifetime MDD, 935 with BD-I and lifetime MDE, and 494 with BD-II and lifetime MDE. Differences on sociodemographic characteristics and clinical features, course, and treatment patterns of MDE were analyzed. Results: Most depressive symptoms, family psychiatric history, anxiety disorders, alcohol and drug use disorders, and personality disorders were more frequentand number of depressive symptoms per MDE was higheramong subjects with BD-I, followed by BD-II, and MDD. BD-I individuals experienced a higher number of lifetime MDEs, had a poorer quality of life, and received significantly more treatment for MDE than BD-II and MDD subjects. Individuals with BD-I and BD-II experienced their first mood episode about ten years earlier than those with MDD (21.2, 20.5, and 30.4 years, respectively). Conclusions: Our results support the existence of a spectrum of severity of MDE, with highest severity for BD-I, followed by BD-II and MDD, suggesting the utility of dimensional assessments in current categorical classifications.
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