Article
Psychiatry
Ching-Fang Sun, Zeeshan Mansuri, Chintan Trivedi, Ramu Vadukapuram, Abhishek Reddy
Summary: The study aimed to evaluate the prevalence of demographic characteristics and psychiatric disorders in adolescents with and without homicidal ideation (HI). The results showed a higher prevalence of psychiatric illnesses such as depression, anxiety, and bipolar disorder in adolescents with HI in the inpatient setting. White and black races were more prevalent in patients with homicidal ideation.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Psychiatry
Steven L. Dubovsky, Biswarup M. Ghosh, Jordan C. Serotte, Victoria Cranwell
Summary: Psychotic depression is considered an independent trait that may accompany mood disorders of varying severity, with acute treatment typically involving a combination of antidepressants, antipsychotic drugs, or electroconvulsive therapy. Limited information exists on maintenance treatment for unipolar psychotic depression and on acute and chronic treatment for psychotic bipolar disorder, leading to a reliance on clinical experience for treatment decision-making.
PSYCHOTHERAPY AND PSYCHOSOMATICS
(2021)
Article
Clinical Neurology
Raphael O. Cerqueira, Carolina Ziebold, Daniel Cavalcante, Giovany Oliveira, Javiera Vasquez, Juan Undurraga, Alfonso Gonzalez-Valderrama, Ruben Nachar, Carlos Lopez-Jaramillo, Cristiano Noto, Nicolas Crossley, Ary Gadelha
Summary: This study compares patients with affective and non-affective psychosis (A-FEP and NA-FEP) in a Latin American sample. The findings suggest that characteristics of FEP patients could be utilized to enhance diagnosis and inform treatment decisions.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Psychiatry
Lauro Estivalete Marchionatti, Thyago Antonelli-Salgado, Isadora Nunes Erthal, Savio Luiz Santos Lopes, Luiza Silveira Lucas, Diego Barreto Reboucas, Ives Cavalcante Passos
Summary: This systematic review on the impact of disease progression in the treatment of bipolar disorder patients found that efficacy decreases with clinical progression, supporting early intervention. However, tailored recommendations cannot be made based on disease stages currently, highlighting the need for further research.
PSYCHIATRY RESEARCH
(2022)
Article
Psychology, Clinical
Igor Nenadic, Tina Meller, Simon Schmitt, Frederike Stein, Katharina Brosch, Johannes Mosebach, Ulrich Ettinger, Phillip Grant, Susanne Meinert, Nils Opel, Hannah Lemke, Stella Fingas, Katharina Foerster, Tim Hahn, Andreas Jansen, Till F. M. Andlauer, Andreas J. Forstner, Stefanie Heilmann-Heimbach, Alisha S. M. Hall, Swapnil Awasthi, Stephan Ripke, Stephanie H. Witt, Marcella Rietschel, Bertram Mueller-Myhsok, Markus M. Noethen, Udo Dannlowski, Axel Krug, Fabian Streit, Tilo Kircher
Summary: This study found that schizotypy may share less genetic risk with schizophrenia and is not significantly associated with the genetic risk of affective disorders.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Clinical Neurology
Samantha N. Sherwood, Gabrielle A. Carlson, Andrew J. Freeman
Summary: The diagnosis of bipolar disorder among youth in the United States increased significantly between the mid-1990s and mid-2000s. However, from the mid-2000s to 2010, there was a decrease in BD diagnosis rates for children, while rates continued to increase for adolescents. Population-adjusted rates initially increased until the mid-2000s and then decreased until 2010 for both children and adolescents.
Article
Psychiatry
John de Back Jr, Erin P. Vaughan, Emily C. Kemp, Paul J. Frick, Emily L. Robertson, Toni M. Walker, Paige Picou
Summary: Due to the need for early identification of bipolar spectrum disorders, the newly developed Mood Disorder Assessment Schedule (MDAS) was tested in a sample of 396 inpatient adolescents. The MDAS showed stronger clinical utility than the standard diagnostic interview in identifying individuals at risk for bipolar spectrum disorders. This promising diagnostic tool may facilitate earlier diagnosis and prevent harmful effects of improper treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychology, Clinical
Victoria Rodriguez, Luis Alameda, Diego Quattrone, Giada Tripoli, Charlotte Gayer-Anderson, Edoardo Spinazzola, Giulia Trotta, Hannah E. Jongsma, Simona Stilo, Caterina La Cascia, Laura Ferraro, Daniele La Barbera, Antonio Lasalvia, Sarah Tosato, Ilaria Tarricone, Elena Bonora, Stephane Jamain, Jean-Paul Selten, Eva Velthorst, Lieuwe de Haan, Pierre-Michel Llorca, Manuel Arrojo, Julio Bobes, Miguel Bernardo, Celso Arango, James Kirkbride, Peter B. Jones, Bart P. Rutten, Alexander Richards, Pak C. Sham, Michael O'Donovan, Jim Van Os, Craig Morgan, Marta Di Forti, Robin M. Murray, Evangelos Vassos
Summary: This study suggests that combining polygenic risk scores (PRS) for severe psychiatric disorders with prediction models for psychosis phenotypes can improve discrimination ability and enhance our understanding of these phenotypes. PRS may have potential usefulness in specific populations such as those at high risk or in the early stages of psychosis.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Psychiatry
Mark L. Vickers, Yoon Kwon Choi, Lars Eriksson, Yekaterina Polyakova-Nelson, Zorica Jokovic, Stephen D. Parker, Vikas Moudgil, Judith A. Dean, Joseph Debattista, James G. Scott
Summary: Research and clinical practice addressing sexual and reproductive health in young people with psychosis, including issues such as pregnancy, sexual violence, and gender, are crucial.
SCHIZOPHRENIA BULLETIN
(2023)
Review
Psychiatry
Nina Vindegaard, Helene Speyer, Merete Nordentoft, Simon Rasmussen, Michael Eriksen Benros
Summary: This review article explores alterations in gut microbiota of patients with psychotic disorders, bipolar disorder or depression compared to healthy controls. The findings suggest specific changes in microbiota composition in these patients, but caution is advised due to biases and methodological variability in the included studies. Larger studies are needed to further investigate the relationship between gut microbiota and mental disorders, while also considering various factors that may influence the results.
SCHIZOPHRENIA RESEARCH
(2021)
Article
Clinical Neurology
Danielle A. Goldman, Anjali Sankar, Alexandra Rich, Jihoon A. Kim, Brian Pittman, R. Todd Constable, Dustin Scheinost, Hilary P. Blumberg
Summary: This study aimed to identify functional connectivity differences between depressions of bipolar disorder (BD-Dep) and depressions of major depressive disorder (MDD-Dep). The results showed that there were significant differences in functional connectivity patterns between these two groups, suggesting the potential for early diagnosis and treatment strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Clinical Neurology
Gin S. Malhi, Maedeh Jadidi, Erica Bell
Summary: This article examines the ongoing debate on the diagnosis of bipolar disorder in children and adolescents. The lack of consensus in the field has hindered progress in understanding the true prevalence of pediatric bipolar disorder. The article proposes a solution to break this deadlock.
Article
Multidisciplinary Sciences
Monica Aas, Ole A. Andreassen, Johannes Gjerstad, Linn Rodevand, Gabriela Hjell, Ingrid Torp Johansen, Synve Hoffart Lunding, Monica B. E. G. Ormerod, Trine V. Lagerverg, Nils Eiel Steen, Srdjan Djurovic, Ibrahim Akkouh
Summary: Exposure to early life trauma increases the risk of psychopathology, and ANK3 mRNA levels have been found to moderate the association between childhood trauma and affective traits in mental disorders.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Lorenza Lucidi, Mauro Pettorruso, Federica Vellante, Francesco Di Carlo, Franca Ceci, Maria Chiara Santovito, Ilenia Di Muzio, Michele Fornaro, Antonio Ventriglio, Carmine Tomasetti, Alessandro Valchera, Alessandro Gentile, Yong-Ku Kim, Giovanni Martinotti, Silvia Fraticelli, Massimo Di Giannantonio, Domenico De Berardis
Summary: The gut microbiota plays a crucial role in maintaining homeostasis, growth, and digestive processes. It also influences the intercommunication system between the gut and the brain, potentially impacting the pathogenesis and clinical management of Bipolar Disorder. Current literature suggests a relationship between compositional alterations in the gut microbiota and BD, with potential benefits in treating BD symptoms through modifications in the microbiota composition. Further research is needed to explore the potential of correcting gut microbiota alterations as a novel strategy in BD management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Nicole R. Wong, Kayla E. Carta, Marc J. Weintraub, David J. Miklowitz
Summary: Family-focused therapy (FFT) is associated with longer intervals between mood episodes and reductions in suicidal ideation among adolescents at risk for bipolar disorders. Therapeutic alliance between adolescents/parents and their therapists is correlated with symptomatic outcomes of adolescents over 18 weeks. Enhancing adolescents' engagement in therapy may strengthen the long-term effects of family interventions.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Psychology, Developmental
Melissa H. Black, Melissa Scott, Elliot Baker-Young, Craig Thompson, Sarah McGarry, Maya Hayden-Evans, Zelma Snyman, Frank Zimmermann, Viktor Kacic, Torbjorn Falkmer, Marcel Romanos, Sven Boelte, Sonya Girdler, Benjamin Milbourn
Summary: Suicide among post-secondary students is a significant public health concern. While there have been studies on suicide prevention programs, the effective elements of these interventions are still unknown. This study reviewed the literature and identified potential effective elements of suicide prevention programs for post-secondary students. Gatekeeper training programs were found to be the most common type of intervention. These programs have the potential to improve students' engagement with mental health services, knowledge, help-seeking attitudes and behaviors, and gatekeeper-related outcomes.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Behavioral Sciences
Patrick D. Quinn, David Lopez Perez, Daniel P. Kennedy, Sven Bolte, Brian D'Onofrio, Paul Lichtenstein, Terje Falck-Ytter
Summary: This study examines the contributions of genes and environments to visual search performance and its relationship with general intelligence. The findings suggest that visual search performance is moderately heritable, but only a small portion of its genetic variance is shared with intelligence.
GENES BRAIN AND BEHAVIOR
(2022)
Article
Psychology, Developmental
John Hasslinger, Ulf Jonsson, Sven Bolte
Summary: This study evaluated the effects of neurocognitive training methods on targeted cognitive functions in children and adolescents with ADHD. The results showed that working-memory training had superior effects on spatial and verbal working-memory compared to neurofeedback and treatment as usual, with only partial sustainability during follow-up. No other consistent effects were observed.
JOURNAL OF ATTENTION DISORDERS
(2022)
Editorial Material
Psychology, Clinical
Pei-Yin Pan, Samuele Cortese, Sven Bolte
PSYCHOLOGICAL MEDICINE
(2023)
Article
Rehabilitation
Hampus Bejno, Lise Roll-Pettersson, Lars Klintwall, Ulrika Langh, Samuel L. Odom, Sven Bolte
Summary: This pre-registered study aimed to evaluate the Swedish Autism Program Environment Rating Scale (APERS-P-SE) as a means to promote the quality of the pre-school learning environment for children on the autism spectrum. The results showed that APERS-P-SE assessment can significantly improve the quality of the learning environment, but the impact on children and pre-school staff was not significant.
SCANDINAVIAN JOURNAL OF OCCUPATIONAL THERAPY
(2023)
Review
Psychology, Developmental
Matthew Jones, Marita Falkmer, Ben Milbourn, Tele Tan, Sven Bolte, Sonya Girdler
Summary: This study identified three core elements of strength-based technology programs for youth with ASD through a systematic review of the literature: mutual respect, demonstrating skills, and interests.
REVIEW JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Rehabilitation
Emily D'Arcy, Kiah Evans, Bahareh Afsharnejad, Benjamin Milbourn, Sven Bolte, Sonya Girdler
Summary: This study investigated the assessment of functioning practices and barriers to using best practice in the disability sector in Australia. The results revealed a lack of clear transdisciplinary conceptualisation of functioning in current practice, with limited time, large caseloads, availability of appropriate tools, and lack of clarity from funding bodies being the main barriers.
AUSTRALIAN OCCUPATIONAL THERAPY JOURNAL
(2023)
Review
Behavioral Sciences
Jan Buitelaar, Sven Bolte, Daniel Brandeis, Arthur Caye, Nina Christmann, Samuele Cortese, David Coghill, Stephen V. Faraone, Barbara Franke, Markus Gleitz, Corina U. Greven, Sandra Kooij, Douglas Teixeira Leffa, Nanda Rommelse, Jeffrey H. Newcorn, Guilherme V. Polanczyk, Luis Augusto Rohde, Emily Simonoff, Mark Stein, Benedetto Vitiello, Yanki Yazgan, Michael Roesler, Manfred Doepfner, Tobias Banaschewski
Summary: ADHD is a complex neurodevelopmental condition with no curative treatments available. Pharmacological treatments are generally effective and safe, but there is significant variability among patients in terms of treatment response and tolerability. There is currently a lack of evidence-based decision tools for allocating treatments based on patient characteristics. Further research is needed to identify biomarkers that can predict treatment response.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Review
Clinical Neurology
Sven Bolte, Janina Neufeld, Peter B. Marschik, Zachary J. Williams, Louise Gallagher, Meng-Chuan Lai
Summary: There are qualitative and quantitative differences in health conditions between individuals of different birth-assigned sexes, gender identities, and gender experiences, which require personalized care. It is important to study the moderating and mediating effects of sex and gender factors on impairment, disability, wellbeing, and health, especially for neurodivergent individuals. Researchers have started to investigate the mechanisms through which sex and gender variables affect the manifestations of neurodevelopmental conditions.
NATURE REVIEWS NEUROLOGY
(2023)
Article
Biology
Irzam Hardiansyah, Par Nystroem, Mark J. J. Taylor, Sven Bolte, Angelica Ronald, Terje Falck-Ytter
Summary: This study finds that a distinct organization of global motion processing is associated with autistic symptoms in toddlerhood, based on EEG data from nearly 500 five month old infants.
COMMUNICATIONS BIOLOGY
(2023)
Article
Psychology, Developmental
Maria Loethberg, Tatja Hirvikoski, Sonya Girdler, Sven Boelte, Ulf Jonsson
Summary: In Sweden, housing support is provided to people with neurodevelopmental conditions, primarily autism or ADHD, who require daily living support. This study aimed to explore support workers' perspectives on current practice in housing support for young adults with neurodevelopmental conditions. The interviews highlighted the complexity of the service and the need for more knowledge about neurodevelopmental conditions. The results raise important questions about how housing support should be organized and delivered to meet specific needs and ensure equal services across municipalities.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Psychology, Developmental
Hanna Agius, Anne-Kristina Luoto, Anna Backman, Carina Eriksdotter, Nitya Jayaram-Lindstrom, Sven Bolte, Tatja Hirvikoski
Summary: Autistic adults face high stress levels and struggle to cope with stressors. Mindfulness-based stress reduction shows promise as it helps individuals utilize their own resources to regulate stress responses. A feasibility study was conducted to determine the effectiveness of mindfulness-based stress reduction in autistic adults. The results showed that participants found the intervention logical and beneficial, with reduced stress symptoms and improved stress-coping skills.
Article
Psychiatry
Simone Zuffa, Patrick Schimmel, Ayoze Gonzalez-Santana, Clara Belzer, Jan Knol, Sven Bolte, Terje Falck-Ytter, Hans Forssberg, Jonathan Swann, Rochellys Diaz Heijtz
Summary: Evidence suggests that the microbiota-gut-brain axis is involved in the neurobiology of Autism Spectrum Disorder (ASD). This study examined the development of the fecal microbiota and metabolome in infants with and without a family history of ASD. It was found that infants at elevated-likelihood of ASD had a different microbial composition, with lower levels of Bifidobacterium and higher levels of Clostridium and Klebsiella species compared to low-likelihood infants. The study also revealed a correlation between certain microbes and gamma-aminobutyric acid (GABA) levels, which may have implications for behavioral variability later in life.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychology, Developmental
Maja Rudling, Par Nystrom, Giorgia Bussu, Sven Bolte, Terje Falck-Ytter
Summary: Direct gaze is an important communicative signal, but attenuated responses to it do not reliably differentiate infants with or without subsequent autism. Although infants with elevated likelihood of autism and subsequent diagnosis tend to look away quicker, this measure does not differentiate between the two elevated likelihood groups.
Article
Psychology, Educational
Linda Plantin Ewe, Mona Holmqvist, Sven Bolte
Summary: This study examines the impact of teachers' professional development of their relational competence with students with ADHD and/or ASD on teachers' and students' perceptions of their teacher-student relationships. The findings suggest that enhancing teachers' understanding of relational competence concerning students with neurodiversity will improve both their own perceptions and those of neurodiverse female students. However, directing teachers' focus towards one student group (ND students) risks diminishing teachers' attention towards other student groups, potentially explaining the poorer follow-up results among neurotypical boys.
EMOTIONAL AND BEHAVIOURAL DIFFICULTIES
(2023)