Perfusion seed cultures improve biopharmaceutical fed-batch production capacity and product quality

Case Study: An accelerated 8-day monoclonal antibody production process based on high seeding densities

(2013) Ishai Padawer et al.   BIOTECHNOLOGY PROGRESS

Effects of bubble-liquid two-phase turbulent hydrodynamics on cell damage in sparged bioreactor

(2013) Yang Liu et al.   BIOTECHNOLOGY PROGRESS

Controlling trisulfide modification in recombinant monoclonal antibody produced in fed-batch cell culture

(2012) Rashmi Kshirsagar et al.   BIOTECHNOLOGY AND BIOENGINEERING

Integrated continuous production of recombinant therapeutic proteins

(2012) Veena Warikoo et al.   BIOTECHNOLOGY AND BIOENGINEERING

Optimizing capacity utilization by large scale 3000 L perfusion in seed train bioreactors

(2012) Michael Pohlscheidt et al.   BIOTECHNOLOGY PROGRESS

CHO cells in biotechnology for production of recombinant proteins: current state and further potential

(2011) Jee Yon Kim et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Insights into large-scale cell-culture reactors: II. Gas-phase mixing and CO2 stripping

(2011) Christian Sieblist et al.   Biotechnology Journal

Acceptable changes in quality attributes of glycosylated biopharmaceuticals

(2011) Martin Schiestl et al.   NATURE BIOTECHNOLOGY

Process analysis of reduced specific productivity of TNFR-Fc in Chinese hamster ovary cells at high cell density

(2011) Tian-Ci Kou et al.   PROCESS BIOCHEMISTRY

Methods in mammalian cell line engineering: from random mutagenesis to sequence-specific approaches

(2010) Oliver Krämer et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment

(2010) Yao-Ming Huang et al.   BIOTECHNOLOGY PROGRESS

Cell culture processes for monoclonal antibody production

(2010) Feng Li et al.   mAbs

Charge variants in IgG1

(2010) Leslie A. Khawli et al.   mAbs

Protein folding and conformational stress in microbial cells producing recombinant proteins: a host comparative overview

(2008) Brigitte Gasser et al.   Microbial Cell Factories

Enhanced Production of Monomeric Interferon-β by CHO Cells through the Control of Culture Conditions

(2005) J. Rodriguez et al.   BIOTECHNOLOGY PROGRESS

Effects of Elevated pCO2 and Osmolality on Growth of CHO Cells and Production of Antibody-Fusion Protein B1: A Case Study

(2005) Marie M. Zhu et al.   BIOTECHNOLOGY PROGRESS